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1. Full Text Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
by Richter, Julia and Schlesner, Matthias and Hoffmann, Steve and Kreuz, Markus and Leich, Ellen and Burkhardt, Birgit and Rosolowski, MacIej and Ammerpohl, Ole and Wagener, Rabea and Bernhart, Stephan H and Lenze, Dido and Szczepanowski, Monika and Paulsen, Maren and Lipinski, Simone and Russell, Robert B and Adam-Klages, Sabine and Apic, Gordana and Claviez, Alexander and Hasenclever, Dirk and Hovestadt, Volker and Hornig, Nadine and Korbel, Jan O and Kube, Dieter and Langenberger, David and Lawerenz, Chris and Lisfeld, Jasmin and Meyer, Katharina and Picelli, Simone and Pischimarov, Jordan and Radlwimmer, Bernhard and Rausch, Tobias and Rohde, Marius and Schilhabel, Markus and Scholtysik, René and Spang, Rainer and Trautmann, Heiko and Zenz, Thorsten and Borkhardt, Arndt and Drexler, Hans G and Möller, Peter and MacLeod, Roderick A. F and Pott, Christiane and Schreiber, Stefan and Trümper, Lorenz and Loeffler, Markus and Stadler, Peter F and Lichter, Peter and Eils, Roland and Küppers, Ralf and Hummel, Michael and Klapper, Wolfram and Rosenstiel, Philip and Rosenwald, Andreas and Brors, Benedikt and Siebert, Reiner and ICGC MMML-Seq Project and the ICGC MMML-Seq Project
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1316 - 1320
Burkitt lymphoma is a mature aggressive B-cell lymphoma derived from germinal center B cells(1). Its cytogenetic hallmark is the Burkitt translocation... 
INACTIVATION | DIAGNOSIS | B-CELL LYMPHOMA | MYC | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | MICE | PROTEINS | CANCER | Chromosomes, Human, Pair 8 - genetics | Somatic Hypermutation, Immunoglobulin | Humans | Inhibitor of Differentiation Proteins - genetics | Molecular Sequence Data | Male | Chromosome Mapping | Transcriptome - genetics | Sequence Analysis, DNA | Genes, Immunoglobulin | Base Sequence | Genes, myc - genetics | Burkitt Lymphoma - genetics | Female | Mutation | Genome, Human | Neoplasm Proteins - genetics | Chromosomes, Human, Pair 14 - genetics | Cohort Studies | Translocation, Genetic - genetics | Usage | Prognosis | Gene mutations | Exome sequencing | Development and progression | Diagnosis | Research | Health aspects | Risk factors | Burkitt's lymphoma | Proteins | Awards & honors | DNA methylation | Lymphomas | Genomes
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2. Full Text An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
by Boldt, K and Reeuwijk, J. van and Lu, Q and Koutroumpas, K and Nguyen, T.T.M and Texier, Y and Beersum, S.E.C. van and Horn, N and Willer, J.R and Mans, D.A and Dougherty, G and Lamers, I.J and Coene, K.L.M and Arts, H.H and Betts, M.J and Beyer, T and Bolat, E and Gloeckner, C.J and Haidari, K and Hetterschijt, E.C and Iaconis, D and Jenkins, D and Klose, F and Knapp, B and Latour, B.L and Letteboer, S.J.F and Marcelis, C.L.M and Mitic, D and Morleo, M and Oud, M.M and Riemersma, M and Rix, S and Terhal, P.A and Toedt, G and Dam, T.J.P. van and Vrieze, E. de and Wissinger, Y and Wu, K.M and Apic, G and Beales, P.L and Blacque, O.E and Gibson, T.J and Huynen, M.A and Katsanis, N and Kremer, H and Omran, H and WIjk, E. van and Wolfrum, U and Kepes, F and Davis, E.E and Franco, B and Giles, R.H and Ueffing, M and Russell, R.B and Roepman, R and UK10K Rare Dis Grp and UK10K Rare Diseases Group
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 11491
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate... 
NETWORK REVEALS | CELLS | COMPLEX | TANDEM AFFINITY PURIFICATION | MICROTUBULE | MULTIDISCIPLINARY SCIENCES | CILIOGENESIS | MUTATIONS | INTRAFLAGELLAR TRANSPORT | STATISTICAL-MODEL | PRIMARY CILIA | Humans | Proteins - isolation & purification | Protein Interaction Maps | Spine - abnormalities | Ciliopathies - genetics | Muscle Hypotonia - therapy | DNA Mutational Analysis | Systems Analysis | Mass Spectrometry | HEK293 Cells | Fibroblasts | Dwarfism - pathology | Proteomics - methods | Spine - pathology | Chromatography, Affinity - methods | Molecular Targeted Therapy - methods | Ciliopathies - therapy | Datasets as Topic | Muscle Hypotonia - genetics | Cilia - metabolism | Proteins - genetics | Dwarfism - genetics | Muscle Hypotonia - pathology | Protein Interaction Mapping - methods | Dwarfism - therapy | Proteins - metabolism | Biological Transport - physiology | Ciliopathies - pathology
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3. Full Text Quantified Constraint Satisfaction Problem on Semicomplete Digraphs
by apić, Petar and Marković, Petar and Martin, Barnaby
ACM Transactions on Computational Logic (TOCL), ISSN 1529-3785, 04/2017, Volume 18, Issue 1, pp. 1 - 47
We study the (non-uniform) quantified constraint satisfaction problem QCSP( H ) as H ranges over semicomplete digraphs. We obtain a complexity-theoretic... 
complexity | polymorphism | semicomplete digraphs | Quantified constraints | Design | Algorithms | Semicomplete digraphs | F.2.2 [analysis of algorithms and problem complexity]: nonnumerical algorithms and problems | G.2.1 [discrete mathematics]: combinatorics | F.4.1 [mathematical logic and formal languages]: mathematical logic | Performance | Complexity | Polymorphism | COMPUTER SCIENCE, THEORY & METHODS | LOGIC
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4. Full Text Domain combinations in archaeal, eubacterial and eukaryotic proteomes
by Apic, Gordana and Gough, Julian and Teichmann, Sarah A
Journal of Molecular Biology, ISSN 0022-2836, 2001, Volume 310, Issue 2, pp. 311 - 325
There is a limited repertoire of domain families that are duplicated and combined in different ways to form the set of proteins in a genome. Proteins are gene... 
structural genomics | domain combinations | recombination | gene duplication | Recombination | Gene duplication | Structural genomics | Domain combinations | SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | NETWORKS | HIDDEN MARKOV-MODELS | CAENORHABDITIS-ELEGANS | EVOLUTION | FAMILIES | COMPREHENSIVE STRUCTURAL CENSUS | SUPERFAMILY PROTEINS | COMPLETE GENOME | Gene Duplication | Eukaryotic Cells - chemistry | Conserved Sequence - genetics | Proteome - genetics | Genomics | Humans | Archaea - chemistry | Eukaryotic Cells - metabolism | Phylogeny | Proteome - chemistry | Eubacterium - chemistry | Recombination, Genetic - genetics | Tandem Repeat Sequences - genetics | Multigene Family - genetics | Protein Structure, Tertiary | Repetitive Sequences, Amino Acid - genetics | Proteome - classification | Yeasts - chemistry | Mutation - genetics | Databases as Topic | Yeasts - genetics | Animals | Eubacterium - genetics | Archaea - genetics | Genome | Evolution, Molecular | proteomes
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5. Full Text Differentiation of human pluripotent stem cells (hPSC) into neurons: A fast, reproducible and inducible system for neurotoxicity screening
by Aleksic, J and Geti, I and Apic, G and Stoop, A and Kotter, M
Toxicology Letters, ISSN 0378-4274, 10/2018, Volume 295, pp. S125 - S125
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6. Full Text Insights into cancer severity from biomolecular interaction mechanisms
by Raimondi, Francesco and Singh, Gurdeep and Betts, Matthew J and Apic, Gordana and Vukotic, Ranka and Andreone, Pietro and Stein, Lincoln and Russell, Robert B
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 34490
To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has... 
MULTIDISCIPLINARY SCIENCES | GENES | MUTATIONS | Neoplasms - metabolism | Neoplasms - genetics | Models, Biological | Humans | Mutation | Neoplasm Proteins - genetics | Neoplasm Proteins - metabolism | Neoplasms - pathology | Interfaces | Proteins | Next-generation sequencing | Nucleic acids | Protein structure | Cancer
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7. Full Text Insights into cancer severity from biomolecular interaction mechanisms (vol 6, 34490, 2016)
by Raimondi, F and Singh, G and Betts, MJ and Apic, G and Vukotic, R and Andreone, P and Stein, L and Russell, RB
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2017, Volume 7
MULTIDISCIPLINARY SCIENCES
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8. Full Text SysWiz database and software tool providing an insight into mechanism of action of molecules associated with ciliopathies
by Apic, G
Cilia, ISSN 2046-2530, 11/2012, Volume 1, Issue S1, pp. P12 - P12
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9. Full Text Differences in the Placement of the Tibial Tunnel During Reconstruction of the Anterior Cruciate Ligament With and Without Computer-Assisted Navigation
by Frieder Mauch and Goran Apic and Ulrich Becker and Gerhard Bauer
The American Journal of Sports Medicine, ISSN 0363-5465, 11/2007, Volume 35, Issue 11, pp. 1824 - 1832
Background: Next to graft fixation, correct positioning of the tibial and femoral tunnel is a deciding factor for the clinical result of anterior cruciate... 
Reconstruction | Arthroscopy | Navigation | Anterior cruciate ligament (ACL) | Tunnel placement | TENDON | SPORT SCIENCES | navigation | LANDMARKS | PATELLAR-LIGAMENT | reconstruction | tunnel placement | arthroscopy | GRAFT | ORTHOPEDICS | INTERFERENCE SCREW | anterior cruciate ligament (ACL) | Anterior Cruciate Ligament - surgery | Prospective Studies | Anterior Cruciate Ligament Injuries | Humans | Middle Aged | Reconstructive Surgical Procedures - methods | Tibia - diagnostic imaging | Male | Surgery, Computer-Assisted - methods | Treatment Outcome | Athletic Injuries - surgery | Arthroscopy - methods | Bone-Patellar Tendon-Bone Grafting | Tibia - surgery | Radiography | Biomechanical Phenomena | Anterior Cruciate Ligament - diagnostic imaging | Adolescent | Athletic Injuries - diagnostic imaging | Range of Motion, Articular | Adult | Female | Physiological aspects | Surgery, Plastic | Research | Tibia | Health aspects | Knee | Surgeons | Standard deviation | Athletes | Ligaments | Skin & tissue grafts
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10. Full Text Mechismo: Predicting the mechanistic impact of mutations and modifications on molecular interactions
by Betts, Matthew J and Lu, Qianhao and Jiang, Ying Ying and Drusko, Armin and Wichmann, Oliver and Utz, Mathias and Valtierra-Gutiérrez, Ilse A and Schlesner, Matthias and Jaeger, Natalie and Jones, David T and Pfister, Stefan and Lichter, Peter and Eils, Roland and Siebert, Reiner and Bork, Peer and Apic, Gordana and Gavin, Anne-Claude and Russell, Robert B
Nucleic Acids Research, ISSN 0305-1048, 01/2015, Volume 43, Issue 2, pp. e10 - e10
Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences... 
INTERACTION DATABASE | RESOURCES | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | STRUCTURAL CLASSIFICATION | NETWORKS | UPDATE | GENOME | Proteins - genetics | Neoplasms - genetics | Databases, Protein | Humans | Proteomics | Protein Conformation | High-Throughput Nucleotide Sequencing | Mutation | Protein Interaction Mapping | Methods Online
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11. Full Text Illuminating drug discovery with biological pathways
by Apic, Gordana and Ignjatovic, Tijana and Boyer, Scott and Russell, Robert B
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 8, pp. 1872 - 1877
Systems biology promises to impact significantly on the drug discovery process. One of its ultimate goals is to provide an understanding of the complete set of... 
Biological pathways | Systems biology | Drug discovery | systems biology | BILE-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INTERACTION MAP | NETWORKS | biological pathways | CYCLOOXYGENASES | CELL BIOLOGY | SYNTHASE | COMPLEMENTARY-DNA | BIOPHYSICS | drug discovery | DATABASE | PROTEIN-PROTEIN INTERACTIONS | Feedback, Physiological | Animals | Databases, Protein | Drug-Related Side Effects and Adverse Reactions | Humans | Gene Expression Regulation | Drug Delivery Systems | Protein Interaction Mapping | Drugs
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12. Full Text Content disputes in Wikipedia reflect geopolitical instability
by Apic, Gordana and Betts, Matthew J and Russell, Robert B
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20902
Indicators that rank countries according socioeconomic measurements are important tools for regional development and political reform. Those currently in... 
PROTEIN NETWORKS | COMPLEX NETWORKS | BIOLOGY | Geography | Politics | Dissent and Disputes | Internet | Internationality | Social networks | Correlation | Web 2.0 | Stability | Social sciences | Geopolitics | Socio-economic aspects | Encyclopedias | Regional development | Neutrality | Regional planning | Research | Electronic commerce | DNA repair | Proteins | Studies | Internet access | Algorithms | Reproducibility | Indicators | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
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13. Full Text Combinations of protein-chemical complex structures reveal new targets for established drugs
by Kalinina, Olga V and Wichmann, Oliver and Apic, Gordana and Russell, Robert B
PLoS Computational Biology, ISSN 1553-734X, 05/2011, Volume 7, Issue 5, p. e1002043
Biological networks are powerful tools for predicting undocumented relationships between molecules. The underlying principle is that existing interactions... 
ALPHA-LINOLENATE-DEFICIENCY | SYSTEM | DATABASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IDENTIFICATION | BINDING | Computational Biology - methods | Humans | Models, Molecular | Drug Discovery - methods | Pharmaceutical Preparations - metabolism | Protein Kinase Inhibitors | Animals | Proteins - metabolism | Protein Kinases | Computer Simulation | Databases, Protein | Pharmaceutical Preparations - chemistry | Protein Binding | Mice | Protein Interaction Domains and Motifs | Proteins - chemistry | Binding Sites | Drugs | Physiological aspects | Research | Health aspects | Protein-protein interactions | Protein binding | N.M.R | Ionizing radiation | Growth rate | Coumarin | Computer applications | Proteins | Ligands | Candidates | Chemicals
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14. Full Text Domain recombination: A workhorse for evolutionary innovation
by Apic, Gordana and Russell, Robert B
Science Signaling, ISSN 1945-0877, 09/2010, Volume 3, Issue 139, pp. pe30 - pe30
Although the combination of modular domains within proteins has been proposed as a determining feature of evolutionary innovation and flexibility, direct... 
NETWORKS | MODULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN DOMAINS | ARCHITECTURES | CELL BIOLOGY | Protein Structure, Tertiary | Amino Acid Sequence | Recombination, Genetic - physiology | Oligonucleotide Array Sequence Analysis | Signal Transduction | Epigenesis, Genetic | Humans | Gene Expression Regulation - physiology | Molecular Sequence Data | Inflammation | Proteins - genetics | Sequence Homology, Amino Acid | Animals | Mice | Apoptosis | Chromatin - chemistry | Evolution, Molecular
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15. Full Text ProtChemSI: a network of protein-chemical structural interactions
by Kalinina, Olga V and Wichmann, Oliver and Apic, Gordana and Russell, Robert B
Nucleic Acids Research, ISSN 0305-1048, 1/2012, Volume 40, Issue D1, pp. D549 - D553
Progress in structure determination methods means that the set of experimentally determined 3D structures of proteins in complex with small molecules is... 
SYSTEM | SENESCENCE | SMALL MOLECULES | DATABASE | BINDING AFFINITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | User-Computer Interface | Ligands | Protein Conformation | Binding Sites | Databases, Protein | Data processing | Models | Databases
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16. Full Text Der streckseitige Endgliedbasisbruch am Finger
: Ergebnisse nach konservativer und operativer Behandlung
by Apic, G and Apic, G and Mentzel, M and Mentzel, M and Röhm, A and Röhm, A and Schöll, H and Schöll, H and Gülke, J and Gülke, J
Der Unfallchirurg, ISSN 0177-5537, 6/2014, Volume 117, Issue 6, pp. 533 - 538
Nach morphologischen Kriterien wurden 56 dorsale Endgliedbasisfrakturen unterteilt und retrospektiv nach 4 Monaten hinsichtlich ihres radiologischen... 
Treatment, splint | Behandlung, operative | Treatment, operative | Indications | Luxation fracture, palmar | Medicine/Public Health, general | Vergleich | Medicine & Public Health | Indikation | Sports Medicine | Behandlung, konservative | Comparison | Traumatic Surgery | Verrenkungsbruch, palmarer | Treatment | Luxation fracture | splint | palmar | operative
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17. Full Text Distal phalangeal fractures of the finger; Results of conservative and surgical treatment/Der streckseitige Endgliedbasisbruch am Finger; Ergebnisse nach konservativer und operativer Behandlung
by Apic, G and Mentzel, M and Rohm, A and Scholl, H and Gulke, J
Der Unfallchirurg, ISSN 0177-5537, 06/2014, Volume 117, Issue 6, p. 533
Hintergrund Frakturen mit einer Subluxation waren mit 3 Fallen selten und wurden operiert. Die Frakturen ohne Subluxation wiesen mehrheitlich ein... 
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