Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1316 - 1320
Burkitt lymphoma is a mature aggressive B-cell lymphoma derived from germinal center B cells(1). Its cytogenetic hallmark is the Burkitt translocation...
INACTIVATION | DIAGNOSIS | B-CELL LYMPHOMA | MYC | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | MICE | PROTEINS | CANCER | Chromosomes, Human, Pair 8 - genetics | Somatic Hypermutation, Immunoglobulin | Humans | Inhibitor of Differentiation Proteins - genetics | Molecular Sequence Data | Male | Chromosome Mapping | Transcriptome - genetics | Sequence Analysis, DNA | Genes, Immunoglobulin | Base Sequence | Genes, myc - genetics | Burkitt Lymphoma - genetics | Female | Mutation | Genome, Human | Neoplasm Proteins - genetics | Chromosomes, Human, Pair 14 - genetics | Cohort Studies | Translocation, Genetic - genetics | Usage | Prognosis | Gene mutations | Exome sequencing | Development and progression | Diagnosis | Research | Health aspects | Risk factors | Burkitt's lymphoma | Proteins | Awards & honors | DNA methylation | Lymphomas | Genomes
INACTIVATION | DIAGNOSIS | B-CELL LYMPHOMA | MYC | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | MICE | PROTEINS | CANCER | Chromosomes, Human, Pair 8 - genetics | Somatic Hypermutation, Immunoglobulin | Humans | Inhibitor of Differentiation Proteins - genetics | Molecular Sequence Data | Male | Chromosome Mapping | Transcriptome - genetics | Sequence Analysis, DNA | Genes, Immunoglobulin | Base Sequence | Genes, myc - genetics | Burkitt Lymphoma - genetics | Female | Mutation | Genome, Human | Neoplasm Proteins - genetics | Chromosomes, Human, Pair 14 - genetics | Cohort Studies | Translocation, Genetic - genetics | Usage | Prognosis | Gene mutations | Exome sequencing | Development and progression | Diagnosis | Research | Health aspects | Risk factors | Burkitt's lymphoma | Proteins | Awards & honors | DNA methylation | Lymphomas | Genomes
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An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 11491
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate...
NETWORK REVEALS | CELLS | COMPLEX | TANDEM AFFINITY PURIFICATION | MICROTUBULE | MULTIDISCIPLINARY SCIENCES | CILIOGENESIS | MUTATIONS | INTRAFLAGELLAR TRANSPORT | STATISTICAL-MODEL | PRIMARY CILIA | Humans | Proteins - isolation & purification | Protein Interaction Maps | Spine - abnormalities | Ciliopathies - genetics | Muscle Hypotonia - therapy | DNA Mutational Analysis | Systems Analysis | Mass Spectrometry | HEK293 Cells | Fibroblasts | Dwarfism - pathology | Proteomics - methods | Spine - pathology | Chromatography, Affinity - methods | Molecular Targeted Therapy - methods | Ciliopathies - therapy | Datasets as Topic | Muscle Hypotonia - genetics | Cilia - metabolism | Proteins - genetics | Dwarfism - genetics | Muscle Hypotonia - pathology | Protein Interaction Mapping - methods | Dwarfism - therapy | Proteins - metabolism | Biological Transport - physiology | Ciliopathies - pathology
NETWORK REVEALS | CELLS | COMPLEX | TANDEM AFFINITY PURIFICATION | MICROTUBULE | MULTIDISCIPLINARY SCIENCES | CILIOGENESIS | MUTATIONS | INTRAFLAGELLAR TRANSPORT | STATISTICAL-MODEL | PRIMARY CILIA | Humans | Proteins - isolation & purification | Protein Interaction Maps | Spine - abnormalities | Ciliopathies - genetics | Muscle Hypotonia - therapy | DNA Mutational Analysis | Systems Analysis | Mass Spectrometry | HEK293 Cells | Fibroblasts | Dwarfism - pathology | Proteomics - methods | Spine - pathology | Chromatography, Affinity - methods | Molecular Targeted Therapy - methods | Ciliopathies - therapy | Datasets as Topic | Muscle Hypotonia - genetics | Cilia - metabolism | Proteins - genetics | Dwarfism - genetics | Muscle Hypotonia - pathology | Protein Interaction Mapping - methods | Dwarfism - therapy | Proteins - metabolism | Biological Transport - physiology | Ciliopathies - pathology
Journal Article
ACM Transactions on Computational Logic (TOCL), ISSN 1529-3785, 04/2017, Volume 18, Issue 1, pp. 1 - 47
We study the (non-uniform) quantified constraint satisfaction problem QCSP( H ) as H ranges over semicomplete digraphs. We obtain a complexity-theoretic...
complexity | polymorphism | semicomplete digraphs | Quantified constraints | Design | Algorithms | Semicomplete digraphs | F.2.2 [analysis of algorithms and problem complexity]: nonnumerical algorithms and problems | G.2.1 [discrete mathematics]: combinatorics | F.4.1 [mathematical logic and formal languages]: mathematical logic | Performance | Complexity | Polymorphism | COMPUTER SCIENCE, THEORY & METHODS | LOGIC
complexity | polymorphism | semicomplete digraphs | Quantified constraints | Design | Algorithms | Semicomplete digraphs | F.2.2 [analysis of algorithms and problem complexity]: nonnumerical algorithms and problems | G.2.1 [discrete mathematics]: combinatorics | F.4.1 [mathematical logic and formal languages]: mathematical logic | Performance | Complexity | Polymorphism | COMPUTER SCIENCE, THEORY & METHODS | LOGIC
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2001, Volume 310, Issue 2, pp. 311 - 325
There is a limited repertoire of domain families that are duplicated and combined in different ways to form the set of proteins in a genome. Proteins are gene...
structural genomics | domain combinations | recombination | gene duplication | Recombination | Gene duplication | Structural genomics | Domain combinations | SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | NETWORKS | HIDDEN MARKOV-MODELS | CAENORHABDITIS-ELEGANS | EVOLUTION | FAMILIES | COMPREHENSIVE STRUCTURAL CENSUS | SUPERFAMILY PROTEINS | COMPLETE GENOME | Gene Duplication | Eukaryotic Cells - chemistry | Conserved Sequence - genetics | Proteome - genetics | Genomics | Humans | Archaea - chemistry | Eukaryotic Cells - metabolism | Phylogeny | Proteome - chemistry | Eubacterium - chemistry | Recombination, Genetic - genetics | Tandem Repeat Sequences - genetics | Multigene Family - genetics | Protein Structure, Tertiary | Repetitive Sequences, Amino Acid - genetics | Proteome - classification | Yeasts - chemistry | Mutation - genetics | Databases as Topic | Yeasts - genetics | Animals | Eubacterium - genetics | Archaea - genetics | Genome | Evolution, Molecular | proteomes
structural genomics | domain combinations | recombination | gene duplication | Recombination | Gene duplication | Structural genomics | Domain combinations | SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | NETWORKS | HIDDEN MARKOV-MODELS | CAENORHABDITIS-ELEGANS | EVOLUTION | FAMILIES | COMPREHENSIVE STRUCTURAL CENSUS | SUPERFAMILY PROTEINS | COMPLETE GENOME | Gene Duplication | Eukaryotic Cells - chemistry | Conserved Sequence - genetics | Proteome - genetics | Genomics | Humans | Archaea - chemistry | Eukaryotic Cells - metabolism | Phylogeny | Proteome - chemistry | Eubacterium - chemistry | Recombination, Genetic - genetics | Tandem Repeat Sequences - genetics | Multigene Family - genetics | Protein Structure, Tertiary | Repetitive Sequences, Amino Acid - genetics | Proteome - classification | Yeasts - chemistry | Mutation - genetics | Databases as Topic | Yeasts - genetics | Animals | Eubacterium - genetics | Archaea - genetics | Genome | Evolution, Molecular | proteomes
Journal Article
Toxicology Letters, ISSN 0378-4274, 10/2018, Volume 295, pp. S125 - S125
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 34490
To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has...
MULTIDISCIPLINARY SCIENCES | GENES | MUTATIONS | Neoplasms - metabolism | Neoplasms - genetics | Models, Biological | Humans | Mutation | Neoplasm Proteins - genetics | Neoplasm Proteins - metabolism | Neoplasms - pathology | Interfaces | Proteins | Next-generation sequencing | Nucleic acids | Protein structure | Cancer
MULTIDISCIPLINARY SCIENCES | GENES | MUTATIONS | Neoplasms - metabolism | Neoplasms - genetics | Models, Biological | Humans | Mutation | Neoplasm Proteins - genetics | Neoplasm Proteins - metabolism | Neoplasms - pathology | Interfaces | Proteins | Next-generation sequencing | Nucleic acids | Protein structure | Cancer
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SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2017, Volume 7
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Cilia, ISSN 2046-2530, 11/2012, Volume 1, Issue S1, pp. P12 - P12
Journal Article
The American Journal of Sports Medicine, ISSN 0363-5465, 11/2007, Volume 35, Issue 11, pp. 1824 - 1832
Background: Next to graft fixation, correct positioning of the tibial and femoral tunnel is a deciding factor for the clinical result of anterior cruciate...
Reconstruction | Arthroscopy | Navigation | Anterior cruciate ligament (ACL) | Tunnel placement | TENDON | SPORT SCIENCES | navigation | LANDMARKS | PATELLAR-LIGAMENT | reconstruction | tunnel placement | arthroscopy | GRAFT | ORTHOPEDICS | INTERFERENCE SCREW | anterior cruciate ligament (ACL) | Anterior Cruciate Ligament - surgery | Prospective Studies | Anterior Cruciate Ligament Injuries | Humans | Middle Aged | Reconstructive Surgical Procedures - methods | Tibia - diagnostic imaging | Male | Surgery, Computer-Assisted - methods | Treatment Outcome | Athletic Injuries - surgery | Arthroscopy - methods | Bone-Patellar Tendon-Bone Grafting | Tibia - surgery | Radiography | Biomechanical Phenomena | Anterior Cruciate Ligament - diagnostic imaging | Adolescent | Athletic Injuries - diagnostic imaging | Range of Motion, Articular | Adult | Female | Physiological aspects | Surgery, Plastic | Research | Tibia | Health aspects | Knee | Surgeons | Standard deviation | Athletes | Ligaments | Skin & tissue grafts
Reconstruction | Arthroscopy | Navigation | Anterior cruciate ligament (ACL) | Tunnel placement | TENDON | SPORT SCIENCES | navigation | LANDMARKS | PATELLAR-LIGAMENT | reconstruction | tunnel placement | arthroscopy | GRAFT | ORTHOPEDICS | INTERFERENCE SCREW | anterior cruciate ligament (ACL) | Anterior Cruciate Ligament - surgery | Prospective Studies | Anterior Cruciate Ligament Injuries | Humans | Middle Aged | Reconstructive Surgical Procedures - methods | Tibia - diagnostic imaging | Male | Surgery, Computer-Assisted - methods | Treatment Outcome | Athletic Injuries - surgery | Arthroscopy - methods | Bone-Patellar Tendon-Bone Grafting | Tibia - surgery | Radiography | Biomechanical Phenomena | Anterior Cruciate Ligament - diagnostic imaging | Adolescent | Athletic Injuries - diagnostic imaging | Range of Motion, Articular | Adult | Female | Physiological aspects | Surgery, Plastic | Research | Tibia | Health aspects | Knee | Surgeons | Standard deviation | Athletes | Ligaments | Skin & tissue grafts
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 8, pp. 1872 - 1877
Systems biology promises to impact significantly on the drug discovery process. One of its ultimate goals is to provide an understanding of the complete set of...
Biological pathways | Systems biology | Drug discovery | systems biology | BILE-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INTERACTION MAP | NETWORKS | biological pathways | CYCLOOXYGENASES | CELL BIOLOGY | SYNTHASE | COMPLEMENTARY-DNA | BIOPHYSICS | drug discovery | DATABASE | PROTEIN-PROTEIN INTERACTIONS | Feedback, Physiological | Animals | Databases, Protein | Drug-Related Side Effects and Adverse Reactions | Humans | Gene Expression Regulation | Drug Delivery Systems | Protein Interaction Mapping | Drugs
Biological pathways | Systems biology | Drug discovery | systems biology | BILE-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INTERACTION MAP | NETWORKS | biological pathways | CYCLOOXYGENASES | CELL BIOLOGY | SYNTHASE | COMPLEMENTARY-DNA | BIOPHYSICS | drug discovery | DATABASE | PROTEIN-PROTEIN INTERACTIONS | Feedback, Physiological | Animals | Databases, Protein | Drug-Related Side Effects and Adverse Reactions | Humans | Gene Expression Regulation | Drug Delivery Systems | Protein Interaction Mapping | Drugs
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2015, Volume 43, Issue 2, pp. e10 - e10
Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences...
INTERACTION DATABASE | RESOURCES | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | STRUCTURAL CLASSIFICATION | NETWORKS | UPDATE | GENOME | Proteins - genetics | Neoplasms - genetics | Databases, Protein | Humans | Proteomics | Protein Conformation | High-Throughput Nucleotide Sequencing | Mutation | Protein Interaction Mapping | Methods Online
INTERACTION DATABASE | RESOURCES | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | STRUCTURAL CLASSIFICATION | NETWORKS | UPDATE | GENOME | Proteins - genetics | Neoplasms - genetics | Databases, Protein | Humans | Proteomics | Protein Conformation | High-Throughput Nucleotide Sequencing | Mutation | Protein Interaction Mapping | Methods Online
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20902
Indicators that rank countries according socioeconomic measurements are important tools for regional development and political reform. Those currently in...
PROTEIN NETWORKS | COMPLEX NETWORKS | BIOLOGY | Geography | Politics | Dissent and Disputes | Internet | Internationality | Social networks | Correlation | Web 2.0 | Stability | Social sciences | Geopolitics | Socio-economic aspects | Encyclopedias | Regional development | Neutrality | Regional planning | Research | Electronic commerce | DNA repair | Proteins | Studies | Internet access | Algorithms | Reproducibility | Indicators | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
PROTEIN NETWORKS | COMPLEX NETWORKS | BIOLOGY | Geography | Politics | Dissent and Disputes | Internet | Internationality | Social networks | Correlation | Web 2.0 | Stability | Social sciences | Geopolitics | Socio-economic aspects | Encyclopedias | Regional development | Neutrality | Regional planning | Research | Electronic commerce | DNA repair | Proteins | Studies | Internet access | Algorithms | Reproducibility | Indicators | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 05/2011, Volume 7, Issue 5, p. e1002043
Biological networks are powerful tools for predicting undocumented relationships between molecules. The underlying principle is that existing interactions...
ALPHA-LINOLENATE-DEFICIENCY | SYSTEM | SMALL MOLECULES | DATABASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IDENTIFICATION | BINDING | Computational Biology - methods | Humans | Models, Molecular | Drug Discovery - methods | Pharmaceutical Preparations - metabolism | Protein Kinase Inhibitors | Animals | Proteins - metabolism | Protein Kinases | Computer Simulation | Databases, Protein | Pharmaceutical Preparations - chemistry | Protein Binding | Mice | Protein Interaction Domains and Motifs | Proteins - chemistry | Binding Sites | Drugs | Physiological aspects | Research | Health aspects | Protein-protein interactions | Protein binding | N.M.R | Ionizing radiation | Growth rate | Coumarin | Computer applications | Proteins | Ligands | Candidates | Chemicals
ALPHA-LINOLENATE-DEFICIENCY | SYSTEM | SMALL MOLECULES | DATABASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IDENTIFICATION | BINDING | Computational Biology - methods | Humans | Models, Molecular | Drug Discovery - methods | Pharmaceutical Preparations - metabolism | Protein Kinase Inhibitors | Animals | Proteins - metabolism | Protein Kinases | Computer Simulation | Databases, Protein | Pharmaceutical Preparations - chemistry | Protein Binding | Mice | Protein Interaction Domains and Motifs | Proteins - chemistry | Binding Sites | Drugs | Physiological aspects | Research | Health aspects | Protein-protein interactions | Protein binding | N.M.R | Ionizing radiation | Growth rate | Coumarin | Computer applications | Proteins | Ligands | Candidates | Chemicals
Journal Article
Science Signaling, ISSN 1945-0877, 09/2010, Volume 3, Issue 139, pp. pe30 - pe30
Although the combination of modular domains within proteins has been proposed as a determining feature of evolutionary innovation and flexibility, direct...
NETWORKS | MODULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN DOMAINS | ARCHITECTURES | CELL BIOLOGY | Protein Structure, Tertiary | Amino Acid Sequence | Recombination, Genetic - physiology | Oligonucleotide Array Sequence Analysis | Signal Transduction | Epigenesis, Genetic | Humans | Gene Expression Regulation - physiology | Molecular Sequence Data | Inflammation | Proteins - genetics | Sequence Homology, Amino Acid | Animals | Mice | Apoptosis | Chromatin - chemistry | Evolution, Molecular
NETWORKS | MODULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN DOMAINS | ARCHITECTURES | CELL BIOLOGY | Protein Structure, Tertiary | Amino Acid Sequence | Recombination, Genetic - physiology | Oligonucleotide Array Sequence Analysis | Signal Transduction | Epigenesis, Genetic | Humans | Gene Expression Regulation - physiology | Molecular Sequence Data | Inflammation | Proteins - genetics | Sequence Homology, Amino Acid | Animals | Mice | Apoptosis | Chromatin - chemistry | Evolution, Molecular
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 1/2012, Volume 40, Issue D1, pp. D549 - D553
Progress in structure determination methods means that the set of experimentally determined 3D structures of proteins in complex with small molecules is...
SYSTEM | SENESCENCE | SMALL MOLECULES | DATABASE | BINDING AFFINITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | User-Computer Interface | Ligands | Protein Conformation | Binding Sites | Databases, Protein | Data processing | Models | Databases
SYSTEM | SENESCENCE | SMALL MOLECULES | DATABASE | BINDING AFFINITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | User-Computer Interface | Ligands | Protein Conformation | Binding Sites | Databases, Protein | Data processing | Models | Databases
Journal Article
Der Unfallchirurg, ISSN 0177-5537, 6/2014, Volume 117, Issue 6, pp. 533 - 538
Nach morphologischen Kriterien wurden 56 dorsale Endgliedbasisfrakturen unterteilt und retrospektiv nach 4 Monaten hinsichtlich ihres radiologischen...
Treatment, splint | Behandlung, operative | Treatment, operative | Indications | Luxation fracture, palmar | Medicine/Public Health, general | Vergleich | Medicine & Public Health | Indikation | Sports Medicine | Behandlung, konservative | Comparison | Traumatic Surgery | Verrenkungsbruch, palmarer | Treatment | Luxation fracture | splint | palmar | operative
Treatment, splint | Behandlung, operative | Treatment, operative | Indications | Luxation fracture, palmar | Medicine/Public Health, general | Vergleich | Medicine & Public Health | Indikation | Sports Medicine | Behandlung, konservative | Comparison | Traumatic Surgery | Verrenkungsbruch, palmarer | Treatment | Luxation fracture | splint | palmar | operative
Journal Article
Der Unfallchirurg, ISSN 0177-5537, 06/2014, Volume 117, Issue 6, p. 533
Hintergrund Frakturen mit einer Subluxation waren mit 3 Fallen selten und wurden operiert. Die Frakturen ohne Subluxation wiesen mehrheitlich ein...
Journal Article