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science & technology (55) 55
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humans (41) 41
mitochondria (32) 32
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mitochondria - drug effects (17) 17
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reactive oxygen species - metabolism (10) 10
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antioxidants (8) 8
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1. Full Text Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications
by Apostolova, Nadezda and Victor, Victor M
Antioxidants & redox signaling, ISSN 1523-0864, 03/2015, Volume 22, Issue 8, pp. 686 - 729
Comprehensive Invited Review | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Animals | Oxidation-Reduction | Antioxidants - metabolism | Humans | Mitochondria - metabolism | Autophagy | Apoptosis | Antioxidants | Mitochondria | Research | Health aspects | Dietary supplements | Index Medicus
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2. Full Text Efavirenz and the CNS: What we already know and questions that need to be answered
by Apostolova, Nadezda and Funes, Haryes A and Blas-Garcia, Ana and Galindo, Maria J and Alvarez, Angeles and Esplugues, Juan V
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 10/2015, Volume 70, Issue 10, pp. 2693 - 2708
Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Anti-HIV Agents - pharmacology | Pharmacogenetics | Cytochrome P-450 Enzyme Inhibitors - therapeutic use | Cytochrome P-450 CYP2B6 - genetics | Anti-HIV Agents - adverse effects | HIV Infections - genetics | Humans | Antiretroviral Therapy, Highly Active - adverse effects | Reverse Transcriptase Inhibitors - pharmacology | Benzoxazines - adverse effects | Cytochrome P-450 Enzyme Inhibitors - adverse effects | Benzoxazines - therapeutic use | Reverse Transcriptase Inhibitors - adverse effects | Central Nervous System Diseases - etiology | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Benzoxazines - pharmacology | HIV Infections - complications | Central Nervous System - drug effects | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Polymorphism, Single Nucleotide | Reverse Transcriptase Inhibitors - therapeutic use | Disease Models, Animal | Psychosis | Antiretroviral drugs | Neurotoxicity | Bioenergetics | Human immunodeficiency virus--HIV | Index Medicus
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3. Mitochondria as a pharmacological target: A clue for efficacy and a reason for Toxicity
by Apostolova, Nadezda
Current pharmaceutical design, ISSN 1381-6128, 07/2011, Volume 17, Issue 20, pp. 1984 - 1985
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Molecular Targeted Therapy - adverse effects | Mitochondria - drug effects | Mitochondria - physiology | Humans | Molecular Targeted Therapy - methods
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4. Full Text Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines
by Funes, Haryes A and Blas-garcia, Ana and Esplugues, Juan V and Apostolova, Nadezda
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 08/2015, Volume 70, Issue 8, pp. 2249 - 2254
Mitochondria | Neurotoxicity | Side effects | HIV | Respiration | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Cell Line | Humans | Anti-Retroviral Agents - pharmacology | Neuroglia - physiology | Mitochondria - metabolism | Mitochondria - drug effects | Neuroglia - drug effects | Adenosine Triphosphate - metabolism | Benzoxazines - pharmacology | Cell Respiration - drug effects | Neurons - physiology | Neurons - drug effects | Energy Metabolism - drug effects | Antiretroviral drugs | Brain | Inhibitor drugs | Bioenergetics | Tumors | Index Medicus
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5. Mitochondria sentencing about cellular life and death: A matter of oxidative stress
by Apostolova, Nadezda and Blas-Garcia, Ana and Esplugues, Juan V
Current pharmaceutical design, ISSN 1381-6128, 2011, Volume 17, Issue 36, pp. 4047 - 4060
Oxidative stress | Mitochondria | Reactive oxygen species | Mitoptosis | Mitophagy | Apoptosis | Necrosis | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Mitochondrial Diseases - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Calcium - metabolism | Cell Survival | Humans | Mitochondrial Diseases - metabolism | Oxidative Phosphorylation | Mitochondria - metabolism | Mitochondria - pathology | Autophagy | Animals | Cellular Senescence | Mitochondrial Proteins - metabolism
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6. Full Text Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
by Haryes A. Funes and Nadezda Apostolova and Fernando Alegre and Ana Blas-Garcia and Angeles Alvarez and Miguel Marti-Cabrera and Juan V. Esplugues
The Journal of infectious diseases, ISSN 0022-1899, 11/2014, Volume 210, Issue 9, pp. 1385 - 1395
HIV/AIDS | Brain | Lactates | Side effects | Neurons | Astrocytes | Neuroglia | Central nervous system | Cell lines | Superoxides | Glycolysis | nitric oxide | neurotoxicity | HIV | mitochondria | HIV-associated neurocognitive disorders | efavirenz | central nervous system | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Astrocytes - drug effects | Cell Survival - drug effects | Rats, Wistar | Humans | Rats | Reverse Transcriptase Inhibitors - pharmacology | Benzoxazines - adverse effects | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Neuroglia - drug effects | Dose-Response Relationship, Drug | Reverse Transcriptase Inhibitors - adverse effects | Animals | Oxygen Consumption - drug effects | Benzoxazines - pharmacology | Cell Respiration - drug effects | Superoxides - metabolism | Cell Line, Tumor | Neurons - drug effects | Energy Metabolism - drug effects | Complications and side effects | Patient outcomes | Dosage and administration | Mitochondrial diseases | Research | Drug therapy | Efavirenz | Index Medicus | Abridged Index Medicus
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7. Full Text Involvement of Nitric Oxide in the Mitochondrial Action of Efavirenz: A Differential Effect on Neurons and Glial Cells
by Nadezda Apostolova and Haryes A. Funes and Ana Blas-Garcia and Fernando Alegre and Miriam Polo and Juan V. Esplugues
The Journal of infectious diseases, ISSN 0022-1899, 6/2015, Volume 211, Issue 12, pp. 1953 - 1958
HIV/AIDS | electron transport chain | nitric oxide | HIV | mitochondria | NNRTI | efavirenz | central nervous system | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Cell Line | Anti-HIV Agents - toxicity | Nitric Oxide Synthase Type II - antagonists & inhibitors | Humans | Neuroglia - metabolism | Mitochondria - metabolism | Neurons - metabolism | Nitric Oxide - metabolism | Benzoxazines - toxicity | Usage | Nitric oxide | Influence | Dosage and administration | Mitochondrial diseases | Research | HIV (Viruses) | Efavirenz | Index Medicus | Abridged Index Medicus
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8. Full Text Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic TargetsReviewing Editors: Markus Bachschmid, Dylan Burger, Vittorio Calabrese, Amadou Camara, Lukas Kubala, Giuseppe Poli, and Chandan K. Sen
by Rovira-Llopis, Susana and Apostolova, Nadezda and Bañuls, Celia and Muntané, Jordi and Rocha, Milagros and Victor, Victor M
Antioxidants & redox signaling, ISSN 1523-0864, 09/2018, Volume 29, Issue 8, pp. 749 - 791
Comprehensive Invited Review | Sirtuins | Oxidative stress | Complications | Pathogenesis | Molecular interactions | Crosstalk | Diabetes mellitus | Activation | Inflammation | Metabolism | Molecular chains | Interleukin 18 | Mitochondria | Hyperglycemia | Pyrin protein | Interleukins | Arteriosclerosis | Editors | Atherosclerosis | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Metabolic disorders
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