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1. Full Text Role of Autophagy in Cell Survival in Liver Injury
by Apostolova, Nadezda
2014, Volume 3, 12
Liver diseases | Liver | Mitochondrial DNA
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2. Full Text Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic TargetsReviewing Editors: Markus Bachschmid, Dylan Burger, Vittorio Calabrese, Amadou Camara, Lukas Kubala, Giuseppe Poli, and Chandan K. Sen
by Rovira-Llopis, Susana and Apostolova, Nadezda and Bañuls, Celia and Muntané, Jordi and Rocha, Milagros and Victor, Victor M
Antioxidants & Redox Signaling, ISSN 1523-0864, 09/2018, Volume 29, Issue 8, pp. 749 - 791
Significance: Type 2 diabetes mellitus and hyperglycemia can lead to the development of comorbidities such as atherosclerosis and microvascular/macrovascular... 
Comprehensive Invited Review | Sirtuins | Oxidative stress | Complications | Pathogenesis | Molecular interactions | Crosstalk | Diabetes mellitus | Activation | Inflammation | Metabolism | Molecular chains | Interleukin 18 | Mitochondria | Hyperglycemia | Pyrin protein | Interleukins | Arteriosclerosis | Editors | Atherosclerosis | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Metabolic disorders
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3. Full Text Guidelines for the use and interpretation of assays for monitoring autophagy
by Klionsky, Daniel J and Abdalla, Fabio C and Abeliovich, Hagai and Abraham, Robert T and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agholme, Lotta and Agnello, Maria and Agostinis, Patrizia and Aguirre-Ghiso, Julio A and Ahn, Hyung Jun and Ait-Mohamed, Ouardia and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akira, Shizuo and Al-Younes, Hesham M and Al-Zeer, Munir A and Albert, Matthew L and Albin, Roger L and Alegre-Abarrategui, Javier and Aleo, Maria Francesca and Alirezaei, Mehrdad and Almasan, Alexandru and Almonte-Becerril, Maylin and Amano, Atsuo and Amaravadi, Ravi K and Amarnath, Shoba and Amer, Amal O and Andrieu-Abadie, Nathalie and Anantharam, Vellareddy and Ann, David K and Anoopkumar-Dukie, Shailendra and Aoki, Hiroshi and Apostolova, Nadezda and Arancia, Giuseppe and Aris, John P and Asanuma, Katsuhiko and Asare, Nana Y.O and Ashida, Hisashi and Askanas, Valerie and Askew, David S and Auberger, Patrick and Baba, Misuzu and Backues, Steven K and Baehrecke, Eric H and Bahr, Ben A and Bai, Xue-Yuan and Bailly, Yannick and Baiocchi, Robert and Baldini, Giulia and Balduini, Walter and Ballabio, Andrea and Bamber, Bruce A and Bampton, Edward T.W and Juhász, Gábor and Bartholomew, Clinton R and Bassham, Diane C and Bast, Robert C and Batoko, Henri and Bay, Boon-Huat and Beau, Isabelle and Béchet, Daniel M and Begley, Thomas J and Behl, Christian and Behrends, Christian and Bekri, Soumeya and Bellaire, Bryan and Bendall, Linda J and Benetti, Luca and Berliocchi, Laura and Bernardi, Henri and Bernassola, Francesca and Besteiro, Sébastien and Bhatia-Kissova, Ingrid and Bi, Xiaoning and Biard-Piechaczyk, Martine and Blum, Janice S and Boise, Lawrence H and Bonaldo, Paolo and Boone, David L and Bornhauser, Beat C and Bortoluci, Karina R and Bossis, Ioannis and Bost, Frédéric and Bourquin, Jean-Pierre and Boya, Patricia and Boyer-Guittaut, Michaël and Bozhkov, Peter V and Brady, Nathan R and Brancolini, Claudio and Brech, Andreas and Brenman, Jay E and Brennand, Ana and Bresnick, Emery H and Brest, Patrick and Bridges, Dave and Bristol, Molly L and Brookes, Paul S and Brown, Eric J and Brumell, John H and ... and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Geriatrik and Institutionen för medicin och hälsa and Farmakologi and Experimentell patologi and Hälsouniversitetet and Cellbiologi
Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 445 - 544
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and... 
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Index Medicus | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
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4. Full Text Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines
by Funes, Haryes A and Blas-garcia, Ana and Esplugues, Juan V and Apostolova, Nadezda
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 08/2015, Volume 70, Issue 8, pp. 2249 - 2254
Background: The NNRTI efavirenz is among the most widely employed antiretroviral drugs. Although it is considered safe, efavirenz has been linked with several... 
Mitochondria | Neurotoxicity | Side effects | HIV | Respiration | INFECTIOUS DISEASES | neurotoxicity | BIOENERGETICS | mitochondria | DISEASE | side effects | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | respiration | DYSFUNCTION | EXTRACELLULAR FLUX | Cell Line | Humans | Anti-Retroviral Agents - pharmacology | Neuroglia - physiology | Mitochondria - metabolism | Mitochondria - drug effects | Neuroglia - drug effects | Adenosine Triphosphate - metabolism | Benzoxazines - pharmacology | Cell Respiration - drug effects | Neurons - physiology | Neurons - drug effects | Energy Metabolism - drug effects | Antiretroviral drugs | Brain | Inhibitor drugs | Bioenergetics | Tumors | Index Medicus
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5. Full Text Neuronal bioenergetics and acute mitochondrial dysfunction: a clue to understanding the central nervous system side effects of efavirenz
by Funes, Haryes A and Funes, Haryes A and Apostolova, Nadezda and Alegre, Fernando and Blas-Garcia, Ana and Alvarez, Angeles and Marti-Cabrera, Miguel and Esplugues, Juan V
Journal of Infectious Diseases, ISSN 0022-1899, 2014, Volume 210, Issue 9, pp. 1385 - 1395
Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main... 
nitric oxide | neurotoxicity | HIV | mitochondria | HIV-associated neurocognitive disorders | efavirenz | central nervous system | INFECTIOUS DISEASES | ENERGY | DEMENTIA | DISORDERS | MICROBIOLOGY | MECHANISMS | IMMUNOLOGY | ASTROCYTES | HIV-INFECTED PATIENTS | NEUROPSYCHIATRIC ADVERSE EVENTS | PLASMA | CYP2B6 | NITRIC-OXIDE | Astrocytes - drug effects | Cell Survival - drug effects | Rats, Wistar | Humans | Rats | Reverse Transcriptase Inhibitors - pharmacology | Benzoxazines - adverse effects | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Neuroglia - drug effects | Dose-Response Relationship, Drug | Reverse Transcriptase Inhibitors - adverse effects | Animals | Oxygen Consumption - drug effects | Benzoxazines - pharmacology | Cell Respiration - drug effects | Superoxides - metabolism | Cell Line, Tumor | Neurons - drug effects | Energy Metabolism - drug effects | Complications and side effects | Patient outcomes | Central nervous system | Dosage and administration | Mitochondrial diseases | Research | Drug therapy | Efavirenz | Index Medicus | Abridged Index Medicus
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6. Mitochondria as a pharmacological target: A clue for efficacy and a reason for Toxicity
by Apostolova, Nadezda
Current Pharmaceutical Design, ISSN 1381-6128, 07/2011, Volume 17, Issue 20, pp. 1984 - 1985
PHARMACOLOGY & PHARMACY | DRUGS | Molecular Targeted Therapy - adverse effects | Mitochondria - drug effects | Mitochondria - physiology | Humans | Molecular Targeted Therapy - methods
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7. Full Text Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival‐promoting autophagy
by Apostolova, Nadezda and Gomez‐Sucerquia, Leysa J and Gortat, Anna and Blas‐Garcia, Ana and Esplugues, Juan V
Hepatology, ISSN 0270-9139, 09/2011, Volume 54, Issue 3, pp. 1009 - 1019
Hepatotoxicity is a very common side effect associated with the pharmacological treatment of human immunodeficiency virus (HIV) infection and its pathogenesis... 
PROTEASE INHIBITOR | CARCINOMA-CELLS | BROAD-SPECTRUM | HEPATIC CELLS | REVERSE-TRANSCRIPTASE INHIBITORS | INDUCED APOPTOSIS | ENHANCED OXIDATIVE STRESS | ENDOPLASMIC-RETICULUM STRESS | GASTROENTEROLOGY & HEPATOLOGY | ISOLATED RAT HEPATOCYTES | HIV-INFECTED PATIENTS | Cell Survival - drug effects | Anti-HIV Agents - toxicity | Humans | Autophagy - physiology | HeLa Cells | Mitochondria - drug effects | Mitochondria - pathology | Mitochondria - physiology | Autophagy - drug effects | Benzoxazines - toxicity | Chemical and Drug Induced Liver Injury - etiology | Autophagy | Human immunodeficiency virus--HIV | Index Medicus
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8. Full Text Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells
by Blas‐García, Ana and Apostolova, Nadezda and Ballesteros, Daniel and Monleón, Daniel and Morales, Jose M and Rocha, Milagros and Victor, Victor M and Esplugues, Juan V
Hepatology, ISSN 0270-9139, 07/2010, Volume 52, Issue 1, pp. 115 - 125
Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been... 
APOPTOSIS | REVERSE-TRANSCRIPTASE INHIBITORS | LIVER | NITRIC-OXIDE | ANTIRETROVIRAL THERAPY | INFECTION | HEPATOTOXICITY | DYSFUNCTION | NEVIRAPINE | GASTROENTEROLOGY & HEPATOLOGY | ADVERSE EVENTS | Anti-HIV Agents - pharmacology | Protein Kinases - metabolism | Humans | Rats | Male | Hepatocytes - metabolism | Rats, Sprague-Dawley | Mitochondria, Liver - physiology | Mitochondria, Liver - drug effects | Animals | Oxygen Consumption - drug effects | Benzoxazines - pharmacology | Lipid Metabolism - drug effects | Lipids - analysis | Hepatocytes - drug effects | Antiretroviral drugs | Lipids | Kinases | Human immunodeficiency virus--HIV | Index Medicus
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9. Full Text Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz
by Blas-García, Ana and Blas-García, Ana and Polo, Miriam and Polo, Miriam and Alegre, Fernando and Alegre, Fernando and Funes, Haryes A and Funes, Haryes A and Martínez, Esteban and Martínez, Esteban and Apostolova, Nadezda and Apostolova, Nadezda and Esplugues, Juan V and Esplugues, Juan V
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 11/2014, Volume 69, Issue 11, pp. 2995 - 3000
Growing evidence associates the non-nucleoside reverse transcriptase inhibitor efavirenz with several adverse events. Newer antiretrovirals, such as the... 
adverse effects | CNS | HIV | hepatotoxicity | mitochondria | INFECTIOUS DISEASES | LIVER TOXICITY | MICROBIOLOGY | HIV-1-INFECTED PATIENTS | TREATMENT-NAIVE | INHIBITION | DRUGS | PHARMACOLOGY & PHARMACY | STRESS | HUMAN HEPATIC CELLS | Nitriles - toxicity | Reverse Transcriptase Inhibitors - toxicity | Anti-HIV Agents - toxicity | Darunavir | Rilpivirine | Humans | Cells, Cultured | Rats | Mitochondria - metabolism | Hepatocytes - metabolism | Mitochondria - drug effects | Pyrrolidinones - toxicity | Animals | Pyrimidines - toxicity | Cell Line, Tumor | Drug Resistance, Viral - drug effects | Sulfonamides - toxicity | Neurons - metabolism | Neurons - drug effects | Raltegravir Potassium | Benzoxazines - toxicity | Hepatocytes - drug effects | Proteins | Antiretroviral drugs | Toxicology | Protease inhibitors | Cellular biology | Neurons | Cytotoxicity | Index Medicus
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10. Full Text Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells
by Miova, Biljana and Dinevska‐Kjovkarovska, Suzana and Esplugues, Juan V and Apostolova, Nadezda
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2015, Volume 116, Issue 10, pp. 2365 - 2374
The relevance of heat preconditioning resides in its ability to protect cells from different kinds of injury by induction of heat shock proteins, a process in... 
LIVER REGENERATION | HEAT PRECONDITIONING | HSP70 | ASPIRIN | SHOCK PROTEINS | LIVER-TRANSPLANTATION | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | P53 | CELL BIOLOGY | SODIUM-SALICYLATE | EXPRESSION | MODULATION | GENE-TRANSCRIPTION | Tumor Suppressor Protein p53 - biosynthesis | Humans | HSP70 Heat-Shock Proteins - genetics | Hepatocytes - metabolism | Hot Temperature | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Tumor Suppressor Protein p53 - genetics | Aspirin - administration & dosage | Heat-Shock Response - genetics | Hep G2 Cells | Gene Expression Regulation - drug effects | RNA, Messenger - biosynthesis | Cytoprotection - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | HSP70 Heat-Shock Proteins - biosynthesis | Aspirin | RNA | Liver | Physiological aspects | Heat shock proteins | Stress (Physiology) | Tumor proteins | Gene expression | Index Medicus
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