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Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5921, pp. 1610 - 1614
The interface between antibody and antigen is often depicted as a lock and key, suggesting that an antibody surface can accommodate only one antigen. Here, we... 
Antigens | Cell growth | DNA | Medical treatment | Antibodies | Amino acids | Reports | Breast cancer | Genetic mutation | Binding sites | Tumors | BREAST-CANCER | ANGSTROM RESOLUTION | COMPLEX | SOMATIC HYPERMUTATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DIVERSITY | MOLECULAR-BASIS | ENDOTHELIAL GROWTH-FACTOR | XENOGRAFTS | Antibody Specificity | Complementarity Determining Regions - genetics | Epitopes - metabolism | Humans | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Antibodies, Bispecific - genetics | Epitopes - immunology | Vascular Endothelial Growth Factor A - chemistry | Antibodies, Monoclonal, Humanized | Thermodynamics | Receptor, ErbB-2 - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Protein Structure, Tertiary | Binding Sites, Antibody - genetics | Models, Molecular | Antibody Affinity | Vascular Endothelial Growth Factor A - immunology | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Antibodies, Bispecific - therapeutic use | Antibodies, Monoclonal - genetics | Animals | Genetic Engineering | Mutagenesis | Complementarity Determining Regions - immunology | Antibodies, Bispecific - chemistry | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - drug therapy | Trastuzumab | Viral antibodies | Therapeutics | Research | Properties | Vascular endothelial growth factor | Homeopathy | Materia medica and therapeutics | Proteins | Biotechnology | Cellular biology | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 09/2008, Volume 6, Issue 9, pp. 2043 - 2059
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 6, pp. 3639 - 3654
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2007, Volume 26, Issue 23, pp. 4902 - 4912
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5255 - 5264
The emergence of drug resistance is a primary concern in any cancer treatment, including with targeted kinase inhibitors as exemplified by the appearance of... 
POINT MUTATIONS | LUNG-CANCER | KINASE INHIBITION | ONCOLOGY | ACQUIRED-RESISTANCE | CLINICAL RESISTANCE | GENE AMPLIFICATION | GEFITINIB RESISTANCE | SOMATIC MUTATIONS | NILOTINIB | CHRONIC MYELOID-LEUKEMIA | Humans | Receptors, Growth Factor - antagonists & inhibitors | Crystallography, X-Ray | Aminopyridines - metabolism | Mutation, Missense | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Receptors, Growth Factor - genetics | Neoplasms - genetics | DNA Mutational Analysis | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Models, Molecular | Pyrazoles - metabolism | Receptors, Growth Factor - chemistry | Neoplasms - drug therapy | Proto-Oncogene Proteins c-met - genetics | Quinolines - metabolism | Point Mutation | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Drug Resistance, Neoplasm - genetics | Tyrosine - metabolism | Animals | Mutagenesis | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | DNA, Neoplasm - genetics | Proto-Oncogene Proteins c-met - chemistry | Enzyme Activation - genetics | Cell Line, Transformed | Amino Acid Substitution | Protein Kinase Inhibitors - metabolism
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3325 - 3349
In the preceding manuscript [Moreau et al. 2018, 10.1021/acs.jmedchem.7b01691] we described a successful fragment-based lead discovery (FBLD) strategy for... 
PHOSPHINOXYDE ALS OLEFINIERUNGSREAGENZIEN | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | MULTIDRUG EFFLUX PUMPS | ESCHERICHIA-COLI | ARYL HALIDES | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | COENZYME-A | RESISTANCE GENE MCR-1 | MOLECULAR-MECHANISMS | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Escherichia coli Proteins - genetics | Nucleotidyltransferases - genetics | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3309 - 3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a... 
COENZYME-A BIOSYNTHESIS | MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | LEAD DISCOVERY | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | N-PENTYLPANTOTHENAMIDE | ANTIBACTERIAL DISCOVERY | BETA-LACTAMASES | RESISTANCE GENE MCR-1 | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Pseudomonas aeruginosa - enzymology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - drug effects | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article