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1. Full Text Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjogren's Syndrome
by Verstappen, Gwenny M and Meiners, Petra M and Corneth, Odilia B. J and Visser, Annie and Arends, Suzanne and Abdulahad, Wayel H and Heniks, Rudi W and Vissink, Arjan and Kroese, Frans G. M and Bootsma, Henika
Arthritis & Rheumatology, ISSN 2326-5191, 09/2017, Volume 69, Issue 9, pp. 1850 - 1861
Objective. To assess the effect of abatacept (CTLA-4Ig), which limits T cell activation, on homeostasis of CD4+ T cell subsets and T cell-dependent B cell... 
RHEUMATOID-ARTHRITIS | BRUTONS TYROSINE KINASE | BONE-MARROW | DIFFERENTIATION | ANTIBODY-RESPONSES | ICOS | PLASMA-CELLS | DISEASE-ACTIVITY | LYMPHOCYTES | ANTIGEN | RHEUMATOLOGY | Abatacept - pharmacology | Prospective Studies | Interleukins - blood | Sjogren's Syndrome - drug therapy | Humans | Middle Aged | Sjogren's Syndrome - immunology | Male | Chemokine CXCL13 - blood | Plasma Cells - drug effects | T-Lymphocytes, Helper-Inducer - drug effects | B-Lymphocytes - drug effects | Flow Cytometry | Lymphocyte Activation - drug effects | Adult | Female | Immunosuppressive Agents - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Flow cytometry | Sjogren's syndrome | Parotid gland | Hyperactivity | CD45RA antigen | Interleukin | CXCL13 protein | Medical services | Homeostasis | Effector cells | Activation | Lymphocytes T | Cell activation | CXCR5 protein | Lymphocytes | Interleukin 21 | Foxp3 protein | Mathematical models | Activation analysis | Cytokines | CXCR3 protein | Patients | CCR6 protein | CD4 antigen | Serum levels | Cytometry | Lymphocytes B | ICOS protein | Apoptosis
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2. Full Text Pegylated Interferon Alfa-2b Add-on Treatment in Hepatitis B Virus Envelope Antigen-Positive Chronic Hepatitis B Patients Treated with Nucleos(t)ide Analogue: A Randomized, Controlled Trial (PEGON)
by Chi, Heng and Hansen, Bettina E and Guo, Simin and Zhang, Ning Ping and Qi, Xun and Chen, Liang and Guo, Qing and Arends, Pauline and Wang, Ji-Yao and Verhey, Elke and de Knegt, Robert J and Xie, Qing and Janssen, Harry L. A
The Journal of Infectious Diseases, ISSN 0022-1899, 04/2017, Volume 215, Issue 7, pp. 1085 - 1093
Abstract Background. We studied whether 48 weeks of pegylated interferon alfa-2b (peginterferon) add-on therapy increases serological response in hepatitis B... 
Antiviral therapy | HBeAg seroconversion | Combination therapy | Interferon naive | INFECTIOUS DISEASES | MULTICENTER | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | LAMIVUDINE | THERAPY | PEGINTERFERON ALPHA-2A | GENOTYPE-B | HBSAG LOSS | ADEFOVIR DIPIVOXIL | combination therapy | NEGATIVE PATIENTS | interferon naive | Tenofovir - therapeutic use | Guanine - analogs & derivatives | Humans | Middle Aged | Logistic Models | Male | Treatment Outcome | Antiviral Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | DNA, Viral - blood | Interferon-alpha - administration & dosage | Netherlands | Hepatitis B, Chronic - drug therapy | China | Adult | Female | Hepatitis B virus | Drug Therapy, Combination | Hepatitis B e Antigens - blood | Guanine - therapeutic use | Usage | Care and treatment | Nucleoside analogs
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3. Full Text Liver decompensation in HIV/Hepatitis B coinfection in the combination antiretroviral therapy era does not seem increased compared to hepatitis B mono-infection
by Lieveld, Faya I and Smit, Colette and Richter, Clemens and van Erpecum, Karel J and Spanier, Bernhard W. M and Gisolf, Elisabeth H and Vrolijk, Jan M and Siersema, Peter D and Hoepelman, Andy I. M and Reiss, Peter and Arends, Joop E
Liver international, ISSN 1478-3223, 2019, Volume 39, Issue 3, pp. 470 - 483
Background & Aims: HIV/hepatitis B virus (HBV) coinfected subjects are thought to have faster progression to end-stage liver disease (ESLD) than HBV... 
end‐stage liver disease | human immunodeficiency virus | hepatitis B virus | hepatocellular carcinoma | liver decompensation | end-stage liver disease | MORTALITY | ENTECAVIR | FOLLOW-UP | AIDS | HUMAN-IMMUNODEFICIENCY-VIRUS | HEPATOCELLULAR-CARCINOMA | IMPACT | HIV-INFECTION | NAIVE PATIENTS | GASTROENTEROLOGY & HEPATOLOGY | PROGRESSION | Highly active antiretroviral therapy | Antiviral agents | Comorbidity | Liver | Comparative analysis | HIV (Viruses) | Health aspects | Hepatitis B | Syngeneic grafts | Viruses | Hepatocellular carcinoma | Transplantation | Tenofovir | Time dependence | Hepatitis | Regression models | Allografts | Antiretroviral agents | Human immunodeficiency virus--HIV | Hepatitis B virus | Hypertension | Alanine | Liver diseases | Statistical analysis | Mortality | Regression analysis | Patients | Antiretroviral therapy | Cirrhosis | Alanine transaminase | Hepatitis C virus | Hepatitis C | Liver transplantation
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4. Full Text IgE‐expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis
by Heeringa, J. J and Rijvers, L and Arends, N. J and Driessen, G. J and Pasmans, S. G and Dongen, J. J. M and Jongste, J. C and Zelm, M. C
Allergy, ISSN 0105-4538, 06/2018, Volume 73, Issue 6, pp. 1331 - 1336
Despite the critical role of soluble IgE in the pathology of IgE‐mediated allergic disease, little is known about abnormalities in the memory B cells and... 
plasmablast | asthma | flow cytometry | IgE | memory B cell | PATHWAYS | QUILIZUMAB | RANDOMIZED-TRIAL | INNATE LYMPHOID-CELLS | IMMUNOLOGY | RHINITIS | MUCOSA | RESPONSES | IN-VITRO | ALLERGY | ORIGINATE | T-CELLS | Food allergy | Asthma in children | Atopic dermatitis | Immunoglobulin E | Children | B cells | Health aspects | CD27 antigen | Food allergies | Flow cytometry | Immunological memory | Memory cells | Leukocytes (eosinophilic) | Abnormalities | Medical treatment | Allergic diseases | Lymphocytes T | Dermatitis | Patients | Blood | Asthma | Lymphocytes B | Plasma cells | Food hypersensitivity | Food | Eosinophils
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5. Full Text B Cell Depletion Therapy Normalizes Circulating Follicular Th Cells in Primary Sjögren Syndrome
by Verstappen, Gwenny M and Kroese, Frans G. M and Meiners, Petra M and Corneth, Odilia B and Huitema, Minke G and Haacke, Erlin A and van der Vegt, Bert and Arends, Suzanne and Vissink, Arjan and Bootsma, Henika and Abdulahad, Wayel H
The Journal of Rheumatology, ISSN 0315-162X, 01/2017, Volume 44, Issue 1, pp. 49 - 58
Objective. To assess the effect of B cell depletion therapy on effector CD4+ T cell homeostasis and its relation to objective measures of disease activity in... 
RITUXIMAB TREATMENT | SJOGREN SYNDROME | CONTROLLED-TRIAL | HELPER-CELLS | SALIVARY-GLANDS | B LYMPHOCYTES | CYTOKINE PRODUCTION | T LYMPHOCYTES | AUTOIMMUNITY | RITUXIMAB | DISEASE | DOUBLE-BLIND | DIFFERENTIATION | EXPRESSION | EFFICACY | RHEUMATOLOGY | INTERLEUKIN-17 | Sjogren's Syndrome - pathology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Sjogren's Syndrome - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Sjogren's Syndrome - immunology | Male | Treatment Outcome | Sjogren's Syndrome - metabolism | Rituximab - therapeutic use | Flow Cytometry | Lymphocyte Count | Adult | Female | CD4-Positive T-Lymphocytes | T-Lymphocytes, Helper-Inducer - pathology | B-Lymphocytes - pathology | Lymphocyte Depletion - methods | B-Lymphocytes - metabolism
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6. Full Text Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir
by Papatheodoridis, George V and Dalekos, George N and Yurdaydin, Cihan and Buti, Maria and Goulis, John and Arends, Pauline and Sypsa, Vana and Manolakopoulos, Spilios and Mangia, Giampaolo and Gatselis, Nikolaos and Keskın, Onur and Savvidou, Savvoula and Hansen, Bettina E and Papaioannou, Christos and Galanis, Kostantinos and Idilman, Ramazan and Colombo, Massimo and Esteban, Rafael and Janssen, Harry L.A and Lampertico, Pietro
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 62, Issue 2, pp. 363 - 370
Graphical abstract 
Gastroenterology and Hepatology | Tenofovir | Cirrhosis | CU-HCC | Entecavir | REACH-B | Hepatocellular carcinoma | Risk scores | GAG-HCC | Hepatitis B | SCORE | MANAGEMENT | RISK | OPEN-LABEL | LIVER-DISEASE | LAMIVUDINE | VIRUS INFECTION | DISOPROXIL FUMARATE | NUCLEOS(T)IDE ANALOG THERAPY | GASTROENTEROLOGY & HEPATOLOGY | Follow-Up Studies | Guanine - analogs & derivatives | Humans | Middle Aged | Netherlands - epidemiology | Male | Incidence | Liver Neoplasms - etiology | Time Factors | Adenine - therapeutic use | Adult | Female | Carcinoma, Hepatocellular - etiology | Retrospective Studies | Reverse Transcriptase Inhibitors - therapeutic use | Guanine - therapeutic use | Carcinoma, Hepatocellular - ethnology | Adenine - analogs & derivatives | Organophosphonates - therapeutic use | Antiviral Agents - therapeutic use | Hepatitis B, Chronic - ethnology | Risk Factors | European Continental Ancestry Group | Greece - epidemiology | Liver Neoplasms - ethnology | Hepatitis B, Chronic - drug therapy | Turkey - epidemiology | Spain - epidemiology | Antiviral agents
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7. Full Text Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians
by Arends, Pauline and Sonneveld, Milan J and Zoutendijk, Roeland and Carey, Ivana and Brown, Ashley and Fasano, Massimo and Mutimer, David and Deterding, Katja and Reijnders, Jurriën G P and Oo, Ye and Petersen, Jörg and van Bömmel, Florian and de Knegt, Robert J and Santantonio, Teresa and Berg, Thomas and Welzel, Tania M and Wedemeyer, Heiner and Buti, Maria and Pradat, Pierre and Zoulim, Fabien and Hansen, Bettina and Janssen, Harry L A and VIRGIL Surveillance Study Grp and VIRGIL Surveillance Study Group
Gut, ISSN 0017-5749, 08/2015, Volume 64, Issue 8, pp. 1289 - 1295
BackgroundHepatocellular carcinoma (HCC) risk-scores may predict HCC in Asian entecavir (ETV)-treated patients. We aimed to study risk factors and performance... 
GASTROENTEROLOGY & HEPATOLOGY | THERAPY | Follow-Up Studies | Risk Assessment | Guanine - analogs & derivatives | Hepatitis B, Chronic - ethnology | Humans | Middle Aged | Risk Factors | DNA, Viral - analysis | European Continental Ancestry Group | Male | Antiviral Agents | Incidence | Liver Neoplasms - ethnology | Liver Neoplasms - etiology | Hepatitis B, Chronic - complications | Hepatitis B, Chronic - drug therapy | Hepatitis B virus - genetics | Adult | Female | Carcinoma, Hepatocellular - etiology | Retrospective Studies | United Kingdom - epidemiology | Guanine - therapeutic use | Carcinoma, Hepatocellular - ethnology | Care and treatment | Entecavir | Dosage and administration | Whites | Hepatoma | Health aspects | Risk factors | Antigens | Hepatitis | Liver cancer | Ultrasonic imaging | Medical imaging | Population | Interferon | Clinical medicine | Deoxyribonucleic acid--DNA
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8. Full Text Reduced risk of relapse after long‐term nucleos(t)ide analogue consolidation therapy for chronic hepatitis B
by Chi, H and Hansen, B. E and Yim, C and Arends, P and Abu‐Amara, M and Eijk, A. A and Feld, J. J and Knegt, R. J and Wong, D. K. H and Janssen, H. L. A
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 05/2015, Volume 41, Issue 9, pp. 867 - 876
Summary Background Before stopping nucleos(t)ide analogue (NA) treatment in chronic hepatitis B (CHB), 6–12 months of consolidation therapy is recommended. Aim... 
VIRUS | SEROCONVERSION | CIRRHOSIS | DNA | PHARMACOLOGY & PHARMACY | HBSAG | GASTROENTEROLOGY & HEPATOLOGY | DISCONTINUATION | Recurrence | Hepatitis B, Chronic - drug therapy | Follow-Up Studies | Antiviral Agents - therapeutic use | Humans | Middle Aged | Adult | Female | Male | Treatment Outcome | Hepatitis B e Antigens - analysis | Hepatitis B Surface Antigens - analysis
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9. Full Text Flares during long‐term entecavir therapy in chronic hepatitis B
by Chi, Heng and Arends, Pauline and Reijnders, Jurriën G P and Carey, Ivana and Brown, Ashley and Fasano, Massimo and Mutimer, David and Deterding, Katja and Oo, Ye H and Petersen, Jörg and Bommel, Florian and Knegt, Robert J and Santantonio, Teresa A and Berg, Thomas and Welzel, Tania M and Wedemeyer, Heiner and Buti, Maria and Pradat, Pierre and Zoulim, Fabien and Hansen, Bettina E and Janssen, Harry L A and VIRGIL Surveillance Study Grp and VIRGIL Surveillance Study Group (European surveillance network for vigilance against viral resistance)
Journal of Gastroenterology and Hepatology, ISSN 0815-9319, 11/2016, Volume 31, Issue 11, pp. 1882 - 1887
Background and Aim The incidence and consequences of flares during first‐line nucleos(t)ide analogue therapy are largely unknown. We aimed to investigate the... 
chronic hepatitis B | flare | nucleos(t)ide analogue | ALT | entecavir | RISK | LAMIVUDINE THERAPY | LIVER-DISEASE | HEPATOCELLULAR-CARCINOMA | T-CELL RESPONSES | VIRUS INFECTION | GASTROENTEROLOGY & HEPATOLOGY | ACUTE EXACERBATION | Follow-Up Studies | Antiviral Agents - therapeutic use | Guanine - analogs & derivatives | Humans | Middle Aged | Male | Alanine Transaminase - blood | Biomarkers - blood | Hepatitis B, Chronic - enzymology | Hepatitis B Surface Antigens - blood | DNA, Viral - blood | Hepatitis B, Chronic - virology | Hepatitis B, Chronic - drug therapy | Antiviral Agents - adverse effects | Hepatitis B virus - genetics | Adult | Female | Guanine - adverse effects | Hepatitis B virus - isolation & purification | Hepatitis B e Antigens - blood | Guanine - therapeutic use | Drug resistance | Patient compliance | Entecavir | Hepatitis B | Life Sciences | Cancer
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10. Full Text Loss of intrahepatic HBsAg expression predicts sustained response to peginterferon and is reflected by pronounced serum HBsAg decline
by Arends, P and Rijckborst, V and Zondervan, P. E and Buster, E and Cakaloglu, Y and Ferenci, P and Tabak, F and Akarca, U. S and Simon, K and Sonneveld, M. J and Hansen, B. E and Janssen, H. L. A
Journal of Viral Hepatitis, ISSN 1352-0504, 12/2014, Volume 21, Issue 12, pp. 897 - 904
Summary There is a lack of knowledge regarding the effect of peginterferon (PEG‐IFN) on the expression of intrahepatic hepatitis B core and surface antigen... 
chronic hepatitis B | intrahepatic staining | immunohistochemistry | hepatitis B surface antigen | hepatitis B core antigen | peginterferon | ALPHA-2A | INFECTIOUS DISEASES | HEPATITIS-B-VIRUS | NATURAL-HISTORY | COMBINATION | CCCDNA | TRIAL | LAMIVUDINE | VIROLOGY | DNA | SURFACE-ANTIGEN | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Liver - virology | Liver - pathology | Prognosis | Humans | Middle Aged | Hepatitis B Core Antigens - analysis | Male | Treatment Outcome | Alanine Transaminase - blood | Interferons - therapeutic use | Hepatitis B, Chronic - diagnosis | Hepatitis B e Antigens - analysis | Hepatitis B Surface Antigens - analysis | Viral Load | Hepatitis B Surface Antigens - blood | DNA, Viral - blood | Hepatitis B, Chronic - virology | Young Adult | Hepatitis B, Chronic - drug therapy | Biopsy | Adult | Female | Immunohistochemistry | Hepatitis | Interferon
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11. Full Text Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
by Mansouri, Larry and Noerenberg, Daniel and Young, Emma and Mylonas, Elena and Abdulla, Maysaa and Frick, Mareike and Asmar, Fazila and Ljungström, Viktor and Schneider, Markus and Yoshida, Kenichi and Skaftason, Aron and Pandzic, Tatjana and Gonzalez, Blanca and Tasidou, Anna and Waldhueter, Nils and Rivas-Delgado, Alfredo and Angelopoulou, Maria and Ziepert, Marita and Arends, Christopher Maximilian and Couronné, Lucile and Lenze, Dido and Baldus, Claudia D and Bastard, Christian and Okosun, Jessica and Fitzgibbon, Jude and Dörken, Bernd and Drexler, Hans G and Roos-Weil, Damien and Schmitt, Clemens A and Munch-Petersen, Helga D and Zenz, Thorsten and Hansmann, Martin-Leo and Strefford, Jonathan C and Enblad, Gunilla and Bernard, Olivier A and Ralfkiaer, Elisabeth and Erlanson, Martin and Korkolopoulou, Penelope and Hultdin, Magnus and Papadaki, Theodora and Grønbæk, Kirsten and Lopez-Guillermo, Armando and Ogawa, Seishi and Küppers, Ralf and Stamatopoulos, Kostas and Stavroyianni, Niki and Kanellis, George and Rosenwald, Andreas and Campo, Elias and Amini, Rose-Marie and Ott, German and Vassilakopoulos, Theodoros P and Hummel, Michael and Rosenquist, Richard and Damm, Frederik and Medicinska fakulteten and Patologi and Institutionen för medicinsk biovetenskap and Institutionen för strålningsvetenskaper and Onkologi and Umeå universitet
Blood, ISSN 0006-4971, 2016, Volume 128, Issue 23, pp. 2666 - 2670
We recently reported a truncating deletion in the NFKBIE gene, which encodes IkB epsilon, a negative feedback regulator of NF-kB, in clinically aggressive... 
ZONE LYMPHOMA | RITUXIMAB | DEREGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | NF-KAPPA-B | SOMATIC MUTATIONS | EPSILON | Lymphoma, B-Cell - mortality | Mediastinal Neoplasms - genetics | Humans | Middle Aged | Male | Mediastinal Neoplasms - mortality | Proto-Oncogene Proteins - genetics | Survival Rate | Lymphoma, B-Cell - genetics | I-kappa B Proteins - genetics | Disease-Free Survival | Gene Deletion | Adolescent | Adult | Female | Aged | Biomarkers, Tumor - genetics | Clinical Medicine | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cancer and Oncology | Klinisk medicin | Cell- och molekylärbiologi | Cancer och onkologi
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12. Full Text B-TUD-1: A versatile mesoporous catalyst
by Ranoux, A and Djanashvili, K and Arends, I.W.C.E and Hanefeld, U
RSC Adv., 2013, 3, 21524, ISSN 2046-2069, 08/2013, Volume 3, Issue 44, pp. 21524 - 21534
Novel amorphous mesoporous borosilicate, B-TUD-1, was prepared to test its performance for different sustainable reactions. The structure of the material, the... 
Gold for Gold | Open Access | CYCLOHEXANE OXIDATION | TUD-1 | PRINS REACTION | IR-BETA ZEOLITE | BORIC-ACID | IONIC LIQUID | CITRONELLAL | MOLECULAR-SIEVES | ATRANE ROUTE | HETEROGENEOUS CATALYST | CHEMISTRY, MULTIDISCIPLINARY | Citronellal | Borosilicate | Solvents | Boron | Transmission electron microscopy | Catalysts | Recycled | Leaching
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