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1. Centros de referencia: Hospital Infantil Universitario Niño Jesús
by Argente Oliver, Jesús
Revista Espanola de Pediatria, ISSN 0034-947X, 07/2013, Volume 69, Issue 4, pp. 175 - 176
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2. Servicio de Endocrinología, Crecimiento y Nutrición del H. Infantil Universitario Niño Jesús
by Argente Oliver, Jesús
Revista Espanola de Pediatria, ISSN 0034-947X, 07/2013, Volume 69, Issue 4, pp. 177 - 186
Normal and pathological growth | Pediatric endocrinology | Diabetes | Hormones
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3. Full Text Mutations in pregnancy‐associated plasma protein A2 cause short stature due to low IGF‐I availability
by Dauber, Andrew and Muñoz‐Calvo, María T and Barrios, Vicente and Domené, Horacio M and Kloverpris, Soren and Serra‐Juhé, Clara and Desikan, Vardhini and Pozo, Jesús and Muzumdar, Radhika and Martos‐Moreno, Gabriel Á and Hawkins, Federico and Jasper, Héctor G and Conover, Cheryl A and Frystyk, Jan and Yakar, Shoshana and Hwa, Vivian and Chowen, Julie A and Oxvig, Claus and Rosenfeld, Ron G and Pérez‐Jurado, Luis A and Argente, Jesús
EMBO Molecular Medicine, ISSN 1757-4676, 04/2016, Volume 8, Issue 4, pp. 363 - 374
Mutations in multiple genes of the growth hormone/ IGF ‐I axis have been identified in syndromes marked by growth failure. However, no pathogenic human... 
IGF | binding proteins | bone | delayed growth | growth hormone | bioavailability | Delayed growth | IGF-binding proteins | Bone | IGF bioavailability | Growth hormone | BIOACTIVITY | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR SYSTEM | PROTEOLYSIS | CHILDREN | GENE | INTRAUTERINE | PAPP-A | KNOCKOUT | EXPRESSION | Pregnancy-Associated Plasma Protein-A - genetics | Humans | Child, Preschool | Male | Insulin-Like Growth Factor Binding Proteins - metabolism | Young Adult | Dwarfism - genetics | Adolescent | Female | Dwarfism - pathology | Mutation | Pregnancy-Associated Plasma Protein-A - metabolism | Child | Longitudinal Studies | Insulin-Like Growth Factor I - metabolism | Somatotropin | Pregnant women | Analysis | Bones | Genetic aspects | Binding proteins | Density | Blood proteins | Protein binding | Genes | Menopause | Biological activity | Pregnancy | Proteins | Microencephaly | Proteolysis | Conflicts of interest | Growth hormones | Bone (long) | Metalloproteinase | Bone density | Physical growth | Age | Proteïnes | Fixació | IGF‐binding proteins | Hormones | Genetics, Gene Therapy & Genetic Disease
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4. Full Text Challenges in the Management of Short Stature
by Argente, Jesús
Hormone Research in Paediatrics, ISSN 1663-2818, 02/2016, Volume 85, Issue 1, pp. 2 - 10
Human growth, from fetal life to adolescence, is dynamic and a good marker of health. Growth is a complex process influenced by genetic, hormonal, nutritional... 
Mini Review | Practical algorithm | Short stature | Therapeutic options | Normal height | Growth | DIAGNOSIS | LABILE SUBUNIT DEFICIENCY | CHILDREN | THERAPY | ENDOCRINOLOGY & METABOLISM | IDIOPATHIC SHORT STATURE | LERI-WEILL DYSCHONDROSTEOSIS | PEDIATRICS | RECEPTOR GENE | MUTATIONS | PITUITARY-HORMONE DEFICIENCY | GROWTH-FACTOR-I | Hearing Loss, Sensorineural - metabolism | Growth Disorders - pathology | Humans | Insulin-Like Growth Factor II - deficiency | Child, Preschool | Hearing Loss, Sensorineural - pathology | Insulin-Like Growth Factor I - deficiency | Human Growth Hormone - deficiency | Infant | Male | Hearing Loss, Sensorineural - genetics | Insulin-Like Growth Factor I - genetics | Growth Disorders - metabolism | Hearing Loss, Sensorineural - therapy | Adolescent | Female | Growth Disorders - genetics | Growth Disorders - therapy | Child | Infant, Newborn | Insulin-Like Growth Factor I - metabolism
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5. Full Text Plasma Concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: Relationship to psychiatric comorbidity
by Pedraz, María and Martín-Velasco, Ana Isabel and García-Marchena, Nuria and Araos, Pedro and Serrano, Antonia and Romero-Sanchiz, Pablo and Suárez, Juan and Castilla-Ortega, Estela and Barrios, Vicente and Campos-Cloute, Rafael and Ruiz, Juan Jesús and Torrens, Marta and Chowen, Julie Ann and Argente, Jesús and De La Torre, Rafael and Santín, Luis Javier and Villanúa, María Ángeles and De Fonseca, Fernando Rodríguez and Pavón, Francisco Javier
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0118610
Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders. Monitoring... 
INSULIN | RESEARCH INTERVIEW | DSM-5 CRITERIA | DEPRESSION | ALCOHOL | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | MENTAL-DISORDERS | NEUROPLASTICITY | BRAIN | GROWTH-FACTOR-I | Immunoassay | Chemokines - blood | Prevalence | Cross-Sectional Studies | Humans | Middle Aged | Insulin-Like Growth Factor Binding Protein 3 - blood | Male | Mental Disorders - complications | Brain-Derived Neurotrophic Factor - blood | Cocaine-Related Disorders - epidemiology | Insulin-Like Growth Factor I - analysis | Young Adult | Cocaine-Related Disorders - complications | Radioimmunoassay | Adolescent | Adult | Female | Interviews as Topic | Aged | Mental Disorders - diagnosis | Cocaine-Related Disorders - diagnosis | Cytokines - blood | Comorbidity | Analysis | Substance abuse | Anxiety | Cocaine | Health aspects | Prevalence studies (Epidemiology) | Protein binding | Drug abuse | Brain | CXCL12 protein | Peptides | Mental disorders | Insulin-like growth factor I | Pathogenesis | Bipolar disorder | Systematic review | Insulin-like growth factors | Neurogenesis | Plasticity (neural) | Insulin-like growth factor-binding protein 3 | Fractalkine | Bioindicators | Ethanolamine | Cell survival | Narcotics | Inflammation | Neurotrophic factors | SDF-1 protein | Insulin | Substance use | Brain-derived neurotrophic factor | Mood | Addiction | Body mass | Anxieties | Correlation analysis | Biomarkers | Diagnostic systems | Chemokines | Drogoaddicció | Cocaïna | Psiquiatria
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6. Full Text Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
by Kim, Jae Geun and Suyama, Shigetomo and Koch, Marco and Jin, Sungho and Argente-Arizon, Pilar and Argente, Jesús and Liu, Zhong-Wu and Zimmer, Marcelo R and Jeong, Jin Kwon and Szigeti-Buck, Klara and Gao, Yuanqing and Garcia-Caceres, Cristina and Yi, Chun-Xia and Salmaso, Natalina and Vaccarino, Flora M and Chowen, Julie and Diano, Sabrina and Dietrich, Marcelo O and Tschöp, Matthias H and Horvath, Tamas L
Nature neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 7, pp. 908 - 910
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic... 
POMC NEURONS | OBESITY | ARCUATE NUCLEUS | RECEPTORS | NEUROSCIENCES | GLUTAMATE | Immunohistochemistry | Glial Fibrillary Acidic Protein - genetics | Cell Count | Male | Glial Fibrillary Acidic Protein - metabolism | Nerve Net - physiology | Pro-Opiomelanocortin - physiology | Eating - physiology | Melanocortins - physiology | Excitatory Postsynaptic Potentials - physiology | Leptin - physiology | RNA, Messenger - biosynthesis | In Situ Hybridization | Neurons - physiology | Real-Time Polymerase Chain Reaction | Hypothalamus - physiology | RNA, Messenger - genetics | Leptin - genetics | Microscopy, Electron | Mice, Knockout | Pulmonary Gas Exchange - physiology | Astrocytes - physiology | Animals | Hypothalamus - cytology | Signal Transduction - physiology | Mice | Primary Cell Culture | Physiological aspects | Research | Neurons | Astrocytes | Leptin
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7. Full Text Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
by Fuente-Martiń, Esther and García-Cáceres, Cristina and Granado, Miriam and De Ceballos, Mariá L and Sánchez-Garrido, Miguel Ángel and Sarman, Beatrix and Liu, Zhong-Wu and Dietrich, Marcelo O and Tena-Sempere, Manuel and Argente-Arizón, Pilar and Díaz, Francisca and Argente, Jesús and Horvath, Tamas L and Chowen, Julie A
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3900 - 3913
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADULT RATS | FOOD-INTAKE | IMMUNOHISTOCHEMICAL LOCALIZATION | MOUSE EMBRYOS | GENE-EXPRESSION | WEIGHT-GAIN | ARCUATE NUCLEUS | GLIAL-CELLS | UP-REGULATION | FEEDING CIRCUITS | Glucose Transport Proteins, Facilitative - metabolism | Neurons - pathology | Dietary Fats - adverse effects | Obesity - chemically induced | Rats, Wistar | Leptin - metabolism | Astrocytes - pathology | Rats | Hypothalamus - pathology | Obesity - metabolism | Obesity - pathology | Pro-Opiomelanocortin - metabolism | Amino Acid Transport System X-AG - metabolism | Animals | Hypothalamus - metabolism | Dietary Fats - pharmacology | Mice | Neurons - metabolism | Astrocytes - metabolism | Glucose metabolism | Astrocytes | Leptin | Physiological aspects | Hypothalamus | Glutamate | Health aspects
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8. Full Text Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency
by Muñoz-Calvo, María T and Barrios, Vicente and Pozo, Jesús and Chowen, Julie A and Martos-Moreno, Gabriel Á and Hawkins, Federico and Dauber, Andrew and Domené, Horacio M and Yakar, Shoshana and Rosenfeld, Ron G and Pérez-Jurado, Luis A and Oxvig, Claus and Frystyk, Jan and Argente, Jesús
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2016, Volume 101, Issue 11, pp. 3879 - 3883
Context: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that specifically cleaves IGFBP-3 and IGFBP-5. Mutations in the PAPP-A2 gene... 
ENDOCRINOLOGY & METABOLISM | CHILDREN | Recombinant Proteins - therapeutic use | Pregnancy-Associated Plasma Protein-A - genetics | Frameshift Mutation | Exons | Growth Disorders - drug therapy | Humans | Male | Treatment Outcome | Insulin-Like Growth Factor I - genetics | Recombinant Proteins - adverse effects | Recombinant Proteins - administration & dosage | Homozygote | Pregnancy-Associated Plasma Protein-A - deficiency | Insulin-Like Growth Factor I - administration & dosage | Insulin-Like Growth Factor I - adverse effects | Female | Codon, Terminator | Growth Disorders - genetics | Insulin-Like Growth Factor I - therapeutic use | Child | Siblings
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9. Full Text Central precocious puberty, functional and tumor-related
by Soriano-Guillén, Leandro and Argente, Jesús
Best Practice & Research Clinical Endocrinology & Metabolism, ISSN 1521-690X, 06/2019, Volume 33, Issue 3, p. 101262
Precocious puberty is defined as the appearance of secondary sex characteristics before 8 years of age in girls and before 9 years of age in boys. Central... 
puberty | GnRH test | central precocious puberty | MRI | pelvic ultrasound | GnRH analogs
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10. Full Text Response to growth hormone in patients with RNPC3 mutations
by Martos‐Moreno, Gabriel Á and Travieso‐Suárez, Lourdes and Pozo‐Román, Jesús and Muñoz‐Calvo, María T and Chowen, Julie A and Frilander, Mikko J and Pérez‐Jurado, Luis A and Hawkins, Federico G and Argente, Jesús
EMBO Molecular Medicine, ISSN 1757-4676, 07/2018, Volume 10, Issue 7, p. n/a
After 6 years of Growth Hormone ( GH ) therapy, three patients with a defect in minor spliceosome mRNA processing leading to an incompletely understood GH... 
DENSITY | MEDICINE, RESEARCH & EXPERIMENTAL | DEFICIENCY | CHILDREN | Somatotropin | Genetic aspects | Somatotropina | Hormones | Correspondence | Genetics, Gene Therapy & Genetic Disease | Pharmacology & Drug Discovery | Development & Differentiation
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11. Full Text Polycystic kidney disease with hyperinsulinemic hypoglycemia caused by a promoter mutation in phosphomannomutase 2
by Cabezas, Oscar Rubio and Flanagan, Sarah E and Stanescu, Horia and García-Martínez, Elena and Caswell, Richard and Lango-Allen, Hana and Antón-Gamero, Montserrat and Argente, Jesús and Bussell, Anna-Marie and Brandli, Andre and Cheshire, Chris and Crowne, Elizabeth and Dumitriu, Simona and Drynda, Robert and Hamilton-Shield, Julian P and Hayes, Wesley and Hofherr, Alexis and Iancu, Daniela and Issler, Naomi and Jefferies, Craig and Jones, Peter and Johnson, Matthew and Kesselheim, Anne and Klootwijk, Enriko and Koettgen, Michael and Lewis, Wendy and Martos, José María and Mozere, Monika and Norman, Jill and Patel, Vaksha and Parrish, Andrew and Pérez-Cerdá, Celia and Pozo, Jesús and Rahman, Sofia A and Sebire, Neil and Tekman, Mehmet and Turnpenny, Peter D and Van'T Hoff, William and Viering, Daan H.H.M and Weedon, Michael N and Wilson, Patricia and Guay-Woodford, Lisa and Kleta, Robert and Hussain, Khalid and Ellard, Sian and Bockenhauer, Detlef
Journal of the American Society of Nephrology, ISSN 1046-6673, 08/2017, Volume 28, Issue 8, pp. 2529 - 2539
Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are rare, genetically heterogeneous disorders. The co-occurrence of these... 
DIAGNOSIS | HUMAN GENOME | MANAGEMENT | GENETICS | INFANTS | CONGENITAL DISORDERS | PHENOTYPE | UROLOGY & NEPHROLOGY | GLYCOSYLATION | LIVER-DISEASE | CHROMATIN INTERACTIONS | Polycystic Kidney Diseases - genetics | Phosphotransferases (Phosphomutases) - genetics | Humans | Child, Preschool | Congenital Hyperinsulinism - complications | Infant | Male | Polycystic Kidney Diseases - complications | Promoter Regions, Genetic - genetics | Congenital Hyperinsulinism - genetics | Female | Mutation | Infant, Newborn | ZNF143 | Clinical Research | hyperinsulinemic hypoglycemia | polycystic kidney disease | PMM2 | glycosylation | promoter
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12. Full Text Ghrelin: A link between energy homeostasis and the immune system
by Chowen, Julie A and Argente, Jesús
Endocrinology, ISSN 0013-7227, 07/2017, Volume 158, Issue 7, pp. 2077 - 2081
OBESITY | ACTIVATION | DISEASES | HORMONE | METABOLISM | HIGH-FAT DIET | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | CONSUMPTION | HYPOTHALAMUS | Homeostasis | Energy balance | Ghrelin | Immune system
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13. Full Text One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology
by Argente, Jesús and Chowen, Julie A and Pérez‐Jurado, Luis A and Frystyk, Jan and Oxvig, Claus
EMBO Molecular Medicine, ISSN 1757-4676, 10/2017, Volume 9, Issue 10, pp. 1338 - 1345
The discovery of a mutation in a specific gene can be very important for determining the pathophysiology underlying the disease of a patient and may also help... 
IGFBP | A2 | IGF | stanniocalcins (STC1, STC2) | PAPP | PAPP-A | IGF-1 | PAPP-A2 | IGFBPs | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-HORMONE INSENSITIVITY | MULTIPLE ENDOCRINE ABNORMALITIES | FACTOR AXIS | FACTOR-I | SHORT STATURE | PLASMA-PROTEIN-A | INSULIN | stanniocalcins (STCT, STC2) | POSTNATAL-GROWTH | TRANSGENIC MICE | Pregnancy-Associated Plasma Protein-A - genetics | Human Growth Hormone - genetics | Humans | Glycoproteins - metabolism | Mice, Transgenic | Insulin-Like Growth Factor I - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Human Growth Hormone - metabolism | Proteolysis | Female | Mice | Mutation | Pregnancy-Associated Plasma Protein-A - metabolism | Human Development - physiology | Insulin-Like Growth Factor I - metabolism | Physiological aspects | Somatotropin | Proteases | Blood proteins | Pregnancy | Insulin-like growth factor I | Spatial discrimination | Insulin-like growth factors | Metalloproteinase | Growth hormone | Insulin | IGF‐1 | PAPP‐A2 | PAPP‐A | Stanniocalcins (STC1, STC2) | Genetics, Gene Therapy & Genetic Disease | Review
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14. Full Text Sex differences in psychiatric comorbidity and plasma biomarkers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings
by Pedraz, María and Araos, Pedro and García-Marchena, Nuria and Serrano, Antonia and Romero-Sanchiz, Pablo and Suárez, Juan and Castilla-Ortega, Estela and Mayoral-Cleries, Fermín and Ruiz, Juan Jesús and Pastor, Antoni and Barrios, Vicente and Chowen, Julie A and Argente, Jesús and Torrens, Marta and De la Torre, Rafael and De Fonseca, Fernando Rodríguez and Pavón, Francisco Javier
Frontiers in Psychiatry, ISSN 1664-0640, 2015, Volume 6, p. 17
There are sex differences in the progression of drug addiction, relapse, and response to therapies. Because biological factors participate in these... 
Biomarker | Endocannabinoid | Cytokine | Sex | Outpatient | Psychiatric comorbidity | Cocaine use disorders | Abstinence | cytokine | endocannabinoid | GONADAL-HORMONES | SUBSTANCE-ABUSERS | IMMUNE-RESPONSE | DSM-IV | PSYCHIATRY | sex | cocaine use disorders | outpatient | biomarker | RESEARCH INTERVIEW | MOOD DISORDERS | MENTAL-DISORDERS | ENDOCANNABINOID LEVELS | abstinence | USERS | INDEPENDENT DISORDERS | psychiatric comorbidity | Efectes fisiològics | Cocaïna | Comorbiditat | Psiquiatria
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