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1. Full Text Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
by Michela Di Virgilio and Elsa Callen and Arito Yamane and Wenzhu Zhang and Mila Jankovic and Alexander D. Gitlin and Niklas Feldhahn and Wolfgang Resch and Thiago Y. Oliveira and Brian T. Chait and André Nussenzweig and Rafael Casellas and Davide F. Robbiani and Michel C. Nussenzweig
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6120, pp. 711 - 715
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to the loss of genetic information and chromosome rearrangements. The... 
Proteins | Phosphorylation | B lymphocytes | DNA damage | DNA | REPORTS | Cell cycle | Genomes | DNA repair | Chromosomes | Genotypes | B-LYMPHOCYTES | RECOMBINATION | REGULATOR | REPAIR | REPLICATION | 53BP1 | MULTIDISCIPLINARY SCIENCES | END RESECTION | AID | DAMAGE | TELOMERES | Genomic Instability | Tumor Suppressor Proteins - antagonists & inhibitors | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | S Phase | Protein-Serine-Threonine Kinases - antagonists & inhibitors | G2 Phase | Telomere-Binding Proteins - metabolism | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | DNA - metabolism | G1 Phase | Animals | B-Lymphocytes - immunology | DNA Repair | Mice | Tumor Suppressor p53-Binding Protein 1 | Immunoglobulins | Research | Properties | Genomics | Breaking | Deoxyribonucleic acid | Damage | Online | Repair | Switching
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2. Full Text Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
by Kuchen, Stefan and Li, Zhiyu and Sun, Hong-wei and Casellas, Rafael and Nussenzweig, Michel C and Yamane, Arito and Resch, Wolfgang and Kuo, Nan and Robbiani, Davide F and McBride, Kevin
Nature Immunology, ISSN 1529-2908, 01/2011, Volume 12, Issue 1, pp. 62 - 69
The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, leading to tumorigenesis. The extent of AID's promiscuity and its... 
RNA-POLYMERASE-II | ACTIVATION-INDUCED DEAMINASE | SOMATIC HYPERMUTATION | KINASE-A | REPLICATION PROTEIN-A | IMMUNOGLOBULIN GENES | C-MYC | IG GENES | CLASS-SWITCH RECOMBINATION | IMMUNOLOGY | CELL LYMPHOMAS | Lipopolysaccharides - metabolism | Chromatin Assembly and Disassembly - genetics | Lipopolysaccharides - immunology | Promoter Regions, Genetic - genetics | Cell Transformation, Neoplastic - genetics | Replication Protein A - genetics | B-Lymphocytes - pathology | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Genes, Immunoglobulin - genetics | Somatic Hypermutation, Immunoglobulin | Cytidine Deaminase - genetics | Interleukin-4 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Replication Protein A - metabolism | Mice, Knockout | Interleukin-4 - immunology | Cell Transformation, Neoplastic - immunology | Animals | B-Lymphocytes - immunology | Cytidine Deaminase - metabolism | Genes, myc - genetics | High-Throughput Nucleotide Sequencing | Mice | Enzymes | Usage | Gene mutations | Physiological aspects | Hydrolases | Genetic aspects | B cells | Research | Nucleotide sequencing | Health aspects
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3. Full Text c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
by Nie, Zuqin and Hu, Gangqing and Wei, Gang and Cui, Kairong and Yamane, Arito and Resch, Wolfgang and Wang, Ruoning and Green, Douglas R and Tessarollo, Lino and Casellas, Rafael and Zhao, Keji and Levens, David
Cell, ISSN 0092-8674, 09/2012, Volume 151, Issue 1, pp. 68 - 79
The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism, and differentiation at the... 
ONCOGENES | LYMPHOMA CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GRAPHICAL USER-INTERFACE | TRANSCRIPTION FACTOR MYC | FIBROBLASTS | GENOME | RNA-POLYMERASE | REVEALS | CELL BIOLOGY | Lymphocytes - metabolism | Embryonic Stem Cells - metabolism | Promoter Regions, Genetic | Animals | Humans | Transcriptional Activation | Mice | Spleen - cytology | DNA-Directed RNA Polymerases - metabolism | Genome | Proto-Oncogene Proteins c-myc - metabolism | B-Lymphocytes - metabolism | Chromatin | RNA | Lymphocytes | Analysis | Genes | Genomics | Genetic research | Physiological aspects | Embryonic stem cells
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4. Full Text Regulation of MicroRNA Expression and Abundance during Lymphopoiesis
by Kuchen, Stefan and Resch, Wolfgang and Yamane, Arito and Kuo, Nan and Li, Zhiyu and Chakraborty, Tirtha and Wei, Lai and Laurence, Arian and Yasuda, Tomoharu and Peng, Siying and Hu-Li, Jane and Lu, Kristina and Dubois, Wendy and Kitamura, Yoshiaki and Charles, Nicolas and Sun, Hong-wei and Muljo, Stefan and Schwartzberg, Pamela L and Paul, William E and O'Shea, John and Rajewsky, Klaus and Casellas, Rafael
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 6, pp. 828 - 839
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We... 
SYSBIO | MOLIMMUNO | POSTTRANSCRIPTIONAL REGULATION | HOST GENES | STEM-CELLS | CAENORHABDITIS-ELEGANS | SMALL RNAS | INDUCED CYTIDINE DEAMINASE | MOUSE OOCYTES | B-CELL DIFFERENTIATION | C-ELEGANS | IMMUNOLOGY | T-CELLS | Gene Expression | Animals | Gene Expression Regulation - genetics | Lymphocytes | Epigenesis, Genetic | Humans | Lymphopoiesis - genetics | Mice | MicroRNAs - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genetic disorders | Messenger RNA | Oncology, Experimental | Genetic research | Biosynthesis | Research | Gene expression | Cancer | Proteins | Spleen | MicroRNAs | Stem cells | Bone marrow | Genomes | RNA polymerase | Immune system
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5. Full Text DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
by Hakim, Ofir and Resch, Wolfgang and Yamane, Arito and Klein, Isaac and Kieffer-Kwon, Kyong-Rim and Jankovic, Mila and Oliveira, Thiago and Bothmer, Anne and Voss, Ty C and Ansarah-Sobrinho, Camilo and Mathe, Ewy and Liang, Genqing and Cobell, Jesse and Nakahashi, Hirotaka and Robbiani, Davide F and Nussenzweig, Andre and Hager, Gordon L and Nussenzweig, Michel C and Casellas, Rafael
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 69 - 74
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements,... 
ORGANIZATION | CELLS | HUMAN GENOME | MULTIDISCIPLINARY SCIENCES | BREAKS | CLASS-SWITCH RECOMBINATION | MECHANISMS | AID | IDENTIFICATION | REARRANGEMENTS | SEQUENCING REVEALS | Chromosome Positioning | B-Lymphocytes - cytology | Chromosomes, Mammalian - genetics | Cytidine Deaminase - genetics | Cells, Cultured | Genome - genetics | Replication Protein A - metabolism | DNA Breaks, Double-Stranded | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | Cytidine Deaminase - metabolism | Genes, myc - genetics | Cytidine Deaminase - deficiency | DNA Damage - genetics | Mice | B-Lymphocytes - pathology | Chromosomes, Mammalian - metabolism | B-Lymphocytes - metabolism | Immunoglobulin Heavy Chains - genetics | Translocation, Genetic - genetics | Translocation (Genetics) | DNA damage | Physiological aspects | Development and progression | Genetic aspects | B cells | Health aspects | Cancer | Proteins | Software | Immunology | Chromosomes | Genes
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6. Full Text A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code
by Nakahashi, Hirotaka and Kwon, Kyong-Rim Kieffer and Resch, Wolfgang and Vian, Laura and Dose, Marei and Stavreva, Diana and Hakim, Ofir and Pruett, Nathanael and Nelson, Steevenson and Yamane, Arito and Qian, Jason and Dubois, Wendy and Welsh, Scott and Phair, Robert D and Pugh, B. Franklin and Lobanenkov, Victor and Hager, Gordon L and Casellas, Rafael
Cell Reports, ISSN 2211-1247, 05/2013, Volume 3, Issue 5, pp. 1678 - 1689
The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc... 
ZINC FINGERS | PROTEIN-DNA INTERACTIONS | GENE | CHROMATIN | EMBRYONIC STEM-CELLS | TRANSCRIPTION | SITES | BINDING PROTEIN | IDENTIFICATION | REGULATORY ELEMENTS | CELL BIOLOGY | Repressor Proteins - chemistry | Mice, Inbred C57BL | Repressor Proteins - genetics | Male | Chromosome Mapping | Animals | Nucleotide Motifs | CCCTC-Binding Factor | Zinc Fingers - genetics | Mice | Genome | Binding Sites | B-Lymphocytes - metabolism | Repressor Proteins - metabolism | Photobleaching
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7. Full Text Overexpression of B‐cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response
by Tahara, Kenichi and Takizawa, Makiko and Yamane, Arito and Osaki, Yohei and Ishizaki, Takuma and Mitsui, Takeki and Yokohama, Akihiko and Saitoh, Takayuki and Tsukamoto, Norifumi and Matsumoto, Morio and Murakami, Hirokazu and Nojima, Yoshihisa and Handa, Hiroshi
Cancer Science, ISSN 1347-9032, 08/2017, Volume 108, Issue 8, pp. 1556 - 1564
B‐cell lymphoma 6 (BCL6) attenuates DNA damage response (DDR) through gene repression and facilitates tolerance to genomic instability during immunoglobulin... 
multiple myeloma | ATM | BCL6 | DNA repair | IL‐6 | IL-6 | MULTIPLE-MYELOMA | CYTIDINE DEAMINASE AID | ACTIVATION | CLASS SWITCH RECOMBINATION | TRANSLOCATIONS | GENOMIC INSTABILITY | ONCOLOGY | SPI-B | BCL6 BTB DOMAIN | DIFFERENTIATION | Genomic Instability | Up-Regulation | Cytidine Deaminase - genetics | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling - methods | Gene Regulatory Networks | Proto-Oncogene Proteins c-bcl-6 - genetics | Sequence Analysis, RNA - methods | Phenotype | Cell Line, Tumor | DNA Damage | Ataxia Telangiectasia Mutated Proteins - genetics | Multiple Myeloma - genetics | RNA | DNA damage | Genes | Multiple myeloma | Development and progression | B cells | Genetic transcription | Interleukins | Analysis | DNA | Genetic research | Lymphomas | Genetic aspects | Cancer | Flow cytometry | Genomes | Genomic instability | Cell cycle | Bone marrow | Ataxia | Deoxyribonucleic acid--DNA | Medical research | Immunoglobulins | Cell differentiation | Gene expression | Lymphoma | Immunological tolerance | Studies | Gene silencing | Lymphocytes B | External stimuli | Plasma cells | Ataxia telangiectasia mutated protein | Mutation | Cytidine deaminase | Bcl-6 protein | Original
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8. Full Text The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
by Ji, Yanhong and Resch, Wolfgang and Corbett, Elizabeth and Yamane, Arito and Casellas, Rafael and Schatz, David G
Cell, ISSN 0092-8674, 04/2010, Volume 141, Issue 3, pp. 419 - 431
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene... 
PROTEINS | MOLIMMUNO | DNA | Proteins | Molimmuno | CHROMOSOMAL TRANSLOCATIONS | REPAIR | HISTONE H3 | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACCESSIBILITY | V(D)J RECOMBINATION | HEAVY-CHAIN LOCUS | SYNAPTIC COMPLEX | CLEAVAGE | DNA BREAKS | CELL BIOLOGY | Gene Rearrangement, T-Lymphocyte | Homeodomain Proteins - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Genes, T-Cell Receptor beta | DNA-Binding Proteins - metabolism | Genes, Immunoglobulin Heavy Chain | Immunoglobulin kappa-Chains - genetics | Animals | Recombination, Genetic | Genes, T-Cell Receptor alpha | Gene Rearrangement, B-Lymphocyte | Mice | Antigens | Chromatin | Anopheles | Lysine | Oncology, Experimental | Skin diseases | Research | Cancer | Protein binding
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9. Full Text Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes
by Klein, Isaac A and Resch, Wolfgang and Jankovic, Mila and Oliveira, Thiago and Yamane, Arito and Nakahashi, Hirotaka and Di Virgilio, Michela and Bothmer, Anne and Nussenzweig, Andre and Nussenzweig, Michel C and Robbiani, Davide F and Casellas, Rafael
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 1, pp. 95 - 106
Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of... 
GENOMIC INSTABILITY | CYTIDINE DEAMINASE AID | SOMATIC HYPERMUTATION | CELL LYMPHOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CANCER GENOME | CLASS-SWITCH RECOMBINATION | FOLLICULAR LYMPHOMA | BCL6 GENE | DNA BREAKS | CELL BIOLOGY | Translocation, Genetic | Humans | Cells, Cultured | Spleen - cytology | Genes, myc | Animals | Mutagenesis | Neoplasms - genetics | Cytidine Deaminase - metabolism | Mice | Genome | Sequence Analysis, DNA - methods | B-Lymphocytes - metabolism | Immunoglobulin Heavy Chains - genetics | Sarcoma | Lymphocytes | Oncology, Experimental | Genomics | Leukemia | Stem cells | Lymphomas | Genomes | Research | Cancer | Chromosome translocations | Territory | double prime B-cell lymphoma | Lymphocytes B | Transcription | DNA damage | Activation-induced cytidine deaminase | Chromosome rearrangements
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10. Full Text Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
by Pavri, Rushad and Gazumyan, Anna and Jankovic, Mila and Di Virgilio, Michela and Klein, Isaac and Ansarah-Sobrinho, Camilo and Resch, Wolfgang and Yamane, Arito and San-Martin, Bernardo Reina and Barreto, Vasco and Nieland, Thomas J and Root, David E and Casellas, Rafael and Nussenzweig, Michel C
Cell, ISSN 0092-8674, 10/2010, Volume 143, Issue 1, pp. 122 - 133
Activation-induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody... 
MOLIMMUNO | DNA | Molimmuno | TRANSCRIPTION ELONGATION-FACTOR | PROTEIN-KINASE-A | CENTER B-CELLS | SOMATIC HYPERMUTATION | IMMUNOGLOBULIN GENES | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | ANTIBODY DIVERSIFICATION ENZYME | CLASS-SWITCH RECOMBINATION | SINGLE-STRANDED-DNA | P-TEFB | CELL BIOLOGY | Cell Line | Chromosomal Proteins, Non-Histone - metabolism | Humans | Immunoglobulins - genetics | RNA Polymerase II - metabolism | Transcriptional Elongation Factors - metabolism | Animals | Cytidine Deaminase - metabolism | Cell Line, Tumor | Mice | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Fibroblasts - metabolism | Viral antibodies | RNA | Oncology, Experimental | Antibodies | Skin diseases | Research | Cancer
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