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SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5844 - 15
Transverse aortic constriction (TAC) is a well-established model of pressure overload-induced cardiac hypertrophy and failure in mice. The degree of... 
FIBROSIS | PRESSURE-OVERLOAD | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | CARDIAC-HYPERTROPHY | ANIMAL-MODELS | DYSFUNCTION | OUTCOMES | EXPRESSION | PROGRESSION | Atrophy | Animal models | Phenotypes | Echocardiography | Surgery | Fibrosis | Aorta | Ventricle | Gene expression | Heart diseases | Hypertrophy | Structure-function relationships
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3311 - 3329
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 18, pp. 6702 - 6707
Journal Article
Journal Article
Heart Rhythm, ISSN 1547-5271, 2017, Volume 14, Issue 9, pp. 1406 - 1416
Background The incidence of sudden arrhythmic death is markedly increased in diabetics. Objective Develop a mouse model for Post MI VT in the diabetic heart... 
Cardiovascular | T-Wave alternans | QRS | ventricular tachycardia | statins | myocardial infarction | Ca2+ handling proteins | Akita mouse | Ca2+ alternans | diabetes
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e70802
Right ventricular (RV) failure is a major cause of mortality in acute or chronic lung disease and left heart failure. The objective of this study was to... 
FIBROSIS | GROWTH-FACTOR-BETA | TGF-BETA | MYOCARDIAL-INFARCTION | PULMONARY ARTERIAL-HYPERTENSION | LOAD | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | VOLUME RELATIONSHIPS | DYSFUNCTION | RIGHT-HEART-FAILURE | Heart Conduction System | Transforming Growth Factor beta1 - metabolism | Organ Size | Male | Ventricular Remodeling | Animals | Fibrosis | Ventricular Dysfunction, Right - physiopathology | Heart Ventricles - metabolism | Mice | Ventricular Pressure | Hemodynamics | Ventricular Dysfunction, Right - metabolism | Calcineurin - metabolism | Heart Ventricles - pathology | Ventricular Dysfunction, Right - pathology | Disease Models, Animal | Heart failure | Medical research | Catheterization | Analysis | Medicine, Experimental | Respiratory tract diseases | Transforming growth factors | Health aspects | Heart | Animal models | Heart attacks | Calcineurin | Tissue analysis | Remodeling | Kinases | Proteins | Peak pressure | Aorta | Cardiology | Heart diseases | Growth factors | Stroke | Transforming growth factor-b1 | Pulmonary arteries | Lung diseases | Thorax | Gene expression | Pressure | Coronary artery disease | Pulmonary artery | Pulmonary hypertension | Resistance | Medicine | Studies | Ostomy | Coronary vessels | Conductance | Ventricle | Laboratory animals | Hypertrophy | Veins & arteries | Structure-function relationships
Journal Article
by G. Todd Milne and on behalf of the Ironwood team and Peter Sandner and Kathleen A. Lincoln and Paul C. Harrison and Hongxing Chen and Hong Wang and Holly Clifford and Hu Sheng Qian and Diane Wong and Chris Sarko and Ryan Fryer and Jeremy Richman and Glenn A. Reinhart and Carine M. Boustany and Steven S. Pullen and Henriette Andresen and Lise Román Moltzau and Alessandro Cataliotti and Finn Olav Levy and Robert Lukowski and Sandra Frankenreiter and Andreas Friebe and Timothy Calamaras and Robert Baumgartner and Angela McLaughlin and Mark Aronovitz and Wendy Baur and Guang-Rong Wang and Navin Kapur and Richard Karas and Robert Blanton and Stefan Hell and Scott A. Waldman and Jieru E. Lin and Francheska Colon-Gonzalez and Gilbert W. Kim and Erik S. Blomain and Dante Merlino and Adam Snook and Jeanette Erdmann and Jana Wobst and Thorsten Kessler and Heribert Schunkert and Ulrich Walter and Oliver Pagel and Elena Walter and Stepan Gambaryan and Albert Smolenski and Kerstin Jurk and Rene Zahedi and James R. Klinger and Raymond L. Benza and Paul A. Corris and David Langleben and Robert Naeije and Gérald Simonneau and Christian Meier and Pablo Colorado and Mi Kyung Chang and Dennis Busse and Marius M. Hoeper and Jaime L. Masferrer and Sarah Jacobson and Guang Liu and Renee Sarno and Sylvie Bernier and Ping Zhang and G. Todd Milne and Roger Flores-Costa and Mark Currie and Katherine Hall and Dorit Möhrle and Katrin Reimann and Steffen Wolter and Markus Wolters and Evanthia Mergia and Nicole Eichert and Hyun-Soon Geisler and Peter Ruth and Andreas Friebe and Robert Feil and Ulrike Zimmermann and Doris Koesling and Marlies Knipper and Lukas Rüttiger and Yasutake Tanaka and Atsuko Okamoto and Takashi Nojiri and Motofumi Kumazoe and Takeshi Tokudome and Koichi Miura and Jun Hino and Hiroshi Hosoda and Mikiya Miyazato and Kenji Kangawa and Vikas Kapil and Amrita Ahluwalia and Nazareno Paolocci and Philip Eaton and ...
BMC Pharmacology and Toxicology, 10/2017, Volume 18, Issue S1, pp. 1 - 35
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 11, pp. 2555 - 2555
  Compared to Vehicle, rBMP9 treatment increased total body mass (p=0.02) and reduced both lung mass (p<0.01) and LV mass (p<0.01) after TAC. rBMP9 reduced LV... 
Cardiovascular | Internal Medicine | Proteins | Rodents | Collagen
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2014, Volume 34, Issue 2, pp. 355 - 364
OBJECTIVE—Vascular remodeling occurs after endothelial injury, resulting in smooth muscle cell (SMC) proliferation and vascular fibrosis. We previously... 
placental growth factor | receptors mineralocorticoid | vascular endothelial growth factor receptor-1 | aldosterone | myocytes smooth muscle | MORTALITY | OXIDATIVE STRESS | EVENTS | receptors | smooth muscle | myocytes | mineralocorticoid | BLOOD-PRESSURE | SPIRONOLACTONE | PERIPHERAL VASCULAR DISEASE | EPLERENONE | HYPERTENSION | HEMATOLOGY | EXPRESSION | BLOCKER | GENE-TRANSCRIPTION | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Receptors, Mineralocorticoid - agonists | Receptors, Mineralocorticoid - genetics | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Muscle, Smooth, Vascular - metabolism | Pregnancy Proteins - genetics | Myocytes, Smooth Muscle - pathology | Male | Pregnancy Proteins - metabolism | RNA, Messenger - metabolism | Receptors, Mineralocorticoid - deficiency | Time Factors | Carotid Artery Injuries - genetics | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Carotid Artery Injuries - metabolism | Carotid Artery Injuries - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Endothelial Cells - metabolism | Mice, Inbred C57BL | Aldosterone - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Animals | Fibrosis | Placenta Growth Factor | Carotid Arteries - pathology | Cell Proliferation - drug effects | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | smooth muscle cells | mineralocorticoid receptor | vascular remodeling | VEGF
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2010, Volume 120, Issue 11, pp. 3891 - 3900
Journal Article