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1. Full Text Incidence of propofol-related infusion syndrome in critically ill adults: A prospective, multicenter study
by Roberts, Russel J and Barletta, Jeffrey F and Fong, Jeffrey J and Schumaker, Greg and Kuper, Philip J and Papadopoulos, Stella and Yogaratnam, Dinesh and Kendall, Elise and Xamplas, Renee and Gerlach, Anthony T and Szumita, Paul M and Anger, Kevin E and Arpino, Paul A and Voils, Stacey A and Grgurich, Philip and Ruthazer, Robin and Devlin, John W
Critical Care, ISSN 1364-8535, 10/2009, Volume 13, Issue 5, pp. R169 - R169
Introduction While propofol is associated with an infusion syndrome (PRIS) that may cause death, the incidence of PRIS is unknown. Determining the incidence of... 
FATAL MYOCARDIAL FAILURE | ANESTHESIA | METABOLIC-ACIDOSIS | INTENSIVE-CARE-UNIT | CARDIAC-SURGERY | LACTIC-ACIDOSIS | PATIENT | DEATH | RHABDOMYOLYSIS | CHILDREN | CRITICAL CARE MEDICINE | Anesthetics, Intravenous - adverse effects | Intensive Care Units | Arrhythmias, Cardiac - chemically induced | Prospective Studies | Humans | Middle Aged | Critical Illness | Male | Academic Medical Centers | Syndrome | Incidence | Anesthetics, Intravenous - administration & dosage | Adult | Female | Aged | Propofol - administration & dosage | Heart Failure - chemically induced | Propofol - adverse effects | Drugs | Prevention | Complications and side effects | Care and treatment | Critically ill | Patient outcomes | Adverse and side effects | Dosage and administration | Propofol | Risk factors | Research
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2. Full Text Practical Pharmacologic Aspects of Therapeutic Hypothermia After Cardiac Arrest
by Arpino, Paul A and Greer, David M
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 01/2008, Volume 28, Issue 1, pp. 102 - 111
Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results,... 
pharmacokinetics | physiology | therapeutic hypothermia | cardiac arrest | pharmacology | Therapeutic hypothermia | Pharmacology | Physiology | Pharmacokinetics | Cardiac arrest | VENTRICULAR-FIBRILLATION | MILD HYPOTHERMIA | RENAL-FUNCTION | CARDIOPULMONARY BYPASS | CRITICALLY-ILL | MYOCARDIAL TEMPERATURE | OXYGEN-UPTAKE | BRETYLIUM TOSYLATE | PHARMACOLOGY & PHARMACY | HEMODYNAMIC-RESPONSES | INTENSIVE INSULIN THERAPY | Hypothermia, Induced - adverse effects | Risk Assessment | Drug Therapy - methods | Humans | Hypothermia, Induced - methods | Heart Arrest - physiopathology | Heart Arrest - therapy
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3. Full Text Evaluation of a vancomycin dosing nomogram based on the Modification of Diet in Renal Disease equation in intensive care unit patients
by Golenia, Brandy S., PharmD and Levine, Alexander R., PharmD and Moawad, Iman M., PharmD and Yeh, D. Dante, MD and Arpino, Paul A., PharmD
Journal of Critical Care, ISSN 0883-9441, 2013, Volume 28, Issue 5, pp. 710 - 716
Abstract Purpose The purpose of the study is to evaluate the effectiveness of a vancomycin nomogram using actual body weight and the Modification of Diet in... 
Critical Care | ICU | Vancomycin | Antibiotics | Dosing nomogram | VENTILATOR-ASSOCIATED PNEUMONIA | KIDNEY-FUNCTION | GUIDELINES | OUTCOMES | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Intensive Care Units | Vancomycin - administration & dosage | Body Weight | Prospective Studies | Humans | Middle Aged | Critical Illness | Male | Vancomycin - pharmacokinetics | Anti-Bacterial Agents - pharmacokinetics | Nomograms | Female | Retrospective Studies | Anti-Bacterial Agents - administration & dosage | Analysis | Kidney diseases | Index Medicus
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4. Full Text Evaluation of 2 Nomogram-Based Strategies for Dosing Argatroban in Patients With Known or Suspected Heparin-Induced Thrombocytopenia
by Arpino, Paul A and Goeller, Adrienne J and Fatalo, Anthony and Van Cott, Elizabeth M
Clinical and Applied Thrombosis/Hemostasis, ISSN 1076-0296, 4/2015, Volume 21, Issue 3, pp. 260 - 265
No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study... 
anticoagulants | nomogram | sliding scale | argatroban | direct thrombin inhibitors | THERAPY | THROMBOSIS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Pipecolic Acids - administration & dosage | Thrombocytopenia - drug therapy | Humans | Middle Aged | Nomograms | Heparin - administration & dosage | Female | Male | Aged | Antithrombins - administration & dosage | Thrombocytopenia - chemically induced | Heparin - adverse effects
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5. Full Text Effect of Renal Function on the Pharmacodynamics of Argatroban
by Arpino, Paul A and Hallisey, Robert K
Annals of Pharmacotherapy, ISSN 1060-0280, 1/2004, Volume 38, Issue 1, pp. 25 - 29
BACKGROUND: Argatroban is a direct thrombin inhibitor used to treat heparin-induced thrombocytopenia (HIT). Argatroban is primarily cleared by hepatic... 
Argatroban | Renal insufficiency | Heparin-induced thrombocytopenia | SERUM CREATININE | MANAGEMENT | VENOUS THROMBOEMBOLISM | FVIII-C | argatroban | renal insufficiency | heparin-induced thrombocytopenia | ELEVATION | PHARMACOLOGY & PHARMACY | PREDICTION | Kidney - physiology | Liver Function Tests | Injections, Intravenous | Kidney - drug effects | Prospective Studies | Drug Administration Schedule | Humans | Middle Aged | Pipecolic Acids - pharmacokinetics | Metabolic Clearance Rate | Treatment Outcome | Data Collection | Kidney Function Tests | Patient Selection | Pipecolic Acids - administration & dosage | Partial Thromboplastin Time | Pipecolic Acids - therapeutic use | Creatinine - blood | Aged
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6. Full Text Teratogenic effects of antiepileptic drugs: Use of an international database on malformations and drug exposure (MADRE)
by Arpino, C and Brescianini, S and Robert, E and Castilla, EE and Cocchi, G and Cornel, MC and de Vigan, C and Lancaster, PAL and Merlob, P and Sumiyoshi, Y and Zampino, G and Renzi, C and Resano, A and Mastroiacovo, P
Epilepsia, ISSN 0013-9580, 11/2000, Volume 41, Issue 11, pp. 1436 - 1443
Purpose: The study goal was to assess teratogenic effects of antiepileptic drugs (AEDs) through the use of a surveillance system (MADRE) of infants with... 
antiepileptic drugs | INUTERO EXPOSURE | risk factors | MATERNAL EPILEPSY | NEURAL-TUBE DEFECTS | CARBAMAZEPINE | VALPROIC ACID | malformation registries | PREGNANCY | SPINA-BIFIDA | WOMEN | teratogenesis | COMMON ODDS RATIO | 2X2 CONTINGENCY-TABLES | Teratogenesis | Malformation registries | Antiepileptic drugs | Risk factors | CLINICAL NEUROLOGY | Product Surveillance, Postmarketing - statistics & numerical data | World Health Organization | Abnormalities, Drug-Induced - epidemiology | Global Health | Humans | Risk Factors | Databases, Factual - statistics & numerical data | Anticonvulsants - therapeutic use | Pregnancy | Anticonvulsants - adverse effects | Registries - statistics & numerical data | Abnormalities, Drug-Induced - etiology | Epilepsy - drug therapy | Female
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7. Full Text Multicenter Trial of Desirudin for the Prophylaxis of Thrombosis
: An Alternative to Heparin-Based Anticoagulation (DESIR-ABLE)
by Bergese, Sergio D and Minkowitz, Harold S and Arpino, Paul A and Sane, David C and Levy, Jerrold H
Clinical and Applied Thrombosis/Hemostasis, ISSN 1076-0296, 7/2013, Volume 19, Issue 4, pp. 418 - 423
Desirudin, a subcutaneously (SC) administered direct thrombin inhibitor, is indicated for prevention of venous thromboembolic events (VTEs) after total joint... 
anticoagulants | bleeding | deep venous thrombosis | thrombocytopenia | venous thromboembolism | RECOMBINANT HIRUDIN | FACTOR 4/HEPARIN ANTIBODIES | MANAGEMENT | EFFICACY | PREVENTION | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | THROMBOEMBOLISM | HEMATOLOGY | Recombinant Proteins - therapeutic use | Hirudins | Antithrombins - therapeutic use | Humans | Middle Aged | Anticoagulants - therapeutic use | Heparin - therapeutic use | Male | Young Adult | Aged, 80 and over | Adult | Female | Aged | Thrombosis - drug therapy | Thrombosis - prevention & control | Surgical Procedures, Operative - methods
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8. Full Text Use of the Chromogenic Factor X Assay to Predict the International Normalized Ratio in Patients Transitioning from Argatroban to Warfarin
by Arpino, Paul A and Demirjian, Zareh and Cott, Elizabeth M
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 02/2005, Volume 25, Issue 2, pp. 157 - 164
Study Objective. To determine the clinical utility of the chromogenic factor X level for conversion from argatroban to warfarin in hospitalized patients.... 
chromogenic factor X | INR | international normalized ratio | argatroban | warfarin | Argatroban | Warfarin | International normalized ratio | Chromogenic factor X | ANTICOAGULANTS | MANAGEMENT | LEPIRUDIN | PHARMACOLOGY & PHARMACY | HEPARIN-INDUCED THROMBOCYTOPENIA | VALUES | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Hospitals, University | Anticoagulants - therapeutic use | Male | Factor X - drug effects | Pipecolic Acids - pharmacology | Warfarin - pharmacology | Warfarin - therapeutic use | International Normalized Ratio | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Pipecolic Acids - therapeutic use | Female | ROC Curve | Aged | Chromogenic Compounds
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9. Full Text Dabigatran: A review of clinical and pharmacoeconomic evidence
by Reddy, Prabashni and Atay, Julie K and Selbovitz, Leslie G and Connors, Jean Marie and Piazza, Gregory and Block, Caroline Cole and Arpino, Paul A and Berliner, Nancy and Hutter Jr, Adolph M and Fischer, Michael A and Kuter, David and Weitzman, James and Sherwood, Geoffery K and Almozlino, Avraham and Giugliano, Robert P
Critical Pathways in Cardiology, ISSN 1535-282X, 09/2011, Volume 10, Issue 3, pp. 117 - 127
Dabigatran etexilate is the first commercially available oral direct thrombin inhibitor. A single trial has studied patients at risk for stroke associated with... 
dabigatran | atrial fibrillation | cost | venous thromboembolism | orthopedic surgery | Economics, Pharmaceutical | Venous Thromboembolism - prevention & control | Cost-Benefit Analysis | Humans | Pyridines - economics | Quality of Life | Antithrombin Proteins | Benzimidazoles - pharmacology | Pyridines - pharmacology | Benzimidazoles - economics | Dabigatran | Venous Thromboembolism - blood
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10. Full Text Comparing the activated clotting times obtained from 2 point-of-care devices in patients receiving unfractionated heparin during percutaneous coronary intervention
by Arpino, Paul A and Cronin-Jenkins, Susan and Misiano, Domenic and Van Cott, Elizabeth
Point of Care, ISSN 1533-029X, 03/2008, Volume 7, Issue 1, pp. 30 - 33
Activated clotting time | Percutaneous coronary intervention | Heparin | Monitoring
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11. Full Text Teratogenic effects of antiepileptic drugs: Use of an international database on Malformations and Drug Exposure (MADRE)
by Arpino, Carla and Brescianini, Sonia and Robert, Elisabeth and Castilla, Eduardo E and Cocchi, Guido and Cornel, Martina C and De Vigan, Catherine and Lancaster, Paul A.L and Merlob, Paul and Sumiyoshi, Yoshio and Zampino, Giuseppe and Renzi, Cristina and Rosano, Aldo and Mastroiacovo, Pierpaolo
Epilepsia, ISSN 0013-9580, 01/2000, Volume 41, Issue 11, pp. 1436 - 1443
Purpose: The study goal was to assess teratogenic effects of antiepileptic drugs (AEDs) through the use of a surveillance system (MADRE) of infants with... 
Teratogenesis | Neurology | Clinical Neurology | Malformation registries | Antiepileptic drugs | Risk factors
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12. Full Text Optimization of the instrumental parameters of a combined liquid chromatograph-mass spectrometer, coupled by an interface for direct liquid introduction : II. Nebulization of Liquids by Diaphragms
by Arpino, Patrick J and Krien, Paul and Vajta, Sophie and Devant, Gerard
Journal of Chromatography A, ISSN 0021-9673, 1981, Volume 203, Issue C, pp. 117 - 130
Direct liquid introduction interfaces for combined liquid chromatography-mass spectrometry (LC-MS) require a flow restriction to limit input liquid flow-rates... 
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13. Full Text Optimization of the instrumental parameters of a combined liquid chromatograph—mass spectrometer, coupled by an interface for direct liquid introduction : I. Performance of the vacuum equipment
by Arpino, Patrick J and Guiochon, Georges and Krien, Paul and Devant, Gerard
Journal of Chromatography A, ISSN 0021-9673, 1979, Volume 185, Issue C, pp. 529 - 547
The direct introduction of liquid solutions into the vacuum space of a mass spectrometer for liquid chromatography-mass spectrometry (LC-MS) purposes requires... 
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14. Full Text Mortality after surgery in Europe: a 7 day cohort study
by Pearse, Rupert M, Dr and Moreno, Rui P, Prof and Bauer, Peter, Prof and Pelosi, Paolo, Prof and Metnitz, Philipp, Prof and Spies, Claudia, Prof and Vallet, Benoit, Prof and Vincent, Jean-Louis, Prof and Hoeft, Andreas, Prof and Rhodes, Andrew, FRCP and Trial Grp European Soc Intensive and Trial Grp European Soc and European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and the European Society of Anaesthesiology and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Clinical Sciences, Department of Anesthesiology and Intensive care and Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård and Sahlgrenska Academy
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9847, pp. 1059 - 1065
Summary Background Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and... 
Internal Medicine | POPULATION | MEDICINE, GENERAL & INTERNAL | NONCARDIAC SURGERY | POSTOPERATIVE COMPLICATIONS | CANCER-SURGERY | LONG-TERM SURVIVAL | SURGICAL QUALITY IMPROVEMENT | RISK | INPATIENT SURGERY | CRITICAL-CARE | MAJOR SURGERY | Critical Care - statistics & numerical data | Hospital Mortality | Surgical Procedures, Operative - mortality | Humans | Middle Aged | Europe - epidemiology | Hospitalization - statistics & numerical data | Male | Treatment Outcome | Postoperative Care - methods | Adult | Female | Postoperative Care - statistics & numerical data | Aged | Length of Stay - statistics & numerical data | Cohort Studies | Austria | Demographic aspects | Mortality | United Kingdom | Portugal | Postoperative care | Health aspects | Risk factors | Anestesi och intensivvård | Anesthesiology and Intensive Care
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