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Journal of Immunology, ISSN 0022-1767, 12/2018, Volume 201, Issue 11, pp. 3373 - 3382
The A20-binding inhibitor of NF-kappa B 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2... 
TPL-2 KINASE | KAPPA-B-KINASE | UBIQUITIN CHAINS | INFLAMMATORY-BOWEL-DISEASE | MAP KINASE | MACROPHAGES | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B1 P105 | POLYUBIQUITIN BINDING | OPTIMAL ACTIVATION
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 05/2008, Volume 27, Issue 10, pp. 2701 - 2713
The hippocampus is involved in learning and memory. Previously, we have shown that the acquisition of the behavioural immobility response after a forced swim... 
Immobility | Mouse | Rat | Epigenetics | Mitogen-activated protein kinase | Histone | Stress | EPIGENETIC MECHANISMS | stress | MEMORY FORMATION | DENDRITIC MORPHOLOGY | immobility | rat | INDUCED PHOSPHORYLATION | MAP KINASE | FASCIA-DENTATA | DISTINCT PATTERNS | NEUROSCIENCES | epigenetics | CHICKEN PROGESTERONE-RECEPTOR | mitogen-activated protein kinase | mouse | GLUCOCORTICOID-RECEPTOR | ADENYLYL CYCLASES | histone | MAP Kinase Signaling System - physiology | Phosphorylation | Rats, Wistar | Receptors, Mineralocorticoid - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Fear - physiology | Swimming - psychology | Stress, Psychological - metabolism | Neurons - metabolism | Acetylation | Mineralocorticoid Receptor Antagonists | Dentate Gyrus - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Proto-Oncogene Proteins c-fos - metabolism | Rats | Behavior, Animal - physiology | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Dentate Gyrus - cytology | Animals | Histones - genetics | Freezing Reaction, Cataleptic - physiology | Proto-Oncogene Proteins c-fos - genetics | Mice | Histones - metabolism | Stress, Psychological - physiopathology | Methyl aspartate | Neurons | Neurosciences | Index Medicus
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2019, Volume 116, Issue 27, pp. 13293 - 13298
The linear ubiquitin assembly complex (LUBAC) comprises 3 components: HOIP, HOIL-1, and Sharpin, of which HOIP and HOIL-1 are both members of the RBR subfamily... 
ACTIVATION | COMPLEX | MULTIDISCIPLINARY SCIENCES | LINEAR UBIQUITINATION | KINASE | IKK-BETA | LUBAC | IRAK | SHARPIN | TAK1 | TRAF6 | PELLINO | CHAINS | NEMO | Toll-like receptor | MYD88 | Oligomers | Ubiquitin | Amino acids | Hydroxides | Ligases | Cells | IRAK protein | Hydroxylamine | Threonine | Serine | Intracellular signalling | Macrophages | Substrates | Mammalian cells | Immune systems | Proteins | MyD88 protein | Toll-like receptors | Ubiquitin-protein ligase | Biological Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12764 - 12769
Journal Article
Current Biology, ISSN 0960-9822, 04/2000, Volume 10, Issue 8, pp. 439 - 448
Background: Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are activated by phosphorylation of two... 
INSULIN | MECHANISM | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | P70(S6K) | BIOLOGY | RIBOSOMAL S6 KINASE | C-ZETA | PHOSPHOINOSITIDE 3-KINASE | HOMOLOGY | PDK1 | Insulin-Like Growth Factor I - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Ribosomal Protein S6 Kinases - metabolism | Multienzyme Complexes - metabolism | Glycogen Synthase Kinase 3 | Immunoblotting | Proto-Oncogene Proteins - chemistry | AMP-Activated Protein Kinases | Stem Cells - enzymology | Gene Deletion | Calcium-Calmodulin-Dependent Protein Kinases - pharmacology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Proto-Oncogene Proteins c-akt | Calcium-Calmodulin-Dependent Protein Kinases - chemistry | Animals | Mice | Protein-Serine-Threonine Kinases - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa | 3-phosphoinositide-dependent protein kinase 1 | ribosomal S6 kinase | Protein kinase B | MSK1 protein | AMP-activated protein kinase | AGC kinase | Index Medicus
Journal Article
Journal of the Royal Army Medical Corps, ISSN 0035-8665, 2018, Volume 165, Issue 3, pp. 204 - 205
This case report outlines the presentation and management of a young soldier who sustained a lower limb acacia thorn injury while on exercise in Kenya. The... 
primary care | accident & emergency medicine | orthopaedic & trauma surgery | adult orthopaedics | MEDICINE, GENERAL & INTERNAL
Journal Article
Cancer Research, ISSN 0008-5472, 06/2009, Volume 69, Issue 11, pp. 4648 - 4655
Activating Ras mutations occur in a large portion of human tumors. Yet, the signaling pathways involved in Ras-induced tumor formation remain incompletely... 
CANCER-CELLS | P38 | ONCOLOGY | INVOLUCRIN PROMOTER ACTIVITY | EPITHELIAL CARCINOGENESIS | MAP KINASE | GENE-EXPRESSION | CELL PROLIFERATION | EPIDERMAL-KERATINOCYTES | SIGNAL-TRANSDUCTION PATHWAY | MOUSE SKIN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 38, pp. 15247 - 15252
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 22, pp. 19469 - 19482
Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased risk of developing tumors in those affected. The causative gene is a... 
Journal Article