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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 38, pp. 15247 - 15252
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 532, Issue 7597, pp. 122 - 126
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 10, p. e13669
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62509
...Author(s): Judit Remenyi 1, Mirjam W. M. van den Bosch 2, Oleg Palygin 3, Rajen B. Mistry 3, Colin McKenzie 3, Andrew Macdonald 4, Gyorgy Hutvagner 1, J. Simon... 
HIPPOCAMPUS | ACTIVATION | CREB | COCAINE INTAKE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | MSK1 | GENERATION | EXPRESSION | MICRORNA | Electric Stimulation | Interferon-beta - immunology | Synaptic Transmission - genetics | Male | MicroRNAs - metabolism | Neurons - cytology | Synapses - genetics | Neocortex - metabolism | Neuronal Plasticity - genetics | Synapses - metabolism | Female | Neurons - metabolism | Receptors, AMPA - genetics | Excitatory Postsynaptic Potentials - genetics | Receptors, AMPA - metabolism | Fibroblasts - virology | Sendai virus - physiology | Interferon-beta - biosynthesis | Long-Term Potentiation - genetics | Hippocampus - cytology | Mice, Knockout | Hippocampus - metabolism | Animals | Fibroblasts - immunology | Neocortex - cytology | Mice | MicroRNAs - genetics | Primary Cell Culture | Virus diseases | Infection | MicroRNA | Cytokines | Analysis | Health aspects | Neurophysiology | Potentiation | Neural plasticity | Phosphorylation | Immune response | Long-term potentiation | Paired-pulse facilitation | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Proteins | Receptors | Synaptic transmission | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Coding | Rodents | Plasticity | Stem cells | Synaptic plasticity | Fibroblasts | Life sciences | Genetic engineering | Receptor mechanisms | Neocortex | Chromosomes | Hippocampus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 16986 - 16991
Macrophages acquire strikingly different properties that enable them to play key roles during the initiation, propagation, and resolution of inflammation.... 
14-3-3 proteins | Bacteriophages | Phosphorylation | Messenger RNA | Antiinflammatories | Cytokines | Secretion | Drug regulation | Genes | Macrophages | MRT67307 | HG-9-91-01 | AMPK-related kinases | Toll-like receptor | MRT199665 | MULTIDISCIPLINARY SCIENCES | CYTOKINE | FAMILY | CROSS-TALK | CREB | IN-VIVO | AMPK | RECEPTORS | POLARIZATION | INNATE IMMUNITY | Pyrimidines - chemical synthesis | DNA, Complementary - genetics | Immunoblotting | DNA Primers - genetics | Pyrimidines - chemistry | RNA Interference | Phenylurea Compounds - chemistry | Cyclobutanes - pharmacology | Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Interleukin-10 - metabolism | Molecular Structure | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Morpholines - chemical synthesis | Cell Line | Cytokines - metabolism | Magnetic Resonance Spectroscopy | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | Inflammation - immunology | Pyrimidines - pharmacology | Cyclobutanes - chemical synthesis | Mice, Knockout | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Phenylurea Compounds - chemical synthesis | Analysis of Variance | Interleukin-10 - genetics | Fluorescent Antibody Technique | Proteomics | Mice | Phenylurea Compounds - pharmacology | Indans - pharmacology | Physiological aspects | Toll-like receptors | Research | Phosphotransferases | Health aspects | Biological Sciences
Journal Article