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humans (5) 5
pharmacology & pharmacy (5) 5
dose-response relationship, drug (4) 4
index medicus (4) 4
animals (3) 3
arrhythmia (3) 3
cell line (3) 3
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field potential (2) 2
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propanolamines - pharmacology (2) 2
qt and qtc interval (2) 2
qt prolongation (2) 2
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receptors, lysosphingolipid - agonists (2) 2
risk (2) 2
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arrhythmias, cardiac - physiopathology (1) 1
assays (1) 1
autoimmune diseases - drug therapy (1) 1
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1. Full Text Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk
by Sugahara, Kunio and Maeda, Yasuhiro and Shimano, Kyoko and Mogami, Akira and Kataoka, Hirotoshi and Ogawa, Kei and Hikida, Kumiko and Kumagai, Hiroshi and Asayama, Mahoko and Yamamoto, Toshinobu and Harada, Tomohiko and Ni, Pingping and Inoue, Shinsuke and Kawaguchi, Atsuhiro
British Journal of Pharmacology, ISSN 0007-1188, 01/2017, Volume 174, Issue 1, pp. 15 - 27
BACKGROUND AND PURPOSE We conducted preclinical and clinical studies to examine the pharmacological, particularly cardiac, effects of amiselimod (MT-1303), a... 
RELAPSING MULTIPLE-SCLEROSIS | ORAL FINGOLIMOD | BASIC DRUGS | LYMPHOCYTE RECIRCULATION | CONCISE GUIDE | KINASE TYPE-2 | DOUBLE-BLIND | CARDIAC RATE | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | CONTROLLED PHASE-2 TRIAL | Organophosphates - administration & dosage | Cell Line | Humans | Macaca fascicularis | Rats | Male | Structure-Activity Relationship | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Organophosphates - pharmacology | Animals | Bradycardia - metabolism | Propanolamines - chemistry | Receptors, Lysosphingolipid - agonists | Organophosphates - chemistry | Molecular Structure | Propanolamines - administration & dosage | Propanolamines - pharmacology | Receptors, Lysosphingolipid - metabolism | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Bradycardia - drug therapy | Phosphates | Bradycardia | Heart beat | Lymphocytes | Health aspects | Sphingosine | Research Papers | Research Paper
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2. Full Text CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia — Effects of 7 reference compounds at 10 facilities
by Kitaguchi, Takashi and Moriyama, Yuta and Taniguchi, Tomohiko and Ojima, Atsuko and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Morita, Maya and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Tanaka, Kohji and Washio, Ikumi and Miyamoto, Norimasa
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 03/2016, Volume 78, pp. 93 - 102
Drug-induced QT prolongation is a major safety issue during drug development because it may lead to lethal ventricular arrhythmias. In this study, we evaluated... 
QT prolongation | CSAHi | Field potential | Proarrhythmia | Multi-electrode array | Torsade de pointes | Human induced pluripotent stem cell-derived cardiomyocytes | TERFENADINE | TORSADES-DE-POINTES | INTERVAL PROLONGATION | CARDIAC SAFETY | REPOLARIZATION | IN-VITRO | MODELS | ELECTROPHYSIOLOGY | PHARMACOLOGY | ASSAYS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Predictive Value of Tests | Congresses as Topic | Arrhythmias, Cardiac - chemically induced | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Humans | Long QT Syndrome - chemically induced | Cell Culture Techniques - methods | Cryopreservation - methods | Long QT Syndrome - diagnosis | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Arrhythmias, Cardiac - diagnosis | Pharmaceutical Preparations - administration & dosage | Drug-Related Side Effects and Adverse Reactions - diagnosis | Arrhythmia | Analysis | Heart cells | Index Medicus
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3. Full Text Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts
by Asayama, Mahoko and Kurokawa, Junko and Shirakawa, Kiyoshi and Okuyama, Hisashi and Kagawa, Toshiki and Okada, Jun-ichi and Sugiura, Seiryo and Hisada, Toshiaki and Furukawa, Tetsushi
Journal of Pharmacological Sciences, ISSN 1347-8613, 2013, Volume 121, Issue 1, pp. 1 - 8
In short QT syndrome, inherited gain-of-function mutations in the human gene (hERG) K channel have been associated with development of fatal arrhythmias. This... 
KCNH2 | hERG activator | pro-arrhythmia | QT and QTc interval | IKr channel | I-Kr channel | MOLECULAR DETERMINANTS | MECHANISMS | QT INTERVAL PROLONGATION | GUINEA-PIG | REPOLARIZATION | STRUCTURAL BASIS | 1,3-BIS-(2-HYDROXY-5-TRIFLUOROMETHYL-PHENYL)-UREA NS1643 | PHARMACOLOGY & PHARMACY | MUTATIONS | K+ CHANNEL | POTASSIUM CHANNEL | Guinea Pigs | Humans | Cells, Cultured | Ether-A-Go-Go Potassium Channels - metabolism | Electrocardiography - drug effects | Male | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Dogs | Heart - drug effects | Benzamides - pharmacology | In Vitro Techniques | Electrophysiological Phenomena - drug effects
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4. Full Text Telemetry study in common marmosets for in vivo cardiovascular risk assessment
by Maekawa, Motoko and Kagawa, Toshiki and Asayama, Mahoko and Baba, Nobuyuki and Wasaki, Chikako
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2015, Volume 75, pp. 181 - 181
Cardiovascular diseases | Risk assessment
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5. Full Text Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk
: Amiselimod: pharmacology and effects on heart rate
by Sugahara, Kunio and Maeda, Yasuhiro and Shimano, Kyoko and Mogami, Akira and Kataoka, Hirotoshi and Ogawa, Kei and Hikida, Kumiko and Kumagai, Hiroshi and Asayama, Mahoko and Yamamoto, Toshinobu and Harada, Tomohiko and Ni, Pingping and Inoue, Shinsuke and Kawaguchi, Atsuhiro
British Journal of Pharmacology, ISSN 0007-1188, 01/2017, Volume 174, Issue 1, pp. 15 - 27
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6. Full Text Removal of sphingosine 1-phosphate receptor-3 (S1P3) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P1 agonists with reduced effect on heart rate
by Hamada, Maiko and Nakamura, Mitsuharu and Kiuchi, Masatoshi and Marukawa, Kaoru and Tomatsu, Ayumi and Shimano, Kyoko and Sato, Noriko and Sugahara, Kunio and Asayama, Mahoko and Takagi, Kan and Adachi, Kunitomo
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
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7. Full Text A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
by Kakusaka, Shoko and Asayama, Mahoko and Kaihara, Asami and Sasano, Tetsuo and Suzuki, Takeshi and Kurokawa, Junko and Furukawa, Tetsushi
Journal of Pharmacological Sciences, ISSN 1347-8613, 2009, Volume 109, Issue 1, pp. 152 - 156
We recently reported that physiological concentrations of 17 -estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K currents (hERG... 
estrogen | K+ channel (hERG) | heart | Heart | channel (hERG) | Estrogen | INTERVAL | DE-POINTES | CARDIAC REPOLARIZATION | RISK | INDUCED QT PROLONGATION | WOMEN | DIFFERENCE | ESTRADIOL | GENDER | PHARMACOLOGY & PHARMACY | HORMONES | Membrane Potentials - drug effects | Cell Line | Estrone - pharmacology | Gene Expression | Estrogens - pharmacology | Humans | Receptors, Estrogen - antagonists & inhibitors | Estrogen Antagonists - pharmacology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Membrane Potentials - physiology | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Estrogens - chemistry | Estrone - analogs & derivatives | Estrone - chemistry | Ether-A-Go-Go Potassium Channels - physiology | Molecular Structure | Estradiol - pharmacology | Receptors, Estrogen - physiology
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8. Full Text Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts
by Mahoko Asayama and Junko Kurokawa and Kiyoshi Shirakawa and Hisashi Okuyama and Toshiki Kagawa and Jun-ichi Okada and Seiryo Sugiura and Toshiaki Hisada and Tetsushi Furukawa and Tokyo Medical and Dental University and Department of Bio-informational Pharmacology and Safety Evaluation Research Laboratories and the University of Tokyo and Research Division and Graduate School of Frontier Sciences and Medical Research Institute and Mitsubishi Tanabe Pharma Corporation
Journal of Pharmacological Sciences, ISSN 1347-8613, 2013, Volume 121, Issue 1, pp. 1 - 8
In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K+ channel have been associated with development of... 
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9. Full Text CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes
by Kitaguchi, Takashi and Moriyama, Yuta and Taniguchi, Tomohiko and Maeda, Sanae and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Miyamoto, Norimasa
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 05/2017, Volume 85, pp. 73 - 81
The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method... 
QT prolongation | CSAHi | Field potential | Proarrhythmia | Multi-electrode array | Torsade de pointes | Human induced pluripotent stem cell-derived cardiomyocytes | Methods | SAFETY | RISK | GUINEA-PIG | REPOLARIZATION | TORSADE-DE-POINTES | THOROUGH QT | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NORMAL SINUS RHYTHM | ONSET ATRIAL-FIBRILLATION | INTER-FACILITY | Drug Evaluation, Preclinical - methods | Cardiotoxins - pharmacology | Arrhythmias, Cardiac - chemically induced | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Humans | Cells, Cultured | Ion Channels - physiology | Cardiotonic Agents - pharmacology | Arrhythmias, Cardiac - physiopathology | Ion Channels - antagonists & inhibitors | Dose-Response Relationship, Drug | Heart Rate - drug effects | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Heart Rate - physiology | Ion Channels - agonists | Drugs | Usage | Arrhythmia | Stem cells | Heart cells | Embryonic stem cells | Flat panel displays
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10. Full Text Removal of Sphingosine 1-Phosphate Receptor-3 (S1P(3)) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P(1) Agonists with Reduced Effect on Heart Rate
by Hamada, M and Nakamura, M and Kiuchi, M and Marukawa, K and Tomatsu, A and Shimano, K and Sato, N and Sugahara, K and Asayama, M and Takagi, K and Adachi, K
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate... 
SEQUESTRATION | CHEMISTRY, MEDICINAL | INHIBITION | FTY720 | REJECTION | SPHINGOSINE-1-PHOSPHATE | IMMUNOSUPPRESSANT | KRP-203 | LYASE | Cricetulus | Rats, Inbred F344 | Biphenyl Compounds - adverse effects | Male | Structure-Activity Relationship | Immunologic Factors - chemical synthesis | Heart Rate - drug effects | Propylene Glycols - adverse effects | Biphenyl Compounds - pharmacology | Propanolamines - chemical synthesis | Propylene Glycols - pharmacology | Cell Line | Cricetinae | Propylene Glycols - chemical synthesis | Rats | Propanolamines - adverse effects | Rats, Sprague-Dawley | Animals | Biphenyl Compounds - chemical synthesis | Lymphocyte Count | Receptors, Lysosphingolipid - agonists | Immunologic Factors - adverse effects | Mice | Mice, Inbred BALB C | Propanolamines - pharmacology | Immunologic Factors - pharmacology
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11. Full Text CSAHi study: Evaluation of MED64 multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia
by Kitaguchi, Takashi and Moriyama, Yuta and Miyamoto, Norimasa and Taniguchi, Tomohiko and Ojima, Atsuko and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Morita, Maya and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Washio, Ikumi and Ishimura, Masakazu
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2016, Volume 81, pp. 384 - 385
Arrhythmia | Analysis
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12. Full Text A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
by Shoko Kakusaka and and Mahoko Asayama and Asami Kaihara and Tetsuo Sasano and Takeshi Suzuki and Junko Kurokawa and Tetsushi Furukawa and Tokyo Medical and Dental University and Department of Bio-Informational Pharmacology and Safety Research Division and Division of Basic Biological Sciences and Faculty of Pharmacy and Medical Research Institute and Keio University and Mitsubishi Tanabe Pharma Corporation
Journal of Pharmacological Sciences, ISSN 1347-8613, 2009, Volume 109, Issue 1, pp. 152 - 156
We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG... 
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13. Full Text Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1Agonists with Reduced Effect on Heart Rate
by Hamada, Maiko and Nakamura, Mitsuharu and Kiuchi, Masatoshi and Marukawa, Kaoru and Tomatsu, Ayumi and Shimano, Kyoko and Sato, Noriko and Sugahara, Kunio and Asayama, Mahoko and Takagi, Kan and Adachi, Kunitomo
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
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14. Full Text Usefulness of guinea pig Langendorff heart assay for predicting QT prolongat
by Takagi, Kan and Ishitsuka, Toshimasa and Asayama, Mahoko and Wasaki, Masahiko and Mutai, Mamoru
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 2008, Volume 58, Issue 2, pp. 163 - 163
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15. Full Text Delay of QT prolongation to pharmacokinetics in haloperidol
by Maekawa, Motoko and Ishitsuka, Toshimasa and Harada, Hiroyuki and Asayama, Mahoko and Takagi, Kan and Inamura, Naoki and Shintaku, Yoshihisa and Okimoto, Hiroko and Wasaki, Masahiko and Mutai, Mamoru
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 2008, Volume 58, Issue 2, pp. 163 - 163
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