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humans (5) 5
life sciences & biomedicine (5) 5
pharmacology & pharmacy (5) 5
science & technology (5) 5
dose-response relationship, drug (4) 4
animals (3) 3
arrhythmia (3) 3
cardiovascular diseases (3) 3
cell line (3) 3
male (3) 3
analysis (2) 2
arrhythmias, cardiac - chemically induced (2) 2
cells, cultured (2) 2
congenital, hereditary, and neonatal diseases and abnormalities (2) 2
csahi (2) 2
estrogen (2) 2
field potential (2) 2
heart (2) 2
heart cells (2) 2
heart rate - drug effects (2) 2
human induced pluripotent stem cell-derived cardiomyocytes (2) 2
induced pluripotent stem cells - drug effects (2) 2
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k+ channel (2) 2
molecular structure (2) 2
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proarrhythmia (2) 2
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qt prolongation (2) 2
rats (2) 2
rats, sprague-dawley (2) 2
receptors, lysosphingolipid - agonists (2) 2
structure-activity relationship (2) 2
therapeutics. pharmacology (2) 2
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toxicology (2) 2
arrhythmias, cardiac - diagnosis (1) 1
arrhythmias, cardiac - physiopathology (1) 1
autoimmune diseases - drug therapy (1) 1
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benzamides - pharmacology (1) 1
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bradycardia - drug therapy (1) 1
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cardiotonic agents - pharmacology (1) 1
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cardiovascular system (1) 1
cell culture techniques - methods (1) 1
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drug evaluation, preclinical - methods (1) 1
drug-related side effects and adverse reactions - diagnosis (1) 1
drugs (1) 1
effect (1) 1
electrocardiography - drug effects (1) 1
electrophysiological phenomena - drug effects (1) 1
embryonic stem cells (1) 1
erg1 potassium channel (1) 1
estradiol - pharmacology (1) 1
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estrone (1) 1
estrone - analogs & derivatives (1) 1
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ether-a-go-go potassium channels - genetics (1) 1
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ether-a-go-go potassium channels - physiology (1) 1
flat panel displays (1) 1
gene expression (1) 1
guinea pigs (1) 1
health aspects (1) 1
heart - drug effects (1) 1
heart beat (1) 1
heart rate - physiology (1) 1
herg (1) 1
herg activator (1) 1
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i[kr] channel (1) 1
ikr channel (1) 1
immunologic factors - adverse effects (1) 1
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immunologic factors - pharmacology (1) 1
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ion channels - agonists (1) 1
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1. Full Text Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk
by Sugahara, Kunio and Maeda, Yasuhiro and Shimano, Kyoko and Mogami, Akira and Kataoka, Hirotoshi and Ogawa, Kei and Hikida, Kumiko and Kumagai, Hiroshi and Asayama, Mahoko and Yamamoto, Toshinobu and Harada, Tomohiko and Ni, Pingping and Inoue, Shinsuke and Kawaguchi, Atsuhiro
British journal of pharmacology, ISSN 0007-1188, 01/2017, Volume 174, Issue 1, pp. 15 - 27
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Organophosphates - administration & dosage | Cell Line | Humans | Macaca fascicularis | Rats | Male | Structure-Activity Relationship | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Organophosphates - pharmacology | Animals | Bradycardia - metabolism | Propanolamines - chemistry | Receptors, Lysosphingolipid - agonists | Sphingosine-1-Phosphate Receptors | Organophosphates - chemistry | Molecular Structure | Propanolamines - administration & dosage | Propanolamines - pharmacology | Receptors, Lysosphingolipid - metabolism | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Bradycardia - drug therapy | Phosphates | Bradycardia | Heart beat | Lymphocytes | Health aspects | Sphingosine | Index Medicus | Research Papers | Research Paper
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2. Full Text Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts
by Asayama, Mahoko and Kurokawa, Junko and Shirakawa, Kiyoshi and Okuyama, Hisashi and Kagawa, Toshiki and Okada, Jun-ichi and Sugiura, Seiryo and Hisada, Toshiaki and Furukawa, Tetsushi and Tokyo Medical and Dental University and Department of Bio-informational Pharmacology and Safety Evaluation Research Laboratories and the University of Tokyo and Research Division and Graduate School of Frontier Sciences and Medical Research Institute and Mitsubishi Tanabe Pharma Corporation
Journal of pharmacological sciences, ISSN 1347-8613, 2013, Volume 121, Issue 1, pp. 1 - 8
KCNH2 | hERG activator | pro-arrhythmia | QT and QTc interval | IKr channel | Pro-arrhythmia | HERG activator | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Guinea Pigs | Humans | Cells, Cultured | Ether-A-Go-Go Potassium Channels - metabolism | Electrocardiography - drug effects | Male | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Dogs | Heart - drug effects | Benzamides - pharmacology | In Vitro Techniques | Electrophysiological Phenomena - drug effects | Index Medicus
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3. Full Text CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia — Effects of 7 reference compounds at 10 facilities
by Kitaguchi, Takashi and Moriyama, Yuta and Taniguchi, Tomohiko and Ojima, Atsuko and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Morita, Maya and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Tanaka, Kohji and Washio, Ikumi and Miyamoto, Norimasa
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 03/2016, Volume 78, pp. 93 - 102
QT prolongation | CSAHi | Field potential | Proarrhythmia | Multi-electrode array | Torsade de pointes | Human induced pluripotent stem cell-derived cardiomyocytes | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Predictive Value of Tests | Congresses as Topic | Arrhythmias, Cardiac - chemically induced | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Humans | Long QT Syndrome - chemically induced | Cell Culture Techniques - methods | Cryopreservation - methods | Long QT Syndrome - diagnosis | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Arrhythmias, Cardiac - diagnosis | Pharmaceutical Preparations - administration & dosage | Drug-Related Side Effects and Adverse Reactions - diagnosis | Arrhythmia | Analysis | Heart cells | Index Medicus
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4. Full Text Comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi–The second stage) –Ca2+ transient platform
by Takasuna, Kiyoshi and Honda, Yayoi and Asayama, Mahoko and Mitsui, Hideaki and Nagano, Chifumi and Kato, Natsumi and Hisada, Sunao
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 09/2019, Volume 99, pp. 106595 - 106595
Index Medicus
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5. Full Text A receptor-independent effect of estrone sulfate on the hERG channel
by Kakusaka, Shoko and Asayama, Mahoko and Kaihara, Asami and Sasano, Tetsuo and Suzuki, Takeshi and Kurokawa, Junko and Furukawa, Tetsushi
Journal of pharmacological sciences, ISSN 1347-8613, 2009, Volume 109, Issue 1, pp. 152 - 156
Heart | channel (hERG) | Estrogen | Index Medicus
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6. Full Text Telemetry study in common marmosets for in vivo cardiovascular risk assessment
by Maekawa, Motoko and Kagawa, Toshiki and Asayama, Mahoko and Baba, Nobuyuki and Wasaki, Chikako
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 09/2015, Volume 75, pp. 181 - 181
Cardiovascular diseases | Risk assessment
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7. Full Text CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes
by Kitaguchi, Takashi and Moriyama, Yuta and Taniguchi, Tomohiko and Maeda, Sanae and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Miyamoto, Norimasa
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 05/2017, Volume 85, pp. 73 - 81
QT prolongation | CSAHi | Field potential | Proarrhythmia | Multi-electrode array | Torsade de pointes | Human induced pluripotent stem cell-derived cardiomyocytes | Methods | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Drug Evaluation, Preclinical - methods | Cardiotoxins - pharmacology | Arrhythmias, Cardiac - chemically induced | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Humans | Cells, Cultured | Ion Channels - physiology | Cardiotonic Agents - pharmacology | Arrhythmias, Cardiac - physiopathology | Ion Channels - antagonists & inhibitors | Dose-Response Relationship, Drug | Heart Rate - drug effects | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Heart Rate - physiology | Ion Channels - agonists | Drugs | Usage | Arrhythmia | Stem cells | Heart cells | Embryonic stem cells | Flat panel displays | Index Medicus
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8. Full Text Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk
: Amiselimod: pharmacology and effects on heart rate
by Sugahara, Kunio and Maeda, Yasuhiro and Shimano, Kyoko and Mogami, Akira and Kataoka, Hirotoshi and Ogawa, Kei and Hikida, Kumiko and Kumagai, Hiroshi and Asayama, Mahoko and Yamamoto, Toshinobu and Harada, Tomohiko and Ni, Pingping and Inoue, Shinsuke and Kawaguchi, Atsuhiro
British journal of pharmacology, ISSN 0007-1188, 01/2017, Volume 174, Issue 1, pp. 15 - 27
Journal Article
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9. Full Text Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate
by Hamada, Maiko and Nakamura, Mitsuharu and Kiuchi, Masatoshi and Marukawa, Kaoru and Tomatsu, Ayumi and Shimano, Kyoko and Sato, Noriko and Sugahara, Kunio and Asayama, Mahoko and Takagi, Kan and Adachi, Kunitomo
Journal of medicinal chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
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10. Full Text Comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi-The second stage) -Ca 2+ transient platform
by Takasuna, Kiyoshi and Honda, Yayoi and Asayama, Mahoko and Mitsui, Hideaki and Nagano, Chifumi and Kato, Natsumi and Hisada, Sunao
Journal of pharmacological and toxicological methods, 09/2019, Volume 99, p. 106595
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11. Full Text A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
by Kakusaka, Shoko and Asayama, Mahoko and Kaihara, Asami and Sasano, Tetsuo and Suzuki, Takeshi and Kurokawa, Junko and Furukawa, Tetsushi and Tokyo Medical and Dental University and Department of Bio-Informational Pharmacology and Safety Research Division and Division of Basic Biological Sciences and Faculty of Pharmacy and Medical Research Institute and Keio University and Mitsubishi Tanabe Pharma Corporation
Journal of pharmacological sciences, ISSN 1347-8613, 2009, Volume 109, Issue 1, pp. 152 - 156
estrogen | K+ channel (hERG) | heart | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Membrane Potentials - drug effects | Cell Line | Estrone - pharmacology | Gene Expression | Estrogens - pharmacology | Humans | Receptors, Estrogen - antagonists & inhibitors | Estrogen Antagonists - pharmacology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Membrane Potentials - physiology | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Estrogens - chemistry | Estrone - analogs & derivatives | Estrone - chemistry | Ether-A-Go-Go Potassium Channels - physiology | Molecular Structure | Estradiol - pharmacology | Receptors, Estrogen - physiology
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12. Full Text CSAHi study: Evaluation of MED64 multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia
by Kitaguchi, Takashi and Moriyama, Yuta and Miyamoto, Norimasa and Taniguchi, Tomohiko and Ojima, Atsuko and Ando, Hiroyuki and Uda, Takaaki and Otabe, Koji and Oguchi, Masao and Shimizu, Shigekazu and Saito, Hiroyuki and Morita, Maya and Toratani, Atsushi and Asayama, Mahoko and Yamamoto, Wataru and Matsumoto, Emi and Saji, Daisuke and Ohnaka, Hiroki and Washio, Ikumi and Ishimura, Masakazu
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 09/2016, Volume 81, pp. 384 - 385
Arrhythmia | Analysis
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13. Full Text Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1Agonists with Reduced Effect on Heart Rate
by Hamada, Maiko and Nakamura, Mitsuharu and Kiuchi, Masatoshi and Marukawa, Kaoru and Tomatsu, Ayumi and Shimano, Kyoko and Sato, Noriko and Sugahara, Kunio and Asayama, Mahoko and Takagi, Kan and Adachi, Kunitomo
Journal of medicinal chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
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14. Full Text Usefulness of guinea pig Langendorff heart assay for predicting QT prolongat
by Takagi, Kan and Ishitsuka, Toshimasa and Asayama, Mahoko and Wasaki, Masahiko and Mutai, Mamoru
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 2008, Volume 58, Issue 2, pp. 163 - 163
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15. Full Text Delay of QT prolongation to pharmacokinetics in haloperidol
by Maekawa, Motoko and Ishitsuka, Toshimasa and Harada, Hiroyuki and Asayama, Mahoko and Takagi, Kan and Inamura, Naoki and Shintaku, Yoshihisa and Okimoto, Hiroko and Wasaki, Masahiko and Mutai, Mamoru
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 2008, Volume 58, Issue 2, pp. 163 - 163
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16. Full Text Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate
by Hamada, Maiko and Nakamura, Mitsuharu and Kiuchi, Masatoshi and Marukawa, Kaoru and Tomatsu, Ayumi and Shimano, Kyoko and Sato, Noriko and Sugahara, Kunio and Asayama, Mahoko and Takagi, Kan and Adachi, Kunitomo
Journal of medicinal chemistry, 04/2010, Volume 53, Issue 8, pp. 3154 - 3168
Cricetulus | Rats, Inbred F344 | Biphenyl Compounds - adverse effects | Male | Structure-Activity Relationship | Immunologic Factors - chemical synthesis | Heart Rate - drug effects | Propylene Glycols - adverse effects | Biphenyl Compounds - pharmacology | Propanolamines - chemical synthesis | Propylene Glycols - pharmacology | Cell Line | Cricetinae | Propylene Glycols - chemical synthesis | Rats | Propanolamines - adverse effects | Rats, Sprague-Dawley | Animals | Biphenyl Compounds - chemical synthesis | Lymphocyte Count | Receptors, Lysosphingolipid - agonists | Immunologic Factors - adverse effects | Mice | Mice, Inbred BALB C | Propanolamines - pharmacology | Immunologic Factors - pharmacology | Index Medicus
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