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by Su, Zhan and Gay, Laura J and Strange, Amy and Palles, Claire and Band, Gavin and Whiteman, David C and Lescai, Francesco and Langford, Cordelia and Nanji, Manoj and Edkins, Sarah and van der Winkel, Anouk and Levine, David and Sasieni, Peter and Bellenguez, Céline and Howarth, Kimberley and Freeman, Colin and Trudgill, Nigel and Tucker, Art T and Pirinen, Matti and Peppelenbosch, Maikel P and van der Laan, Luc J. W and Kuipers, Ernst J and nth, Joost P. H and Peters, Wilbert H and Reynolds, John V and Kelleher, Dermot P and McManus, Ross and Grabsch, Heike and Prenen, Hans and Bisschops, Raf and Krishnadath, Kausila and Siersema, Peter D and van Baal, Jantine W. P. M and Middleton, Mark and Petty, Russell and Gillies, Richard and Burch, Nicola and Bhandari, Pradeep and Paterson, Stuart and Edwards, Cathryn and Penman, Ian and Vaidya, Kishor and Ang, Yeng and Murray, Iain and Patel, Praful and Ye, Weimin and Mullins, Paul and Wu, Anna H and Bird, Nigel C and Dallal, Helen and Shaheen, Nicholas J and Murray, Liam J and Koss, Konrad and Bernstein, Leslie and Romero, Yvonne and Hardie, Laura J and Zhang, Rui and Winter, Helen and Corley, Douglas A and Panter, Simon and Risch, Harvey A and Reid, Brian J and Sargeant, Ian and Gammon, Marilie D and Smart, Howard and Dhar, Anjan and McMurtry, Hugh and Ali, Haythem and Liu, Geoffrey and Casson, Alan G and Chow, Wong-Ho and Rutter, Matt and Tawil, Ashref and Morris, Danielle and Nwokolo, Chuka and Isaacs, Peter and Rodgers, Colin and Ragunath, Krish and MacDonald, Chris and Haigh, Chris and Monk, David and Davies, Gareth and Wajed, Saj and Johnston, David and Gibbons, Michael and Cullen, Sue and Church, Nicholas and Langley, Ruth and Griffin, Michael and Alderson, Derek and Deloukas, Panos and Hunt, Sarah E and Gray, Emma and nov, Serge and Potter, Simon C and Tashakkori-Ghanbaria, Avazeh and Anderson, Mark and Brooks, Claire and Blackwell, Jenefer M and Bramon, Elvira and ... and Wellcome Trust Case Control Consor and Esophageal Adenocarcinoma Genetics and Wellcome Trust Case Control Consortium 2 and Esophageal Adenocarcinoma Genetics Consortium and The Wellcome Trust Case Control Consortium 2 and The Esophageal Adenocarcinoma Genetics Consortium
Nature genetics, ISSN 1061-4036, 2012, Volume 44, Issue 10, pp. 1131 - +
Journal Article
by Palles, Claire and Chegwidden, Laura and Li, Xinzhong and Findlay, John M and Farnham, Garry and Castro Giner, Francesc and Peppelenbosch, Maikel P and Kovac, Michal and Adams, Claire L and Prenen, Hans and Briggs, Sarah and Harrison, Rebecca and Sanders, Scott and MacDonald, David and Haigh, Chris and Tucker, Art and Love, Sharon and Nanji, Manoj and Decaestecker, John and Ferry, David and Rathbone, Barrie and Hapeshi, Julie and Barr, Hugh and Moayyedi, Paul and Watson, Peter and Zietek, Barbara and Maroo, Neera and Gay, Laura and Underwood, Tim and Boulter, Lisa and McMurtry, Hugh and Monk, David and Patel, Praful and Ragunath, Krish and Al Dulaimi, David and Murray, Iain and Koss, Konrad and Veitch, Anew and Trudgill, Nigel and Nwokolo, Chuka and Rembacken, Bjorn and Atherfold, Paul and Green, Elaine and Ang, Yeng and Kuipers, Ernst J and Chow, Wu and Paterson, Stuart and Kai, Sudarshan and Beales, Ian and Grimley, Charles and Mullins, Paul and Beckett, Conrad and Farrant, Mark and Dixon, Anew and Kelly, Sean and Johnson, Matthew and Wajed, Shahjehan and Dhar, Anjan and Sawyer, Elinor and Roylance, Rebecca and Onstad, Lynn and Gammon, Marilie D and Corley, Douglas A and Shaheen, Nicholas J and Bird, Nigel C and Hardie, Laura J and Reid, Brian J and Ye, Weimin and Liu, Geoffrey and Romero, Yvonne and Bernstein, Leslie and Wu, Anna H and Casson, Alan G and Fitzgerald, Rebecca and Whiteman, David C and Risch, Harvey A and Levine, David M and Vaughan, Tom L and Verhaar, Auke P and van den Brande, Jan and Toxopeus, Eelke L and Spaander, Manon C and Wijnhoven, Bas P. L and van der Laan, Luc J. W and Krishnadath, Kausilia and Wijmenga, Cisca and Trynka, Gosia and McManus, Ross and Reynolds, John V and O'Sullivan, Jacintha and MacMathuna, Paaic and McGarrigle, Sarah A and Kelleher, Dermot and Vermeire, Severine and Cleynen, Isabelle and Bisschops, Raf and Tomlinson, Ian and Jankowski, Janusz
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 2, pp. 367 - 378
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2006, Volume 69, Issue 3, pp. 1033 - 1040
The highly inducible enzyme, hemeoxygenase-1 (HO-1), metabolizes heme, thereby protecting a variety of cells against oxidative stress and apoptosis.... 
SIGNAL-TRANSDUCTION | PROTEIN-KINASE PATHWAY | OXIDATIVE STRESS | EPITHELIAL-CELLS | CARBON-MONOXIDE | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | HEME OXYGENASE-1 GENE | NECROSIS-FACTOR-ALPHA | TRANSCRIPTION FACTOR | CONFERS RESISTANCE
Journal Article
Gut, ISSN 0017-5749, 2010, Volume 59, Issue 2, pp. 156 - 163
Background Barrett's oesophagus is a common premalignant lesion caused partly by acid reflux. Although the requisite therapy, proton pump inhibitors (PPIs),... 
GASTRIC-MUCOSA | LANSOPRAZOLE | GASTROESOPHAGEAL-REFLUX DISEASE | ADENOCARCINOMA | REGENERATION | GENE-EXPRESSION | METAPLASIA | PROLIFERATION | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | HELICOBACTER-PYLORI | Enzyme-Linked Immunosorbent Assay - methods | Humans | Middle Aged | Male | Precancerous Conditions - metabolism | Gastric Mucosa - metabolism | Esophageal Neoplasms - pathology | Dose-Response Relationship, Drug | Gastrins - biosynthesis | Precancerous Conditions - drug therapy | Barrett Esophagus - pathology | Esophageal Neoplasms - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | Adult | Female | Precancerous Conditions - pathology | Gastrins - genetics | Tumor Cells, Cultured | Gastrins - pharmacology | Barrett Esophagus - metabolism | Proton Pump Inhibitors - adverse effects | Gene Expression | Receptor, Cholecystokinin B - biosynthesis | RNA, Messenger - genetics | Esophagus - metabolism | Proton Pump Inhibitors - therapeutic use | Receptor, Cholecystokinin B - genetics | Cell Movement - drug effects | Barrett Esophagus - drug therapy | Aged | Cell Proliferation - drug effects | Esophageal Neoplasms - drug therapy | Complications and side effects | Barrett's esophagus | Gastrin | Physiological aspects | Development and progression | Proton pump inhibitors | Research | Chemokine receptors | Studies | Endoscopy | Expansion | Cloning | Cell cycle | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
by Palles, Claire and Chegwidden, Laura and Li, Xinzhong and Findlay, John M and Farnham, Garry and Castro Giner, Francesc and Peppelenbosch, Maikel P and Kovac, Michal and Adams, Claire L and Prenen, Hans and Briggs, Sarah and Harrison, Rebecca and Sanders, Scott and MacDonald, David and Haigh, Chris and Tucker, Art and Love, Sharon and Nanji, Manoj and deCaestecker, John and Ferry, David and Rathbone, Barrie and Hapeshi, Julie and Barr, Hugh and Moayyedi, Paul and Watson, Peter and Zietek, Barbara and Maroo, Neera and Gay, Laura and Underwood, Tim and Boulter, Lisa and McMurtry, Hugh and Monk, David and Patel, Praful and Ragunath, Krish and Al Dulaimi, David and Murray, Iain and Koss, Konrad and Veitch, Andrew and Trudgill, Nigel and Nwokolo, Chuka and Rembacken, Bjorn and Atherfold, Paul and Green, Elaine and Ang, Yeng and Kuipers, Ernst J and Chow, Wu and Paterson, Stuart and Kadri, Sudarshan and Beales, Ian and Grimley, Charles and Mullins, Paul and Beckett, Conrad and Farrant, Mark and Dixon, Andrew and Kelly, Sean and Johnson, Matthew and Wajed, Shahjehan and Dhar, Anjan and Sawyer, Elinor and Roylance, Rebecca and Onstad, Lynn and Gammon, Marilie D and Corley, Douglas A and Shaheen, Nicholas J and Bird, Nigel C and Hardie, Laura J and Reid, Brian J and Ye, Weimin and Liu, Geoffrey and Romero, Yvonne and Bernstein, Leslie and Wu, Anna H and Casson, Alan G and Fitzgerald, Rebecca and Whiteman, David C and Risch, Harvey A and Levine, David M and Vaughan, Tom L and Verhaar, Auke P and van den Brande, Jan and Toxopeus, Eelke L and Spaander, Manon C and Wijnhoven, Bas P.L and van der Laan, Luc J.W and Krishnadath, Kausilia and Wijmenga, Cisca and Trynka, Gosia and McManus, Ross and Reynolds, John V and O’Sullivan, Jacintha and MacMathuna, Padraic and McGarrigle, Sarah A and Kelleher, Dermot and Vermeire, Severine and Cleynen, Isabelle and Bisschops, Raf and Tomlinson, Ian and Jankowski, Janusz
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 2, pp. 367 - 378
Journal Article
by Palles, Claire and Chegwidden, Laura and Li, Xinzhong and Findlay, John M and Farnham, Garry and Giner, Francesc Castro and Peppelenbosch, Maikel P and Kovac, Michal and Adams, Claire L and Prenen, Hans and Briggs, Sarah and Harrison, Rebecca and Sanders, Scott and MacDonald, David and Haigh, Chris and Tucker, Art and Love, Sharon and Nanji, Manoj and Decaestecker, John and Ferry, David and Rathbone, Barrie and Hapeshi, Julie and Barr, Hugh and Moayyedi, Paul and Watson, Peter and Zietek, Barbara and Maroo, Neera and Gay, Laura and Underwood, Tim and Boulter, Lisa and McMurtry, Hugh and Monk, David and Patel, Praful and Ragunath, Krish and Al Dulaimi, David and Murray, Iain and Koss, Konrad and Veitch, Anew and Trudgill, Nigel and Nwokolo, Chuka and Rembacken, Bjorn and Atherfold, Paul and Green, Elaine and Ang, Yeng and Kuipers, Ernst J and Chow, Wu and Paterson, Stuart and Kai, Sudarshan and Beales, Ian and Grimley, Charles and Mullins, Paul and Beckett, Conrad and Farrant, Mark and Dixon, Anew and Kelly, Sean and Johnson, Matthew and Wajed, Shahjehan and Dhar, Anjan and Sawyer, Elinor and Roylance, Rebecca and Onstad, Lynn and Gammon, Marilie D and Corley, Douglas A and Shaheen, Nicholas J and Bird, Nigel C and Hardie, Laura J and Reid, Brian J and Ye, Weimin and Liu, Geoffrey and Romero, Yvonne and Bernstein, Leslie and Wu, Anna H and Casson, Alan G and Fitzgerald, Rebecca and Whiteman, David C and Risch, Harvey A and Levine, David M and Vaughan, Tom L and Verhaar, Auke P and van den Brande, Jan and Toxopeus, Eelke L and Spaander, Manon C and Wijnhoven, Bas P. L and van der Laan, Luc J. W and Krishnadath, Kausilia and Wijmenga, Cisca and Trynka, Gosia and McManus, Ross and Reynolds, John V and O'Sullivan, Jacintha and MacMathuna, Paaic and McGarrigle, Sarah A and Kelleher, Dermot and Vermeire, Severine and Cleynen, Isabelle and Bisschops, Raf and Tomlinson, Ian and Jankowski, Janusz
Gastroenterology, ISSN 0016-5085, 02/2015, Volume 148, Issue 2, pp. 367 - 378
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single... 
Journal Article
by Palles, Claire and Chegwidden, Laura and Li, Xinzhong and Findlay, John M and Farnham, Garry and Castro Giner, Francesc and Peppelenbosch, Maikel and Kovac, Michal and Adams, Claire and Prenen, Hans and Briggs, Sarah and Harrison, Rebecca and Sanders, Scott and Macdonald, David and Haigh, Katharina and Tucker, Art and Love, Sharon and Nanji, Manoj and Decaestecker, John and Ferry, David and Rathbone, Barrie and Hapeshi, Julie and Barr, Hugh and Moayyedi, Paul and Watson, Peter and Zietek, Barbara and Maroo, Neera and Gay, Laura and Underwood, Tim and Boulter, Lisa and McMurtry, Hugh and Monk, Alastair and Patel, Poulam and Ragunath, Krish and Al Dulaimi, David and Murray, Iain and Koss, Clara and Veitch, Anew and Trudgill, Nigel and Nwokolo, Chuka and Rembacken, B and Atherfold, Paul and Green, Elaine K and Ang, Yeng and Kuipers, Ernst and Chow, Wu and Paterson, Stuart and Kai, Sudarshan and Beales, Ian and Grimley, Charles and Mullins, Paul and Beckett, Conrad and Farrant, Mark and Dixon, Anew and Kelly, Sean and Johnson, Matthew and Wajed, Shahjehan and Dhar, Archana and Sawyer, Elinor and Roylance, Rebecca and Onstad, Lynn and Gammon, Marilie and Corley, Douglas and Shaheen, Nazima and Bird, Nigel and Hardie, Bruce and Reid, Brian and Ye, Weimin and Liu, Geoffrey and Romero, Yvonne and Bernstein, Leslie and Wu, Anna H and Casson, Alan and Fitzgerald, Rebecca and Whiteman, David C and Risch, Harvey and Levine, David M and Vaughan, Thomas and Verhaar, Auke and Van Den Brande, Jan and Toxopeus, Eelke and Spaander, Manon and Wijnhoven, Bas and Laan, Luc and Krishnadath, Kausilia and Wijmenga, Cisca and Trynka, Gosia and McManus, Ross and Reynolds, John V and O'Sullivan, Jacintha and Macmathuna, Paaic and McGarrigle, Sarah A and Kelleher, Dermot and Vermeire, Séverine and Cleynen, Isabelle and Bisschops, Raf and Tomlinson, Ian and Jankowski, Janusz Antoni
Gastroenterology, ISSN 0016-5085, 01/2015, Volume 148, Issue 2, pp. 367 - 378
textabstractBackground & Aims Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated... 
Journal Article
by Su, Zhan and Gay, Laura J and Strange, Amy and Palles, Claire and Band, Gavin and Whiteman, David C and Lescai, Francesco and Langford, Cordelia and Nanji, Manoj and Edkins, Sarah and van der Winkel, Anouk and Levine, David and Sasieni, Peter and Bellenguez, Celine and Howarth, Kimberley and Freeman, Colin and Trudgill, Nigel and Tucker, Art T and Pirinen, Matti and Peppelenbosch, Maikel P and van der Laan, Luc J. W and Kuipers, Ernst J and nth, Joost P. H and Peters, Wilbert H and Reynolds, John V and Kelleher, Dermot P and McManus, Ross and Grabsch, Heike and Prenen, Hans and Bisschops, Raf and Krishnadath, Kausila and Siersema, Peter D and van Baal, Jantine W. P. M and Middleton, Mark and Petty, Russell and Gillies, Richard and Burch, Nicola and Bhandari, Pradeep and Paterson, Stuart and Edwards, Cathryn and Penman, Ian and Vaidya, Kishor and Ang, Yeng and Murray, Iain and Patel, Praful and Ye, Weimin and Mullins, Paul and Wu, Anna H and Bird, Nigel C and Dallal, Helen and Shaheen, Nicholas J and Murray, Liam J and Koss, Konrad and Bernstein, Leslie and Romero, Yvonne and Hardie, Laura J and Zhang, Rui and Winter, Helen and Corley, Douglas A and Panter, Simon and Risch, Harvey A and Reid, Brian J and Sargeant, Ian and Gammon, Marilie D and Smart, Howard and Dhar, Anjan and McMurtry, Hugh and Ali, Haythem and Liu, Geoffrey and Casson, Alan G and Chow, Wong-Ho and Rutter, Matt and Tawil, Ashref and Morris, Danielle and Nwokolo, Chuka and Isaacs, Peter and Rodgers, Colin and Ragunath, Krish and MacDonald, Chris and Haigh, Chris and Monk, David and Davies, Gareth and Wajed, Saj and Johnston, David and Gibbons, Michael and Cullen, Sue and Church, Nicholas and Langley, Ruth and Griffin, Michael and Alderson, Derek and Deloukas, Panos and Hunt, Sarah E and Gray, Emma and nov, Serge and Potter, Simon C and Tashakkori-Ghanbaria, Avazeh and Anderson, Mark and Brooks, Claire and Blackwell, Jenefer M and Bramon, Elvira and ...
Nature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1131 - +
Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly... 
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 2000, Volume 37, Issue 11, pp. 675 - 683
We previously demonstrated that stimulation of human T-lymphocytes with calcium ionophores induced the phosphorylation and enzymatic activation of ERK2. We now... 
p56 | CaM-Kinase | T-lymphocytes | Calcium | ERK
Journal Article
Archives of Disease in Childhood, ISSN 0040-6376, 02/2006, Volume 59, Issue 2, p. 156
Aims: The National Pathology Alliance benchmarking review has completed six years of data collection and analysis of the workload and organisation of... 
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2006, Volume 69, Issue 3, p. 1033
The highly inducible enzyme, hemeoxygenase-1 (HO-1), metabolizes heme, thereby protecting a variety of cells against oxidative stress and apoptosis.... 
Journal Article
Cellular Signalling, ISSN 0898-6568, 2001, Volume 13, Issue 1, pp. 65 - 69
Lysates from the Jurkat T lymphocyte cell line were immunoblotted with anti-Pyk2, and two major forms of Pyk2 were identified. When lysates from the p56... 
p56Lck | T lymphocytes | CADTK | Pyk2 | CAK-β | RAFTK | CD45
Journal Article
Molecular Immunology, ISSN 0161-5890, 2000, Volume 37, Issue 11, pp. 675 - 683
Journal Article