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2011, ISBN 9780444518927, Volume 103
Book Chapter
2.
Full Text
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Nature (London), ISSN 0028-0836, 04/2017, Volume 544, Issue 7650, pp. 367 - 371
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System - metabolism | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Stress, Physiological | Male | Protein Aggregation, Pathological - therapy | Ataxin-2 - genetics | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Cytoplasmic Granules - metabolism | Oligonucleotides, Antisense - therapeutic use | Female | Protein Aggregation, Pathological - genetics | Motor Skills - physiology | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Mice, Transgenic | Longevity | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Disease Progression | Ataxin-2 - deficiency | Mice, Knockout | Animals | Oligonucleotides, Antisense - genetics | Amyotrophic Lateral Sclerosis - metabolism | Survival Analysis | Oligonucleotides, Antisense - administration & dosage | Mice | Proteins | Pathology | Hypotheses | Neurodegeneration | Neurons | Transgenic animals | Rodents | Nervous system | Mutation | Dementia | Recruitment | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 2020, Volume 21, Issue 3, p. 967
RBP | Spectroscopy | Translation | Molecular Biology | ITGB3 | Megakaryopoiesis | ATAXIN2 | MEG-01 | ATXN2 | Computer Science Applications | Hemostasis | PECAM1 | Catalysis | Inorganic Chemistry | MRNA | Physical and Theoretical Chemistry | Organic Chemistry | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | meg-01 | itgb3 | rbp | megakaryopoiesis | atxn2 | translation | mrna | pecam1 | hemostasis | ataxin2
Journal Article
Nature (London), ISSN 0028-0836, 08/2010, Volume 466, Issue 7310, pp. 1069 - 1075
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Drosophila - drug effects | Neurons - pathology | Saccharomyces cerevisiae - genetics | Humans | Middle Aged | Peptides - genetics | Male | Saccharomyces cerevisiae - drug effects | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Young Adult | Ataxins | Aged, 80 and over | Adult | Female | Drosophila - genetics | Cell Line | Genetic Predisposition to Disease | Peptides - chemistry | Amyotrophic Lateral Sclerosis - genetics | DNA-Binding Proteins - toxicity | Risk Factors | Repetitive Sequences, Amino Acid - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Aged | Proteins | Yeast | Insects | Pathogenesis | Toxicity | Genes | Genetics | Amyotrophic lateral sclerosis | Mutation | Kinases | Health risk assessment | Index Medicus
Journal Article
Cerebellum (London, England), ISSN 1473-4222, 6/2008, Volume 7, Issue 2, pp. 115 - 124
Neurology | Neurosciences | Biomedicine | ataxin-2 | spinocerebellar ataxia type 2 | olivo-ponto-cerebellar atrophy | Neurobiology | neurodegeneration | Wadia-Swami or Menzel type of ataxia | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Spinocerebellar Ataxias - diagnosis | Ataxins | Diagnosis, Differential | Genes, Dominant | Cerebellar Cortex - pathology | Humans | Brain - pathology | Spinocerebellar Ataxias - pathology | Nerve Tissue Proteins - genetics | RNA - genetics | RNA - metabolism | Spinocerebellar Ataxias - genetics | Proteins | Medical research | Ataxia | Index Medicus
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 06/2019, Volume 12, Issue 6, p. dmm039396
Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Nociception | Sensation | Parkinson Disease - pathology | Animals | Dopaminergic Neurons - pathology | Humans | Motor Activity | Parkinson Disease - physiopathology | Disease Models, Animal | Index Medicus | Pain | 302 | Non-motor Parkinson's disease | Mitogenesis | Sensory neuropathy | Review | Synuclein | Mitophagy | Protein aggregate
Journal Article
Cell metabolism, ISSN 1550-4131, 01/2015, Volume 21, Issue 1, pp. 95 - 108
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Protein Biosynthesis | Humans | Drosophila Proteins - metabolism | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Ubiquitination | Guanine Nucleotide Exchange Factors - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Guanine Nucleotide Exchange Factors - genetics | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Rats | Nuclear Proteins - metabolism | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | DNA-Binding Proteins - genetics | Rats, Sprague-Dawley | Mitochondrial Membranes - metabolism | Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism | Animals | Electron Transport Chain Complex Proteins - metabolism | Drosophila Proteins - genetics | Lipid Peroxidation | Ubiquitin-Protein Ligases - genetics | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Biosynthesis | Mitochondrial DNA | Messenger RNA | Genetic translation | Genomics | Index Medicus
Journal Article
Annals of neurology, ISSN 0364-5134, 04/2012, Volume 71, Issue 4, pp. 458 - 469
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Diseases of striated muscles. Neuromuscular diseases | Amino Acid Sequence | Genetic Predisposition to Disease - genetics | Humans | Molecular Sequence Data | Genotype | Male | Torticollis - genetics | DNA Mutational Analysis | Pedigree | Adult | Female | Mutation | Nuclear Proteins - genetics | Genetic Linkage | Muscular system | FDA approval | Index Medicus
Journal Article