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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 263 - 15
Tumour sequencing identifies highly recurrent point mutations in cancer driver genes, but rare functional mutations are hard to distinguish from large numbers... 
PROTEIN | DATABASE | ANNOTATIONS | MULTIDISCIPLINARY SCIENCES | REGIONS | CLASSIFICATION | NETWORKS | HOTSPOTS | RESIDUES | SOMATIC MUTATIONS | RESOURCE | Mutation | DCC protein | Netrin-1 | Computer applications | Cancer | Tumors
Journal Article
The New Phytologist, ISSN 0028-646X, 2/2010, Volume 185, Issue 3, pp. 687 - 700
The stereospecific 5β-reduction of progesterone is a required step for cardiac glycoside biosynthesis in foxglove plants. Recently, we have isolated the gene... 
Enzymes | Leaves | Complementary DNA | RNA | Metabolites | Genes | Cardenolides | Biosynthesis | Biochemistry | Plants | heterologous protein induction | plant defense | short‐chain dehydrogenase/reductase (SDR) family | cardenolide biosynthesis | teroid 5β‐reductase | wounding and abiotic stress | Short-chain dehydrogenase/reductase (SDR) family | Cardenolide biosynthesis | Heterologous protein induction | Plant defense | Wounding and abiotic stress | Steroid 5β-reductase | SHOOT CULTURES | SECONDARY METABOLISM | short-chain dehydrogenase/reductase (SDR) family | TISSUE-CULTURES | PROGESTERONE 5-BETA-REDUCTASE | PLANT SCIENCES | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | PURPUREA | DIGITALIS-LANATA EHRH | ENZYME | steroid 5 beta-reductase | OBSCURA | EXPRESSION | Digitalis - genetics | Amino Acid Sequence | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cardenolides - metabolism | RNA, Messenger - genetics | DNA, Complementary - genetics | Digitalis - immunology | Models, Molecular | Molecular Sequence Data | Gene Expression Profiling | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Oxidoreductases - chemistry | Sequence Analysis, DNA | Metabolic Networks and Pathways | Genes, Plant - genetics | Digitalis - enzymology | Cloning, Molecular | Gene Expression Regulation, Plant | Kinetics | Index Medicus
Journal Article
Journal Article
Current Proteomics, ISSN 1570-1646, 03/2014, Volume 11, Issue 3, pp. 210 - 217
The large collection of mutated genes in the cancer genome mapping onto a reduced set of signalling pathways highlights the paramount importance of signalling... 
Cell signalling | Signalling pathway | Tumour heterogeneity | Signalling network | Polypharmacology | Oncogene | HUMAN BREAST | signalling pathway | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PATTERNS | MECHANISMS | oncogene | SOMATIC MUTATIONS | DISCOVERY | ADDICTION | polypharmacology | signalling network | RESISTANCE | EXPRESSION | tumour heterogeneity | SYSTEMS BIOLOGY
Journal Article
Plant Physiology, ISSN 0032-0889, 04/2009, Volume 149, Issue 4, pp. 1648 - 1660
We recently reported that aspartate (Asp) biosynthesis in plant chloroplasts is catalyzed by two different Asp aminotransferases (AAT): a previously... 
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 61, pp. 102898 - 102911
The FGFR3-TACC3 fusion is an oncogenic driver in diverse malignancies, including bladder cancer, characterized by upregulated tyrosine kinase activity. To gain... 
Signaling pathways | Quantitative phosphoproteomics | FGFR-TACC-fusion | Network analysis | Cancer | PROTEIN | TRANSLOCATIONS | quantitative phosphoproteomics | DOWN-REGULATION | TACC | IDENTIFICATION | FGFR | CELL BIOLOGY | BREAST-CANCER CELLS | GENE FUSIONS | signaling pathways | INHIBITION | PATHWAY | cancer | network analysis
Journal Article
Journal Article
Bioinformatics, ISSN 1367-4803, 08/2013, Volume 29, Issue 16, pp. 1934 - 1937
Motivation: Polypharmacology (the ability of a single drug to affect multiple targets) is a key feature that may explain part of the decreasing success of... 
PROTEIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FAMILIES | GENOME | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Proteins - drug effects | Proteins - metabolism | Phylogeny | Polypharmacology | Humans | Protein Structure, Tertiary - drug effects | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 4/2009, Volume 149, Issue 4, pp. 1648 - 1660
Journal Article
BioEssays, ISSN 0265-9247, 01/2005, Volume 27, Issue 1, pp. 57 - 63
Journal Article
Journal of Chemical Theory and Computation, ISSN 1549-9618, 06/2011, Volume 7, Issue 6, pp. 1935 - 1942
Selective intervention of mammalian histidine decarboxylase (EC 4.1.1.22) could provide a useful antihistaminic strategy against many different pathologies. It... 
AMINO-ACID DECARBOXYLASE | STABILITY | PURIFICATION | LIVER | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | DYNAMICS | CHEMISTRY, PHYSICAL | PROTEIN-PROTEIN INTERACTIONS | RESIDUE | FEATURES
Journal Article
New Phytologist, ISSN 0028-646X, 02/2010, Volume 185, Issue 3, p. 687
The stereospecific 5[beta]-reduction of progesterone is a required step for cardiac glycoside biosynthesis in foxglove plants. Recently, we have isolated the... 
Anopheles | Hydrogen peroxide | Pharmacy | Physiological aspects | Chemical properties | Universities and colleges | Progesterone
Journal Article
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