Breast Cancer Research and Treatment, ISSN 0167-6806, 07/2016, Volume 158, Issue 2, p. 263
Gametogenetin-binding protein 2 (GGNBP2) is encoded in human chromosome 17q12-q23, a region known as a breast and ovarian cancer susceptibility locus. GGNBP2,...
Care and treatment | Estrogen | Cancer cells | Phenols | Breast cancer | Disease susceptibility | DNA binding proteins | Gene expression | Cancer | Protein binding | Ovarian cancer
Care and treatment | Estrogen | Cancer cells | Phenols | Breast cancer | Disease susceptibility | DNA binding proteins | Gene expression | Cancer | Protein binding | Ovarian cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2016, Volume 113, Issue 34, p. 9551
Understanding the mechanisms of early cardiac fate determination may lead to better approaches in promoting heart regeneration. We used a mesoderm posterior...
Heart | Gene expression | Ribonucleic acid--RNA | Chromosomes | Cells | Binding sites
Heart | Gene expression | Ribonucleic acid--RNA | Chromosomes | Cells | Binding sites
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5863, pp. 611 - 613
In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of...
Phosphorylation | Phosphatases | Premature ovarian failure | Granulosa cells | Reports | Mice | Ovaries | Adulthood | Follicles | Oocytes | Age | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | Protein Kinases - metabolism | PTEN Phosphohydrolase - genetics | Oocytes - growth & development | Ovary - anatomy & histology | Signal Transduction | PTEN Phosphohydrolase - physiology | Organ Size | Mice, Transgenic | Ovary - physiology | Phosphatidylinositol 3-Kinases - metabolism | Ovulation | Oocytes - cytology | Animals | Oocytes - physiology | Follicular Atresia | Ribosomal Protein S6 - metabolism | Ovarian Follicle - physiology | Female | Primary Ovarian Insufficiency - physiopathology | TOR Serine-Threonine Kinases | Ovarian Follicle - cytology | Control | Genetic aspects | Properties | Animal reproduction | Genetics | Molecular biology | Females | Rodents | Menopause | Mice; Transgenic | Ovary/anatomy & histology/physiology | Oocytes/cytology/growth & development/physiology | Ovarian Failure; Premature/physiopathology | Ovarian Follicle/cytology/physiology | Ribosomal Protein S6/metabolism | PTEN Phosphohydrolase/genetics/physiology | Protein Kinases/metabolism | 1-Phosphatidylinositol 3-Kinase/metabolism
Phosphorylation | Phosphatases | Premature ovarian failure | Granulosa cells | Reports | Mice | Ovaries | Adulthood | Follicles | Oocytes | Age | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | Protein Kinases - metabolism | PTEN Phosphohydrolase - genetics | Oocytes - growth & development | Ovary - anatomy & histology | Signal Transduction | PTEN Phosphohydrolase - physiology | Organ Size | Mice, Transgenic | Ovary - physiology | Phosphatidylinositol 3-Kinases - metabolism | Ovulation | Oocytes - cytology | Animals | Oocytes - physiology | Follicular Atresia | Ribosomal Protein S6 - metabolism | Ovarian Follicle - physiology | Female | Primary Ovarian Insufficiency - physiopathology | TOR Serine-Threonine Kinases | Ovarian Follicle - cytology | Control | Genetic aspects | Properties | Animal reproduction | Genetics | Molecular biology | Females | Rodents | Menopause | Mice; Transgenic | Ovary/anatomy & histology/physiology | Oocytes/cytology/growth & development/physiology | Ovarian Failure; Premature/physiopathology | Ovarian Follicle/cytology/physiology | Ribosomal Protein S6/metabolism | PTEN Phosphohydrolase/genetics/physiology | Protein Kinases/metabolism | 1-Phosphatidylinositol 3-Kinase/metabolism
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2008, Volume 10, Issue 6, pp. 731 - 739
Nanog and Oct4 are essential transcription factors that regulate self-renewal and pluripotency of ES cells. However, the mechanisms by which Nanog and Oct4...
MAINTENANCE | NETWORK | DNA METHYLATION | CLONING | INTERACTS | PLURIPOTENCY | HOMOLOG | NURD | EXPRESSION | FIBROBLASTS | CELL BIOLOGY | Octamer Transcription Factor-3 - physiology | Embryonic Stem Cells - cytology | Nanog Homeobox Protein | Exons | Histone Deacetylases - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Cell Lineage | Animals | Cell Nucleus - metabolism | RNA Interference | Models, Biological | Transcription, Genetic | Cell Differentiation | Mice | Homeodomain Proteins - physiology | Physiological aspects | DNA binding proteins | Research | Embryonic stem cells | Gene expression
MAINTENANCE | NETWORK | DNA METHYLATION | CLONING | INTERACTS | PLURIPOTENCY | HOMOLOG | NURD | EXPRESSION | FIBROBLASTS | CELL BIOLOGY | Octamer Transcription Factor-3 - physiology | Embryonic Stem Cells - cytology | Nanog Homeobox Protein | Exons | Histone Deacetylases - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Cell Lineage | Animals | Cell Nucleus - metabolism | RNA Interference | Models, Biological | Transcription, Genetic | Cell Differentiation | Mice | Homeodomain Proteins - physiology | Physiological aspects | DNA binding proteins | Research | Embryonic stem cells | Gene expression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2014, Volume 111, Issue 5, p. E572
The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53...
Cellular biology | MicroRNAs | Stem cells
Cellular biology | MicroRNAs | Stem cells
Journal Article
STEM CELLS, ISSN 1066-5099, 06/2013, Volume 31, Issue 6, pp. 1213 - 1217
Oct4 is the gatekeeper of stem cell pluripotency, but recent evidences also support Oct4 as a key regulator of germ layer formation and lineage commitment. How...
Embryonic stem cells | Differentiation | Progenitor cells | Cardiac myocytes | Pluripotency | COMPLEX | SELF-RENEWAL | SPECIFICATION | FACTOR-BINDING SITES | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | OCT-3/4 | Embryonic Stem Cells - metabolism | Promoter Regions, Genetic | Basic Helix-Loop-Helix Transcription Factors - genetics | Embryonic Stem Cells - cytology | Signal Transduction | Heart - physiology | Lymphoid Enhancer-Binding Factor 1 - genetics | Wnt Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | TCF Transcription Factors - metabolism | Cell Lineage | Point Mutation | Animals | Wnt Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | SOXB1 Transcription Factors - genetics | Octamer Transcription Factor-3 - metabolism | Mice | TCF Transcription Factors - genetics | Gene mutations | Information management | Cellular biology | Stem cells
Embryonic stem cells | Differentiation | Progenitor cells | Cardiac myocytes | Pluripotency | COMPLEX | SELF-RENEWAL | SPECIFICATION | FACTOR-BINDING SITES | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SOX2 | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | HEMATOLOGY | TRANSCRIPTIONAL REGULATION | OCT-3/4 | Embryonic Stem Cells - metabolism | Promoter Regions, Genetic | Basic Helix-Loop-Helix Transcription Factors - genetics | Embryonic Stem Cells - cytology | Signal Transduction | Heart - physiology | Lymphoid Enhancer-Binding Factor 1 - genetics | Wnt Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | SOXB1 Transcription Factors - metabolism | Octamer Transcription Factor-3 - genetics | TCF Transcription Factors - metabolism | Cell Lineage | Point Mutation | Animals | Wnt Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | SOXB1 Transcription Factors - genetics | Octamer Transcription Factor-3 - metabolism | Mice | TCF Transcription Factors - genetics | Gene mutations | Information management | Cellular biology | Stem cells
Journal Article
Genome Research, ISSN 1088-9051, 08/2012, Volume 22, Issue 8, pp. 1541 - 1548
Genetic mapping of mutations in model systems has facilitated the identification of genes contributing to fundamental biological processes including human...
ZEBRAFISH | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GENERATION | MICE | LINEAGES | Markov Chains | Gene Frequency | Mice, Inbred C57BL | Male | DNA Mutational Analysis - methods | Zebrafish - genetics | Homozygote | Animals | Time Factors | Chromosomes - genetics | Recombination, Genetic | Chromosome Mapping - methods | Alleles | Female | Mice | Polymorphism, Single Nucleotide | Software | Mutation | Genomics - methods | Crosses, Genetic | Usage | Chromosome mapping | Nucleotide sequencing | Research | Gene mutations | DNA sequencing | Method
ZEBRAFISH | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GENERATION | MICE | LINEAGES | Markov Chains | Gene Frequency | Mice, Inbred C57BL | Male | DNA Mutational Analysis - methods | Zebrafish - genetics | Homozygote | Animals | Time Factors | Chromosomes - genetics | Recombination, Genetic | Chromosome Mapping - methods | Alleles | Female | Mice | Polymorphism, Single Nucleotide | Software | Mutation | Genomics - methods | Crosses, Genetic | Usage | Chromosome mapping | Nucleotide sequencing | Research | Gene mutations | DNA sequencing | Method
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 34, pp. 9551 - 9556
Understanding the mechanisms of early cardiac fate determination may lead to better approaches in promoting heart regeneration. We used a mesoderm posterior 1...
miR-322 | microRNA | miR-424 | miR-503 | Cardiomyocyte | MESP1 | MYOTONIC-DYSTROPHY TYPE-1 | MULTIDISCIPLINARY SCIENCES | MOUSE | MIR-17-92 CLUSTER | MICRORNAS | CUGBP1 | MESSENGER-RNA | cardiomyocyte | EMBRYONIC STEM-CELLS | DIFFERENTIATION | CYCLE | RNA, Untranslated - metabolism | Embryo, Mammalian | MicroRNAs - metabolism | Mouse Embryonic Stem Cells - cytology | Gene Expression Profiling | Mesoderm - cytology | RNA, Untranslated - genetics | Mouse Embryonic Stem Cells - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | CELF1 Protein - genetics | Integrases - metabolism | Cell Differentiation | Cell Lineage - genetics | Genes, Reporter | Basic Helix-Loop-Helix Transcription Factors - genetics | Morphogenesis - genetics | Myocytes, Cardiac - cytology | Signal Transduction | Bacterial Proteins - genetics | Mice, Transgenic | CELF1 Protein - metabolism | Animals | Mesoderm - growth & development | Myocytes, Cardiac - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mesoderm - metabolism | Mice | MicroRNAs - genetics | Primary Cell Culture | Integrases - genetics | Luminescent Proteins - metabolism | Genetic aspects | MicroRNA | Gene expression | Health aspects | Heart cells | Biological Sciences
miR-322 | microRNA | miR-424 | miR-503 | Cardiomyocyte | MESP1 | MYOTONIC-DYSTROPHY TYPE-1 | MULTIDISCIPLINARY SCIENCES | MOUSE | MIR-17-92 CLUSTER | MICRORNAS | CUGBP1 | MESSENGER-RNA | cardiomyocyte | EMBRYONIC STEM-CELLS | DIFFERENTIATION | CYCLE | RNA, Untranslated - metabolism | Embryo, Mammalian | MicroRNAs - metabolism | Mouse Embryonic Stem Cells - cytology | Gene Expression Profiling | Mesoderm - cytology | RNA, Untranslated - genetics | Mouse Embryonic Stem Cells - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | CELF1 Protein - genetics | Integrases - metabolism | Cell Differentiation | Cell Lineage - genetics | Genes, Reporter | Basic Helix-Loop-Helix Transcription Factors - genetics | Morphogenesis - genetics | Myocytes, Cardiac - cytology | Signal Transduction | Bacterial Proteins - genetics | Mice, Transgenic | CELF1 Protein - metabolism | Animals | Mesoderm - growth & development | Myocytes, Cardiac - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mesoderm - metabolism | Mice | MicroRNAs - genetics | Primary Cell Culture | Integrases - genetics | Luminescent Proteins - metabolism | Genetic aspects | MicroRNA | Gene expression | Health aspects | Heart cells | Biological Sciences
Journal Article
Developmental Dynamics, ISSN 1058-8388, 04/2015, Volume 244, Issue 4, pp. 619 - 627
Background: Mammalian first lineage segregation generates trophectoderm (TE) and pluripotent inner cell mass (ICM), which provides an ideal model for studying...
expression pattern | porcine early embryo | transcriptional factors | TE/ICM specification | Transcriptional factors | Expression pattern | Porcine early embryo | STEM-CELLS | INNER CELL MASS | ANATOMY & MORPHOLOGY | TRANSCRIPTIONAL NETWORK | ICM specification | DEVELOPMENTAL BIOLOGY | BLASTOCYST | TROPHECTODERM | PATTERN | PREIMPLANTATION EMBRYOS | GENERATION | DIFFERENTIATION | EXPRESSION | Blastocyst - cytology | Gene Expression Profiling | Gene Regulatory Networks | SOXB1 Transcription Factors - metabolism | Pluripotent Stem Cells - metabolism | Cell Lineage | Oocytes - cytology | Animals | Blastocyst Inner Cell Mass - metabolism | Gene Expression Regulation, Developmental | Swine - embryology | Octamer Transcription Factor-3 - metabolism | Cell Differentiation | Swine | Analysis
expression pattern | porcine early embryo | transcriptional factors | TE/ICM specification | Transcriptional factors | Expression pattern | Porcine early embryo | STEM-CELLS | INNER CELL MASS | ANATOMY & MORPHOLOGY | TRANSCRIPTIONAL NETWORK | ICM specification | DEVELOPMENTAL BIOLOGY | BLASTOCYST | TROPHECTODERM | PATTERN | PREIMPLANTATION EMBRYOS | GENERATION | DIFFERENTIATION | EXPRESSION | Blastocyst - cytology | Gene Expression Profiling | Gene Regulatory Networks | SOXB1 Transcription Factors - metabolism | Pluripotent Stem Cells - metabolism | Cell Lineage | Oocytes - cytology | Animals | Blastocyst Inner Cell Mass - metabolism | Gene Expression Regulation, Developmental | Swine - embryology | Octamer Transcription Factor-3 - metabolism | Cell Differentiation | Swine | Analysis
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 10/2005, Volume 25, Issue 19, pp. 8507 - 8519
ERRATUM ( vol. 25 , p. 10204 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious...
RESPONSE ELEMENT | SOX2 | RENEWAL | GERMLINE-SPECIFIC EXPRESSION | DNA-BINDING | MOUSE EMBRYOGENESIS | OCTAMER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR OCT4 | NANOG | ES CELLS | CELL BIOLOGY | Nuclear Receptor Subfamily 6, Group A, Member 1 | Homeodomain Proteins - metabolism | Male | Stem Cells - cytology | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | In Situ Hybridization | Transfection | Chromatin Immunoprecipitation | Time Factors | Tretinoin - metabolism | Female | Cell Differentiation | SOXB1 Transcription Factors | Fibroblast Growth Factor 4 - metabolism | Tretinoin - pharmacology | Cell Line | DNA-Binding Proteins - physiology | Nanog Homeobox Protein | Response Elements | Signal Transduction | Down-Regulation | Genotype | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - physiology | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Blotting, Western | Blotting, Northern | Phenotype | Animals | Embryo, Mammalian - cytology | Octamer Transcription Factor-3 - metabolism | Protein Binding | Trans-Activators - metabolism | Mice | Models, Genetic | Microscopy, Fluorescence | Receptors, Cytoplasmic and Nuclear - metabolism | Gene Expression
RESPONSE ELEMENT | SOX2 | RENEWAL | GERMLINE-SPECIFIC EXPRESSION | DNA-BINDING | MOUSE EMBRYOGENESIS | OCTAMER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR OCT4 | NANOG | ES CELLS | CELL BIOLOGY | Nuclear Receptor Subfamily 6, Group A, Member 1 | Homeodomain Proteins - metabolism | Male | Stem Cells - cytology | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | In Situ Hybridization | Transfection | Chromatin Immunoprecipitation | Time Factors | Tretinoin - metabolism | Female | Cell Differentiation | SOXB1 Transcription Factors | Fibroblast Growth Factor 4 - metabolism | Tretinoin - pharmacology | Cell Line | DNA-Binding Proteins - physiology | Nanog Homeobox Protein | Response Elements | Signal Transduction | Down-Regulation | Genotype | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - physiology | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Blotting, Western | Blotting, Northern | Phenotype | Animals | Embryo, Mammalian - cytology | Octamer Transcription Factor-3 - metabolism | Protein Binding | Trans-Activators - metabolism | Mice | Models, Genetic | Microscopy, Fluorescence | Receptors, Cytoplasmic and Nuclear - metabolism | Gene Expression
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2005, Volume 25, Issue 9, pp. 3492 - 3505
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
MOUSE DEVELOPMENT | STEM-CELLS | DIFFERENTIAL EXPRESSION | MAMMALIAN EMBRYO | FETOPROTEIN TRANSCRIPTION FACTOR | REGULATORY ELEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOG-1 CONTROLS | STEROIDOGENIC FACTOR-I | FACTOR FTF GENE | GENOME BROWSER | CELL BIOLOGY | Octamer Transcription Factor-3 | Up-Regulation | Gene Expression Regulation, Developmental - genetics | DNA-Binding Proteins - analysis | DNA-Binding Proteins - metabolism | Genes, Lethal | Stem Cells | Cell Differentiation - genetics | Response Elements - genetics | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Down-Regulation | Blastocyst - chemistry | Embryonic Development - genetics | Gene Silencing | Embryonic Development - physiology | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Animals | Embryo, Mammalian - cytology | Receptors, Cytoplasmic and Nuclear - analysis | Mice | Transcription Factors - analysis | Gene Expression
MOUSE DEVELOPMENT | STEM-CELLS | DIFFERENTIAL EXPRESSION | MAMMALIAN EMBRYO | FETOPROTEIN TRANSCRIPTION FACTOR | REGULATORY ELEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOG-1 CONTROLS | STEROIDOGENIC FACTOR-I | FACTOR FTF GENE | GENOME BROWSER | CELL BIOLOGY | Octamer Transcription Factor-3 | Up-Regulation | Gene Expression Regulation, Developmental - genetics | DNA-Binding Proteins - analysis | DNA-Binding Proteins - metabolism | Genes, Lethal | Stem Cells | Cell Differentiation - genetics | Response Elements - genetics | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Down-Regulation | Blastocyst - chemistry | Embryonic Development - genetics | Gene Silencing | Embryonic Development - physiology | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Animals | Embryo, Mammalian - cytology | Receptors, Cytoplasmic and Nuclear - analysis | Mice | Transcription Factors - analysis | Gene Expression
Journal Article
Biology of Reproduction, ISSN 0006-3363, 11/2004, Volume 71, Issue 5, pp. 1469 - 1474
Oocyte-specific deletion of ovarian genes using Cre/loxP technology provides an excellent tool to understand their physiological roles during folliculogenesis,...
Gamete biology | Oogenesis | Ovary | Folliculogenesis | Gametogenesis | Cre | Conditional knockout | Ovum | Oocyte development | MAMMALIAN OVARY | folliculogenesis | ANDROGEN RECEPTOR | STEM-CELLS | CELL NUCLEAR FACTOR | gametogenesis | oocyte development | MOUSE | gamete biology | ovum | SERTOLI-CELLS | oogenesis | INACTIVATION | ovary | REPRODUCTIVE BIOLOGY | KNOCKOUT | MUTATIONS | conditional knockout | COMMUNICATION | Egg Proteins - metabolism | Nuclear Receptor Subfamily 6, Group A, Member 1 | Membrane Glycoproteins - metabolism | Receptors, Cytoplasmic and Nuclear | Ovary - growth & development | Receptors, Retinoic Acid - genetics | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Oocytes - enzymology | Growth Differentiation Factor 9 | Gene Deletion | Female | Integrases - metabolism | Zona Pellucida Glycoproteins | Oocytes - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | DNA-Binding Proteins - genetics | Bone Morphogenetic Protein 15 | Animals | Ovary - enzymology | Homeodomain Proteins | Mice | Integrases - genetics
Gamete biology | Oogenesis | Ovary | Folliculogenesis | Gametogenesis | Cre | Conditional knockout | Ovum | Oocyte development | MAMMALIAN OVARY | folliculogenesis | ANDROGEN RECEPTOR | STEM-CELLS | CELL NUCLEAR FACTOR | gametogenesis | oocyte development | MOUSE | gamete biology | ovum | SERTOLI-CELLS | oogenesis | INACTIVATION | ovary | REPRODUCTIVE BIOLOGY | KNOCKOUT | MUTATIONS | conditional knockout | COMMUNICATION | Egg Proteins - metabolism | Nuclear Receptor Subfamily 6, Group A, Member 1 | Membrane Glycoproteins - metabolism | Receptors, Cytoplasmic and Nuclear | Ovary - growth & development | Receptors, Retinoic Acid - genetics | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Oocytes - enzymology | Growth Differentiation Factor 9 | Gene Deletion | Female | Integrases - metabolism | Zona Pellucida Glycoproteins | Oocytes - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | DNA-Binding Proteins - genetics | Bone Morphogenetic Protein 15 | Animals | Ovary - enzymology | Homeodomain Proteins | Mice | Integrases - genetics
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2015, Volume 33, Issue 11, pp. 3254 - 3265
MESP1 is considered the first sign of the nascent cardiac mesoderm and plays a critical role in the appearance of cardiac progenitors, while exhibiting a...
Differentiation | Embryonic stem cells | Developmental biology | Genomics | Cell signaling | KEY REGULATOR | CARDIOVASCULAR PROGENITOR SPECIFICATION | CARDIAC MESODERM | RESTRICTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | HEART | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | HEMATOLOGY | LINEAGE | BINDING | Gene Targeting - methods | Basic Helix-Loop-Helix Transcription Factors - genetics | Mesoderm - embryology | Endoderm - physiology | Endoderm - embryology | Male | Embryonic Stem Cells - physiology | Cell Lineage - physiology | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Myocytes, Cardiac - physiology | Mesoderm - physiology | Mice | Transcriptional Activation - physiology | Genome-Wide Association Study - methods | Cell Differentiation - physiology | Cell Line, Transformed | Protein Binding - physiology | Heart | Epigenetic inheritance | Genes
Differentiation | Embryonic stem cells | Developmental biology | Genomics | Cell signaling | KEY REGULATOR | CARDIOVASCULAR PROGENITOR SPECIFICATION | CARDIAC MESODERM | RESTRICTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | HEART | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | HEMATOLOGY | LINEAGE | BINDING | Gene Targeting - methods | Basic Helix-Loop-Helix Transcription Factors - genetics | Mesoderm - embryology | Endoderm - physiology | Endoderm - embryology | Male | Embryonic Stem Cells - physiology | Cell Lineage - physiology | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Myocytes, Cardiac - physiology | Mesoderm - physiology | Mice | Transcriptional Activation - physiology | Genome-Wide Association Study - methods | Cell Differentiation - physiology | Cell Line, Transformed | Protein Binding - physiology | Heart | Epigenetic inheritance | Genes
Journal Article
Stem Cell Research, ISSN 1873-5061, 08/2018, Volume 31, pp. 27 - 30
A skin biopsy was obtained from a 14-year-old female patient with a history of Myelomeningocele. Dermal fibroblasts were isolated and reprogrammed with Sendai...
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Female | Infant | Spinal Dysraphism - pathology | Spinal Dysraphism - metabolism | Humans | Induced Pluripotent Stem Cells - metabolism | Spina bifida | Stem cell research | Genetic aspects | Research | Gene expression
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Female | Infant | Spinal Dysraphism - pathology | Spinal Dysraphism - metabolism | Humans | Induced Pluripotent Stem Cells - metabolism | Spina bifida | Stem cell research | Genetic aspects | Research | Gene expression
Journal Article
Cellular Reprogramming, ISSN 2152-4971, 02/2018, Volume 20, Issue 1, pp. 27 - 37
p53 is a barrier to somatic cell reprogramming. Deletion or transient suppression of p53 increases the efficiency of reprogramming of somatic cells into...
cardiomyocyte differentiation | reprogramming | transdifferentiation | Oct4 | fibroblast | p53 | PROGENITORS | DNA-DAMAGE | SUPPRESSION | CELL & TISSUE ENGINEERING | PLURIPOTENT STEM-CELLS | HEART | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | FUNCTIONAL CARDIOMYOCYTES | GENERATION | DIFFERENTIATION | T-GENE | EXPRESSION | Ectoderm | Transcription factors | p53 Protein | Oct-4 protein | Mesoderm | Stem cell transplantation | Chains | Myocytes | Kinases | Clonal deletion | Calcium-binding protein | Myosin | Deletion | Fibroblasts | Inhibition | Heart diseases | Endoderm | Repressing | Cardiac muscle | Reciprocity | Muscles | Cardiomyocytes | Embryo fibroblasts | Embryos | Troponin T | Troponin | Troponin I | Somatic cells | Islet-1 protein | Cell lines | Stem cells | Biomarkers | Pluripotency
cardiomyocyte differentiation | reprogramming | transdifferentiation | Oct4 | fibroblast | p53 | PROGENITORS | DNA-DAMAGE | SUPPRESSION | CELL & TISSUE ENGINEERING | PLURIPOTENT STEM-CELLS | HEART | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | FUNCTIONAL CARDIOMYOCYTES | GENERATION | DIFFERENTIATION | T-GENE | EXPRESSION | Ectoderm | Transcription factors | p53 Protein | Oct-4 protein | Mesoderm | Stem cell transplantation | Chains | Myocytes | Kinases | Clonal deletion | Calcium-binding protein | Myosin | Deletion | Fibroblasts | Inhibition | Heart diseases | Endoderm | Repressing | Cardiac muscle | Reciprocity | Muscles | Cardiomyocytes | Embryo fibroblasts | Embryos | Troponin T | Troponin | Troponin I | Somatic cells | Islet-1 protein | Cell lines | Stem cells | Biomarkers | Pluripotency
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63532
Embryonic stem (ES) cells have several unique attributes, the two most important of which are they can differentiate into all cell types in the body and they...
NANOG GENE-EXPRESSION | SIGNALING PATHWAYS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTIONAL NETWORK | KRUPPEL-LIKE FACTOR-4 | SELF-RENEWAL | STATE | PLURIPOTENCY | DIFFERENTIATION | KLF4 | ES CELLS | Cell Line | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Carbon-Nitrogen Ligases - metabolism | Gene Expression - drug effects | Humans | Tetracycline - pharmacology | Escherichia coli Proteins - metabolism | Gene Knock-In Techniques | Proteins - genetics | Animals | Chromatin Immunoprecipitation | Embryonic Stem Cells - drug effects | Streptavidin - metabolism | Kruppel-Like Transcription Factors - metabolism | Doxycycline - pharmacology | Cell Proliferation - drug effects | Mice | Biotinylation - drug effects | Biotinylation - genetics | Repressor Proteins - metabolism | Biotin | Embryonic stem cells | Ligases | Genes | Cell culture | Chromatin | Transcription factors | Immunoprecipitation | DNA polymerase | Genomics | Homologous recombination | Embryo cells | Stem cell transplantation | Homology | Recombinase | Proteins | Cell growth | Allografts | E coli | Rodents | Cell cycle | Streptavidin | Deoxyribonucleic acid--DNA | Biotinylation | Cloning | Gene expression | Embryos | Loci | Cre recombinase | BirA protein | Cellular biology | Doxycycline | Stem cells | In vivo methods and tests | Beads | Deoxyribonucleic acid | DNA
NANOG GENE-EXPRESSION | SIGNALING PATHWAYS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTIONAL NETWORK | KRUPPEL-LIKE FACTOR-4 | SELF-RENEWAL | STATE | PLURIPOTENCY | DIFFERENTIATION | KLF4 | ES CELLS | Cell Line | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Carbon-Nitrogen Ligases - metabolism | Gene Expression - drug effects | Humans | Tetracycline - pharmacology | Escherichia coli Proteins - metabolism | Gene Knock-In Techniques | Proteins - genetics | Animals | Chromatin Immunoprecipitation | Embryonic Stem Cells - drug effects | Streptavidin - metabolism | Kruppel-Like Transcription Factors - metabolism | Doxycycline - pharmacology | Cell Proliferation - drug effects | Mice | Biotinylation - drug effects | Biotinylation - genetics | Repressor Proteins - metabolism | Biotin | Embryonic stem cells | Ligases | Genes | Cell culture | Chromatin | Transcription factors | Immunoprecipitation | DNA polymerase | Genomics | Homologous recombination | Embryo cells | Stem cell transplantation | Homology | Recombinase | Proteins | Cell growth | Allografts | E coli | Rodents | Cell cycle | Streptavidin | Deoxyribonucleic acid--DNA | Biotinylation | Cloning | Gene expression | Embryos | Loci | Cre recombinase | BirA protein | Cellular biology | Doxycycline | Stem cells | In vivo methods and tests | Beads | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 5, pp. 1674 - 1674
The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53...
PNAS Plus: Significance Statements | LIMB | STEM-CELLS | METASTASIS | MULTIDISCIPLINARY SCIENCES | PLURIPOTENCY | EPITHELIAL DEVELOPMENT | MICRORNAS | P63 | EPIDERMAL MORPHOGENESIS | TAP63 | P53 | RNA-Binding Proteins - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Transcription Factors - deficiency | MicroRNAs - metabolism | Gene Expression Profiling | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Adult | Transcription, Genetic | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Nanog Homeobox Protein | RNA, Messenger - genetics | Keratinocytes - cytology | Phosphoproteins - genetics | Transcription Factors - genetics | Down-Regulation - genetics | Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | Proteins - metabolism | Trans-Activators - deficiency | Embryo, Mammalian - cytology | Keratinocytes - metabolism | Multipotent Stem Cells - cytology | Octamer Transcription Factor-3 - metabolism | Phosphoproteins - deficiency | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Chimera | Epidermis - cytology | PNAS Plus | Biological Sciences
PNAS Plus: Significance Statements | LIMB | STEM-CELLS | METASTASIS | MULTIDISCIPLINARY SCIENCES | PLURIPOTENCY | EPITHELIAL DEVELOPMENT | MICRORNAS | P63 | EPIDERMAL MORPHOGENESIS | TAP63 | P53 | RNA-Binding Proteins - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Transcription Factors - deficiency | MicroRNAs - metabolism | Gene Expression Profiling | Phosphoproteins - metabolism | RNA, Messenger - metabolism | SOXB1 Transcription Factors - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Adult | Transcription, Genetic | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Nanog Homeobox Protein | RNA, Messenger - genetics | Keratinocytes - cytology | Phosphoproteins - genetics | Transcription Factors - genetics | Down-Regulation - genetics | Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | Proteins - metabolism | Trans-Activators - deficiency | Embryo, Mammalian - cytology | Keratinocytes - metabolism | Multipotent Stem Cells - cytology | Octamer Transcription Factor-3 - metabolism | Phosphoproteins - deficiency | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Chimera | Epidermis - cytology | PNAS Plus | Biological Sciences
Journal Article
1999, 2nd ed., The practical approach series, ISBN 9780199636976, Volume no. 201., xxii, 303
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