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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 7, pp. 2554 - 2559
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1458, pp. 273 - 290
The tumor microenvironment is a complex and heterogeneous milieu in which cancer cells undergo metabolic reprogramming to fuel their growth. Cancer cell lines... 
GC-MS | Metabolomics | Stable isotope | Silylation | Methoximation | Hypoxia | Nutrients | Microenvironment | Neoplasms - metabolism | Gas Chromatography-Mass Spectrometry | Humans | Cells, Cultured | Cell Line, Tumor | Metabolome | Tumor Microenvironment | Workflow | Neoplasms - pathology | Metabolomics - methods | Hypoxia - metabolism | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2013, Volume 17, Issue 1, pp. 113 - 124
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 698 - 711
mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases... 
MAMMALIAN TARGET | RAPAMYCIN | BINDING PARTNER | SKELETAL-MUSCLE | DIFFERENTIAL TRANSLATION | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | GENOME-WIDE | MOTIF PHOSPHORYLATION | CELL-GROWTH | COMPLEX 2 | CELL BIOLOGY | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondrial Turnover | Adenosine Triphosphate - biosynthesis | Mechanistic Target of Rapamycin Complex 2 | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Cell Nucleus - metabolism | Cell Respiration | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Autophagy - genetics | DNA, Mitochondrial - biosynthesis | Eukaryotic Initiation Factors - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Mitochondria - metabolism | Genome, Human - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Mice | Adaptor Proteins, Signal Transducing - metabolism | RNA | Physiological aspects | Biosynthesis | Mitochondrial DNA | Diabetes | Binding proteins | Heart diseases | Genetic translation | Protein binding | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49513 - e49513
KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with... 
APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | COMPLEX-II | MECHANISM | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | ATAXIA-TELANGIECTASIA GENE | IDENTIFICATION | Phosphorylation | Cell Proliferation | Humans | Metformin - metabolism | Pyrones - pharmacology | Ketoglutaric Acids - chemistry | DNA-Binding Proteins - metabolism | Citric Acid - chemistry | Membrane Potential, Mitochondrial | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Metformin - pharmacology | Cell Cycle Proteins - metabolism | Oxygen Consumption | Fumarates - chemistry | Morpholines - pharmacology | Ataxia Telangiectasia Mutated Proteins | Citric Acid Cycle | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Malates - chemistry | Succinic Acid - chemistry | Cell Line, Tumor | HeLa Cells | Lactates | Glucose metabolism | Ionizing radiation | Analysis | Physiological aspects | Metformin | Glucose | Dextrose | Tricarboxylic acid cycle | Energy metabolism | Oncology | Kinases | Experiments | DNA repair | Cancer therapies | Electron transport chain | Mitochondria | Cell growth | Energy | Metabolites | Fibroblasts | Ataxia | Membrane potential | Deoxyribonucleic acid--DNA | Medical research | Metabolism | Citric acid | Disease prevention | Inhibitors | Oxidative phosphorylation | Malate | Glycolysis | Tumor suppressor genes | Ataxia telangiectasia mutated protein | Lactic acid | Electron transport | Respiration | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 195 - 207
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2014, Volume 111, Issue 7, pp. 2554 - 2559
One of the major metabolic changes associated with cellular transformation is enhanced nutrient utilization, which supports tumor progression by fueling both... 
Tumor suppressor genes | Cell research | Nuclear reprogramming | Research | Properties | Cancer cells | Biosynthesis | Bioenergetics | Cellular biology | Metabolism | Kinases | Tumors
Journal Article
Diabetologia, ISSN 0012-186X, 2015, Volume 58, Issue 1, pp. 149 - 157
Conclusions/interpretation: Our data show that G0s2 is a physiological regulator of adiposity and energy metabolism and is a potential target in the treatment... 
Obesity | Human Physiology | ATGL | Metabolic Diseases | Energy expenditure | Internal Medicine | G0s2 | Lipolysis | Thermogenesis | Medicine & Public Health | High-fat diet | Adipose tissue browning | Insulin resistance
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 4, pp. 653 - 668
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 4826 - 4838
The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to... 
CELLS | METFORMIN | REDUCTIVE GLUTAMINE-METABOLISM | MAMMARY-TUMORS | ONCOLOGY | PHOSPHORYLATION | AEROBIC GLYCOLYSIS | GROWTH | MITOCHONDRIA | EXPRESSION | TUMORIGENESIS | Index Medicus
Journal Article
Metabolites, ISSN 2218-1989, 04/2014, Volume 4, Issue 2, pp. 166 - 183
Mitochondria are a focal point in metabolism, given that they play fundamental roles in catabolic, as well as anabolic reactions. Alterations in mitochondrial... 
citric acid cycle | cells | stable isotope tracer analysis | mitochondria | muscle | rotenone | cancer | Neu/ErbB2 | antimycin | GC/MS
Journal Article