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Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 11040 - 11040
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 30, pp. E6231 - E6239
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 256 - 263
The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYTOSINE-ARABINOSIDE | CELLS | ARA-C SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | CELL BIOLOGY | IN-VITRO | DNA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MUTATIONS | EXPRESSION | Cytarabine - pharmacology | Prognosis | Apoptosis - drug effects | Cytarabine - therapeutic use | Humans | Leukemia, Myeloid, Acute - metabolism | SAM Domain and HD Domain-Containing Protein 1 | Child, Preschool | Infant | Male | Viral Regulatory and Accessory Proteins - pharmacology | Molecular Targeted Therapy | Monomeric GTP-Binding Proteins - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Child | Disease Models, Animal | Arabinofuranosylcytosine Triphosphate - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Animals | Monomeric GTP-Binding Proteins - metabolism | Adolescent | Aged | Mice | In Vitro Techniques | Cellular proteins | Molecular targeted therapy | Care and treatment | Cytarabine | Patient outcomes | Drug interactions | Innovations | Development and progression | Genetic aspects | Blood diseases | Health aspects | Biomarkers | Cytotoxicity | Chemotherapy | Gene expression | Leukemia | Index Medicus | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Hematology | Hematologi | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 250 - 14
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been... 
THERMAL SHIFT ASSAY | POLY(ADP-RIBOSE) | PROTEIN | STRUCTURE REFINEMENT | STABILITY | ENZYMES | MULTIDISCIPLINARY SCIENCES | NUDIX HYDROLASES | CHEMICAL PROBES | ENGAGEMENT | MECHANISMS | Cell Proliferation - genetics | Progestins - metabolism | Enzyme Inhibitors - metabolism | Humans | Adenosine Diphosphate Ribose - metabolism | Enzyme Inhibitors - pharmacology | Pyrophosphatases - genetics | Substrate Specificity | Breast Neoplasms - metabolism | Pyrophosphatases - antagonists & inhibitors | Pyrophosphatases - metabolism | Breast Neoplasms - genetics | Cell Nucleus - metabolism | RNA Interference | Signal Transduction - drug effects | Breast Neoplasms - pathology | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Cell Line, Tumor | HL-60 Cells | Female | Cell Proliferation - drug effects | Molecular Structure | Cell Nucleus - drug effects | Cell proliferation | Chromatin | Gene regulation | Sanitation | Breast cancer | Metabolism | Gene expression | ADP | Substrates | Guanine | Chromatin remodeling | Signaling | Inhibitors | Ribose | Progestin | Breast | Adenosine triphosphate | Cancer | Index Medicus | Biological Sciences | Medical Biotechnology | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinsk bioteknologi | Natural Sciences | Cellbiologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Cell Biology
Journal Article
Biochemistry, ISSN 0006-2960, 12/2018, Volume 57, Issue 48, pp. 6715 - 6725
Evidence of physical interaction with the target protein is essential in the development of chemical probes and drugs. The cellular thermal shift assay (CETSA)... 
ISOTHERMAL DENATURATION | AFFINITY | TARGET ENGAGEMENT | MAP KINASE | STABILIZATION | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITORS | PROTEINS | TECHNOLOGY | DISCOVERY | Biological Sciences | Biochemistry and Molecular Biology | Naturvetenskap | Natural Sciences | Biokemi och molekylärbiologi | Biologiska vetenskaper
Journal Article
Journal of Visualized Experiments, ISSN 1940-087X, 11/2018, Volume 2018, Issue 141
Quantitating the interaction of small molecules with their intended protein target is critical for drug development, target validation and chemical probe... 
Cellular thermal shift assay (CETSA) | Single cell resolution | Imaging | High-throughput screening | Target engagement | P38α | Biochemistry | Issue 141 | DRUG | THERMAL SHIFT ASSAY | MULTIDISCIPLINARY SCIENCES | high-throughput screening | target engagement | imaging | p38 alpha | single cell resolution | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0121494 - e0121494
In Mycobacterium tuberculosis the sulfate activating complex provides a key branching point in sulfate assimilation. The complex consists of two polypeptide... 
STATIONARY-PHASE | MACROMOLECULAR STRUCTURES | HUMAN PAPS SYNTHETASE-1 | SULFOTRANSFERASES | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ADENOSINE 5'-PHOSPHOSULFATE KINASE | APS-KINASE | ATP-SULFURYLASE | PENICILLIUM-CHRYSOGENUM | SOFTWARE | Phosphoadenosine Phosphosulfate - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Catalytic Domain | Sulfates - metabolism | Peptides - chemistry | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Molecular Sequence Data | Sulfate Adenylyltransferase - chemistry | Sulfate Adenylyltransferase - metabolism | Nucleotides - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Adenosine Phosphosulfate - metabolism | Sequence Alignment | Peptides - metabolism | Adenosine Triphosphate - metabolism | Mycobacterium tuberculosis - chemistry | Mycobacterium tuberculosis - metabolism | Enzymes | Cysteine | Tuberculosis | Analysis | Crystals | Structure | Sulfates | Assimilation | Laboratories | Chains | Homology | Biochemistry | Biosynthesis | Kinases | ADP | Consortia | Metabolites | Catalysis | Sulfur | Adenosine triphosphate | Crystal structure | Adenosine | Polypeptides | AMP | Feasibility studies | ATP sulfurylase | Biophysics | Metabolism | Substrates | Chemotherapy | Acids | Mutagenesis | Ligands | Sulfate | ATP | Binding sites | Guanosinetriphosphatase | Index Medicus
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9847, pp. 1059 - 1065
Journal Article