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Nature chemical biology, ISSN 1552-4450, 08/2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper. 
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 206, pp. 206ra138 - 206ra138
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2012, Volume 55, Issue 16, pp. 7193 - 7207
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 08/2019, Volume 15, Issue 8, pp. 764 - 775
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2011, Volume 433, Issue 2, pp. 357 - 369
PDK1 (3-phosphoinositide-dependent protein kinase I) activates a group of protein kinases belonging to the AGC [PKA (protein kinase A)/PKG (protein kinase... 
p70 ribosomal S6 kinase (S6K) | Akt/Akt1 | 3-phosphoinositide-dependent protein kinase | Phosphoinositide 3-kinase (PI3K) | p90 ribosomal S6 kinase (RSK) | Kinase inhibitor | Serum- and glucocorticoid-induced protein kinase (SGK) | Cancer | PDK1 | IN-VIVO ROLE | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | UCN-01 7-HYDROXYSTAUROSPORINE | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | KNOCKIN MUTATION | CAENORHABDITIS-ELEGANS | SMALL-MOLECULE INHIBITORS | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | Akt/Akt 1 | serum- and glucocorticoid-induced protein kinase (SGK) | Cyclic AMP-Dependent Protein Kinases - metabolism | Indazoles - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Humans | Cells, Cultured | Substrate Specificity | Pyrimidines - pharmacology | Pyrimidines - chemistry | Indazoles - pharmacology | Protein Kinase Inhibitors - chemistry | Animals | Signal Transduction - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Mice | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. LB-42 - LB-42
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2013, Volume 4, Issue 10, pp. 964 - 968
We recently reported the discovery of GSK2606414 (1), a selective first in class inhibitor of protein kinase R (PKR)-like endoplasrnic reticulum kinase (PERK),... 
fluorine interaction | kinase | PERK | lead optimization | structure-activity relationship | UPR | CHEMISTRY, MEDICINAL | KINASE PERK | PANCREAS | TRANSLATIONAL CONTROL | UNFOLDED PROTEIN RESPONSE | PATHWAY | GROWTH | FLUORINE | STRESS
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 07/2018, Volume 27, Issue 14, pp. 2477 - 2489
Abstract Marinesco-Sjögren syndrome (MSS) is a rare, early onset, autosomal recessive multisystem disorder characterized by cerebellar ataxia, cataracts and... 
UNFOLDED PROTEIN RESPONSE | COCHAPERONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | NUCLEOTIDE EXCHANGE FACTOR | PHENOTYPE | MUTATIONS | MYOPATHY | STRESS | SIL1 | MANIFESTATIONS | GSK2606414
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2010, Volume 1, Issue 8, pp. 439 - 442
Fragment screening of phosphoinositide-dependent kinase-1 (PDK1) in a biochemical kinase assay afforded hits that were characterized and prioritized based on... 
fragment-based drug discovery | binding interactions | ligand efficiency | Aminoindazole PDK1 inhibitors | LIBRARIES | DESIGN | CHEMISTRY, MEDICINAL | KINASE | INDEXES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 6, pp. 1871 - 1895
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2013, Volume 72, Issue 1, pp. 251 - 262
Inhibition of glucose metabolism has recently become an attractive target for cancer treatment. Accordingly, since 2-deoxyglucose (2-DG) competes effectively... 
2-Deoxyglucose | GCN2 | Medicine & Public Health | Oncology | Cancer Research | PERK | Pharmacology/Toxicology | Endoplasmic reticulum stress | Unfolded protein response | OXIDATIVE STRESS | GLUCOSE ANALOGS | PHOSPHORYLATION | 2-DEOXY-D-GLUCOSE | GLYCOSYLATION | CHEMOTHERAPY | GLYCOLYSIS | RADIOSENSITIZATION | ONCOLOGY | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Neoplasms - metabolism | eIF-2 Kinase - metabolism | Humans | Glycosylation - drug effects | Activating Transcription Factor 6 - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | Deoxyglucose - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Biomarkers - metabolism | Unfolded Protein Response - drug effects | Membrane Proteins - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | eIF-2 Kinase - antagonists & inhibitors | Neoplasms - drug therapy | Activating Transcription Factor 6 - metabolism | Animals | Cell Line, Tumor | Activating Transcription Factor 6 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Proteins | Glucose metabolism | Growth | Energy conservation | Cell death | Physiological aspects | Biochemistry | Glucose | Cells | Dextrose | Glutamine | Tumors | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 24, pp. 7489 - 7495
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/1998, Volume 120, Issue 25, pp. 6425 - 6426
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 15, pp. 1937 - 1938
A new and efficient 1,2-carbonyl transposition procedure for the formation of 2-keto pleuromutilin compounds is described. The synthetic sequence is performed... 
CHEMISTRY | CHEMISTRY, ORGANIC | TRICYCLIC SKELETON
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2011, Volume 52, Issue 26, pp. 3376 - 3378
Synthetic approaches are described for the synthesis of 4-alkoxyindole-7-carboxamides and 4-alkoxy-3-cyanoindole-7-carboxamides, which are useful intermediates... 
ACTIVATED INDOLES | REAGENTS | HETEROCYCLES | CONVERSION | NITRILES | CHEMISTRY, ORGANIC | C-7 | CYCLIZATION | ETHYL | Isocyanates | Tetrahedrons | Strategy | Synthesis (chemistry) | Indoles
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2012, Volume 22, Issue 12, pp. 4028 - 4032
Journal Article