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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 207 - 214
Pomaglumetad methionil (LY2140023) is the prodrug of a novel metabotropic glutamate 2/3 receptor agonist (LY404039) being investigated for the treatment of... 
pharmacokinetics | prodrug activation | bioavailability | ADME | accelerator mass spectrometry | Accelerator mass spectrometry | Prodrug activation | Bioavailability | Pharmacokinetics | POTENT | CHEMISTRY, MEDICINAL | VARIANTS | PHARMACOLOGY & PHARMACY | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | Prodrugs - administration & dosage | Activation, Metabolic | Cyclic S-Oxides - administration & dosage | Intestinal Mucosa - metabolism | Prodrugs - analysis | Antipsychotic Agents - adverse effects | Humans | Middle Aged | Biological Availability | Male | Receptors, Metabotropic Glutamate - metabolism | Amino Acids - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Bridged Bicyclo Compounds, Heterocyclic - adverse effects | Intestinal Mucosa - enzymology | Amino Acids - pharmacokinetics | Adult | Peptide Hydrolases - metabolism | Administration, Oral | Bridged Bicyclo Compounds, Heterocyclic - analysis | Cyclic S-Oxides - pharmacokinetics | Amino Acids - analysis | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Antipsychotic Agents - pharmacokinetics | Amino Acids - adverse effects | Antipsychotic Agents - administration & dosage | Cross-Over Studies | Prodrugs - adverse effects | Feces - chemistry | Antipsychotic Agents - analysis | Prodrugs - pharmacokinetics | Models, Biological | Infusions, Intravenous | Receptors, Metabotropic Glutamate - agonists | Cyclic S-Oxides - adverse effects | Cyclic S-Oxides - analysis | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Carbon Radioisotopes | Glutamate | Proteases | Index Medicus
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2019, Volume 68, Issue 1, pp. 137 - 144
LY2599666 is a humanized, affinity-optimized monoclonal antibody antigen-binding fragment linked to a PEG molecule and targets soluble amyloid-beta(A beta)... 
Aβ monomer | pharmacokinetic/pharmacodynamic | Alzheimer's disease | target-mediated drug disposition | PLASMA | ALZHEIMERS-DISEASE | CSF | MODEL | A beta monomer | NEUROSCIENCES | DISPOSITION | Binding | Dosing | Antigens | Pharmacodynamics | Pharmacology | Cerebrospinal fluid | Monomers | Blood-brain barrier | Predictions | Monoclonal antibodies | Amyloid | Mathematical models | Pharmacokinetics | Movement disorders
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2019
Lanabecestat is a human β-site amyloid precursor protein-cleaving enzyme 1 inhibitor in development to slow disease progression in patients with early... 
Index Medicus
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P282 - P282
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 03/2003, Volume 73, Issue 3, pp. 170 - 177
Journal Article
NeuroImage, ISSN 1053-8119, 02/2012, Volume 59, Issue 3, pp. 2362 - 2373
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 6/2012, Volume 52, Issue 6, pp. 904 - 913
Journal Article
Journal Article
NeuroImage, ISSN 1053-8119, 02/2012, Volume 59, Issue 3, pp. 2217 - 2230
Journal Article