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1. Full Text Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization
by Roe, Matthew T and Armstrong, Paul W and Fox, Keith A.A and White, Harvey D and Prabhakaran, Dorairaj and Goodman, Shaun G and Cornel, Jan H and Bhatt, Deepak L and Clemmensen, Peter and Martinez, Felipe and Ardissino, Diego and Nicolau, Jose C and Boden, William E and Gurbel, Paul A and Ruzyllo, Witold and Dalby, Anthony J and McGuire, Darren K and Leiva-Pons, Jose L and Parkhomenko, Alexander and Gottlieb, Shmuel and Topacio, Gracita O and Hamm, Christian and Pavlides, Gregory and Goudev, Assen R and Oto, Ali and Tseng, Chuen-Den and Merkely, Bela and Gasparovic, Vladimir and Corbalan, Ramon and Cinteză, Mircea and McLendon, R. Craig and Winters, Kenneth J and Brown, Eileen B and Lokhnygina, Yuliya and Aylward, Philip E and Huber, Kurt and Hochman, Judith S and Ohman, E. Magnus and TRILOGY ACS Investigators
The New England Journal of Medicine, ISSN 0028-4793, 10/2012, Volume 367, Issue 14, pp. 1297 - 1309
This trial compared the efficacy of antiplatelet therapy with prasugrel or clopidogrel in patients with non–ST-segment elevation MI or unstable angina.... 
MEDICINE, GENERAL & INTERNAL | OUTCOMES | MYOCARDIAL-INFARCTION | MEDICAL-MANAGEMENT | PREDICTORS | STRATEGY | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Myocardial Infarction - epidemiology | Follow-Up Studies | Thiophenes - adverse effects | Ticlopidine - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Angina, Unstable - drug therapy | Ticlopidine - adverse effects | Cardiovascular Diseases - mortality | Female | Stroke - epidemiology | Aspirin - therapeutic use | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Double-Blind Method | Kaplan-Meier Estimate | Purinergic P2 Receptor Antagonists - therapeutic use | Piperazines - therapeutic use | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Purinergic P2 Receptor Antagonists - adverse effects | Acute Coronary Syndrome - drug therapy | Myocardial Infarction - drug therapy | Aged | Myocardial infarction | Cerebral infarction | Aspirin | Heart attacks | Medical imaging | Angina | Angina pectoris | Patients | Bleeding | Ischemia | Patient safety | Clopidogrel | Acute coronary syndromes | Heart diseases | Age
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2. Full Text Bivalirudin for Patients with Acute Coronary Syndromes
by Stone, Gregg W and McLaurin, Brent T and Cox, David A and Bertrand, Michel E and Lincoff, A. Michael and Moses, Jeffrey W and White, Harvey D and Pocock, Stuart J and Ware, James H and Feit, Frederick and Colombo, Antonio and Aylward, Philip E and Cequier, Angel R and Darius, Harald and Desmet, Walter and Ebrahimi, Ramin and Hamon, Martial and Rasmussen, Lars H and Rupprecht, Hans-Jürgen and Hoekstra, James and Mehran, Roxana and Ohman, E. Magnus and ACUITY Investigators
The New England Journal of Medicine, ISSN 0028-4793, 11/2006, Volume 355, Issue 21, pp. 2203 - 2216
In this trial, patients with acute coronary syndromes undergoing an early invasive approach were randomly assigned to treatment with heparin or enoxaparin plus... 
MEDICINE, GENERAL & INTERNAL | INHIBITION | MYOCARDIAL-INFARCTION | REPLACE-2 RANDOMIZED-TRIAL | STRATEGY | PLATELET GLYCOPROTEIN-IIB/IIIA | UNSTABLE ANGINA | ST-SEGMENT ELEVATION | BLOCKADE | INTERVENTION | UNFRACTIONATED HEPARIN | Recombinant Proteins - therapeutic use | Humans | Middle Aged | Heparin - therapeutic use | Male | Enoxaparin - therapeutic use | Recombinant Proteins - adverse effects | Angioplasty, Balloon, Coronary | Angina, Unstable - drug therapy | Aged, 80 and over | Adult | Female | Drug Therapy, Combination | Myocardial Ischemia - epidemiology | Kaplan-Meier Estimate | Anticoagulants - therapeutic use | Anticoagulants - adverse effects | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Hirudins - adverse effects | Angina, Unstable - therapy | Coronary Artery Bypass | Aged | Peptide Fragments - adverse effects | Peptide Fragments - therapeutic use | Hemorrhage - chemically induced | Aggregation | Evaluation | Blood platelets | Drug therapy | Coronary heart disease | Heart attacks | Medical imaging | Mortality | Informed consent | Clinical medicine | Angina pectoris | Acute coronary syndromes | Health education | Patients | Bypass cardiopulmonar | Bypass cardiopulmonary | Malalties coronàries | Anticoagulants (Medicine) | Heparin | Heparina | Anticoagulants (Medicina) | Coronary diseases
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3. Full Text Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
by Tricoci, Pierluigi and Huang, Zhen and Held, Claes and Moliterno, David J and Armstrong, Paul W and Van de Werf, Frans and White, Harvey D and Aylward, Philip E and Wallentin, Lars and Chen, Edmond and Lokhnygina, Yuliya and Pei, Jinglan and Leonardi, Sergio and Rorick, Tyrus L and Kilian, Ann M and Jennings, Lisa H.K and Ambrosio, Giuseppe and Bode, Christoph and Cequier, Angel and Cornel, Jan H and Diaz, Rafael and Erkan, Aycan and Huber, Kurt and Hudson, Michael P and Jiang, Lixin and Jukema, J. Wouter and Lewis, Basil S and Lincoff, A. Michael and Montalescot, Gilles and Nicolau, José Carlos and Ogawa, Hisao and Pfisterer, Matthias and Prieto, Juan Carlos and Ruzyllo, Witold and Sinnaeve, Peter R and Storey, Robert F and Valgimigli, Marco and Whellan, David J and Widimsky, Petr and Strony, John and Harrington, Robert A and Mahaffey, Kenneth W and TRACER Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Uppsala kliniska forskningscentrum (UCR)
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 1, pp. 20 - 33
In this trial, vorapaxar, a protease-activated–receptor 1 antagonist that inhibits thrombin-induced platelet activation, was not effective in reducing the... 
MEDICINE, GENERAL & INTERNAL | PLACEBO | GLYCOPROTEIN IIB/IIIA INHIBITORS | CLOPIDOGREL | TASK-FORCE | SAFETY | DOUBLE-BLIND | ANTIPLATELET THERAPY | Follow-Up Studies | Angioplasty | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Combined Modality Therapy | Lactones - adverse effects | Lactones - therapeutic use | Acute Coronary Syndrome - drug therapy | Intracranial Hemorrhages - chemically induced | Coronary Artery Bypass | Acute Coronary Syndrome - therapy | Aged | Hemorrhage - chemically induced | Antagonists (Biochemistry) | Drugs | Dose-response relationship (Biochemistry) | Dosage and administration | Product/Service Evaluations | Drug therapy | Coronary heart disease | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Cardiovascular disease | Hemorrhage | Bleeding | Investigations | Manuscripts | Ischemia | Blood platelets | Acute coronary syndromes | Research centers | Malalties cardiovasculars | Bypass cardiopulmonar | Medicaments | Bypass cardiopulmonary | Plaquetes sanguínies | Cardiovascular diseases | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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4. Full Text National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016
by Chew, Derek P., MBBS MPH FRACP and Scott, Ian A., MBBS FRACP MHA and Cullen, Louise, MBBS FACEM PhD and French, John K., BMedSC MBChb PhD and Briffa, Tom G., PhD and Tideman, Philip A., MBBS FRACP FCSANZ and Woodruffe, Stephen, BAppSci (HMS) and Kerr, Alistair and Branagan, Maree, MPH and Aylward, Philip E.G., BM BCh PhD FRACP and NHFA CSANZ ACS Guideline Executive and NHFA/CSANZ ACS Guideline 2016 Executive Working Group
Heart, Lung and Circulation, ISSN 1443-9506, 2016, Volume 25, Issue 9, pp. 895 - 951
(f) Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, Brisbane, Qld, Australia; School of Medicine, University of Queensland, Brisbane,... 
Cardiovascular | HIGH-SENSITIVITY-TROPONIN | CARDIAC & CARDIOVASCULAR SYSTEMS | CHEST-PAIN PATIENTS | ACCELERATED DIAGNOSTIC PROTOCOL | LEFT-VENTRICULAR DYSFUNCTION | DUAL ANTIPLATELET THERAPY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SELECTIVE INVASIVE STRATEGY | ACUTE MYOCARDIAL-INFARCTION | EMERGENCY-DEPARTMENT PATIENTS | TIMI RISK SCORE | New Zealand | Societies, Medical | Humans | Acute Coronary Syndrome - diagnosis | Acute Coronary Syndrome - physiopathology | Acute Coronary Syndrome - therapy | Female | Male | Thoracic Surgery | Australia | Practice Guidelines as Topic | Heart failure | Medical colleges | Care and treatment | Emergency medicine | Practice guidelines (Medicine) | Cardiology | Coronary heart disease | Epidemiology | Trade and professional associations | Cardiovascular agents
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5. Full Text Atherothrombotic Risk Stratification and the Efficacy and Safety of Vorapaxar in Patients With Stable Ischemic Heart Disease and Previous Myocardial Infarction
by Bohula, Erin A and Bonaca, Marc P and Braunwald, Eugene and Aylward, Philip E and Corbalan, Ramon and De Ferrari, Gaetano M and He, Ping and Lewis, Basil S and Merlini, Piera A and Murphy, Sabina A and Sabatine, Marc S and Scirica, Benjamin M and Morrow, David A
Circulation, ISSN 0009-7322, 07/2016, Volume 134, Issue 4, pp. 304 - 313
BACKGROUND:Patients with stable ischemic heart disease and previous myocardial infarction (MI) vary in their risk for recurrent cardiovascular events.... 
atherosclerosis | receptors, thrombin | risk assessment | secondary prevention | CARDIAC & CARDIOVASCULAR SYSTEMS | PRACTICE GUIDELINES | MANAGEMENT | EVENTS | SCORE | AMERICAN-COLLEGE | ASSOCIATION TASK-FORCE | PERIPHERAL VASCULAR DISEASE | 50 TRIAL | Recurrence | Humans | Middle Aged | Male | Secondary Prevention | Atherosclerosis - epidemiology | Pyridines - adverse effects | Female | Platelet Aggregation Inhibitors - therapeutic use | Myocardial Infarction - etiology | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Risk Assessment | Kaplan-Meier Estimate | Proportional Hazards Models | Atherosclerosis - complications | Treatment Outcome | Lactones - adverse effects | Myocardial Ischemia - drug therapy | Lactones - therapeutic use | Myocardial Ischemia - etiology | Aged | Myocardial Infarction - prevention & control | Hemorrhage - chemically induced | Clinical trials | Myocardial ischemia | Usage | Care and treatment | Risk factors | Atherosclerosis
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