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chemistry, medicinal (16) 16
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analysis (8) 8
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molecular docking (8) 8
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phthalazine (3) 3
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Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2018, Volume 18, Issue 8, pp. 1184 - 1196
Background: Extensive studies were reported in the synthesis of several phthalazine derivatives as promising anticancer agents as potent VEGFR-2 inhibitors.... 
VEGFR-2 inhibitors | anilinophthalazine derivatives | molecular docking | Triazolo[3,4-a] phthalazine | anticancer agents | vatalanib | CHEMISTRY, MEDICINAL | ASSAY | RECEPTOR-I | ANTITUMOR-ACTIVITY | DISCOVERY | ARYLPHTHALAZINES | PHASE-II TRIAL | POTENT | ONCOLOGY | GROWTH | INHIBITORS
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 05/2019, Volume 352, Issue 5, pp. e1800387 - n/a
A new series of 2‐substituted‐2,3‐dihydrophthalazine‐1,4‐diones ( 2 ‒ 9 ) were designed and synthesized to evaluate their anticonvulsant activity. The... 
phthalazine | molecular docking | anticonvulsant agents | GABA‐A agonists | GABA-A agonists | CHEMISTRY, MEDICINAL | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | INHIBITORS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | GABA | Anticonvulsants | Seizures (Medicine) | Analysis | Neurotoxicity
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2016, Volume 113, pp. 50 - 62
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 12/2017, Volume 350, Issue 12, pp. 1700240 - n/a
Novel series of phthalazine derivatives were designed, synthesized, and evaluated for their anticancer activity against HCT‐116 human colon adenocarcinoma and... 
Triazolo[3,4‐a]phthalazine | VEGFR‐2 inhibitors | Anticancer agents | Molecular docking | VEGFR-2 inhibitors | Triazolo[3,4-a]phthalazine | CHEMISTRY, MEDICINAL | ASSAY | AMG 900 | KINASE INHIBITORS | ANTITUMOR-ACTIVITY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | ARYLPHTHALAZINES | POTENT | PHARMACOLOGY & PHARMACY | ANTI-ANGIOGENIC THERAPY | RECEPTOR-II | ENDOTHELIAL GROWTH-FACTOR | Phthalazines - chemical synthesis | Protein Kinase Inhibitors - chemical synthesis | Adenocarcinoma - pathology | Antineoplastic Agents - chemical synthesis | Colonic Neoplasms - drug therapy | HCT116 Cells | Humans | Structure-Activity Relationship | Phthalazines - chemistry | Antineoplastic Agents - chemistry | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Phthalazines - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | MCF-7 Cells | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Drug Design | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Antimitotic agents | Care and treatment | Colon cancer | Analysis | Resveratrol | Antineoplastic agents | Vascular endothelial growth factor | Cancer | Breast cancer | Colon | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2016, Volume 115, pp. 121 - 131
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 11/2017, Volume 26, Issue 11, pp. 2967 - 2984
Journal Article
Journal of Molecular Structure, ISSN 0022-2860, 02/2017, Volume 1130, pp. 333 - 351
In view of their expected anticonvulsant activity, some novel derivatives of 2,3-dihydrophthalazine-1,4-dione – were designed, synthesized and evaluated using... 
Anticonvulsant | 2,3-Dihydrophthalazine-1,4-dione | Molecular modeling | GABA-A | IN-SILICO PHARMACOLOGY | DIAZEPAM | DRUG DISCOVERY | CHEMISTRY, PHYSICAL | BINDING-SITE | Drugstores | Anticonvulsants | Models | Seizures (Medicine) | Analysis | Pharmacy
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2016, Volume 31, Issue 1, pp. 78 - 89
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 07/2015, pp. 1 - 15
Journal Article
Bulletin of Faculty of Pharmacy, Cairo University, ISSN 1110-0931, 06/2013, Volume 51, Issue 1, pp. 101 - 111
A new series of 2-(3-methyl-2-oxoquinoxalin-1(2 )-yl)- -(4-substitutedphenyl)acetamides ( – ) were designed and synthesized in order to evaluate their... 
Quinoxaline | Anticonvulsant agent | Acetamide | 2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)acetamide
Journal Article