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science & technology (45) 45
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1. Full Text Anti‐Tumorigenic Potential of a Novel Orlistat‐AICAR Combination in Prostate Cancer Cells
by Wright, Clayton and Iyer, Anand Krishnan V and Kaushik, Vivek and Azad, Neelam
Journal of cellular biochemistry, ISSN 0730-2312, 11/2017, Volume 118, Issue 11, pp. 3834 - 3845
PROSTATE CANCER (PCa) | AMPK | AICAR | ORLISTAT | FATTY ACID SYNTHASE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Ribonucleotides - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Lactones - pharmacology | Cell Movement - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Cell Line, Tumor | Resting Phase, Cell Cycle - drug effects | Aminoimidazole Carboxamide - metabolism | G1 Phase Cell Cycle Checkpoints - drug effects | Prostatic Neoplasms - drug therapy | Proteins | Synthesis | Orlistat | Hypoglycemic agents | Fatty acids | Prostate cancer | Vascular endothelial growth factor | Protein binding | AMP | Pharmacology | Kinases | AMP-activated protein kinase | Cancer therapies | Fatty-acid synthase | Anticancer properties | Cell activation | Cell cycle | Sterol regulatory element-binding protein | Prostate | Regulatory proteins | Cancer | Apoptosis | Index Medicus | Fatty Acid Synthase | Prostate cancer (PCa)
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2. Full Text S‐Nitrosylation of Bcl‐2 Negatively Affects Autophagy in Lung Epithelial Cells
by Wright, Clayton and Iyer, Anand Krishnan V and Kulkarni, Yogesh and Azad, Neelam
Journal of cellular biochemistry, ISSN 0730-2312, 02/2016, Volume 117, Issue 2, pp. 521 - 532
BCL‐2 | AUTOPHAGY | NITRIC OXIDE | S‐NITROSYLATION | BECLIN‐1 | BCL-2 | S-NITROSYLATION | BECLIN-1 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Cysteine - analogs & derivatives | Proto-Oncogene Proteins c-bcl-2 - metabolism | Humans | Alveolar Epithelial Cells - metabolism | Cysteine - metabolism | Protein Processing, Post-Translational | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide - metabolism | S-Nitrosothiols - metabolism | Autophagy | Proteins | Cysteine | Nitric oxide | Index Medicus
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3. Full Text Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
by Tia, Neelam and Singh, Alok Kumar and Pandey, Poorti and Azad, Chandra Shekhar and Chaudhary, Pritee and Gambhir, Indrajeet Singh
Gene, ISSN 0378-1119, 03/2018, Volume 648, pp. 97 - 105
Aging | FOXO | Age related disease | Akt | Forkhead box | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Disease - genetics | Humans | Gene Expression Regulation | Signal Transduction - genetics | Cell Physiological Phenomena - genetics | Longevity - genetics | Forkhead Transcription Factors - genetics | Animals | Protein Isoforms - metabolism | Aging - genetics | Forkhead Transcription Factors - metabolism | Aging - metabolism | Protein Isoforms - genetics | Index Medicus
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4. Full Text Anti‐Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres
by Kaushik, Vivek and Yakisich, Juan Sebastian and Azad, Neelam and Kulkarni, Yogesh and Venkatadri, Rajkumar and Wright, Clayton and Rojanasakul, Yon and Iyer, Anand Krishnan V
Journal of cellular physiology, ISSN 0021-9541, 09/2017, Volume 232, Issue 9, pp. 2497 - 2507
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - genetics | Cell Survival - drug effects | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Neoplasm Invasiveness | Humans | Lung Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Cell Movement - drug effects | Strophanthins - pharmacology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Spheroids, Cellular | Cardenolides - pharmacology | Cardiotonic agents | Lung cancer | Analysis | Cancer cells | Development and progression | Respiratory agents | Tumor proteins | Cardiac glycosides | Tumors | Drugs | Cell survival | Leukocyte migration | p53 Protein | Floating | Anticancer properties | Proteins | Pathways | Cell cycle | Glycosides | Biomarkers | Tumor suppressor genes | Heart diseases | Viability | Cell migration | Phagocytosis | Cancer | G1 phase | Apoptosis | Index Medicus
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5. Full Text Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres
by Yakisich, Juan Sebastian and Azad, Neelam and Kaushik, Vivek and Iyer, Anand Krishnan V
Journal of cellular physiology, ISSN 0021-9541, 09/2017, Volume 232, Issue 9, pp. 2280 - 2286
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Cell Plasticity - drug effects | Cell Proliferation | Drug Resistance, Multiple | Neoplastic Stem Cells - drug effects | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Culture Media, Serum-Free - metabolism | Dose-Response Relationship, Drug | MCF-7 Cells | Neoplastic Stem Cells - metabolism | Time Factors | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Spheroids, Cellular | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Down-Regulation | Breast Neoplasms - drug therapy | Cell Adhesion | Phenotype | Signal Transduction - drug effects | Breast Neoplasms - pathology | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Proteins | Drug resistance in microorganisms | Breast cancer | Analysis | Cell culture | Computer simulation | Lung cancer | Chemoresistance | Media | Stimulation | Environmental factors | Drug resistance | Environmental conditions | Culture media | Plastic properties | Cancer | Index Medicus | plasticity | chemoresistance | cancer | stemness | tumorspheres
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6. Full Text Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation
by Yakisich, Juan Sebastian and Venkatadri, Rajkumar and Azad, Neelam and Iyer, Anand Krishnan V
Journal of cellular physiology, ISSN 0021-9541, 08/2017, Volume 232, Issue 8, pp. 2033 - 2043
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Paclitaxel - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - metabolism | Digitoxin - pharmacology | Lung Neoplasms - pathology | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Culture Media, Serum-Free - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | MCF-7 Cells | Time Factors | Female | Antineoplastic Agents - pharmacology | Cell Culture Techniques | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | Drug Resistance, Multiple - genetics | Breast Neoplasms - drug therapy | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Energy Metabolism | Signal Transduction - drug effects | Breast Neoplasms - pathology | Models, Biological | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | ATP Binding Cassette Transporter, Sub-Family B - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Index Medicus
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7. Full Text Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening
by Kaushik, Vivek and Yakisich, Juan S and Way, Lillian Frances and Azad, Neelam and Iyer, Anand K. V
Journal of cellular physiology, ISSN 0021-9541, 04/2019, Volume 234, Issue 4, pp. 4445 - 4453
two‐dimensional (2D) culture | chemoresistance | three‐dimensional (3D) culture | spheroids | drug screening | three-dimensional (3D) culture | two-dimensional (2D) culture | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Cell Survival - drug effects | Colchicine - pharmacology | Hydroxyurea - pharmacology | PC-3 Cells | Cadherins - metabolism | Humans | Culture Media, Serum-Free | Drug Resistance, Neoplasm | Male | Cell Adhesion - drug effects | Antigens, CD - metabolism | Neoplasms - drug therapy | Antibodies - pharmacology | Phenotype | Pyrroles - pharmacology | MCF-7 Cells | Female | Antineoplastic Agents - pharmacology | Cadherins - antagonists & inhibitors | Cell Culture Techniques | Neoplasms - pathology | Spheroids, Cellular | Cell culture | Biotechnology | Tumor cells | Lung cancer | Chemoresistance | Hydroxyurea | Tumor cell lines | Drug screening | Floating structures | E-cadherin | Spheroids | Colchicine | Prostate | Cancer | Tumors | Index Medicus
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8. Full Text Autophagy‐Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog
by Kulkarni, Yogesh M and Kaushik, Vivek and Azad, Neelam and Wright, Clayton and Rojanasakul, Yon and O'Doherty, George and Iyer, Anand Krishnan V
Journal of cellular physiology, ISSN 0021-9541, 04/2016, Volume 231, Issue 4, pp. 817 - 828
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Biomarkers - metabolism | Cell Survival - drug effects | Digoxigenin - analogs & derivatives | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Digitoxin - pharmacology | Lung Neoplasms - pathology | Vacuoles - drug effects | Autophagy - drug effects | Digoxigenin - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Digitoxin - analogs & derivatives | Models, Biological | Superoxides - metabolism | Cell Line, Tumor | Vacuoles - metabolism | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proteins | Superoxide | Lung cancer | Cancer cells | Apoptosis | Index Medicus
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9. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
by Moungjaroen, Jirapan and Nimmannit, Ubonthip and Callery, Patrick S and Wang, Liying and Azad, Neelam and Lipipun, Vimolmas and Chanvorachote, Pithi and Rojanasakul, Yon
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1062 - 1069
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Lung Neoplasms - drug therapy | Oxidants - pharmacology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Caspases - metabolism | Transfection | Superoxide Dismutase - physiology | Genes, bcl-2 - physiology | Plasmids - genetics | Thioctic Acid - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Down-Regulation - drug effects | Enzyme Activation - drug effects | Blotting, Western | Glutathione Peroxidase - genetics | Hydrogen Peroxide - metabolism | Glutathione Peroxidase - physiology | Cell Line, Tumor | Genes, bcl-2 - drug effects | Superoxide Dismutase-1 | Enzyme Activation - physiology | Index Medicus
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10. Full Text Nitrosothiol signaling and protein nitrosation in cell death
by Iyer, Anand Krishnan V and Rojanasakul, Yon and Azad, Neelam
Nitric oxide, ISSN 1089-8603, 11/2014, Volume 42, pp. 9 - 18
Nitrosation | Cell death | Survival | S-nitrosylation | Apoptosis | Cancer | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sulfhydryl Compounds - metabolism | Nitroso Compounds - metabolism | Proteins - metabolism | Signal Transduction | Cell Death | Proteins | Cysteine | Biochemistry | Nitric oxide | Index Medicus
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