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1.
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Anti‐Tumorigenic Potential of a Novel Orlistat‐AICAR Combination in Prostate Cancer Cells
Journal of cellular biochemistry, ISSN 0730-2312, 11/2017, Volume 118, Issue 11, pp. 3834 - 3845
PROSTATE CANCER (PCa) | AMPK | AICAR | ORLISTAT | FATTY ACID SYNTHASE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Ribonucleotides - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Lactones - pharmacology | Cell Movement - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Cell Line, Tumor | Resting Phase, Cell Cycle - drug effects | Aminoimidazole Carboxamide - metabolism | G1 Phase Cell Cycle Checkpoints - drug effects | Prostatic Neoplasms - drug therapy | Proteins | Synthesis | Orlistat | Hypoglycemic agents | Fatty acids | Prostate cancer | Vascular endothelial growth factor | Protein binding | AMP | Pharmacology | Kinases | AMP-activated protein kinase | Cancer therapies | Fatty-acid synthase | Anticancer properties | Cell activation | Cell cycle | Sterol regulatory element-binding protein | Prostate | Regulatory proteins | Cancer | Apoptosis | Index Medicus | Fatty Acid Synthase | Prostate cancer (PCa)
Journal Article
Journal of cellular biochemistry, ISSN 0730-2312, 02/2016, Volume 117, Issue 2, pp. 521 - 532
BCL‐2 | AUTOPHAGY | NITRIC OXIDE | S‐NITROSYLATION | BECLIN‐1 | BCL-2 | S-NITROSYLATION | BECLIN-1 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Cysteine - analogs & derivatives | Proto-Oncogene Proteins c-bcl-2 - metabolism | Humans | Alveolar Epithelial Cells - metabolism | Cysteine - metabolism | Protein Processing, Post-Translational | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide - metabolism | S-Nitrosothiols - metabolism | Autophagy | Proteins | Cysteine | Nitric oxide | Index Medicus
Journal Article
Gene, ISSN 0378-1119, 03/2018, Volume 648, pp. 97 - 105
Aging | FOXO | Age related disease | Akt | Forkhead box | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Disease - genetics | Humans | Gene Expression Regulation | Signal Transduction - genetics | Cell Physiological Phenomena - genetics | Longevity - genetics | Forkhead Transcription Factors - genetics | Animals | Protein Isoforms - metabolism | Aging - genetics | Forkhead Transcription Factors - metabolism | Aging - metabolism | Protein Isoforms - genetics | Index Medicus
Journal Article
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Full Text
Anti‐Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres
Journal of cellular physiology, ISSN 0021-9541, 09/2017, Volume 232, Issue 9, pp. 2497 - 2507
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - genetics | Cell Survival - drug effects | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Neoplasm Invasiveness | Humans | Lung Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Cell Movement - drug effects | Strophanthins - pharmacology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Spheroids, Cellular | Cardenolides - pharmacology | Cardiotonic agents | Lung cancer | Analysis | Cancer cells | Development and progression | Respiratory agents | Tumor proteins | Cardiac glycosides | Tumors | Drugs | Cell survival | Leukocyte migration | p53 Protein | Floating | Anticancer properties | Proteins | Pathways | Cell cycle | Glycosides | Biomarkers | Tumor suppressor genes | Heart diseases | Viability | Cell migration | Phagocytosis | Cancer | G1 phase | Apoptosis | Index Medicus
Journal Article
Journal of cellular physiology, ISSN 0021-9541, 09/2017, Volume 232, Issue 9, pp. 2280 - 2286
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Cell Plasticity - drug effects | Cell Proliferation | Drug Resistance, Multiple | Neoplastic Stem Cells - drug effects | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Culture Media, Serum-Free - metabolism | Dose-Response Relationship, Drug | MCF-7 Cells | Neoplastic Stem Cells - metabolism | Time Factors | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Spheroids, Cellular | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Down-Regulation | Breast Neoplasms - drug therapy | Cell Adhesion | Phenotype | Signal Transduction - drug effects | Breast Neoplasms - pathology | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Proteins | Drug resistance in microorganisms | Breast cancer | Analysis | Cell culture | Computer simulation | Lung cancer | Chemoresistance | Media | Stimulation | Environmental factors | Drug resistance | Environmental conditions | Culture media | Plastic properties | Cancer | Index Medicus | plasticity | chemoresistance | cancer | stemness | tumorspheres
Journal Article
Journal of cellular physiology, ISSN 0021-9541, 08/2017, Volume 232, Issue 8, pp. 2033 - 2043
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Paclitaxel - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - metabolism | Digitoxin - pharmacology | Lung Neoplasms - pathology | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Culture Media, Serum-Free - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | MCF-7 Cells | Time Factors | Female | Antineoplastic Agents - pharmacology | Cell Culture Techniques | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | Drug Resistance, Multiple - genetics | Breast Neoplasms - drug therapy | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Energy Metabolism | Signal Transduction - drug effects | Breast Neoplasms - pathology | Models, Biological | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | ATP Binding Cassette Transporter, Sub-Family B - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal of cellular physiology, ISSN 0021-9541, 04/2019, Volume 234, Issue 4, pp. 4445 - 4453
two‐dimensional (2D) culture | chemoresistance | three‐dimensional (3D) culture | spheroids | drug screening | three-dimensional (3D) culture | two-dimensional (2D) culture | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Cell Survival - drug effects | Colchicine - pharmacology | Hydroxyurea - pharmacology | PC-3 Cells | Cadherins - metabolism | Humans | Culture Media, Serum-Free | Drug Resistance, Neoplasm | Male | Cell Adhesion - drug effects | Antigens, CD - metabolism | Neoplasms - drug therapy | Antibodies - pharmacology | Phenotype | Pyrroles - pharmacology | MCF-7 Cells | Female | Antineoplastic Agents - pharmacology | Cadherins - antagonists & inhibitors | Cell Culture Techniques | Neoplasms - pathology | Spheroids, Cellular | Cell culture | Biotechnology | Tumor cells | Lung cancer | Chemoresistance | Hydroxyurea | Tumor cell lines | Drug screening | Floating structures | E-cadherin | Spheroids | Colchicine | Prostate | Cancer | Tumors | Index Medicus
Journal Article
Journal of cellular physiology, ISSN 0021-9541, 04/2016, Volume 231, Issue 4, pp. 817 - 828
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Biomarkers - metabolism | Cell Survival - drug effects | Digoxigenin - analogs & derivatives | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Digitoxin - pharmacology | Lung Neoplasms - pathology | Vacuoles - drug effects | Autophagy - drug effects | Digoxigenin - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Digitoxin - analogs & derivatives | Models, Biological | Superoxides - metabolism | Cell Line, Tumor | Vacuoles - metabolism | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proteins | Superoxide | Lung cancer | Cancer cells | Apoptosis | Index Medicus
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1062 - 1069
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Lung Neoplasms - drug therapy | Oxidants - pharmacology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Caspases - metabolism | Transfection | Superoxide Dismutase - physiology | Genes, bcl-2 - physiology | Plasmids - genetics | Thioctic Acid - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Down-Regulation - drug effects | Enzyme Activation - drug effects | Blotting, Western | Glutathione Peroxidase - genetics | Hydrogen Peroxide - metabolism | Glutathione Peroxidase - physiology | Cell Line, Tumor | Genes, bcl-2 - drug effects | Superoxide Dismutase-1 | Enzyme Activation - physiology | Index Medicus
Journal Article
Nitric oxide, ISSN 1089-8603, 11/2014, Volume 42, pp. 9 - 18
Nitrosation | Cell death | Survival | S-nitrosylation | Apoptosis | Cancer | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sulfhydryl Compounds - metabolism | Nitroso Compounds - metabolism | Proteins - metabolism | Signal Transduction | Cell Death | Proteins | Cysteine | Biochemistry | Nitric oxide | Index Medicus
Journal Article