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Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10089, pp. 29 - 39
Summary Background Alectinib, a potent, highly selective, CNS-active inhibitor of anaplastic lymphoma kinase (ALK), showed promising efficacy and tolerability... 
Internal Medicine | ANAPLASTIC LYMPHOMA KINASE | MEDICINE, GENERAL & INTERNAL | SAFETY | CH5424802 | AF-001JP | ADVANCED NSCLC | INHIBITORS | CHEMOTHERAPY | Single-Blind Method | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Piperidines - blood | Brain Neoplasms - secondary | Pyridines - adverse effects | Carcinoma, Non-Small-Cell Lung - secondary | Neoplasm Grading | Antineoplastic Agents - adverse effects | Pyrazoles - blood | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Carbazoles - blood | Pyrazoles - adverse effects | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Carbazoles - adverse effects | Lung Neoplasms - enzymology | Kaplan-Meier Estimate | Receptor Protein-Tyrosine Kinases - metabolism | Protein Kinase Inhibitors - blood | Pyridines - blood | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Antineoplastic Agents - blood | Aged | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Medical colleges | Respiratory agents | Care and treatment | Lymphomas | Lung cancer, Non-small cell | Product development | Pharmaceutical industry | Analysis | Toxicity | Funding | Lung cancer | Central nervous system | Medical services | Metastasis | Kinases | Recruitment | Motivation | Audio frequencies | Safety | Toxic diseases | Drug dosages | Protein-tyrosine kinase | Effectiveness | Cut-off | Data processing | Group dynamics | Patients | Survival | Lymphoma | Chemotherapy | Inhibitors | Interactive systems | Death | Mutation | Cancer | Pharmaceuticals
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 06/2019, Volume 34, Issue Supplement_1
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 05/2016, Volume 31, Issue suppl_1, pp. i349 - i349
Journal Article
by Garassino, Marina Chiara and Cho, Byoung-Chul and Kim, Dong-Wan and Kim, Joo-Hang and Kim, Sang-We and Kim, Young-Chul and Mazières, Julien and Vansteenkiste, Johan and Lena, Hervé and Corral Jaime, Jesus and Gray, Jhanelle E and Powderly, John and Chouaid, Christos and Bidoli, Paolo and Wheatley-Price, Paul and Park, Keunchil and Soo, Ross A and Huang, Yifan and Wadsworth, Catherine and Dennis, Phillip A and Rizvi, Naiyer A and Paz-Ares Rodriguez, Luis and Novello, Silvia and Hiret, Sandrine and Schmid, Peter and Laack, Eckart and Califano, Raffaele and Maemondo, Makoto and Chaft, Jamie and Vicente Baz, David and Berghmans, Thierry and Surmont, Veerle and Reck, Martin and Han, Ji-Youn and Holgado Martin, Esther and Belda Iniesta, Cristobal and Oe, Yuichiro and Chella, Antonio and Chopra, Akhil and Robinet, Gilles and Soto Parra, Hector and Thomas, Michael and Cheema, Parneet and Katakami, Nobuyuki and Su, Wu-Chou and Wolf, Juergen and Lee, Jong-Seok and Saka, Hideo and Milella, Michele and Ramos Garcia, Inmaculada and Sibille, Anne and Yokoi, Takashi and Kang, Eun Joo and Atagi, Shinji and Spaeth-Schwalbe, Ernst and Nishio, Makoto and Imamura, Fumio and Gabrail, Nashat and Veillon, Remi and Derijcke, Sofie and Maeda, Tadashi and Zylla, Dylan and Kubiak, Kendra and Santoro, Armando and Uy, Ma. Noemi and Lucien Geater, Sarayut and Italiano, Antoine and Kowalski, Dariusz and Barlesi, Fabrice and Chen, Yuh-Min and Spigel, David and Chewaskulyong, Busyamas and Garcia Gomez, Ramon and Alvarez Alvarez, Rosa and Yang, Chih-Hsin and Hsia, Te-Chun and Denis, Fabrice and Sakai, Hiroshi and Vincent, Mark and Goto, Koichi and Bosch-Barrera, Joaquim and Weiss, Glen and Canon, Jean-Luc and Scholz, Christian and Aglietta, Massimo and Kemmotsu, Hirotsugu and Azuma, Koichi and Bradbury, Penelope and Feld, Ronald and Chachoua, Abraham and Jassem, Jacek and Juergens, Rosalyn and Palmero Sanchez, Ramon and Malcolm, Albert and Vrindavanam, Nandagopal and Kubota, Kaoru and Waller, Cornelius and Waterhouse, David and Coudert, Bruno and Mark, Zsuzsanna and ... and ATLANTIC Investigators
The Lancet Oncology, ISSN 1470-2045, 04/2018, Volume 19, Issue 4, pp. 521 - 536
Immune checkpoint inhibitors are a new standard of care for patients with advanced non-small-cell lung cancer (NSCLC) without tyrosine kinase or anaplastic... 
MULTICENTER | METAANALYSIS | NSCLC | ONCOLOGY | RANDOMIZED CONTROLLED-TRIAL | ATEZOLIZUMAB | IMMUNE CHECKPOINT | NIVOLUMAB | MEDI4736 | CLINICAL ACTIVITY | DOCETAXEL | Lung cancer, Non-small cell | Care and treatment
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 05/2017, Volume 32, Issue suppl_3, pp. iii372 - iii372
Journal Article
Journal of Diabetes Investigation, ISSN 2040-1116, 05/2016, Volume 7, Issue 3, pp. 386 - 395
Journal Article
Cancer Science, ISSN 1347-9032, 12/2018, Volume 109, Issue 12, pp. 3921 - 3933
Liquid biopsy offers a potential alternative to tissue biopsy for detection of genetic alterations in cancer, and it has been introduced into clinical practice... 
afatinib | resistance mechanism | digital PCR | next‐generation sequencing | circulating tumor DNA | next-generation sequencing | 1ST-LINE TREATMENT | AFATINIB TREATMENT | ADENOCARCINOMA | PHASE-III | ACQUIRED-RESISTANCE | OPEN-LABEL | CHEMOTHERAPY | CELL LUNG-CANCER | EGFR T790M MUTATION | ONCOLOGY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Prospective Studies | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Humans | ErbB Receptors - genetics | Drug Resistance, Neoplasm | Treatment Outcome | Tumor Suppressor Protein p53 - genetics | DNA - blood | Polymerase Chain Reaction - methods | Proto-Oncogene Proteins c-met - genetics | GTP Phosphohydrolases - genetics | Protein Kinase Inhibitors - therapeutic use | Sensitivity and Specificity | Carcinoma, Non-Small-Cell Lung - blood | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | High-Throughput Nucleotide Sequencing - methods | Afatinib - therapeutic use | ErbB Receptors - blood | Polymerase chain reaction | Tyrosine | Epidermal growth factor | Analysis | Phenols | Tumor proteins | Lung cancer, Non-small cell | Library collections | Epidermal growth factor receptors | Copy number | Research funding | p53 Protein | Lung cancer | Non-small cell lung carcinoma | Exploration | Quantitation | Cancer therapies | Patients | c-Met protein | Biopsy | Alleles | Drug dosages | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tumors | Pharmaceuticals | Original
Journal Article
Journal Article
by Paz-Ares, Luis and Dvorkin, Mikhail and Chen, Chengshui and Chen, Yen-Hsun and Chen, Yuan and Chen, Yuanbin and Chen, Zhendong and Reinmuth, Niels and Hotta, Katsuyuki and Trukhin, Dmytro and Statsenko, Galina and Hochmair, Maximilian J and Özgüroğlu, Mustafa and Ji, Jun Ho and Voitko, Nataliia and Voitko, Oleksandr and Poltoratskiy, Artem and Ponce, Santiago and Verderame, Francesco and Havel, Libor and Bondarenko, Igor and Kazarnowicz, Andrzej and Losonczy, György and Conev, Nikolay V and Armstrong, Jon and Byrne, Natalie and Shire, Norah and Jiang, Haiyi and Goldman, Jonathan W and Batagelj, Emilio and Casarini, Ignacio and Pastor, Anea Viviana and Sena, Susana Noemi and Zarba, Juan Jose and Burghuber, Otto and Hartl, Sylvia and Lamprecht, Bernd and Studnicka, Michael and Alberto Schlittler, Luis and Augusto Martinelli de Oliveira, Fabricio and Calabrich, Aknar and Colagiovanni Girotto, Gustavo and Dos Reis, Peo and Fausto Nino Gorini, Carlos and Rafael Martins De Marchi, Peo and Serodio da Rocha Baldotto, Clarissa and Sette, Claudia and Zukin, Mauro and Dudov, Assen and Ilieva, Rumyana and Koynov, Krassimir and Krasteva, Rositsa and Tonev, Ivan and Valev, Spartak and Venkova, Violetka and Bi, Minghong and Fang, Jian and Feng, Jifeng and Han, Zhigang and Hu, Jie and Hu, Yi and Li, Wei and Li, Chien-Te and Liang, Zongan and Lin, Zhong and Ma, Shenglin and Ma, Rui and Nan, Kejun and Shu, Yongqian and Wang, Chin-Chou and Wang, Kai and Wang, Mengzhao and Wu, Gang and Wu, Shang-Yin and Yang, Nong and Yang, Zhixiong and Zhang, Wei and Zhang, Helong and Zhao, Yanqiu and Zhao, Jun and Zhou, Jianying and Zhou, Caicun and Zhou, Xiangdong and Kolek, Vitezslav and Koubkova, Leona and Roubec, Jaromir and Skrickova, Jana and Zemanova, Milada and Chouaid, Christos and Hilgers, Werner and Lena, Hervé and Moro-Sibilot, Denis and Robinet, Gilles and Souquet, Pierre-Jean and Alt, Jürgen and Bischoff, Helge and Grohe, Christian and Laack, Eckart and Lang, Susanne and Panse, Jens and ...
The Lancet, ISSN 0140-6736, 11/2019, Volume 394, Issue 10212, pp. 1929 - 1939
Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. Recently, immunotherapy has... 
Etoposide | Care and treatment | Product development | Lung cancer | Analysis | Drugs | Medical services | Radiation | Clinical trials | Metastasis | Cancer therapies | Randomization | Motivation | Platinum | Immunotherapy | Safety | Neutropenia | Small cell lung carcinoma | Maintenance | Radiation therapy | Survival | Patients | Cisplatin | Response rates | Carboplatin | Irradiation | Ligands | Clinical medicine | Solid tumors | Tumors | Apoptosis
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 7/2017, Volume 52, Issue 7, pp. 845 - 854
Journal Article