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PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57820
Pathology studies of progressive multiple sclerosis (MS) indicate a major role of inflammation including Th17-cells and meningeal inflammation with ectopic... 
DENDRITIC CELLS | MESSENGER-RNA | CD86 B7-2 | MULTIDISCIPLINARY SCIENCES | CHEMOKINE RECEPTOR | MENINGEAL INFLAMMATION | ADHESION MOLECULES | EXPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | LESIONS | CORTICAL PATHOLOGY | Inflammation - pathology | Cell Adhesion Molecules - genetics | Humans | Interleukins - cerebrospinal fluid | Middle Aged | Dendritic Cells - pathology | Male | Monocytes - metabolism | Lectins, C-Type - genetics | Interleukin-23 - genetics | Receptors, Interleukin - metabolism | Interleukins - genetics | Flow Cytometry | Interleukin-23 - cerebrospinal fluid | Th17 Cells - metabolism | Inducible T-Cell Co-Stimulator Protein - genetics | Monocytes - pathology | Adult | Female | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Multiple Sclerosis, Chronic Progressive - genetics | Th17 Cells - pathology | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Gene Expression | Lymphocyte Activation | Inflammation - cerebrospinal fluid | Cell Adhesion Molecules - cerebrospinal fluid | Multiple Sclerosis, Chronic Progressive - pathology | Receptors, Interleukin - genetics | Disease Progression | Interleukin-21 Receptor alpha Subunit - metabolism | Inflammation - genetics | Inducible T-Cell Co-Stimulator Protein - metabolism | Interleukin-21 Receptor alpha Subunit - genetics | Receptors, Cell Surface - genetics | Complications and side effects | Multiple sclerosis | Prognosis | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | B cells | Flow cytometry | Neurosciences | Disease | CD8 antigen | Interleukin | Helper cells | Fluid flow | Interleukin 23 | Lymphocytes T | Cerebrospinal fluid | Follicles | Blood | Rodents | Peripheral blood | Interleukin 21 | Age | Cytokines | Dendritic cells | Blood cells | T cell receptors | Gene expression | Patients | CD4 antigen | DC-SIGN protein | Studies | CD83 antigen | Pathology | Neurology | Cytometry | Monocytes | Gene flow | Lymphocytes B | Correlation analysis | ICOS protein | Plasma cells
Journal Article
Multiple Sclerosis Journal, ISSN 1352-4585, 6/2016, Volume 22, Issue 7, pp. 926 - 934
Background: There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF)... 
Progressive multiple sclerosis | clinical trial | CORD | osteopontin | cerebrospinal fluid | methylprednisolone | magnetization transfer ratio | NEUROSCIENCES | BRAIN | CLINICAL NEUROLOGY | Predictive Value of Tests | Recurrence | Glucocorticoids - administration & dosage | Humans | Middle Aged | Male | Methylprednisolone - adverse effects | Multiple Sclerosis, Chronic Progressive - diagnostic imaging | Recovery of Function | Young Adult | Evoked Potentials, Motor | Inflammation Mediators - cerebrospinal fluid | Time Factors | Adult | Female | Multiple Sclerosis, Chronic Progressive - drug therapy | Glucocorticoids - adverse effects | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Multiple Sclerosis, Chronic Progressive - physiopathology | Bone Density | Administration, Oral | Osteopontin - cerebrospinal fluid | Treatment Outcome | Pulse Therapy, Drug | Disease Progression | Diffusion Tensor Imaging | Magnetic Resonance Imaging | Neurologic Examination | Adolescent | Denmark | Aged | Biomarkers - cerebrospinal fluid | Methylprednisolone - administration & dosage | Multiple sclerosis | Nuclear magnetic resonance--NMR | Osteopontin | Cerebrospinal fluid | Motor evoked potentials | Motor task performance | Methylprednisolone | Side effects | Magnetic resonance imaging | Demyelination | Evoked potentials | Bone density | Bone imaging
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 09/2012, Volume 9, Issue 1, pp. 215 - 215
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 05/2019, Volume 330, pp. 90 - 95
Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only... 
POLYFLUOROALKYL SUBSTANCES | VITAMIN-D | POPULATION | INVARIANT T-CELLS | MAIT CELLS | AUTOIMMUNITY | VACCINE ANTIBODY CONCENTRATIONS | RECEPTOR | MECHANISMS | IMMUNOLOGY | NEUROSCIENCES | Viral antibodies | Antibodies | Multiple sclerosis | Risk factors
Journal Article
Multiple Sclerosis Journal, ISSN 1352-4585, 1/2011, Volume 17, Issue 1, pp. 32 - 42
Background:The cytokine osteopontin (OPN) is a potential key player in the immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease... 
Biomarker | immunology | multiple sclerosis | osteopontin | CSF | DEXAMETHASONE | WHITE-MATTER | CLINICAL NEUROLOGY | DISEASE-ACTIVITY | IMMUNE | HIGH-DOSE METHYLPREDNISOLONE | GENE | ACUTE OPTIC NEURITIS | EXPRESSION | T-CELLS | Osteopontin - blood | Up-Regulation | Glucocorticoids - therapeutic use | Methylprednisolone - therapeutic use | Humans | Middle Aged | Demyelinating Diseases - cerebrospinal fluid | Male | Time Factors | Demyelinating Diseases - immunology | Adult | Female | Multiple Sclerosis, Chronic Progressive - drug therapy | Demyelinating Diseases - drug therapy | Disability Evaluation | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Demyelinating Diseases - blood | Multiple Sclerosis, Relapsing-Remitting - immunology | Cross-Sectional Studies | Enzyme-Linked Immunosorbent Assay | Multiple Sclerosis, Chronic Progressive - immunology | Multiple Sclerosis, Relapsing-Remitting - blood | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Multiple Sclerosis, Chronic Progressive - blood | Osteopontin - cerebrospinal fluid | Treatment Outcome | Randomized Controlled Trials as Topic | Diffusion Magnetic Resonance Imaging | Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid | Neurological diseases | Multiple sclerosis | Immunopathogenesis | Clinical trials | Osteopontin | Inflammation | Cerebrospinal fluid | Methylprednisolone | Enzyme-linked immunosorbent assay
Journal Article
Brain and Behavior, ISSN 2162-3279, 02/2018, Volume 8, Issue 2, pp. e00875 - n/a
Journal Article
Multiple Sclerosis Journal, ISSN 1352-4585, 6/2019, Volume 25, Issue 7, pp. 937 - 946
Background: Development of treatments for progressive multiple sclerosis (MS) is challenged by the lack of sensitive and treatment-responsive biomarkers of... 
Primary progressive multiple sclerosis | inflammation | cerebrospinal fluid | axonal damage | methylprednisolone | secondary progressive multiple sclerosis | natalizumab | Multiple sclerosis | Axonogenesis | Demyelination | Clinical trials | Biomarkers | Inflammation | Cerebrospinal fluid | Methylprednisolone | Enzyme-linked immunosorbent assay
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 05/2017, Volume 101, Issue 5, pp. 1211 - 1220
Impact of smoking on circulating immune cells with emphasis on CD26hiCD161hi MAIT cells and ICOSL+ pDCs, in healthy controls and MS patients. Upon chronic... 
ICOSL | CCR6 | CD8 | T cell | pDC | Flow cytometry | Multiple sclerosis | Populations | CD8 antigen | Mucosa | Homeostasis | Lymphocytes T | Smoke | Lymphocytes | Enzyme-linked immunosorbent assay | Immune system | Antigens | Dendritic cells | Secretion | Blood cells | Inflammation | T cell receptors | Patients | CCR6 protein | Cytometry | Monocytes | Lungs | ICOS protein | Leukocytes (granulocytic) | Cigarette smoke | Smoking
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146971
B cells are involved in driving relapsing-remitting multiple sclerosis (RRMS), as demonstrated by the positive effect of therapeutic B-cell depletion. Aside... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-6-DEFICIENT MICE | CYTOKINE RESPONSES | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | HEALTHY-INDIVIDUALS | DISEASE | OLIGODENDROCYTE GLYCOPROTEIN | GLATIRAMER ACETATE | T-CELL | SELF-ANTIGEN | Severity of Illness Index | Peptide Fragments - metabolism | Autoantigens - metabolism | Cytokines - metabolism | Multiple Sclerosis, Relapsing-Remitting - blood | Myelin Basic Protein - metabolism | Humans | Middle Aged | Male | Inflammation | Multiple Sclerosis, Relapsing-Remitting - physiopathology | HLA-DR Serological Subtypes - metabolism | Interleukin-10 - metabolism | Interleukin-6 - biosynthesis | Adult | Female | Leukocytes, Mononuclear - cytology | Tumor Necrosis Factor-alpha - biosynthesis | B-Lymphocytes - metabolism | Lymphocyte receptors | Multiple sclerosis | Ionomycin | Disease | Interleukin | Stimulation | Nervous system | Lymphocytes T | Arthritis | Myelin basic protein | Interleukin 6 | Proteins | Immunology | Lymphocytes | Tumor necrosis factor-TNF | Standard deviation | Antigen presentation | Antigens | Cytokines | Blood & organ donations | Myelin | Rheumatology | Autoantigens | T cell receptors | Tumor necrosis factor-α | Patients | Studies | Neurology | Depletion | Lymphocytes B | Correlation analysis | Interleukin 10 | Monoclonal antibodies | Histocompatibility antigen HLA | Autoimmune diseases
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e47578
In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system... 
B-CELLS | ACTIVATION | TYROSINE PHOSPHORYLATION | REGULATORY CELLS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | FIBRONECTIN | COSTIMULATION | FINGOLIMOD FTY720 | VLA-4 | DISEASE-ACTIVITY | T-Lymphocyte Subsets - immunology | Receptors, OX40 - genetics | Gene Expression - drug effects | Natalizumab | Humans | Central Nervous System - pathology | Male | CD4-Positive T-Lymphocytes - pathology | Immunologic Memory - drug effects | Case-Control Studies | Central Nervous System - immunology | Receptors, OX40 - immunology | CD4-Positive T-Lymphocytes - immunology | Myelin Basic Protein - genetics | T-Lymphocyte Subsets - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Adult | Female | Antibodies, Monoclonal, Humanized - therapeutic use | Cells, Cultured | Cell Migration Inhibition - immunology | Integrin alpha4beta1 - genetics | Myelin Basic Protein - immunology | Integrin alpha4beta1 - immunology | Cell Migration Inhibition - drug effects | Tumor Necrosis Factor-alpha - pharmacology | T-Lymphocyte Subsets - pathology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Central Nervous System - drug effects | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | CD4-Positive T-Lymphocytes - drug effects | Multiple Sclerosis - drug therapy | Flow cytometry | Multiple sclerosis | Transcription factors | Central nervous system | Effector cells | Activation | Lymphocytes T | VLA-4 antigen | Blood | Cell adhesion & migration | Lymphocytes | Extravasation | Lesions | Immune system | Antigens | Immunological memory | Memory cells | Immune response | Cytokines | Myelin | Inflammation | T cell receptors | CD134 antigen | Tumor necrosis factor-α | Gene expression | Patients | Endothelium | CD4 antigen | Studies | Neurology | Monoclonal antibodies | Ligands | Cell migration
Journal Article