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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2019, Volume 27, Issue 13, pp. 2905 - 2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to... 
Fragment screen | Bruton’s Tyrosine Kinase (BTK) | Computer aid drug design (CADD)
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6190 - 6213
Recruitment of suppressive CD4(+) FOXP3(+) regulatory T cells (T-reg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in... 
CELLS | CD4 | CHEMISTRY, MEDICINAL | THERAPY | CHEMOKINE RECEPTOR CCR4 | CCL22/CCR4
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2019, Volume 27, Issue 13, pp. 2905 - 2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to... 
ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | Fragment screen | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Bruton's Tyrosine Kinase (BTK) | DISCOVERY | POTENT | B-CELL | GENE | CLONING | BTK | Computer aid drug design (CADD) | EXPRESSION | TEC FAMILY KINASES | Tyrosine | Phenols | Pharmaceutical industry | Drug approval
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2016, Volume 59, Issue 15, pp. 7252 - 7267
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2008, Volume 18, Issue 17, pp. 4880 - 4884
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2012, Volume 3, Issue 3, pp. 203 - 206
LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte... 
ophthalmic solution | LFA-1/ICAM-1 antagonist | dry eye | SAR 1118 | tetrahydroisoquinoline derivative | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | DRUG-DELIVERY | SJOGRENS-SYNDROME | MECHANISMS | ADHESION | KERATOCONJUNCTIVITIS SICCA | INFLAMMATION | FUNCTION-ASSOCIATED ANTIGEN-1 | IMMUNOLOGICAL SYNAPSE | CYCLOSPORINE
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, pp. 307 - 310
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 17, pp. 5158 - 5161
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 5, pp. 1409 - 1412
Journal Article
Psychotherapy and Psychosomatics, ISSN 0033-3190, 10/2011, Volume 80, Issue 6, pp. I - VI
Journal Article
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