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1. Full Text Delirium in Critically III Children: An International Point Prevalence Study
by Traube, C and Silver, G and Reeder, RW and Doyle, H and Hegel, E and Wolfe, HA and Schneller, C and Chung, MG and Dervan, LA and DiGennaro, JL and Buttram, SDW and Kudchadkar, SR and Madden, K and Hartman, ME and deAlmeida, ML and Walson, K and Ista, E and Baarslag, MA and Salonia, R and Beca, J and Long, D and Kawai, Y and Cheifetz, IM and Gelvez, J and Truemper, EJ and Smith, RL and Peters, ME and O'Meara, AMI and Murphy, S and Bokhary, A and Greenwald, BM and Bell, MJ
CRITICAL CARE MEDICINE, ISSN 0090-3493, 04/2017, Volume 45, Issue 4, pp. 584 - 590
Objectives: To determine prevalence of delirium in critically ill children and explore associated risk factors. Design: Multi-institutional point prevalence... 
RISK-FACTORS | ILL INFANTS | MANAGEMENT | critical care | neurocritical care | pediatric | CORNELL ASSESSMENT | MECHANICALLY VENTILATED PATIENTS | prevalence | ACUTE BRAIN-DYSFUNCTION | INTENSIVE-CARE-UNIT | PEDIATRIC DELIRIUM | SEDATION | TERM COGNITIVE IMPAIRMENT | delirium | CRITICAL CARE MEDICINE
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2. Full Text Cardiovascular risk assessment in haemophilia patients
by Biere-Rafi, S and Baarslag, M. A and Peters, M and Kruip, M. J. H. A and Kraaijenhagen, R. A and den Heijer, M and Büller, H. R and Kamphuisen, P. W
Thrombosis and Haemostasis, ISSN 0340-6245, 2011, Volume 105, Issue 2, pp. 274 - 278
Haemophilia patients have a reduced cardiovascular mortality, which may be the result of a lifelong deficiency of factor VIII or IX. On the other hand, the... 
Cardiovascular Disease | Haemophilia | Diabetes Mellitus | hypertension | Risk Factors | Blood Coagulation, Fibrinolysis and Cellular Haemostasis | Hypertension | Cardiovascular disease | Diabetes mellitus | Risk factors | MORTALITY | FRAMINGHAM | risk factors | PROJECT | THROMBOSIS | diabetes mellitus | DEATH | BLOOD-PRESSURE | HEART-ASSOCIATION | DISEASE | haemophilia | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Dyslipidemias - mortality | Prevalence | Prospective Studies | Dyslipidemias - complications | Humans | Middle Aged | Netherlands - epidemiology | Male | Case-Control Studies | Young Adult | Time Factors | Blood Coagulation | Aged, 80 and over | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality | Adult | Hypertension - mortality | Obesity - mortality | Hemophilia B - mortality | Cardiovascular Diseases - etiology | Hemophilia A - mortality | Risk Assessment | Obesity - complications | Hemophilia B - blood | Biomarkers - blood | Chi-Square Distribution | Hemophilia A - blood | Diabetes Complications - etiology | Diabetes Complications - mortality | Hemophilia A - complications | Hemophilia B - complications | Adolescent | Hypertension - complications | Aged
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3. Full Text The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial (vol 7, e016031, 2017)
by Neubert, A and Baarslag, MA and Dijk, MV
BMJ OPEN, ISSN 2044-6055, 11/2017, Volume 7, Issue 11
MEDICINE, GENERAL & INTERNAL
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4. Full Text Delirium in Critically Ill Children: An International Point Prevalence Study
by Traube, Chani and Silver, Gabrielle and Reeder, Ron W and Doyle, Hannah and Hegel, Emily and Wolfe, Heather A and Schneller, Christopher and Chung, Melissa G and Dervan, Leslie A and DiGennaro, Jane L and Buttram, Sandra D W and Kudchadkar, Sapna R and Madden, Kate and Hartman, Mary E and deAlmeida, Mary L and Walson, Karen and Ista, Erwin and Baarslag, Manuel A and Salonia, Rosanne and Beca, John and Long, Debbie and Kawai, Yu and Cheifetz, Ira M and Gelvez, Javier and Truemper, Edward J and Smith, Rebecca L and Peters, Megan E and O’Meara, AM Iqbal and Murphy, Sarah and Bokhary, Abdulmohsen and Greenwald, Bruce M and Bell, Michael J
Critical Care Medicine, ISSN 0090-3493, 01/2017, Volume 45, Issue 4, pp. 584 - 590
OBJECTIVES:To determine prevalence of delirium in critically ill children and explore associated risk factors. DESIGN:Multi-institutional point prevalence... 
critical care | prevalence | delirium | neurocritical care | pediatric | Delirium - epidemiology | United States - epidemiology | Prevalence | Humans | Netherlands - epidemiology | Risk Factors | Child, Preschool | Coma - epidemiology | Infant | Male | Australia - epidemiology | Critical Illness - psychology | Intensive Care Units, Pediatric - statistics & numerical data | Adolescent | Female | Child | Delirium - diagnosis | Saudi Arabia - epidemiology | Infant, Newborn | New Zealand - epidemiology
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5. Full Text Clinically effective implementation of intravenous paracetamol as primary analgesia after major surgery in neonates and young infants
by Baarslag, Manuel A and Ista, Erwin and de Leeuw, Tom and van Rosmalen, Joost and Tibboel, Dick and van Dijk, Monique and de Wildt, Saskia N
Archives of Disease in Childhood, ISSN 0003-9888, 12/2018, Volume 103, Issue 12, pp. 1168 - 1169
We previously showed that intravenous paracetamol as primary analgesic after major non-cardiac (laparotomy or thoracotomy) surgery in infants <1 year of age... 
paediatric surgery | pain | intensive care | analgesia | PEDIATRICS | Heart | Neonates | Pediatrics | Intensive care | Pain perception | Postoperative period | Intravenous administration | Statistical analysis | Narcotics | Heart surgery | Morphine | Infants | Patients | Ethics | Analgesia | Paracetamol | Pain | Motivation | Analgesics | Neonatal care | Surgery | Opioids | Children
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6. Full Text Quality and clinical supply considerations of Paediatric Investigation Plans for IV preparations—A case study with the FP7 CloSed project
by Hanning, Sara M and Orlu Gul, Mine and Winslade, Jackie and Baarslag, Manuel A and Neubert, Antje and Tuleu, Catherine and CloSed Consortium
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2016, Volume 511, Issue 2, pp. 1158 - 1162
A Paediatric Investigation Plan (PIP) is a development plan that aims to ensure that sufficient data are obtained through studies in paediatrics to support the... 
Paediatric Investigation Plan | Clinical trials | Clonidine | Formulation | Paediatrics | PHARMACOLOGY & PHARMACY | Double-Blind Method | Europe | Humans | Hypnotics and Sedatives - administration & dosage | Child, Preschool | Infant | Male | Hypnotics and Sedatives - standards | Clonidine - supply & distribution | Administration, Intravenous | Hypnotics and Sedatives - supply & distribution | Pediatrics - methods | Adolescent | Female | Pediatrics - standards | Clonidine - administration & dosage | Child | Clonidine - standards | Infant, Newborn | Case studies | Pediatrics | Pharmacy | Investigations | Pediatric pharmacology | Information management | Marketing
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7. Full Text Pharmacological sedation management in the paediatric intensive care unit
by Baarslag, Manuel A and Allegaert, Karel and Knibbe, Catherijne A.J and Dijk, Monique and Tibboel, Dick
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 05/2017, Volume 69, Issue 5, pp. 498 - 513
Objective This review addresses sedation management on paediatric intensive care units and possible gaps in the knowledge of optimal sedation strategies. We... 
paediatrics | critical care | pharmacokinetics | sedation | pharmacodynamics | MECHANICALLY VENTILATED CHILDREN | MIDAZOLAM CLEARANCE | RANDOMIZED CONTROLLED-TRIAL | OPIOID-INDUCED HYPERALGESIA | CHLORAL HYDRATE | COMFORT SCORE | BISPECTRAL INDEX MONITOR | POPULATION PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | CONTINUOUS-INFUSION | CRITICALLY-ILL PATIENTS | Intensive Care Units, Pediatric | Pharmaceutical Preparations - administration & dosage | Child | Humans | Hypnotics and Sedatives - administration & dosage | Pediatric pharmacology | Analysis | Intensive care
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8. Full Text How often do we perform painful and stressful procedures in the paediatric intensive care unit? A prospective observational study
by Baarslag, Manuel A and Jhingoer, Sharan and Ista, Erwin and Allegaert, Karel and Tibboel, Dick and van Dijk, Monique
Australian Critical Care, ISSN 1036-7314, 01/2019, Volume 32, Issue 1, pp. 4 - 10
Adequate analgesia and sedation is crucial in critical care. There is little knowledge on the extent of painful and stressful procedures on children admitted... 
Analgesia | Pain | Children | Paediatric intensive care | Stress | MANAGEMENT | NURSING | DEVICE | INVASIVE PROCEDURES | INTRAVENOUS CANNULATION | RANDOMIZED CONTROLLED-TRIAL | SEDATION | EPIDEMIOLOGY | CRITICAL CARE MEDICINE | Psychological aspects | Intensive care units | Services | Usage | Care and treatment | Stress (Psychology) | Pediatric research
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9. Full Text The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial
by Neubert, Antje and Baarslag, Manuel Alberto and Dijk, Monique van and Rosmalen, Joost van and Standing, Joseph F and Sheng, Yucheng and Rascher, Wolfgang and Roberts, Deborah and Winslade, Jackie and Rawcliffe, Louise and Hanning, Sara M and Metsvaht, Tuuli and Giannuzzi, Viviana and Larsson, Peter and Pokorná, Pavla and Simonetti, Alessandra and Tibboel, Dick and CLOSED Consortium
BMJ Open, ISSN 2044-6055, 06/2017, Volume 7, Issue 6, p. e016031
IntroductionSedation is an essential part of paediatric critical care. Midazolam, often in combination with opioids, is the current gold standard drug.... 
paediatrics | criticalillness | children | sedation | pharmacology | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | INFANTS | RENAL-FUNCTION | ISCHEMIA | INFUSION | CRITICALLY-ILL CHILDREN | ALPHA-ADRENOCEPTOR AGONISTS | MEDICINES | INTRAVENOUS CLONIDINE | ORAL CLONIDINE | Intensive Care Units | Hypnotics and Sedatives - adverse effects | Hypnotics and Sedatives - pharmacokinetics | Clonidine - pharmacokinetics | Humans | Child, Preschool | Clonidine - adverse effects | Infant | Clonidine - therapeutic use | Hypnotics and Sedatives - therapeutic use | Substance Withdrawal Syndrome | Midazolam - pharmacokinetics | Respiration, Artificial | Midazolam - adverse effects | Analgesics, Opioid - administration & dosage | Treatment Failure | Adolescent | Midazolam - therapeutic use | Child Development - drug effects | Child | Research Design | Infant, Newborn | Delirium - chemically induced | Intensive care | Biomedical research | Narcotics | Heart surgery | Clinical trials | Metabolism | Trauma | International organizations | Ethics | Councils | Metabolites | Sepsis | Anesthesia | Ventilation | Regulation | Clinical medicine
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10. Full Text Paracetamol and morphine for infant and neonatal pain; still a long way to go?
by Baarslag, Manuel A and Allegaert, Karel and Van Den Anker, John N and Knibbe, Catherijne A.J and Van Dijk, Monique and Simons, Sinno H.P and Tibboel, Dick
Expert Review of Clinical Pharmacology, ISSN 1751-2433, 01/2017, Volume 10, Issue 1, pp. 111 - 126
Introduction: Pharmacologic pain management in newborns and infants is often based on limited scientific data. To close the knowledge gap, drug-related... 
acetaminophen | Pain | infants | pharmacodynamics | pediatrics | analgesia | pharmacokinetics | neonates | paracetamol | opioids | ANALGESIA-NOCICEPTION INDEX | CRITICALLY-ILL INFANTS | RANDOMIZED CONTROLLED-TRIAL | BLOOD-BRAIN-BARRIER | REVISED PIPP-R | INTENSIVE-CARE-UNIT | DOUBLE-BLIND TRIAL | HEART-RATE-VARIABILITY | HEEL PRICK PAIN | PHARMACOLOGY & PHARMACY | NEWBORN-INFANTS
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11. Full Text Conflict Resolution in Decision Making : Second International Workshop, COREDEMA 2016, the Hague, the Netherlands, August 29-30, 2016, Revised Selected Papers
by Aydoğan, Reyhan and Baarslag, Tim and Gerding, Enrico and Jonker, Catholijn M and Julian, Vicente and Sanchez-Anguix, Victor
04/2017, ISBN 3319572849, 157
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12. Full Text Cardiovascular risk assessment in haemophilia patients
by Biere-Rafi, S and Baarslag, M.A and Peters, M and Kruip, M.J and Kraaijenhagen, R.A and Heijer, M. den and Buller, H.R and Kamphuisen, T.P.W
Thrombosis and Haemostasis, ISSN 0340-6245, 2011, Volume 105, pp. 274 - 278
Haemophilia patients have a reduced cardiovascular mortality, which may be the result of a lifelong deficiency of factor VIII or IX. On the other hand, the... 
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13. Full Text On the mechanism of ITO etching in halogen acids: The influence of oxidizing agents
by van den Meerakker, J.E.A.M and van den Meerakker, J.E.A.M and Baarslag, P.C and Baarslag, P.C and Scholten, M and Scholten, M
Journal of the Electrochemical Society, ISSN 0013-4651, 07/1995, Volume 142, Issue 7, pp. 2321 - 2325
The etching process of polycrystalline tin-doped indium oxide (ITO) films in HCl solutions is investigated by kinetic and electrochemical experiments and the... 
ELECTROCHEMISTRY | OXIDE
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14. Full Text The Etching of a CoNbZr Alloy in H[sub 2]O[sub 2] Solutions A Kinetic Study
by van den Meerakker, J. E. A. M and Baarslag, P. C
Journal of The Electrochemical Society, ISSN 0013-4651, 2000, Volume 147, Issue 6, p. 2227
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15. The behaviour of permalloy in NH\+v\4\-v\F/HF solutions
by van den Meerakker, J. E. A. M and Baarslag |h P. C
Corrosion Science, ISSN 0010-938X, 07/2000, Volume 42, Issue 7, pp. 1169 - 1183
Permalloy is an alloy of 80 at% Ni and 20 at% Fe with excellent magnetic properties. It is electrodeposited as a thin film on a substrate wafer and... 
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16. Full Text CT and 18F-FDG PET for Noninvasive Detection of Splenic Involvement in Patients with Malignant Lymphoma
by de Jong, Pim A and van Ufford, Henriette M. Quarles and Baarslag, Henk-Jan and de Haas, Marie J and Wittebol, Shulamiet H and Quekel, Lorentz G and de Klerk, John M
American Journal of Roentgenology, ISSN 0361-803X, 03/2009, Volume 192, Issue 3, p. 745
The purpose of this study was to determine the sensitivity and specificity of (18)F-FDG PET, CT, and combined PET/CT in the detection of splenic involvement at... 
Lymphoma - diagnostic imaging | Humans | Middle Aged | Splenic Neoplasms - diagnostic imaging | Tomography, X-Ray Computed - methods | Male | Positron-Emission Tomography - methods | Patient Selection | Sensitivity and Specificity | Adolescent | Aged, 80 and over | Adult | Female | Fluorodeoxyglucose F18 | Aged | Retrospective Studies | Neoplasm Staging | Radiopharmaceuticals | Longitudinal Studies
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17. Full Text Arteriography and portal venography on routine follow-up after orthotopic liver transplantation
by Kok, T and Boeve, WJ and Baarslag, HJ and Woesthuis, M and Slooff, MJH and Haagsma, EB and Bijleveld, CMA and Van der Jagt, EJ
Investigative Radiology, ISSN 0020-9996, 11/2000, Volume 35, Issue 11, pp. 653 - 660
RATIONALE AND OBJECTIVES. TO describe the findings of routinely performed angiographic examinations in patients at discharge 2 months after orthotopic liver... 
DIAGNOSIS | liver, portal vein | VASCULAR COMPLICATIONS | RADIOLOGIC EVALUATION | ANGIOGRAPHY | STENOSIS | digital subtraction angiography, comparative studies | liver, hepatic artery | HEPATIC-ARTERY THROMBOSIS | RECIPIENTS | UMCG Approved | transplantation, liver | Digital subtraction angiography | Hepatic artery | Comparative studies | Transplantation | Portal vein | Liver | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Constriction, Pathologic - pathology | Angiography | Follow-Up Studies | Humans | Child, Preschool | Male | Portal Vein - diagnostic imaging | Hepatic Artery - pathology | Time Factors | Adult | Anastomosis, Surgical | Female | Portal Vein - pathology | Hepatic Artery - diagnostic imaging | Constriction, Pathologic - diagnostic imaging | Postoperative Complications - diagnostic imaging | Liver Transplantation - diagnostic imaging
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18. Full Text Prevention of catheter-related venous thrombosis with nadroparin in patients receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled study
: Prevention of catheter-related thrombosis with LMWH
by NIERS, T. M. H and DI NISIO, M and KLERK, C. P. W and BAARSLAG, H. J and BÜLLER, H. R and BIEMOND, B. J
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 09/2007, Volume 5, Issue 9, pp. 1878 - 1882
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