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index medicus (84) 84
animals (75) 75
mice (61) 61
cell biology (37) 37
signal transduction (32) 32
humans (31) 31
proto-oncogene proteins c-raf - metabolism (29) 29
biochemistry & molecular biology (28) 28
phosphorylation (27) 27
cells, cultured (24) 24
apoptosis (23) 23
proto-oncogene proteins c-raf - genetics (23) 23
activation (22) 22
enzyme activation (22) 22
b-raf (19) 19
mice, inbred c57bl (19) 19
article (17) 17
extracellular signal-regulated map kinases - metabolism (15) 15
mice, knockout (15) 15
kinases (13) 13
cancer (12) 12
male (12) 12
immunology (11) 11
oncology (11) 11
pathway (11) 11
raf (11) 11
c-raf (10) 10
macrophages - cytology (10) 10
proto-oncogene proteins b-raf - metabolism (10) 10
transfection (10) 10
c-raf-1 gene (9) 9
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expression (9) 9
map kinase (9) 9
mice, transgenic (9) 9
mitogen-activated protein kinases - metabolism (9) 9
mutation (9) 9
protein-kinase (9) 9
proteins (9) 9
proto-oncogene proteins b-raf - genetics (9) 9
research (9) 9
signal-transduction (9) 9
tumors (9) 9
a-raf (8) 8
abridged index medicus (8) 8
biology (8) 8
cell proliferation (8) 8
cos cells (8) 8
differentiation (8) 8
female (8) 8
growth (8) 8
in-vivo (8) 8
kinase (8) 8
map kinase signaling system (8) 8
protein-serine-threonine kinases - metabolism (8) 8
proto-oncogene proteins - metabolism (8) 8
proto-oncogene proteins c-raf - physiology (8) 8
ras proteins - metabolism (8) 8
time factors (8) 8
amino acid sequence (7) 7
apoptosis - physiology (7) 7
bacteria (7) 7
braf (7) 7
cell line, tumor (7) 7
cells (7) 7
molecular sequence data (7) 7
protein (7) 7
proto-oncogene proteins c-raf (7) 7
raf kinases - metabolism (7) 7
ras (7) 7
rna interference (7) 7
dimerization (6) 6
fibroblasts - metabolism (6) 6
macrophages - drug effects (6) 6
macrophages - enzymology (6) 6
macrophages - immunology (6) 6
macrophages - physiology (6) 6
protein binding (6) 6
ras proteins - genetics (6) 6
transcription factors (6) 6
blotting, western (5) 5
calcium-calmodulin-dependent protein kinases - metabolism (5) 5
cell death (5) 5
cell differentiation - physiology (5) 5
cellular biology (5) 5
erk (5) 5
extracellular signal-regulated kinase (5) 5
feedback phosphorylation (5) 5
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gene expression regulation (5) 5
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macrophage colony-stimulating factor - pharmacology (5) 5
macrophages (5) 5
mice lacking (5) 5
nf-kappa-b (5) 5
physiological aspects (5) 5
signal transduction - physiology (5) 5
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The EMBO Journal, ISSN 0261-4189, 01/2016, Volume 35, Issue 2, pp. 118 - 120
Phosphorylation of the activation loop in RAF kinases has been suggested to be critical for changes in activity. The extent to which the activation segment is... 
ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | B-RAF | KINASES | CELL BIOLOGY | Female | Male | Animals | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins B-raf - metabolism | Kinases | Phosphorylation | Mutation | Signal Transduction | Views | Cancer
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2003, Volume 4, Issue 5, pp. 471 - 477
Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report... 
TRANSCRIPTION FACTORS | TOLL-LIKE RECEPTOR-2 | REGULATORY FACTOR-3 | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE SYNTHASE | IFN-GAMMA | GENE-EXPRESSION | IMMUNOLOGY | MICE LACKING | INNATE IMMUNITY | CUTTING EDGE | Shock, Septic - etiology | Protein-Tyrosine Kinases - metabolism | Male | Shock, Septic - immunology | Protein-Tyrosine Kinases - deficiency | RNA, Messenger - metabolism | DNA-Binding Proteins - deficiency | TYK2 Kinase | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Interferon Regulatory Factor-1 | Interferon-alpha - genetics | Interferon Regulatory Factor-7 | Trans-Activators - genetics | Interferon-beta - genetics | Female | Shock, Septic - genetics | Nitric Oxide - biosynthesis | Gene Expression | Lipopolysaccharides - toxicity | Mice, Inbred C57BL | RNA, Messenger - genetics | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Macrophage Activation | Mice, Knockout | Proteins - genetics | Animals | Proteins - metabolism | Trans-Activators - deficiency | Interferon Type I - genetics | STAT1 Transcription Factor | Trans-Activators - metabolism | Mice | Cytokines - biosynthesis | Index Medicus | Basic Medicine | Immunologi inom det medicinska området | Medical and Health Sciences | Medicin och hälsovetenskap | Immunology in the medical area | Medicinska och farmaceutiska grundvetenskaper
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2014, Volume 588, Issue 15, pp. 2398 - 2406
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 12/2010, Volume 35, Issue 12, p. 660
  The three-tiered Raf-MEK-ERK kinase module is activated downstream of Ras and has been traditionally linked to cellular proliferation. Mammals have three... 
Proteins | Molecules | Biochemistry | Gene expression | Mammals | Kinases | Binding sites | Tumors
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2014, Volume 588, Issue 15, pp. 2398 - 2406
The Raf/Mek/Erk signaling pathway, activated downstream of Ras primarily to promote proliferation, represents the best studied of the evolutionary conserved... 
Mek | Ras | Raf | Cancer therapy | Kinase inhibitor | Protein–protein interaction | Erk | Review
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2016, Volume 39, pp. iv - vi
Journal Article
Science Signaling, ISSN 1945-0877, 10/2018, Volume 11, Issue 554, p. eaar6795
Journal Article
Oncogene, ISSN 0950-9232, 10/2018, Volume 37, Issue 43, pp. 5719 - 5734
Journal Article