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Methods in molecular biology (Clifton, N.J.), 2019, Volume 1935, pp. 11 - 23
In this chapter, we describe a robust normalization method for single-cell RNA sequencing data. The procedure, SCnorm, is implemented in R and is part of... 
Normalization | High-throughput sequencing | Gene expression | Read count | Single-cell RNA-seq
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2017, Volume 15, Issue 12, p. e2004050
From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity... 
PROTEIN-KINASE-A | NUCLEAR-LOCALIZATION | ANTICANCER TREATMENTS | PROMOTER THRESHOLD | METABOLIC CYCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | GENE-EXPRESSION | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | RIBOSOME BIOGENESIS | ENVIRONMENTAL-CHANGES | Saccharomyces cerevisiae - physiology | Transcription Factors - physiology | Saccharomyces cerevisiae - genetics | Sodium Chloride - pharmacology | Stress, Physiological | Transcriptome | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | RNA, Messenger - metabolism | Genetic Variation | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Sequence Analysis, RNA | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - physiology | Bioengineering | Regulators | Salts | Transcription factors | Yeast | Authorship | Laboratories | Gene regulation | Fluorescence | Genomes | Saccharomyces | Kinases | Gene sequencing | Proteins | Heterogeneity | Transcription activation | Cell cycle | Bacteria | Stress response | Bioinformatics | Supervision | Stresses | MAP kinase | Metabolism | Gene expression | Ribonucleic acid--RNA | Environmental stress | Hog1 protein | Variation | Saccharomyces cerevisiae | Health informatics | Methods | Cellular stress response | BASIC BIOLOGICAL SCIENCES | Baking yeast | RNA | Ribonucleic acid
Journal Article
Cell Reports, ISSN 2211-1247, 08/2019, Volume 28, Issue 9, pp. 2247 - 2255.e5
Defects in somitogenesis result in vertebral malformations at birth known as spondylocostal dysostosis (SCDO). Somites are formed with a species-specific... 
HES7 | spondylocostal dysostosis | human embryonic stem cells | segmentation clock | gene oscillation | CAUSES SPONDYLOCOSTAL DYSOSTOSIS | GENE | MECHANISM | MUTATION | NOTCH | OSCILLATIONS | INHIBITOR | VERTEBRATE SEGMENTATION | EXPRESSION | CELL BIOLOGY
Journal Article
Genetics, ISSN 0016-6731, 05/2018, Volume 209, Issue 1, pp. 335 - 356
The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene... 
Module-QTL | Genome-wide association (GWA) | EQTL | β-cell | Mediation analysis | T2D | TYPE-2 DIABETES SUSCEPTIBILITY | COEXPRESSION NETWORK ANALYSIS | genome-wide association (GWA) | SYSTEMS GENETICS | eQTL | ALPHA-CELL | mediation analysis | GLUCOSE-HOMEOSTASIS | R/BIOCONDUCTOR PACKAGE | beta-cell | BETA-CELL DEDIFFERENTIATION | INSULIN-RESISTANCE | GENETICS & HEREDITY | module-QTL | GLYCEMIC TRAITS | GENOME-WIDE ASSOCIATION | Haplotypes | Computational Biology - methods | Islets of Langerhans - physiology | Genetic Association Studies | Quantitative Trait, Heritable | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Regulation | Transcriptome | Genotype | Gene Expression Profiling | Diabetes Mellitus, Type 2 - metabolism | Gene Regulatory Networks | Animals | Diabetes Mellitus, Experimental | Glucagon-Secreting Cells - metabolism | Alleles | Mice | Genome-Wide Association Study - methods | Quantitative Trait Loci | Somatostatin-Secreting Cells - metabolism | Web Browser | Enrichment | Sucrose | Genes | Modules | Chain branching | Amino acids | Genomes | Mapping | Glucose | Population genetics | High fat diet | Human populations | Interleukin 6 | Etiology | Genetics | Physiology | Hepatocyte nuclear factor 4 | Pancreas | Diabetes mellitus (non-insulin dependent) | Bioinformatics | Sugars | Obesity | Phenotypes | Diabetes mellitus | Abundance | Metabolism | Gene expression | Insulin | Loci | Quantitative trait loci | Studies | Diet | Insulin resistance | Gene loci | Diabetes | Islets of Langerhans | Gene mapping | Binding sites | Investigations
Journal Article
PLoS computational biology, ISSN 1553-7358, 12/2019, Volume 15, Issue 12, p. e1007543
Pluripotent stem cells retain the developmental timing of their species of origin in vitro, an observation that suggests the existence of a cell-intrinsic... 
Journal Article
Journal Article
Comparative medicine, ISSN 1532-0820, 08/2016, Volume 66, Issue 4, p. 349
Biomedical translational research frequently incorporates collection of CSF from NHP, because CSF drug levels are used as a surrogate for CNS tissue... 
Journal Article