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1. Full Text Mannitol and the mechanisms behind bronchoconstriction
by Backer, Vibeke
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 10/2019, Volume 144, Issue 4, pp. 931 - 932
Mast cells play a central role in asthma pathophysiology, and both the location and density of mast cells in asthmatic patients are seemingly important for... 
Hyperresponsiveness | exercise | asthma | mannitol | bronchoconstriction | ALLERGY | IMMUNOLOGY | Laboratories | Smooth muscle | Inflammation | Muscle contraction | Asthma | Chymase | Studies | Respiratory tract | Histamine | Bronchoconstriction | Mannitol | Mast cells | In vitro methods and tests | Drug dosages
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2. Full Text Effective treatment of house dust mite–induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial
by Demoly, Pascal, MD, PhD and Emminger, Waltraud, MD and Rehm, Dorte, PhD and Backer, Vibeke, MD and Tommerup, Lene, MSc and Kleine-Tebbe, Jörg, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 444 - 451.e8
Background The SQ HDM SLIT-tablet (ALK) has been developed for treatment of house dust mite (HDM)–induced respiratory allergic disease. Objective This trial... 
Allergy and Immunology | rhinoconjunctivitis | total combined rhinitis score | sublingual immunotherapy tablet | allergen immunotherapy | house dust mite | Allergy immunotherapy | Rhinitis Quality of Life Questionnaire | allergy | sublingual immunotherapy | allergic rhinitis | STANDARDIZATION | EFFICACY | SAFETY | IMMUNOLOGY | CHILDREN | IMMUNOTHERAPY TABLET | CLINICAL-TRIALS | ASTHMA | NORTH-AMERICAN | RESPIRATORY ALLERGY | Rhinitis, Allergic - immunology | Humans | Middle Aged | Risk Factors | Sublingual Immunotherapy - methods | Male | Treatment Outcome | Young Adult | Allergens - administration & dosage | Antigens, Dermatophagoides - immunology | Animals | Allergens - immunology | Time Factors | Adolescent | Adult | Female | Aged | Rhinitis, Allergic - therapy | Pyroglyphidae - immunology | Clinical trials | Product development | Clinics | Consulting services | Allergens | Care and treatment | Rhinitis | Analysis | Immunotherapy | Conjunctivitis | Population | Drug therapy | Allergies | Asthma | Life Sciences | Allergology | Immunology
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3. Full Text SQ house dust mite sublingual immunotherapy for the treatment of adults with house dust mite-induced allergic rhinitis
by Meteran, Howraman and Backer, Vibeke
Expert Review of Clinical Immunology, ISSN 1744-666X, 11/2019, Volume 15, Issue 11, pp. 1127 - 1133
Introduction: Allergic rhinitis (AR) is one of the most common chronic conditions affecting both children and adults. The house dust mites (HDM) account for a... 
asthma | house dust mite | Allergic rhinoconjunctivitis | sublingual | immunotherapy
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4. Full Text Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma: A Randomized Clinical Trial
by Virchow, J. Christian and Backer, Vibeke and Kuna, Piotr and Prieto, Luis and Nolte, Hendrik and Villesen, Hanne Hedegaard and Ljørring, Christian and Riis, Bente and de Blay, Frederic
JAMA, ISSN 0098-7484, 04/2016, Volume 315, Issue 16, pp. 1715 - 1725
IMPORTANCE: The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy–related asthma.... 
Immunotherapy - methods | Administration, Sublingual | Asthma - prevention & control | Tablets | Humans | Immunoglobulin G | Middle Aged | Male | Rhinitis - drug therapy | Young Adult | Allergens - administration & dosage | Antigens, Dermatophagoides - administration & dosage | Asthma - immunology | Adrenergic beta-2 Receptor Agonists - therapeutic use | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Rhinitis - immunology | Double-Blind Method | Administration, Inhalation | Treatment Outcome | Asthma - drug therapy | Disease Progression | Dust | Animals | Adolescent | Quality of Life | Albuterol - therapeutic use | Aged | Adrenal Cortex Hormones - administration & dosage | Pyroglyphidae - immunology | Usage | Care and treatment | House-dust mite | Corticosteroids | Immunotherapy | Dosage and administration | Health aspects | Risk factors | Asthma | Side effects | Drug use | Allergies
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5. Full Text Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD
by Mäkelä, Mika J and Backer, Vibeke and Hedegaard, Morten and Larsson, Kjell
Respiratory Medicine, ISSN 0954-6111, 2013, Volume 107, Issue 10, pp. 1481 - 1490
Summary Suboptimal adherence to pharmacological treatment of asthma and chronic obstructive pulmonary disease (COPD) has adverse effects on disease control and... 
Pulmonary/Respiratory | Respiratory disease | Therapy regimens | Healthcare resources | Clinical outcomes | Quality of life | MILD ASTHMA | CARDIAC & CARDIOVASCULAR SYSTEMS | REPEATED INSTRUCTION | PERSISTENT ASTHMA | OBSTRUCTIVE PULMONARY-DISEASE | PEDIATRIC ASTHMA | RESPIRATORY SYSTEM | FLUTICASONE PROPIONATE/SALMETEROL COMBINATION | CORTICOSTEROID USE | INNER-CITY CHILDREN | MEDICATION ADHERENCE | ORAL MONTELUKAST | Medication Adherence | Health Care Costs - statistics & numerical data | Humans | Respiratory System Agents - administration & dosage | Respiratory System Agents - therapeutic use | Administration, Inhalation | Treatment Outcome | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - economics | Asthma - economics | Nebulizers and Vaporizers | Pulmonary Disease, Chronic Obstructive - drug therapy | Patient outcomes | Health care reform | Medical care | Respiratory agents | Patient compliance | Cost control | Asthma | Quality management | Medical care, Cost of | Studies | Chronic obstructive pulmonary disease | Patient satisfaction | Drug therapy | Mortality | Hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Medicin och hälsovetenskap | Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
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6. Full Text A daily SMS reminder increases adherence to asthma treatment: A three-month follow-up study
by Strandbygaard, Ulla and Thomsen, Simon Francis and Backer, Vibeke
Respiratory Medicine, ISSN 0954-6111, 2009, Volume 104, Issue 2, pp. 166 - 171
Summary Background Poor adherence to asthma treatment is a well-recognised challenge and is associated with increased morbidity, mortality and consumption of... 
Pulmonary/Respiratory | Adherence | Follow-up study | Treatment | Compliance | Telemedicine | Asthma | CARDIAC & CARDIOVASCULAR SYSTEMS | THERAPY | RESPIRATORY SYSTEM | ADULTS | CHILDREN | Medication Adherence - statistics & numerical data | Medication Adherence - psychology | Follow-Up Studies | Anti-Asthmatic Agents - therapeutic use | Humans | Middle Aged | Asthma - psychology | Male | Treatment Outcome | Asthma - drug therapy | Young Adult | Reminder Systems | Adolescent | Adult | Female | Cell Phone | Respiratory Function Tests | Respiratory agents | Patient compliance | Studies | Medicine | Patient education | Cellular telephones | Nitric oxide | Drug dosages | Chronic illnesses
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7. Full Text Early detection of COPD in primary care - The Copenhagen COPD Screening Project
by Lyngsø, Anne Marie and Backer, Vibeke and Gottlieb, Vibeke and Nybo, Birgitte and Østergaard, Marianne S and Frølich, Anne
BMC Public Health, ISSN 1471-2458, 2010, Volume 10, Issue 1, pp. 524 - 524
Background: Chronic Obstructive Pulmonary Disease (COPD) is among the leading causes of death in the world, and further increases in the prevalence and... 
POPULATION | DIAGNOSIS | OBSTRUCTIVE PULMONARY-DISEASE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HIGH-RISK | SMOKERS | GENERAL-PRACTICE | SPIROMETRY | ASTHMA | PRIMARY-HEALTH-CARE | Pulmonary Disease, Chronic Obstructive - diagnosis | Humans | Mass Screening - standards | Denmark - epidemiology | Surveys and Questionnaires | Primary Health Care | Program Evaluation | Respiratory Function Tests | National Health Programs | Early Diagnosis | Pulmonary Disease, Chronic Obstructive - epidemiology | Lung diseases, Obstructive | Care and treatment | Diagnosis | Research | Risk factors | Hospitals | Health services | Mortality | Questionnaires | Committees | Family physicians
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8. Full Text Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome
by Sverrild, Asger, MD, PhD and Kiilerich, Pia, MSc, PhD and Brejnrod, Asker, MSc and Pedersen, Rebecca, MSc, PhD and Porsbjerg, Celeste, MD, PhD and Bergqvist, Anders, MSc and Erjefält, Jonas S., MSc, PhD and Kristiansen, Karsten, MSc and Backer, Vibeke, MD, DMSc
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 140, Issue 2, pp. 407 - 417.e11
Background Asthmatic patients have higher microbiome diversity and an altered composition, with more Proteobacteria and less Bacteroidetes compared with... 
Allergy and Immunology | noneosinophilic asthma | asthma | Airway inflammation | bacteria | microbiome | bronchoalveolar lavage | ACTIVATION | HIGH-THROUGHPUT | MAST-CELLS | PATHOLOGY | MANNITOL | IMMUNOLOGY | OBSTRUCTIVE PULMONARY-DISEASE | ALLERGY | Eosinophilia - metabolism | Sputum - cytology | Asthma - metabolism | Eosinophilia - microbiology | Humans | Male | Eosinophils - immunology | Mannitol - pharmacology | Bronchoalveolar Lavage Fluid - microbiology | Forced Expiratory Volume | Young Adult | Microbiota | Asthma - immunology | Adult | DNA, Bacterial - analysis | Female | Leukocyte Count | Eosinophilia - physiopathology | Asthma - microbiology | Asthma - physiopathology | Neutrophils - immunology | Bacteria - genetics | Bacteria - isolation & purification | Eosinophilia - immunology | Nitric Oxide - metabolism | Inflammation | Asthma | Bacteria | Nitric oxide | Analysis | rRNA 16S | Image processing | Control methods | Diagnostic tests | Infections | Gene sequencing | Respiratory tract | Microorganisms | Bronchoalveolar lavage | Mannitol | Respiratory tract diseases | Alveoli | Deoxyribonucleic acid--DNA | Leukocytes (eosinophilic) | Lung diseases | Neutrophils | Bronchus | Abundance | Leukocytes (neutrophilic) | Gene expression | Patients | Eosinophilia | Image analysis | Biopsy | Sputum | Neutrophilia | DNA sequencing | Eosinophils | Indexing
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9. Full Text Laryngeal dysfunction: Assessment and management for the clinician
by Hull, James H and Backer, Vibeke and Gibson, Peter G and Fowler, Stephen J
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2016, Volume 194, Issue 9, pp. 1062 - 1072
The larynx is one of the most highly innervated organs in humans and serves a number of vitally important, complex, and highly evolved biological functions. On... 
Wheeze | Larynx | Vocal | Dyspnea | Cough | wheeze | vocal | TOXIN TYPE-A | dyspnea | VOCAL-CORD DYSFUNCTION | REFLEX SENSITIVITY | cough | BOTULINUM TOXIN | larynx | INHALED SODIUM CROMOGLYCATE | RESPIRATORY SYSTEM | INDUCED BRONCHOCONSTRICTION | EXERTIONAL DYSPNEA | PLACEBO-CONTROLLED TRIAL | FOLD MOVEMENT | REFRACTORY CHRONIC COUGH | CRITICAL CARE MEDICINE | Laryngeal Diseases - therapy | Laryngeal Diseases - diagnosis | Humans | Larynx - physiopathology | Laryngeal Diseases - physiopathology | Laryngeal Diseases - epidemiology | Laryngoscopy
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10. Full Text Asthma and the elite athlete: Summary of the International Olympic Committee's Consensus Conference, Lausanne, Switzerland, January 22-24, 2008
by Fitch, Kenneth D., MBBS, MD and Sue-Chu, Malcolm, MBChB, PhD and Anderson, Sandra D., PhD, DSc and Boulet, Louis-Philippe, MD, FCCP, FRCPC and Hancox, Robert J., MBChB, MD and McKenzie, Donald C., MD, PhD and Backer, Vibeke, MD, DMSci and Rundell, Kenneth W., PhD and Alonso, Juan M., MD and Kippelen, Pascale, PhD and Cummiskey, Joseph M., MD and Garnier, Alain, MD and Ljungqvist, Arne, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 122, Issue 2, pp. 254 - 260.e7
Respiratory symptoms cannot be relied on to make a diagnosis of asthma and/or airways hyperresponsiveness (AHR) in elite athletes. For this reason, the... 
Allergy and Immunology | airway hyperresponsiveness | environment | Respiratory symptoms | bronchial provocation | endurance training | asthma | exercise-induced bronchoconstriction | Olympic Games | β 2-agonists | agonists | BRONCHIAL HYPERRESPONSIVENESS | RESPIRATORY HEALTH SURVEY | AIRWAY INFLAMMATION | INHALED CORTICOSTEROIDS | IMMUNOLOGY | CROSS-COUNTRY SKIERS | INDUCED BRONCHOSPASM | respiratory symptoms | beta-agonists | ALLERGY | EUCAPNIC VOLUNTARY HYPERVENTILATION | FINE PARTICULATE MATTER | ICE HOCKEY PLAYERS | Asthma, Exercise-Induced - etiology | Bronchoconstriction - physiology | Asthma, Exercise-Induced - diagnosis | Humans | Bronchial Provocation Tests | Adrenergic beta-Agonists - therapeutic use | Asthma, Exercise-Induced - prevention & control | Adrenergic beta-Agonists - adverse effects | Asthma, Exercise-Induced - therapy | Sports | Olympic athletes | Respiratory agents | Conferences, meetings and seminars | Sports associations | Asthma | Ventilation | Physical fitness | Athletes | Gene expression | Olympic games
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11. Full Text Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study
by Sverrild, Asger, MD and Porsbjerg, Celeste, MD, PhD and Thomsen, Simon Francis, MD, PhD and Backer, Vibeke, MD, DMSc
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2010, Volume 126, Issue 5, pp. 952 - 958
Background Studies of selected patient groups have shown that airway hyperresponsiveness (AHR) to mannitol is more specific than methacholine for the diagnosis... 
Allergy and Immunology | airway hyperresponsiveness | epidemiology | inflammation | exhaled nitric oxide | diagnosis | mannitol | methacholine | Asthma | population | Methacholine | Exhaled nitric oxide | Mannitol | Population | Inflammation | Diagnosis | Epidemiology | Airway hyperresponsiveness | TESTS | RESPONSIVENESS | INHALED CORTICOSTEROIDS | SENSITIVITY | MARKERS | ASTHMATIC SUBJECTS | IMMUNOLOGY | CHALLENGE | ALLERGY | ADOLESCENTS | ATOPIC ASTHMA | Asthma - diagnosis | Bronchial Hyperreactivity - chemically induced | Bronchial Provocation Tests - methods | Cross-Sectional Studies | Area Under Curve | Humans | Male | Nitric Oxide - analysis | Young Adult | Sensitivity and Specificity | Adolescent | Female | ROC Curve | Bronchoconstrictor Agents | Exhalation | Nitric Oxide - metabolism | Methacholine Chloride | Respiratory agents | Nitric oxide | Studies
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12. Full Text Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients
by Silkoff, Philip E., MD and Laviolette, Michel, MD and Singh, Dave, MD and FitzGerald, J. Mark, MD and Kelsen, Steven, MD and Backer, Vibeke, MD and Porsbjerg, Celeste M., MD and Girodet, Pierre-Olivier, MD and Berger, Patrick, MD and Kline, Joel N., MD and Chupp, Geoffrey, MD and Susulic, Vedrana S., PhD and Barnathan, Elliot S., MD and Baribaud, Frédéric, PhD and Loza, Matthew J., PhD and Airways Dis Endotyping Personalize and Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 3, pp. 710 - 719
Background The Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study profiled patients with mild, moderate, and severe asthma and nonatopic... 
Allergy and Immunology | phenotypes | type 2 inflammation | airway mucosal gene expression | biomarkers | Asthma | CYTOKINES | MEPOLIZUMAB | EOSINOPHILS | VALIDATION | MONOCLONAL-ANTIBODY | IMMUNOLOGY | PERIOSTIN | EPITHELIAL-CELLS | ALLERGY | EXHALED NITRIC-OXIDE | EXPRESSION | EOTAXIN | Asthma - metabolism | Chemokines, CC - blood | Humans | Middle Aged | Interleukin-13 - immunology | Male | Cell Adhesion Molecules - immunology | Chemokine CCL26 | Eosinophils - immunology | Young Adult | Interleukin-13 - genetics | Asthma - blood | Respiratory Mucosa - immunology | Asthma - immunology | Chemokine CCL17 - immunology | Adult | Female | Chemokines, CC - immunology | Leukocyte Count | Chemokine CCL17 - blood | Biomarkers - metabolism | Severity of Illness Index | Cell Line | Gene Expression | Asthma - physiopathology | Biomarkers - blood | Adolescent | Respiratory Function Tests | Nitric Oxide - metabolism | Medical research | Genes | Immunoglobulin E | Inflammation | Gene expression | Cells | Homeopathy | Materia medica and therapeutics | Nitric oxide | Therapeutics | Medicine, Experimental | Biological markers | Cytokines | Leukocytes (eosinophilic) | Mucosa | Smooth muscle | Population studies | Interleukin 13 | Kinases | Patients | Respiratory tract | Biopsy | Cell lines | Biomarkers | Bioindicators | CCL17 protein | Chemokines
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13. Full Text The Prevalence of Severe Asthma and Low Asthma Control Among Danish Adults
by von Bülow, Anna, MD and Kriegbaum, Margit, MSc, PhD and Backer, Vibeke, MD, DMSc and Porsbjerg, Celeste, MD, PhD
Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 2014, Volume 2, Issue 6, pp. 759 - 767.e2
Background The prevalence of severe asthma is unknown. However, international expert statements estimate that severe asthma represents 5% to 10 % of the entire... 
Internal Medicine | Allergy and Immunology | asthma | Prescription data | Severe asthma | Asthma control | Asthma management | Asthma | MORTALITY | SPECIALIST CARE | MANAGEMENT | INHALED CORTICOSTEROIDS | VALIDATION | GENERAL-PRACTICE | IMMUNOLOGY | ORGANIZATION | ALLERGY | EXACERBATIONS | QUALITY-OF-LIFE | OUTCOMES | Health Resources - utilization | Ambulatory Care - utilization | Prevalence | Age Factors | Anti-Asthmatic Agents - therapeutic use | Humans | Male | Drug Utilization Review | Young Adult | Adult | Female | Registries | Emergency Service, Hospital - utilization | Referral and Consultation - utilization | Asthma - epidemiology | Asthma - diagnosis | Severity of Illness Index | Asthma - physiopathology | Cross-Sectional Studies | Treatment Outcome | Hospitalization | Lung - physiopathology | Asthma - drug therapy | Drug Prescriptions | Lung - drug effects | Adolescent | Denmark - epidemiology | Health Care Surveys | Studies | Prescription drugs | Classification | Population | Chronic obstructive pulmonary disease | Personal identification numbers | Drug dosages | Patients
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