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Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1458 - 1458
Abstract Background: Gilteritinib, a highly selective fms-like tyrosine kinase 3 (FLT3)/AXL inhibitor, demonstrated strong antileukemic activity at doses ≥80... 
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74653
The type III receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3) is expressed on both normal hematopoietic stem cells and acute myeloid leukemia (AML)... 
CELLS | SUBSTRATE-SPECIFICITY | PROTEIN | CONSTITUTIVELY ACTIVATED FLT3 | MULTIDISCIPLINARY SCIENCES | DEGRADATION | RECEPTOR | ENDOPLASMIC-RETICULUM | SERINE/THREONINE KINASES | INHIBITOR | UBIQUITIN-PROTEASOME PATHWAY | Cell Line | Phosphorylation | Cell Proliferation | Signal Transduction | Heat-Shock Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Proto-Oncogene Proteins c-pim-1 - metabolism | Endoplasmic Reticulum - metabolism | Glycosylation | Serine - metabolism | fms-Like Tyrosine Kinase 3 - metabolism | STAT5 Transcription Factor - metabolism | Tyrosine - metabolism | Animals | Mice | Calnexin - metabolism | Mutation | Proteasome Endopeptidase Complex - metabolism | Apoptosis | Tyrosine | Heat shock proteins | Hematopoietic stem cells | Cell proliferation | Hsp90 protein | Leukemia | Feedback loops | Chaperones | Kinases | Positive feedback | Cell surface | Proteins | Signal transduction | Reproduction (copying) | Rodents | Cell cycle | Protein-tyrosine kinase receptors | Inhibition | Protein-tyrosine kinase | Species | Half life | Immunoglobulins | Threonine | Myeloid leukemia | Radioactive half-life | Stat5 protein | Calnexin | Substrates | Medicine | Signaling | Stem cells | Powder injection molding | Flt3 protein | Protein-serine/threonine kinase | Aberration | Endoplasmic reticulum | Acute myeloid leukemia | Heat shock | Cancer
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 07/2019, Volume 132, Issue 7, pp. e616 - e617
Journal Article
British Journal of Haematology, ISSN 0007-1048, 11/2019
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2017, Volume 16, Issue 6, pp. 991 - 1001
The receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3), involved in regulating survival, proliferation, and differentiation of hematopoietic... 
AML | POTENT INHIBITOR | INTENSIVE CHEMOTHERAPY | PTK INHIBITORS | ONCOLOGY | PROMOTES RESISTANCE | RISK MYELODYSPLASTIC SYNDROME | KINASE INHIBITOR | MUTATIONS | SORAFENIB | PHASE-I | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Humans | Protein Multimerization | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Treatment Outcome | Clinical Trials as Topic | Tandem Repeat Sequences | fms-Like Tyrosine Kinase 3 - chemistry | fms-Like Tyrosine Kinase 3 - metabolism | Leukemia, Myeloid, Acute - mortality | fms-Like Tyrosine Kinase 3 - genetics | Drug Resistance, Neoplasm - genetics | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Protein Binding | Protein Interaction Domains and Motifs | Protein Kinase Inhibitors - pharmacology | Mutation | Drug Evaluation, Preclinical | Leukemia, Myeloid, Acute - genetics | Cell proliferation | Tyrosine | Drugs | Medical research | Cell survival | Myeloid leukemia | Leukemia | Clinical trials | Kinases | Survival | Patients | Progenitor cells | Proteasome inhibitors | Hemopoiesis | Signaling | Chemotherapy | Inhibitors | Cells (biology) | Protein-tyrosine kinase receptors | Flt3 protein | Acute myeloid leukemia | Protein-tyrosine kinase | Cancer | FLT3 internal tandem duplication | FLT3 point mutation | FLT3 inhibitors | acute myeloid leukemia | resistance
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3951 - 3951
Abstract Introduction: In 30% of acute myeloid leukemia (AML) patients, internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD) causes... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3763 - 3763
Acute myeloid leukemia (AML) patients unfit for intensive chemotherapy are treated with DNA methyltransferase inhibitors (DNMTis). However, while many AML... 
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 08/2018, Volume 131, Issue 8, pp. e337 - e338
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1276 - 1276
Introduction fms-like tyrosine like kinase 3 internal tandem duplication (FLT3-ITD), present in acute myeloid leukemia (AML) cells of 30% of patients, results... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 2307 - 2307
Introduction Painful vaso-occlusive crisis (VOC) is a hallmark of sickle cell disease (SCD). When the pain cannot be managed with home analgesics, patients... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4736 - 4736
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 08/2018, Volume 11, Issue 1, pp. 101 - 10
Background: Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4... 
Thrombocytopenia | Ruxolitinib | Janus kinase | Myelofibrosis | Transfusion | Anemia | SURVIVAL | EFFICACY | SAFETY | FOLLOW-UP | INCB018424 | ONCOLOGY | MUTATION | DOUBLE-BLIND | JAK2 | INHIBITOR | HEMATOLOGY | AVAILABLE THERAPY | Drugs | Dosage and administration | Research | Drug therapy | Spleen | Studies | Splenomegaly | Blood platelets | Risk groups | Clinical medicine | Patients | Quality of life | Tumors
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 5273 - 5273
Abstract Introduction Despite recent advances in treatment, acute myeloid leukemia (AML) remains difficult to cure with high rates of relapse.... 
Journal Article
Acta Haematologica, ISSN 0001-5792, 11/2019, Volume 142, Issue 4, pp. 233 - 238
Background: Venous thromboembolism (VTE) is a recognized complication of sickle cell disease (SCD), yet the optimal pharmacologic anticoagulant is unknown.... 
Original Paper | RISK-FACTORS | Oral anticoagulant | VTE | RIVAROXABAN | ADULTS | EXTENDED TREATMENT | Anticoagulation | APIXABAN | Sickle cell disease | HEMATOLOGY | Venous thromboembolism
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3886 - 3886
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous disease where malignant clonal proliferation of immature myeloid cells in the bone marrow... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2684 - 2684
Abstract Introduction Acute myeloid leukemia (AML) is a heterogeneous disease that depends on precise risk-stratification for predicting outcomes and... 
Journal Article
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