BMC Cancer, ISSN 1471-2407, 06/2012, Volume 12, Issue 1, pp. 271 - 271
Background: The aim was to compare two standard chemotherapy regimens combined with bevacizumab as first-line treatment in patients with metastatic colorectal...
Irinotecan | Chemotherapy | Capecitabine | Angiogenic markers | Colorectal cancer | Bevacizumab | COLON-CANCER | OSTEOPONTIN | ONCOLOGY | NITRIC-OXIDE | ORAL FLUOROPYRIMIDINES | BICC-C | EXPRESSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Osteopontin - blood | Leucovorin - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - administration & dosage | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Treatment Outcome | Biomarkers - blood | Angiogenic Proteins - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Care and treatment | Patient outcomes | Research | Comparative analysis | Cancer | Clinical trials | Leucovorin | Metastasis | Antineoplastic agents | Antimitotic agents | Cancer patients | Nitric oxide | Product development | Vascular endothelial growth factor | Growth factors
Irinotecan | Chemotherapy | Capecitabine | Angiogenic markers | Colorectal cancer | Bevacizumab | COLON-CANCER | OSTEOPONTIN | ONCOLOGY | NITRIC-OXIDE | ORAL FLUOROPYRIMIDINES | BICC-C | EXPRESSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Osteopontin - blood | Leucovorin - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - administration & dosage | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Treatment Outcome | Biomarkers - blood | Angiogenic Proteins - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Deoxycytidine - analogs & derivatives | Care and treatment | Patient outcomes | Research | Comparative analysis | Cancer | Clinical trials | Leucovorin | Metastasis | Antineoplastic agents | Antimitotic agents | Cancer patients | Nitric oxide | Product development | Vascular endothelial growth factor | Growth factors
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2006, Volume 354, Issue 7, pp. 709 - 718
In a prospective trial of interferon alfa-2b for malignant melanoma, autoantibodies and clinical manifestations of autoimmunity during treatment were...
INTERLEUKIN-2 | METASTATIC MELANOMA | MEDICINE, GENERAL & INTERNAL | THERAPY | HIGH-DOSE INTERFERON | THYROID-DYSFUNCTION | CHRONIC HEPATITIS-C | CUTANEOUS MELANOMA | CANCER | RENAL-CARCINOMA | COOPERATIVE-ONCOLOGY-GROUP | Autoimmunity | Recurrence | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Autoantibodies - blood | Humans | Middle Aged | Male | Recombinant Proteins | Skin Neoplasms - mortality | Adult | Female | Chemotherapy, Adjuvant | Adjuvants, Immunologic - therapeutic use | Skin Neoplasms - immunology | Interferon-alpha - therapeutic use | Proportional Hazards Models | Analysis of Variance | Melanoma - immunology | Melanoma - drug therapy | Survival Analysis | Aged | Neoplasm Staging | Melanoma - mortality | Melanoma | Interferon | Dosage and administration | Research | Drug therapy | Clinical trials | Oncology | Cytokines | Hypothyroidism
INTERLEUKIN-2 | METASTATIC MELANOMA | MEDICINE, GENERAL & INTERNAL | THERAPY | HIGH-DOSE INTERFERON | THYROID-DYSFUNCTION | CHRONIC HEPATITIS-C | CUTANEOUS MELANOMA | CANCER | RENAL-CARCINOMA | COOPERATIVE-ONCOLOGY-GROUP | Autoimmunity | Recurrence | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Autoantibodies - blood | Humans | Middle Aged | Male | Recombinant Proteins | Skin Neoplasms - mortality | Adult | Female | Chemotherapy, Adjuvant | Adjuvants, Immunologic - therapeutic use | Skin Neoplasms - immunology | Interferon-alpha - therapeutic use | Proportional Hazards Models | Analysis of Variance | Melanoma - immunology | Melanoma - drug therapy | Survival Analysis | Aged | Neoplasm Staging | Melanoma - mortality | Melanoma | Interferon | Dosage and administration | Research | Drug therapy | Clinical trials | Oncology | Cytokines | Hypothyroidism
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2008, Volume 9, Issue 10, pp. 962 - 972
Summary Background Somatic mutations of the k-RAS oncogene have been assessed as a mechanism of de-novo resistance to epidermal growth factor receptor (EGFR)...
Hematology, Oncology and Palliative Medicine | TYROSINE KINASE INHIBITORS | PHASE-III TRIAL | DISEASE-CONTROL | PROGNOSTIC-FACTOR | GROWTH-FACTOR-RECEPTOR | ONCOLOGY | KRAS MUTATION | IN-SITU HYBRIDIZATION | ACQUIRED-RESISTANCE | GEFITINIB TREATMENT | GENE COPY NUMBER | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Prognosis | Carcinoma, Non-Small-Cell Lung - genetics | Colonic Neoplasms - drug therapy | Humans | Antibodies, Monoclonal - therapeutic use | Colonic Neoplasms - secondary | Antineoplastic Agents - therapeutic use | Genetic Markers | Drug Resistance, Neoplasm - genetics | Likelihood Functions | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Genes, ras
Hematology, Oncology and Palliative Medicine | TYROSINE KINASE INHIBITORS | PHASE-III TRIAL | DISEASE-CONTROL | PROGNOSTIC-FACTOR | GROWTH-FACTOR-RECEPTOR | ONCOLOGY | KRAS MUTATION | IN-SITU HYBRIDIZATION | ACQUIRED-RESISTANCE | GEFITINIB TREATMENT | GENE COPY NUMBER | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Prognosis | Carcinoma, Non-Small-Cell Lung - genetics | Colonic Neoplasms - drug therapy | Humans | Antibodies, Monoclonal - therapeutic use | Colonic Neoplasms - secondary | Antineoplastic Agents - therapeutic use | Genetic Markers | Drug Resistance, Neoplasm - genetics | Likelihood Functions | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Genes, ras
Journal Article
BMC Cancer, ISSN 1471-2407, 02/2013, Volume 13, Issue 1, pp. 49 - 49
Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis...
PI3K gene mutations | Biomarkers | EGFR ligands | BRAF | KRAS | Cetuximab | Epidermal growth factor receptor | 1ST-LINE TREATMENT | LEUCOVORIN | EPIREGULIN | STATISTICS | FLUOROURACIL | CHEMOTHERAPY | BREAST-CANCER | PANITUMUMAB | MUTATION STATUS | ONCOLOGY | Colorectal Neoplasms - genetics | Humans | Middle Aged | Glycoproteins - metabolism | Male | Antineoplastic Agents - therapeutic use | Epiregulin | Amphiregulin | RNA, Messenger - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | EGF Family of Proteins | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Adenocarcinoma - genetics | Retrospective Studies | Colorectal Neoplasms - metabolism | Genes, ras - genetics | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Epidermal Growth Factor - metabolism | Genotype | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Phosphatidylinositol 3-Kinase - genetics | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - secondary | Aged | Drugs | Adverse and side effects | Research | Drug therapy | Patient outcomes | Colorectal cancer | Medical research | Care and treatment | Genes | Metastasis | Antineoplastic agents | Formaldehyde | Antimitotic agents | Messenger RNA | Epidermal growth factor | Codon | Gene mutations | Analysis | Monoclonal antibodies | Medicine, Experimental | Genetic aspects | Biological markers | Health aspects
PI3K gene mutations | Biomarkers | EGFR ligands | BRAF | KRAS | Cetuximab | Epidermal growth factor receptor | 1ST-LINE TREATMENT | LEUCOVORIN | EPIREGULIN | STATISTICS | FLUOROURACIL | CHEMOTHERAPY | BREAST-CANCER | PANITUMUMAB | MUTATION STATUS | ONCOLOGY | Colorectal Neoplasms - genetics | Humans | Middle Aged | Glycoproteins - metabolism | Male | Antineoplastic Agents - therapeutic use | Epiregulin | Amphiregulin | RNA, Messenger - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | EGF Family of Proteins | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Adenocarcinoma - genetics | Retrospective Studies | Colorectal Neoplasms - metabolism | Genes, ras - genetics | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Epidermal Growth Factor - metabolism | Genotype | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Phosphatidylinositol 3-Kinase - genetics | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - secondary | Aged | Drugs | Adverse and side effects | Research | Drug therapy | Patient outcomes | Colorectal cancer | Medical research | Care and treatment | Genes | Metastasis | Antineoplastic agents | Formaldehyde | Antimitotic agents | Messenger RNA | Epidermal growth factor | Codon | Gene mutations | Analysis | Monoclonal antibodies | Medicine, Experimental | Genetic aspects | Biological markers | Health aspects
Journal Article
BMC Medicine, ISSN 1741-7015, 01/2011, Volume 9, Issue 1, pp. 10 - 10
Background: Colon cancer is a public health problem worldwide. Adjuvant chemotherapy after surgical resection for stage III colon cancer has been shown to...
1ST-LINE TREATMENT | PLUS LEUCOVORIN | 5-FLUOROURACIL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | THERAPY | PERSPECTIVES | CAMPTOTHECINS | OXALIPLATIN | METASTATIC COLORECTAL-CANCER | FOLFIRI | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - therapeutic use | Dose-Response Relationship, Drug | Greece | Young Adult | Fluorouracil - therapeutic use | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Adult | Camptothecin - administration & dosage | Female | Leucovorin - therapeutic use | Chemotherapy, Adjuvant | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Camptothecin - therapeutic use | Kaplan-Meier Estimate | Treatment Outcome | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colonic Neoplasms - pathology | Aged | Neoplasm Staging | Chemotherapy | Usage | Colon cancer | Patient outcomes | Leucovorin | Drug therapy, Combination | Drug therapy | Health aspects | Fluorouracil | Cancer | Medical imaging | Heart attacks | Statistical analysis | Mortality | Colorectal cancer | Clinical trials | Histology | Cancer therapies | Manuscripts | Medicine | Hospitals | Tomography | Clinical medicine | Acquisitions & mergers | Index Medicus
1ST-LINE TREATMENT | PLUS LEUCOVORIN | 5-FLUOROURACIL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | THERAPY | PERSPECTIVES | CAMPTOTHECINS | OXALIPLATIN | METASTATIC COLORECTAL-CANCER | FOLFIRI | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antineoplastic Agents - therapeutic use | Dose-Response Relationship, Drug | Greece | Young Adult | Fluorouracil - therapeutic use | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Adult | Camptothecin - administration & dosage | Female | Leucovorin - therapeutic use | Chemotherapy, Adjuvant | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Camptothecin - therapeutic use | Kaplan-Meier Estimate | Treatment Outcome | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colonic Neoplasms - pathology | Aged | Neoplasm Staging | Chemotherapy | Usage | Colon cancer | Patient outcomes | Leucovorin | Drug therapy, Combination | Drug therapy | Health aspects | Fluorouracil | Cancer | Medical imaging | Heart attacks | Statistical analysis | Mortality | Colorectal cancer | Clinical trials | Histology | Cancer therapies | Manuscripts | Medicine | Hospitals | Tomography | Clinical medicine | Acquisitions & mergers | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, p. e0207707
In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic...
BENEFIT | MESSENGER-RNA EXPRESSION | RECOMMENDATIONS | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | QUANTITATIVE PCR | GROWTH-FACTOR RECEPTORS | PREDICTIVE-VALUE | HER2 | EGFR | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Care and treatment | Prognosis | RNA | Oncology, Experimental | Genes | Development and progression | Breast cancer | Metastasis | Research | Antineoplastic agents | Antimitotic agents | Cancer patients | Cancer | Health sciences | Laboratories | Copy number | Fluorescence | Oncology | Hybridization | Multivariate analysis | Paraffin | Subgroups | Metastases | Proteins | Receptors | Fluorescence in situ hybridization | HER protein | Paraffins | Medical research | Evaluation | Internal medicine | Epidermal growth factor receptors | Health risks | Gene expression | Patients | Survival | ErbB-2 protein | Medicine | Pathology | Gene amplification | Chemotherapy | Hospitals | Breast | Protein expression | PTEN protein | Trastuzumab
BENEFIT | MESSENGER-RNA EXPRESSION | RECOMMENDATIONS | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | QUANTITATIVE PCR | GROWTH-FACTOR RECEPTORS | PREDICTIVE-VALUE | HER2 | EGFR | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Care and treatment | Prognosis | RNA | Oncology, Experimental | Genes | Development and progression | Breast cancer | Metastasis | Research | Antineoplastic agents | Antimitotic agents | Cancer patients | Cancer | Health sciences | Laboratories | Copy number | Fluorescence | Oncology | Hybridization | Multivariate analysis | Paraffin | Subgroups | Metastases | Proteins | Receptors | Fluorescence in situ hybridization | HER protein | Paraffins | Medical research | Evaluation | Internal medicine | Epidermal growth factor receptors | Health risks | Gene expression | Patients | Survival | ErbB-2 protein | Medicine | Pathology | Gene amplification | Chemotherapy | Hospitals | Breast | Protein expression | PTEN protein | Trastuzumab
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e37946
Background: The aim of the present study was to investigate the efficacy of adjuvant dose-dense sequential chemotherapy with epirubicin, paclitaxel, and CMF in...
PHASE-III TRIAL | COOPERATIVE ONCOLOGY GROUP | NEOADJUVANT CHEMOTHERAPY | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | TISSUE MICROARRAYS | BRAIN METASTASES | RISK | DENSE SEQUENTIAL CHEMOTHERAPY | PROGNOSTIC VALUE | DOCETAXEL | Immunohistochemistry | Receptors, Estrogen - metabolism | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Methotrexate - therapeutic use | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Cyclophosphamide - therapeutic use | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Young Adult | Disease-Free Survival | Fluorouracil - therapeutic use | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Chemotherapy, Adjuvant - methods | Epirubicin - therapeutic use | Keratin-5 - metabolism | Adult | Female | Aged | Anthracyclines - therapeutic use | Medical research | Anthracyclines | Estrogen | Adjuvant treatment | Breast cancer | Metastasis | Keratin | Paclitaxel | Medicine, Experimental | Rankings | Progesterone | Health aspects | Cancer | Enrichment | Brain | Cytokeratin | Laboratories | Liver | Estrogens | Clinical trials | Estrogen receptors | Oncology | Nervous system | Paraffin | Cancer therapies | Subgroups | Metastases | Proteins | Cell growth | Mastectomy | Epirubicin | Drug dosages | Risk groups | Epidermal growth factor receptors | Health risks | Patients | Survival | ErbB-2 protein | Medicine | Studies | Pathology | Chemotherapy | Brain research | Hospitals | Anthracycline | Collaboration | Medical prognosis | Biomarkers | Trastuzumab | Tumors
PHASE-III TRIAL | COOPERATIVE ONCOLOGY GROUP | NEOADJUVANT CHEMOTHERAPY | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | TISSUE MICROARRAYS | BRAIN METASTASES | RISK | DENSE SEQUENTIAL CHEMOTHERAPY | PROGNOSTIC VALUE | DOCETAXEL | Immunohistochemistry | Receptors, Estrogen - metabolism | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Methotrexate - therapeutic use | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Cyclophosphamide - therapeutic use | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Young Adult | Disease-Free Survival | Fluorouracil - therapeutic use | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Chemotherapy, Adjuvant - methods | Epirubicin - therapeutic use | Keratin-5 - metabolism | Adult | Female | Aged | Anthracyclines - therapeutic use | Medical research | Anthracyclines | Estrogen | Adjuvant treatment | Breast cancer | Metastasis | Keratin | Paclitaxel | Medicine, Experimental | Rankings | Progesterone | Health aspects | Cancer | Enrichment | Brain | Cytokeratin | Laboratories | Liver | Estrogens | Clinical trials | Estrogen receptors | Oncology | Nervous system | Paraffin | Cancer therapies | Subgroups | Metastases | Proteins | Cell growth | Mastectomy | Epirubicin | Drug dosages | Risk groups | Epidermal growth factor receptors | Health risks | Patients | Survival | ErbB-2 protein | Medicine | Studies | Pathology | Chemotherapy | Brain research | Hospitals | Anthracycline | Collaboration | Medical prognosis | Biomarkers | Trastuzumab | Tumors
Journal Article
BMC Medicine, ISSN 1741-7015, 01/2010, Volume 8, Issue 1, pp. 3 - 3
Background: Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was...
WOMEN | 2ND-LINE | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | CLINICAL-TRIAL | RECURRENT | OVARIALKARZINOM AGO-OVAR | SCHEDULE | CARCINOMA | EPITHELIAL OVARIAN | CHEMOTHERAPY | Prognosis | Ovarian Neoplasms - diagnosis | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Carboplatin - administration & dosage | Paclitaxel - adverse effects | Polyethylene Glycols - adverse effects | Treatment Outcome | Polyethylene Glycols - administration & dosage | Carboplatin - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Doxorubicin - analogs & derivatives | Aged, 80 and over | Adult | Female | Aged | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Antimitotic agents | Research | Antineoplastic agents | Drug therapy | Health aspects | Ovarian cancer | Studies | Chemotherapy | Cancer | Index Medicus
WOMEN | 2ND-LINE | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | CLINICAL-TRIAL | RECURRENT | OVARIALKARZINOM AGO-OVAR | SCHEDULE | CARCINOMA | EPITHELIAL OVARIAN | CHEMOTHERAPY | Prognosis | Ovarian Neoplasms - diagnosis | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Carboplatin - administration & dosage | Paclitaxel - adverse effects | Polyethylene Glycols - adverse effects | Treatment Outcome | Polyethylene Glycols - administration & dosage | Carboplatin - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Doxorubicin - analogs & derivatives | Aged, 80 and over | Adult | Female | Aged | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Antimitotic agents | Research | Antineoplastic agents | Drug therapy | Health aspects | Ovarian cancer | Studies | Chemotherapy | Cancer | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2009, Volume 27, Issue 6, pp. 939 - 944
Purpose A high-dose interferon alfa (IFN-alpha) regimen as reported in E1684 was unique for the incorporation of an induction phase of maximally tolerated...
TRIAL | THERAPY | ONCOLOGY | AMERICAN JOINT COMMITTEE | COOPERATIVE-ONCOLOGY-GROUP | Skin Neoplasms - drug therapy | Drug Administration Schedule | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Recombinant Proteins | Interferon-alpha - administration & dosage | Time Factors | Melanoma - drug therapy | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Chemotherapy, Adjuvant | Melanoma - surgery | Skin Neoplasms - surgery | Index Medicus
TRIAL | THERAPY | ONCOLOGY | AMERICAN JOINT COMMITTEE | COOPERATIVE-ONCOLOGY-GROUP | Skin Neoplasms - drug therapy | Drug Administration Schedule | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Recombinant Proteins | Interferon-alpha - administration & dosage | Time Factors | Melanoma - drug therapy | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Chemotherapy, Adjuvant | Melanoma - surgery | Skin Neoplasms - surgery | Index Medicus
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 7/2012, Volume 134, Issue 1, pp. 353 - 362
In spite the close association of the triple-negative breast cancer immunophenotype with hereditary breast cancers and the BRCA1 pathway, there is a lack of...
Oncology | Hereditary breast–ovarian cancer | BRCA1 | Genetic testing | Medicine & Public Health | Triple-negative breast cancer | Hereditary breast-ovarian cancer | GENOMIC REARRANGEMENTS | FOUNDER MUTATIONS | ESTROGEN-RECEPTOR | PACLITAXEL | EPIRUBICIN | ONCOLOGY | RANDOMIZED PHASE-III | GERMLINE MUTATIONS | DENSE SEQUENTIAL CHEMOTHERAPY | YOUNG-WOMEN | CMF | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Carcinoma, Ductal, Breast - epidemiology | Genetic Testing | Prevalence | Hereditary Breast and Ovarian Cancer Syndrome - diagnosis | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Carcinoma, Lobular - epidemiology | Hereditary Breast and Ovarian Cancer Syndrome - metabolism | Patient Selection | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Lobular - genetics | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Carcinoma, Ductal, Breast - metabolism | Hereditary Breast and Ovarian Cancer Syndrome - genetics | Carcinoma, Lobular - diagnosis | Carcinoma, Ductal, Breast - diagnosis | BRCA1 Protein - genetics | Heterozygote | Aged | Carcinoma, Lobular - metabolism | Hereditary Breast and Ovarian Cancer Syndrome - epidemiology | Mutation | BRCA mutations | Oncology, Experimental | Breast cancer | Research | Toy industry | Genetic screening | Prevalence studies (Epidemiology) | Ovarian cancer | Analysis | DNA | Genetic aspects | Diagnosis | Cancer
Oncology | Hereditary breast–ovarian cancer | BRCA1 | Genetic testing | Medicine & Public Health | Triple-negative breast cancer | Hereditary breast-ovarian cancer | GENOMIC REARRANGEMENTS | FOUNDER MUTATIONS | ESTROGEN-RECEPTOR | PACLITAXEL | EPIRUBICIN | ONCOLOGY | RANDOMIZED PHASE-III | GERMLINE MUTATIONS | DENSE SEQUENTIAL CHEMOTHERAPY | YOUNG-WOMEN | CMF | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Carcinoma, Ductal, Breast - epidemiology | Genetic Testing | Prevalence | Hereditary Breast and Ovarian Cancer Syndrome - diagnosis | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Carcinoma, Lobular - epidemiology | Hereditary Breast and Ovarian Cancer Syndrome - metabolism | Patient Selection | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Lobular - genetics | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Carcinoma, Ductal, Breast - metabolism | Hereditary Breast and Ovarian Cancer Syndrome - genetics | Carcinoma, Lobular - diagnosis | Carcinoma, Ductal, Breast - diagnosis | BRCA1 Protein - genetics | Heterozygote | Aged | Carcinoma, Lobular - metabolism | Hereditary Breast and Ovarian Cancer Syndrome - epidemiology | Mutation | BRCA mutations | Oncology, Experimental | Breast cancer | Research | Toy industry | Genetic screening | Prevalence studies (Epidemiology) | Ovarian cancer | Analysis | DNA | Genetic aspects | Diagnosis | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0140293
Background The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon...
ANDROGEN RECEPTOR | PTEN LOSS | TRASTUZUMAB | SIGNALING PATHWAY | RANDOMIZED PHASE-III | MULTIDISCIPLINARY SCIENCES | FACTOR RECEPTOR 2 | TENSIN HOMOLOG | DENSE SEQUENTIAL CHEMOTHERAPY | ASSOCIATION | PACLITAXEL | Gene mutations | Adjuvant treatment | Physiological aspects | Breast cancer | Genetic aspects | Research | Drug therapy | Cancer | Immunohistochemistry | Statistical analysis | Carcinoma | Clinical trials | AKT protein | Histology | Statistical methods | Insulin-like growth factors | Kinases | Patients | ErbB-2 protein | Subgroups | 1-Phosphatidylinositol 3-kinase | Chemotherapy | Biomarkers | Breast | Sampling methods | Mutation | PTEN protein | Tumors
ANDROGEN RECEPTOR | PTEN LOSS | TRASTUZUMAB | SIGNALING PATHWAY | RANDOMIZED PHASE-III | MULTIDISCIPLINARY SCIENCES | FACTOR RECEPTOR 2 | TENSIN HOMOLOG | DENSE SEQUENTIAL CHEMOTHERAPY | ASSOCIATION | PACLITAXEL | Gene mutations | Adjuvant treatment | Physiological aspects | Breast cancer | Genetic aspects | Research | Drug therapy | Cancer | Immunohistochemistry | Statistical analysis | Carcinoma | Clinical trials | AKT protein | Histology | Statistical methods | Insulin-like growth factors | Kinases | Patients | ErbB-2 protein | Subgroups | 1-Phosphatidylinositol 3-kinase | Chemotherapy | Biomarkers | Breast | Sampling methods | Mutation | PTEN protein | Tumors
Journal Article