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PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e99404 - e99404
Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL... 
BCL-X-L | APOPTOSIS | POTENT | SMALL-MOLECULE INHIBITORS | MCL-1 | MULTIDISCIPLINARY SCIENCES | CHRONIC LYMPHOCYTIC-LEUKEMIA | BH3 MIMETIC ABT-737 | PROTEINS | ABT-263 | FAMILY | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Aniline Compounds - pharmacology | Sulfonamides - chemistry | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Antineoplastic Agents - chemistry | Mice, SCID | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Sulfonamides - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | bcl-X Protein - metabolism | RNA, Small Interfering - metabolism | Prevention | Proteins | Cancer | Tumors | Apoptosis | Cytochrome | Cell culture | Regulators | Animal models | Bax protein | Bcl-2 protein | Leukemia | Lung cancer | Values | Cancer therapies | Cytosol | Mitochondria | Bcl-x protein | Xenografts | Membrane potential | Small cell lung carcinoma | Internal medicine | Melanoma | Caspase | Pharmacology | Embryo fibroblasts | Tumor cell lines | Mcl-1 protein | Membrane proteins | Cytochrome c | Medicine | Inhibitors | Cell death | Cell lines | Lymphomas | Laboratory animals | Index Medicus
Journal Article
Zhongguo Dianji Gongcheng Xuebao = Proceedings of the CSEE, ISSN 0258-8013, 01/2019, Issue 1, p. 31
Cloud computing data center is the important electricity user. Its power consumption increases rapidly with the development of Internet and national digital... 
Cloud computing | Power consumption | Computation | Equipment costs | Electricity consumption | Machine learning | Computer centers | Business machines | Energy management | Artificial intelligence | Optimization
Journal Article
Cancer Research, ISSN 0008-5472, 05/2017, Volume 77, Issue 9, pp. 2476 - 2487
Journal Article
OncoTargets and Therapy, ISSN 1178-6930, 01/2018, Volume 11, p. 7301
Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key regulator of mitochondrial homeostasis. Frequent overexpression of... 
Prevention | Care and treatment | Leukemia | Drug resistance | Drug therapy | Tumor proteins | Vincristine | Cancer | Apoptosis
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 10/2008, Volume 41, Issue 10, pp. 1264 - 1277
Journal Article
Drug Discovery Today: Technologies, ISSN 1740-6749, 04/2019, Volume 31, pp. 43 - 51
The teolysis rgeting himeric (PROTAC) concept has provided an opportunity for the discovery and development of a completely new type of therapy involving... 
Proteins | Epigenetic inheritance | Drug discovery | College teachers | Proteolysis | Analysis
Journal Article
2018 IEEE 24th International Conference on Parallel and Distributed Systems (ICPADS), ISSN 1521-9097, 12/2018, Volume 2018-, pp. 433 - 440
In data center, the optimal server location selection is related to many factors, such as power, temperature and space location. In order to reduce the local... 
genetic algorithm | Data centers | Temperature distribution | Energy consumption | temperature and power sensing | deep learning | Cooling | energy optimization | Computational modeling | Servers | Optimization
Conference Proceeding
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 462 - 481
The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic "readers" and play a... 
CHEMISTRY, MEDICINAL | REACTIVATION | INFLAMMATION | STRATEGY | I-BET762 | DEGRADATION | PROTACS | INHIBITOR OTX015 | CANCER | E3 UBIQUITIN LIGASE | BRD4 | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 5074 - 5074
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e58935 - e58935
Chronic inflammation in the stomach induces metaplasia, the pre-cancerous lesion that precedes inflammation-driven neoplastic transformation. While Hedgehog... 
ACTIVATION | SONIC HEDGEHOG | SIGNALING PATHWAY | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | ATROPHIC GASTRITIS | IL-6 PRODUCTION | KAPPA-B | SUPPRESSOR-CELLS | CANCER | TUMOR MICROENVIRONMENT | Gastritis - metabolism | Oligonucleotide Array Sequence Analysis | Gastritis - genetics | Helicobacter Infections - prevention & control | Ki-67 Antigen - metabolism | Gene Expression Profiling | Antigens, CD - genetics | Helicobacter Infections - pathology | Antigens, CD - metabolism | Gastritis - pathology | Kruppel-Like Transcription Factors - metabolism | Gene Deletion | Gastritis - microbiology | Helicobacter Infections - metabolism | Cytokines - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Gene Expression Regulation - genetics | Mice, Transgenic | Helicobacter Infections - genetics | Carrier Proteins - genetics | Metaplasia | Animals | Carrier Proteins - metabolism | Ki-67 Antigen - genetics | Myeloid Cells - metabolism | Helicobacter felis | Mice | Zinc Finger Protein GLI1 | Myeloid Cells - pathology | Chronic Disease | Kruppel-Like Transcription Factors - genetics | Cytokines - biosynthesis | Infection | DNA microarrays | Analysis | Genes | Helicobacter infections | Inflammation | Cell differentiation | Health aspects | Transformation | Infections | Kinases | Stomach cancer | CD45 antigen | Interleukin 6 | Immunology | Clonal deletion | Rodents | Gastroenterology | Deletion | Neck | Gastric cancer | CD11c antigen | Stomach | Dysplasia | Myeloid cells | CD11b antigen | Cytokines | Internal medicine | Stat3 protein | Tumor necrosis factor-α | Gene expression | Gastritis | Medicine | Signaling | Hedgehog protein | Transformations | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 20, pp. 5855 - 5865
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14_Supplement, pp. 1250 - 1250
Bromodomain and extraterminal (BET) proteins, such as bromodomain-containing protein 2 (BRD2), BRD3 and BRD4, bind lysine acetylated proteins and regulate gene... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4664 - 4682
Journal Article