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Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 11/2019, Volume 33, Issue 21, pp. 1643 - 1651
Rationale The complexity of central nervous system (CNS) drug delivery is the main obstacle with the blood–brain barrier (BBB) known to restrict access of most... 
Spectroscopy | Brain | Antiretroviral drugs | Drug delivery systems | Cerebral cortex | Central nervous system | Ions | Liquid chromatography | Desorption | Chromatography | Spatial distribution | Penetration | Ionization | Scientific imaging | Mass spectrometry | Deposition | Pharmaceuticals
Journal Article
Journal Article
Journal of Molecular Histology, ISSN 1567-2379, 8/2019, Volume 50, Issue 4, pp. 295 - 303
As the HIV epidemic continues to contribute to global morbidity and mortality, the prevalence of HIV-associated neurological disorders (HAND) also continues to... 
Life Sciences | Biomedicine, general | Drug distribution | Rilpivirine | Mass spectrometry imaging | Central nervous system | Developmental Biology | Cell Biology | VISUALIZATION | LC-MS | EFAVIRENZ | EMTRICITABINE | RESISTANCE | CEREBRAL-CORTEX | TENOFOVIR | CELL BIOLOGY | Neurocognitive Disorders - etiology | Reverse Transcriptase Inhibitors - blood | Humans | Rilpivirine - analysis | Rats | Rilpivirine - pharmacokinetics | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Brain - metabolism | Tandem Mass Spectrometry | Reverse Transcriptase Inhibitors - pharmacokinetics | Rilpivirine - therapeutic use | Animals | Neurocognitive Disorders - virology | Rilpivirine - blood | HIV Infections - complications | Chromatography, Liquid | Female | HIV Infections - drug therapy | Reverse Transcriptase Inhibitors - therapeutic use | Highly active antiretroviral therapy | Nervous system diseases | Ionization | Mortality | DNA polymerases | Liquid chromatography | Catalysis | Drug therapy | HIV (Viruses) | Mass spectrometry | Prevalence studies (Epidemiology) | Neuroimaging | Antiretroviral drugs | RNA-directed DNA polymerase | Cortex | Ions | Mass spectroscopy | Cognition | Hypothalamus | Hand | Morbidity | Corpus callosum | Antiretroviral therapy | Neurological diseases | Spatial distribution | Non-nucleoside reverse transcriptase inhibitors | Neurodegeneration | Nucleoside reverse transcriptase inhibitors | Human immunodeficiency virus--HIV | Thalamus | Scientific imaging | Localization
Journal Article
Journal of Molecular Histology, ISSN 1567-2379, 12/2019, Volume 50, Issue 6, pp. 593 - 599
Central nervous system (CNS) HIV infection causes brain tissue inflammation and tissue deficit that contributes to neuroAIDS. This complication is escalated by... 
Life Sciences | Biomedicine, general | BBB | Pharmacokinetics and mass spectrometric imaging | HIV | CNS | Developmental Biology | NeuroAIDS | Cell Biology | Neuroimaging | Antiretroviral drugs | Nevirapine | Blood-brain barrier | Neurodegeneration | Human immunodeficiency virus--HIV | Central nervous system | Mass spectroscopy | Localization
Journal Article
Assay and Drug Development Technologies, ISSN 1540-658X, 10/2019, Volume 17, Issue 7, pp. 322 - 329
The central nervous system has been identified as an anatomical reservoir for HIV due the difficulties in delivering therapeutic agents into the brain and this... 
Drugs | Neuroimaging | Brain | Spectroscopy | Cerebral cortex | Cortex | Central nervous system | Globus pallidus | Ions | Lamivudine | Mass spectroscopy | Cognition | Liquid chromatography | Pharmacology | Chemical compounds | Corpus callosum | Blood-brain barrier | Neurodegeneration | Human immunodeficiency virus--HIV | Neostriatum | Scientific imaging | Pharmacokinetics | Mass spectrometry | Zidovudine
Journal Article
Journal Article
Placenta, ISSN 0143-4004, 08/2019, Volume 83, pp. e73 - e73
Journal Article
RSC Advances, 01/2018, Volume 8, Issue 22, pp. 11902 - 11907
Bedaquiline (BDQ) is the first-in-class United States Food and Drug Administration (US FDA) approved anti-tuberculosis (anti-TB) drug, which is a novel... 
Spectroscopy | Brain | Regulatory agencies | Drug delivery systems | Central nervous system | Ions | Liquid chromatography | Desorption | Chemotherapy | Tuberculosis | Antibiotics | Ionization | Rodents | Mass spectrometry
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1451 - 1456
Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five... 
thermodynamics | HIV | inhibitor | mutant | Protease | HIV Protease Inhibitors - pharmacology | Thermodynamics | HIV Protease - drug effects | HIV Protease - genetics | Inhibitory Concentration 50 | HIV Protease Inhibitors - chemistry | HIV-1 - enzymology | Molecular Docking Simulation | Kinetics | Mutation | HIV Protease - metabolism | protease | hiv
Journal Article
Xenobiotica; the fate of foreign compounds in biological systems, ISSN 0049-8254, 08/2019, pp. 1 - 10
HIV replication in the brain is unopposed due to reduced antiretroviral drug penetration into the central nervous system (CNS). Prevalence of HIV-associated... 
Index Medicus
Journal Article
Physical chemistry chemical physics : PCCP, ISSN 1463-9076, 01/2020
It is well known that understanding the catalytic mechanism of HIV-1 PR is the rationale on which its inhibitors were developed; therefore, a better... 
Journal Article
Journal of Molecular Histology, ISSN 1567-2379, 8/2017, Volume 48, Issue 4, pp. 285 - 292
Journal Article
Journal of Molecular Histology, ISSN 1567-2379, 8/2016, Volume 47, Issue 4, pp. 429 - 435
Journal Article
Journal of Psychiatric Research, ISSN 0022-3956, 05/2019, Volume 112, pp. 7 - 11
Journal Article