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1. Full Text Interferon alpha/beta receptor-deficient mice as a model for ebola virus disease
by Brannan, Jennifer M and Froude, Jeffery W and Prugar, Laura I and Bakken, Russell R and Zak, Samantha E and Daye, Sharon P and Wilhelmsen, Catherine E and Dye, John M
Journal of Infectious Diseases, ISSN 0022-1899, 10/2015, Volume 212, Issue 7, p. S282
Genetically modified mice | Ebola virus infections | Care and treatment | Usage | Interferon | Research
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2. Full Text A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses
by Wec, Anna Z and Nyakatura, Elisabeth K and Herbert, Andrew S and Howell, Katie A and Holtsberg, Frederick W and Bakken, Russell R and Mittler, Eva and Christin, John R and Shulenin, Sergey and Jangra, Rohit K and Bharrhan, Sushma and Kuehne, Ana I and Bornholdt, Zachary A and Flyak, Andrew I and Saphire, Erica Ollmann and Crowe, James E and Aman, M. Javad and Dye, John M and Lai, Jonathan R and Chandran, Kartik
Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6310, pp. 350 - 354
The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8(+) T cell responses. Reports of... 
NIEMANN-PICK C1 | PAN-EBOLAVIRUS | MARBURG VIRUS | VIRUS ENTRY REQUIRES | MULTIDISCIPLINARY SCIENCES | DISEASE | RECEPTOR | SUDAN VIRUSES | INFECTION | GLYCOPROTEIN | EBOLA-VIRUS | Endosomes - virology | Immunotherapy - methods | Hemorrhagic Fever, Ebola - prevention & control | Humans | Antibodies, Bispecific - immunology | Ebolavirus - immunology | Virus Internalization | Hemorrhagic Fever, Ebola - therapy | Antibodies, Neutralizing - immunology | Animals | Binding Sites - immunology | Cell Line, Tumor | Receptors, Virus - immunology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Mice | Mice, Inbred BALB C | Membrane Glycoproteins - immunology | Antibodies, Monoclonal - immunology | Carrier Proteins - immunology | Ebola virus | Prevention | Monoclonal antibodies | Physiological aspects | Ebola virus infections | Immunotherapy | Receptors | Viral diseases | Antibodies | Viruses | Strategy | Malware | Binding sites | Endosomes
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3. Full Text Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses
by Wec, Anna Z and Herbert, Andrew S and Murin, Charles D and Nyakatura, Elisabeth K and Abelson, Dafna M and Fels, J. Maximilian and He, Shihua and James, Rebekah M and de La Vega, Marc-Antoine and Zhu, Wenjun and Bakken, Russell R and Goodwin, Eileen and Turner, Hannah L and Jangra, Rohit K and Zeitlin, Larry and Qiu, Xiangguo and Lai, Jonathan R and Walker, Laura M and Ward, Andrew B and Dye, John M and Chandran, Kartik and Bornholdt, Zachary A
Cell, ISSN 0092-8674, 05/2017, Volume 169, Issue 5, pp. 878 - 890.e15
Experimental monoclonal antibody (mAb) therapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-specific... 
Ebola virus | mouse | infection | ebolavirus | EBOV | neutralization | protection | ferret | human broadly neutralizing antibodies | 15878 | ENTRY REQUIRES | POTENT | COMPLEX | NEUTRALIZING ANTIBODIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | DISEASE | EBOLA-VIRUS GLYCOPROTEIN | ENDOSOMAL CYSTEINE PROTEASES | MEDIATED NEUTRALIZATION | INFECTION | CELL BIOLOGY | Humans | Cercopithecus aethiops | Ebolavirus - immunology | Antibodies, Neutralizing - immunology | Hemorrhagic Fever, Ebola - virology | Ebola Vaccines - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Vero Cells | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Ebolavirus - classification | Survivors | Models, Molecular | Ferrets | Antibodies, Viral - isolation & purification | Antibodies, Neutralizing - isolation & purification | Cross Reactions | Sequence Alignment | Animals | Antibodies, Neutralizing - chemistry | Antibodies, Viral - chemistry | Antibodies, Viral - immunology | Mice | Mice, Inbred BALB C | Kinetics | Antiviral agents | Medical research | Medical colleges | Microbiology | Communicable diseases | Protection and preservation | Machinery | Magneto-electric machines | Monoclonal antibodies | Medicine, Experimental | Health aspects | Antigenic determinants | Resveratrol
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4. Full Text Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
by Bekerman, Elena and Neveu, Gregory and Shulla, Ana and Brannan, Jennifer and Pu, Szu-Yuan and Wang, Stanley and Xiao, Fei and Barouch-Bentov, Rina and Bakken, Russell R and Mateo, Roberto and Govero, Jennifer and Nagamine, Claude M and Diamond, Michael S and De Jonghe, Steven and Herdewijn, Piet and Dye, John M and Randall, Glenn and Einav, Shirit
Journal of Clinical Investigation, ISSN 0021-9738, 04/2017, Volume 127, Issue 4, pp. 1338 - 1352
Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by... 
CELL LUNG-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CLATHRIN-MEDIATED ENDOCYTOSIS | SUNITINIB PLUS ERLOTINIB | TYROSINE KINASE | HEPATITIS-C-VIRUS | CROSS-REACTIVITY | ANTITUMOR-ACTIVITY | DENGUE VIRUS | SORTING SIGNALS | ZIKA VIRUS | Ebolavirus - metabolism | Hemorrhagic Fever, Ebola - prevention & control | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mice, 129 Strain | Virus Internalization - drug effects | Hepacivirus - metabolism | Adaptor Protein Complex 1 - metabolism | Ebolavirus - drug effects | Adaptor Protein Complex 2 - metabolism | Hemorrhagic Fever, Ebola - virology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | Hepatitis C - prevention & control | Protein-Serine-Threonine Kinases - metabolism | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Dengue Virus - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Dengue - virology | Dengue - prevention & control | Protein Transport | Drug Synergism | Pyrroles - pharmacology | Animals | Erlotinib Hydrochloride - pharmacology | Hepatitis C - virology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Dengue Virus - metabolism | Antimitotic agents | Virus diseases | Enzymes | Patient outcomes | Regulation | Host-virus relationships | Antineoplastic agents | Drug therapy | Health aspects | Pathogens | Medical research | Phosphorylation | Viruses | Infections | Roles | Grants | Kinases | Drug resistance | Experiments | Proteins | Studies | Ebola virus | Hypotheses | Infectious diseases | Laboratory animals | Charitable foundations | Viral infections | Cancer
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5. Full Text Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus
by Andrew S. Herbert and Ana I. Kuehne and James F. Barth and Ramon A. Ortiz and Donald K. Nichols and Samantha E. Zak and Spencer W. Stonier and Majidat A. Muhammad and Russell R. Bakken and Laura I. Prugar and Gene G. Olinger and Jennifer L. Groebner and John S. Lee and William D. Pratt and Max Custer and Kurt I. Kamrud and Jonathan F. Smith and Mary Kate Hart and John M. Dye
Journal of Virology, ISSN 0022-538X, 05/2013, Volume 87, Issue 9, pp. 4952 - 4964
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
IMMUNIZATION | MARBURG VIRUS | VIROLOGY | RNA | HEMORRHAGIC-FEVER | DISEASE | ALPHAVIRUS VECTORS | INFECTION | GUINEA-PIGS | EXPRESSION | FAMILY | Viral Envelope Proteins - genetics | Hemorrhagic Fever, Ebola - prevention & control | Humans | Vaccination | Viral Vaccines - genetics | Macaca fascicularis | Viral Envelope Proteins - administration & dosage | Ebolavirus - genetics | Ebolavirus - immunology | Genetic Vectors - genetics | Viral Vaccines - administration & dosage | Encephalitis Virus, Venezuelan Equine - physiology | Animals | Encephalitis Virus, Venezuelan Equine - genetics | Hemorrhagic Fever, Ebola - virology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Genetic Vectors - physiology | Hemorrhagic Fever, Ebola - immunology | Viral Vaccines - immunology | Replicon | Vaccines and Antiviral Agents
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6. Full Text High-Resolution Functional Mapping of the Venezuelan Equine Encephalitis Virus Genome by Insertional Mutagenesis and Massively Parallel Sequencing
: e1001146
by Brett F Beitzel and Russell R Bakken and Jeffrey M Smith and Connie S Schmaljohn
PLoS Pathogens, ISSN 1553-7366, 10/2010, Volume 6, Issue 10
  We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis... 
Proteins | Studies | Microbiology | Mutagenesis | Viruses | Genomes | Mutation | RNA polymerase | Experiments | Molecular weight
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7. Full Text Interferon α/β Receptor-Deficient Mice as a Model for Ebola Virus Disease
by Brannan, Jennifer M and Froude, Jeffery W and Prugar, Laura I and Bakken, Russell R and Zak, Samantha E and Daye, Sharon P and Wilhelmsen, Catherine E and Dye, John M
Journal of Infectious Diseases, ISSN 0022-1899, 10/2015, Volume 212, Issue suppl 2, pp. S282 - S294
A major obstacle in ebolavirus research is the lack of a small-animal model for Sudan virus (SUDV), as well as other wild-type (WT) ebolaviruses. Here, we... 
Ebola virus | Sudan virus | pathogenesis | coagulopathy | mouse model | Ebola virus disease | FAVIPIRAVIR | INFECTIOUS DISEASES | PROTECTION | MICROBIOLOGY | GUINEA-PIGS | IMMUNOLOGY | T-CELL RESPONSES | HEMORRHAGIC-FEVER | SUDAN | RESISTANCE | INFECTION | Cell Line | Ebolavirus - metabolism | Vero Cells - virology | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Glycoproteins - metabolism | Viral Proteins - immunology | Cercopithecus aethiops | Ebolavirus - pathogenicity | Replicon - immunology | Viral Proteins - metabolism | Glycoproteins - immunology | Animals | Vaccination - methods | Hemorrhagic Fever, Ebola - virology | Virulence - immunology | Virulence - physiology | Antibodies, Viral - immunology | Ebola Vaccines - immunology | Mice | Disease Models, Animal
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8. Full Text Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice
by Lehrer, Axel T and Wong, Teri-Ann S and Lieberman, Michael M and Humphreys, Tom and Clements, David E and Bakken, Russell R and Hart, Mary Kate and Pratt, William D and Dye, John M
Vaccine, ISSN 0264-410X, 2017, Volume 36, Issue 22, pp. 3090 - 3100
Abstract Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural... 
Allergy and Immunology | VP24 | Subunit vaccine | VP40 | Recombinant subunit proteins | Zaire ebolavirus | NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | DENDRITIC CELLS | PARTICLES | I INTERFERON RESPONSE | INSECT CELLS | VACCINE | IMMUNOLOGY | MARBURG VIRUSES | HEMORRHAGIC-FEVER | STIMULATING ACTIVITY | Ebolavirus | Adjuvants, Immunologic - administration & dosage | Hemorrhagic Fever, Ebola - prevention & control | Viral Proteins - immunology | Vaccines, Subunit - immunology | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Animals | Immunity, Humoral | Ebola Vaccines - immunology | Female | Viral Envelope Proteins - immunology | Hemorrhagic Fever, Ebola - immunology | Mice | Mice, Inbred BALB C | Viral Matrix Proteins - immunology | Immunity, Cellular | Antibodies, Neutralizing - blood | Medical research | Medical colleges | Hemorrhagic fever | Immune response | Mortality | Disease susceptibility | Recombinant proteins | Homeopathy | Materia medica and therapeutics | Ebola virus | Analysis | Therapeutics | Medicine, Experimental | Health aspects | VP24 protein | Adaptive systems | Disease | Pathogenesis | VP40 protein | Viral diseases | Clinical trials | Viruses | Infections | Vaccines | Hemorrhage | Proteins | Replicating | Lymphocytes | Recombinant | Immune system | Thrombocytopenia | Glycoprotein | Bioterrorism | Immune response (humoral) | Immunogenicity | Insects | Lymphopenia | Viral infections
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9. Full Text Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses
by Frei, Julia C and Nyakatura, Elisabeth K and Zak, Samantha E and Bakken, Russell R and Chandran, Kartik and Dye, John M and Lai, Jonathan R
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 19193
Filoviruses (Ebola and Marburg) cause severe hemorrhagic fever. There are five species of ebolavirus; among these, the Ebola (Zaire) and Sudan viruses (EBOV... 
NONHUMAN-PRIMATES | PROPHYLAXIS | MARBURG VIRUS | SYNTHETIC ANTIBODIES | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ENVELOPE GLYCOPROTEIN | INFECTION | MONOCLONAL-ANTIBODIES | NEUTRALIZATION | Cell Line | Ebolavirus - classification | Hemorrhagic Fever, Ebola - prevention & control | Humans | Antibody Affinity - immunology | Neutralization Tests | Antibodies, Bispecific - immunology | Ebolavirus - immunology | Cross Reactions | Antibodies, Neutralizing - immunology | Animals | Hemorrhagic Fever, Ebola - virology | Antibodies, Viral - chemistry | Protein Engineering | Post-Exposure Prophylaxis | Protein Binding | Antibodies, Bispecific - chemistry | Antibodies, Viral - immunology | Mice | Disease Models, Animal | Ebola virus | Epidemics | Hemorrhagic fever | Antibodies | Viruses | Outbreaks | Epitopes | Hemorrhage | Bispecific antibodies
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10. Full Text Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins
by Nyakatura, Elisabeth K and Zak, Samantha E and Wec, Anna Z and Hofmann, Daniel and Shulenin, Sergey and Bakken, Russell R and Javad Aman, M and Chandran, Kartik and Dye, John M and Lai, Jonathan R
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 6201 - 6211
Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high... 
NONHUMAN-PRIMATES | ENTRY REQUIRES | EBOLAVIRUSES | MARBURG VIRUS | STRUCTURAL BASIS | HUMAN SURVIVOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EBOLA-VIRUS GLYCOPROTEIN | SUDAN VIRUSES | FAMILY FILOVIRIDAE | BROAD PROTECTION | Humans | Mice, Inbred C57BL | Viral Proteins - immunology | Male | Antibodies, Neutralizing - genetics | Antibodies, Monoclonal - isolation & purification | Antibodies, Bispecific - genetics | Antibodies, Bispecific - immunology | Ebolavirus - immunology | Mice, Knockout | Epitopes - immunology | Antibodies, Monoclonal - genetics | Antibodies, Neutralizing - immunology | Glycoproteins - immunology | Animals | Protein Engineering | Marburgvirus - immunology | Antibodies, Viral - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Receptor, Interferon alpha-beta - genetics | Antibodies, Monoclonal - immunology | antibody engineering | Ebola virus | Protein Structure and Folding | protein engineering | antibody | multifunctional protein | infectious disease | immunotherapy | antiviral agent
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11. Full Text Human polyclonal antibodies produced through DNA vaccination of transchromosomal cattle provide mice with post-exposure protection against lethal zaire and Sudan ebolaviruses
by Bounds, Callie E and Kwilas, Steven A and Kuehne, Ana I and Brannan, Jennifer M and Bakken, Russell R and Dye, John M and Hooper, Jay W and Dupuy, Lesley C and Ellefsen, Barry and Hannaman, Drew and Wu, Hua and Jiao, Jin-An and Sullivan, Eddie J and Schmaljohn, Connie S and Schnell, Matthias Johannes
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137786
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and... 
NONHUMAN-PRIMATES | EBOLA-VIRUS-INFECTION | DEFECTIVE INTERFERING VIRUS | PROPHYLAXIS | CHALLENGE | ELECTROPORATION | PARTICLES | HEMORRHAGIC-FEVER | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | INFLUENZA | Antibodies, Viral - metabolism | Hemorrhagic Fever, Ebola - prevention & control | Animals, Genetically Modified | Humans | Post-Exposure Prophylaxis - methods | Sudan | Vaccines, DNA - immunology | Cattle - genetics | Ebolavirus - immunology | Cattle - immunology | Mice, Knockout | Antibodies, Neutralizing - immunology | Animals | Vaccination - methods | Hemorrhagic Fever, Ebola - virology | Ebola Vaccines - immunology | Female | Chromosomes, Artificial, Human - genetics | Mice | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | Democratic Republic of the Congo | Ebola virus | Virus diseases | Prevention | Research | Virus research | Epidemics | Immunoglobulin G | Vaccination | Antibodies | Viruses | Infections | DNA vaccines | Vaccines | Immunology | Cattle | Deoxyribonucleic acid--DNA | Polyclonal antibodies | Enzyme-linked immunosorbent assay | Recombinant | Antigens | Medical research | Immunoglobulins | Glycoprotein | Electroporation | Exposure | Artificial chromosomes | Injection | Gene expression | Fever | Virology | Stomatitis | Infectious diseases | Influenza | Neutralizing | Interferon | Neutralization | Deoxyribonucleic acid | DNA
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12. Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses: e0137786
by Bounds, Callie E and Kwilas, Steven A and Kuehne, Ana I and Brannan, Jennifer M and Bakken, Russell R and Dye, John M and Hooper, Jay W and Dupuy, Lesley C and Ellefsen, Barry and Hannaman, Drew
PLoS ONE, 09/2015, Volume 10, Issue 9
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and... 
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13. Full Text 1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus
by Gupta, Paridhi and Sharma, Anuj and Spurgers, Kevin B and Bakken, Russell R and Eccleston, Lori T and Cohen, Jeffrey W and Honnold, Shelley P and Glass, Pamela J and Maheshwari, Radha K
Vaccine, ISSN 0264-410X, 2016, Volume 34, Issue 25, pp. 2762 - 2765
Highlights • INA-iV3526 provided complete protection against aerosol challenge. • Immunization with INA-iV3526 triggered a strong antibody response. • IM route... 
Allergy and Immunology | Inactivated | Vaccine | Iodonaphthyl azide | Protection | Aerosol challenge | Venezuelan equine encephalitis | NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | STRUCTURAL INTEGRITY | VEEV | ANTIBODY | IMMUNOLOGY | PRESERVATION | RESPONSES | INFECTION | VACCINES | Encephalomyelitis, Venezuelan Equine - prevention & control | Immunoglobulin G - blood | Neutralization Tests | Antibodies, Viral - blood | Azides - chemistry | Viral Vaccines - administration & dosage | Encephalitis Virus, Venezuelan Equine | Vaccines, Inactivated - immunology | Animals | Vaccination - methods | Vaccines, Inactivated - administration & dosage | Aerosols | Mice | Viral Vaccines - immunology | Viral antibodies | Antibodies | Encephalitis | Virulence (Microbiology) | Medical research | Equine encephalomyelitis | Immune response | Communicable diseases | Medicine, Experimental | Survival analysis | Health sciences | Immunization | Colleges & universities | Conflicts of interest | Viruses | Standard deviation | Vaccines | Laboratory animals
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14. Full Text Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge
by Honnold, Shelley P and Bakken, Russell R and Fisher, Diana and Lind, Cathleen M and Cohen, Jeffrey W and Eccleston, Lori T and Spurgers, Kevin B and Maheshwari, Radha K and Glass, Pamela J
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e104708
Currently, there are no FDA-licensed vaccines or therapeutics for eastern equine encephalitis virus (EEEV) for human use. We recently developed several methods... 
PRESERVATION | RESPONSES | IMMUNOGENICITY | STRUCTURAL INTEGRITY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ALPHAVIRUS ENCEPHALITIS | IMMUNE INTERFERENCE | INFECTION | GLYCOPROTEIN | VENEZUELAN | Gamma Rays | Immunity, Mucosal - immunology | Encephalomyelitis, Equine - prevention & control | Formaldehyde - chemistry | Vaccination | Encephalomyelitis, Equine - immunology | Azides - chemistry | Encephalitis Virus, Eastern Equine - classification | Antibodies, Neutralizing - immunology | Vaccines, Attenuated - immunology | Animals | Encephalitis Virus, Eastern Equine - immunology | Antibodies, Viral - immunology | Female | Mice | Mice, Inbred BALB C | Viral Vaccines - immunology | Encephalitis | Health sciences | Medical research | Schedules | Cloning | Immunoglobulin G | Clinical trials | Viruses | Infections | Glycoproteins | Vaccines | Gene expression | Immunoglobulin A | Eastern equine encephalitis | Virology | Proteins | Infectious diseases | Immunogenicity | Influenza | Horses | Aerosols | Mutation
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15. Full Text Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage
by Fenimore, Paul W and Muhammad, Majidat A and Fischer, William M and Foley, Brian T and Bakken, Russell R and Thurmond, James R and Yusim, Karina and Yoon, Hyejin and Parker, Michael and Hart, Mary Kate and Dye, John M and Korber, Bette and Kuiken, Carla
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e44769
We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the... 
RESPONSES | IMMUNITY | HEMORRHAGIC-FEVER | MULTIDISCIPLINARY SCIENCES | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | EBOLA | BREADTH | Hepacivirus - immunology | Humans | AIDS Vaccines - immunology | Viral Proteins - immunology | Drug Design | Ebola Vaccines - immunology | Female | Epitopes, T-Lymphocyte - immunology | Filoviridae Infections - immunology | T-Lymphocytes, Cytotoxic - immunology | Computational Biology - methods | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Filoviridae - metabolism | Ebola Vaccines - administration & dosage | Cross Reactions - immunology | Viral Vaccines - administration & dosage | Viral Hepatitis Vaccines - immunology | Filoviridae - immunology | Animals | Filoviridae Infections - prevention & control | Filoviridae Infections - virology | Survival Analysis | Antibodies, Viral - immunology | Mice | Viral Vaccines - immunology | AIDS vaccines | Analysis | Ebola virus infections | T cells | Hepatitis C virus | HIV (Viruses) | Recombinant proteins | Antigenic determinants | Epidemics | Viral diseases | Cytotoxicity | Outbreaks | Viruses | Lymphocytes T | Biology | Infections | Vaccines | Regulatory approval | Genetic algorithms | Design | Proteins | Ebola virus | Hepatitis | Taxa | Biomedical materials | Human immunodeficiency virus--HIV | Phylogenetics | Biocompatibility | Strains (organisms) | Species | Recombinant |