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Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6310, pp. 350 - 354
Journal Article
Cell, ISSN 0092-8674, 05/2017, Volume 169, Issue 5, pp. 878 - 890.e15
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2017, Volume 127, Issue 4, pp. 1338 - 1352
Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by... 
CELL LUNG-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | CLATHRIN-MEDIATED ENDOCYTOSIS | SUNITINIB PLUS ERLOTINIB | TYROSINE KINASE | HEPATITIS-C-VIRUS | CROSS-REACTIVITY | ANTITUMOR-ACTIVITY | DENGUE VIRUS | SORTING SIGNALS | ZIKA VIRUS | Ebolavirus - metabolism | Hemorrhagic Fever, Ebola - prevention & control | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mice, 129 Strain | Virus Internalization - drug effects | Hepacivirus - metabolism | Adaptor Protein Complex 1 - metabolism | Ebolavirus - drug effects | Adaptor Protein Complex 2 - metabolism | Hemorrhagic Fever, Ebola - virology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | Hepatitis C - prevention & control | Protein-Serine-Threonine Kinases - metabolism | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Dengue Virus - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Dengue - virology | Dengue - prevention & control | Protein Transport | Drug Synergism | Pyrroles - pharmacology | Animals | Erlotinib Hydrochloride - pharmacology | Hepatitis C - virology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Dengue Virus - metabolism | Antimitotic agents | Virus diseases | Enzymes | Patient outcomes | Regulation | Host-virus relationships | Antineoplastic agents | Drug therapy | Health aspects | Pathogens | Medical research | Phosphorylation | Viruses | Infections | Roles | Grants | Kinases | Drug resistance | Experiments | Proteins | Studies | Ebola virus | Hypotheses | Infectious diseases | Laboratory animals | Charitable foundations | Viral infections | Cancer
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2010, Volume 6, Issue 10
  We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis... 
Proteins | Studies | Microbiology | Mutagenesis | Viruses | Genomes | Mutation | RNA polymerase | Experiments | Molecular weight
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 36, Issue 22, pp. 3090 - 3100
Abstract Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural... 
Allergy and Immunology | VP24 | Subunit vaccine | VP40 | Recombinant subunit proteins | Zaire ebolavirus | NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | DENDRITIC CELLS | PARTICLES | I INTERFERON RESPONSE | INSECT CELLS | VACCINE | IMMUNOLOGY | MARBURG VIRUSES | HEMORRHAGIC-FEVER | STIMULATING ACTIVITY | Ebolavirus | Adjuvants, Immunologic - administration & dosage | Hemorrhagic Fever, Ebola - prevention & control | Viral Proteins - immunology | Vaccines, Subunit - immunology | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Animals | Immunity, Humoral | Ebola Vaccines - immunology | Female | Viral Envelope Proteins - immunology | Hemorrhagic Fever, Ebola - immunology | Mice | Mice, Inbred BALB C | Viral Matrix Proteins - immunology | Immunity, Cellular | Antibodies, Neutralizing - blood | Medical research | Medical colleges | Hemorrhagic fever | Immune response | Mortality | Disease susceptibility | Recombinant proteins | Homeopathy | Materia medica and therapeutics | Ebola virus | Analysis | Therapeutics | Medicine, Experimental | Health aspects | VP24 protein | Adaptive systems | Disease | Pathogenesis | VP40 protein | Viral diseases | Clinical trials | Viruses | Infections | Vaccines | Hemorrhage | Proteins | Replicating | Lymphocytes | Recombinant | Immune system | Thrombocytopenia | Glycoprotein | Bioterrorism | Immune response (humoral) | Immunogenicity | Insects | Lymphopenia | Viral infections
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137786
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and... 
NONHUMAN-PRIMATES | EBOLA-VIRUS-INFECTION | DEFECTIVE INTERFERING VIRUS | PROPHYLAXIS | CHALLENGE | ELECTROPORATION | PARTICLES | HEMORRHAGIC-FEVER | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | INFLUENZA | Antibodies, Viral - metabolism | Hemorrhagic Fever, Ebola - prevention & control | Animals, Genetically Modified | Humans | Post-Exposure Prophylaxis - methods | Sudan | Vaccines, DNA - immunology | Cattle - genetics | Ebolavirus - immunology | Cattle - immunology | Mice, Knockout | Antibodies, Neutralizing - immunology | Animals | Vaccination - methods | Hemorrhagic Fever, Ebola - virology | Ebola Vaccines - immunology | Female | Chromosomes, Artificial, Human - genetics | Mice | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | Democratic Republic of the Congo | Ebola virus | Virus diseases | Prevention | Research | Virus research | Epidemics | Immunoglobulin G | Vaccination | Antibodies | Viruses | Infections | DNA vaccines | Vaccines | Immunology | Cattle | Deoxyribonucleic acid--DNA | Polyclonal antibodies | Enzyme-linked immunosorbent assay | Recombinant | Antigens | Medical research | Immunoglobulins | Glycoprotein | Electroporation | Exposure | Artificial chromosomes | Injection | Gene expression | Fever | Virology | Stomatitis | Infectious diseases | Influenza | Neutralizing | Interferon | Neutralization | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, 09/2015, Volume 10, Issue 9
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and... 
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e44769
We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the... 
RESPONSES | IMMUNITY | HEMORRHAGIC-FEVER | MULTIDISCIPLINARY SCIENCES | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | EBOLA | BREADTH | Hepacivirus - immunology | Humans | AIDS Vaccines - immunology | Viral Proteins - immunology | Drug Design | Ebola Vaccines - immunology | Female | Epitopes, T-Lymphocyte - immunology | Filoviridae Infections - immunology | T-Lymphocytes, Cytotoxic - immunology | Computational Biology - methods | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Filoviridae - metabolism | Ebola Vaccines - administration & dosage | Cross Reactions - immunology | Viral Vaccines - administration & dosage | Viral Hepatitis Vaccines - immunology | Filoviridae - immunology | Animals | Filoviridae Infections - prevention & control | Filoviridae Infections - virology | Survival Analysis | Antibodies, Viral - immunology | Mice | Viral Vaccines - immunology | AIDS vaccines | Analysis | Ebola virus infections | T cells | Hepatitis C virus | HIV (Viruses) | Recombinant proteins | Antigenic determinants | Epidemics | Viral diseases | Cytotoxicity | Outbreaks | Viruses | Lymphocytes T | Biology | Infections | Vaccines | Regulatory approval | Genetic algorithms | Design | Proteins | Ebola virus | Hepatitis | Taxa | Biomedical materials | Human immunodeficiency virus--HIV | Phylogenetics | Biocompatibility | Strains (organisms) | Species | Recombinant |