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1. Full Text SYNDROMES OF KETOSIS-PRONE DIABETES
by Balasubramanyam, Ashok
Transactions of the American Clinical and Climatological Association, ISSN 0065-7778, 2019, Volume 130, pp. 145 - 155
Ketosis-prone diabetes (KPD) is a heterogeneous condition characterized by patients who present with diabetic ketoacidosis but lack the phenotype of autoimmune... 
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2. Full Text The role of the immune system in obesity and insulin resistance
by Patel, Payal S and Buras, Eric D and Balasubramanyam, Ashok
Journal of Obesity, ISSN 2090-0708, 2013, Volume 2013, pp. 616193 - 9
The innate immune system provides organisms with rapid and well-coordinated protection from foreign pathogens. However, under certain conditions of metabolic... 
Intra-Abdominal Fat - immunology | Macrophages - physiology | Intra-Abdominal Fat - physiopathology | Signal Transduction | Humans | Adipose Tissue - physiopathology | Cell Death - immunology | Obesity - physiopathology | Inflammation - immunology | Lipolysis | Fatty Acids, Nonesterified - metabolism | Immune System - physiopathology | Insulin Resistance - physiology | Chronic Disease | Macrophages - immunology | Obesity | Complications and side effects | Physiological aspects | Insulin resistance | Research | Risk factors | Immune system | Review
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3. Full Text The villain with a thousand faces
by Balasubramanyam, Ashok
Journal of Diabetes and Its Complications, ISSN 1056-8727, 2014, Volume 28, Issue 4, pp. 434 - 435
Endocrinology & Metabolism | SUBTYPE | ENDOCRINOLOGY & METABOLISM | BETA | Genetic Predisposition to Disease | Animals | Diabetes Mellitus, Type 2 - physiopathology | Models, Biological | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - therapy | Combined Modality Therapy | Diabetes Mellitus, Type 2 - complications | Diabetes Complications - prevention & control | Precision Medicine
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4. Full Text Response to Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of “A+” Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637–2640
by Mulukutla, Surya N and Acevedo-Calado, Maria and Hampe, Christiane S and Pietropaolo, Massimo and Balasubramanyam, Ashok
Diabetes Care, ISSN 0149-5992, 05/2019, Volume 42, Issue 5, pp. e82 - e83
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5. Full Text Autoantibodies to the IA-2 extracellular domain refine the definition of “A+” subtypes of ketosis-prone diabetes
by Mulukutla, Surya N and Acevedo-Calado, Maria and Hampe, Christiane S and Pietropaolo, Massimo and Balasubramanyam, Ashok
Diabetes Care, ISSN 0149-5992, 12/2018, Volume 41, Issue 12, pp. 2637 - 2640
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6. Full Text Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine
by Sekhar, Rajagopal V and Mckay, Siripoom V and Patel, Sanjeet G and Guthikonda, Anuradha P and Reddy, Vasumathi T and Balasubramanyam, Ashok and Jahoor, Farook
Diabetes Care, ISSN 0149-5992, 01/2011, Volume 34, Issue 1, pp. 162 - 167
OBJECTIVE- Sustained hyperglycemia is associated with low cellular levels of the antioxidant glutathione (GSH), which leads to tissue damage attributed to... 
ADULTS | OXIDATIVE STRESS | GLYCEMIC CONTROL | LIPID-PEROXIDATION | ANTIOXIDANT STATUS | ENDOCRINOLOGY & METABOLISM | Glycine - therapeutic use | Glutathione - biosynthesis | Cysteine - therapeutic use | Humans | Middle Aged | Diabetes Mellitus, Type 2 - diet therapy | Female | Male | Diabetes Mellitus, Type 2 - metabolism | Dietary Supplements | Type 2 diabetes | Antioxidants | Hyperglycemia | Diet therapy | Thiols | Metabolites | Dietary supplements | Amino acids | Peroxides | Research | Proteins | Oxidative stress | Plasma | Nutrition research | Rodents | Diabetes | Clinical medicine | Kinases | Isotopes | Original Research
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7. Full Text Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
by Abdelmalek, Manal F and Lazo, Mariana and Horska, Alena and Bonekamp, Susanne and Lipkin, Edward W and Balasubramanyam, Ashok and Bantle, John P and Johnson, Richard J and Diehl, Anna Mae and Clark, Jeanne M and Look AHEAD Res Grp and Fatty Liver Subgroup of Look AHEAD Research Group and and the Fatty Liver Subgroup of the Look AHEAD Research Group
Hepatology, ISSN 0270-9139, 09/2012, Volume 56, Issue 3, pp. 952 - 960
Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic... 
METABOLIC SYNDROME | FATTY LIVER-DISEASE | CIRRHOSIS | DEPLETION | NONALCOHOLIC STEATOHEPATITIS | BEVERAGES | GASTROENTEROLOGY & HEPATOLOGY | URIC-ACID LEVEL | ATP | P-31 MR SPECTROSCOPY | CONSUMPTION | Dietary Carbohydrates - administration & dosage | Obesity - complications | Humans | Middle Aged | Homeostasis | Male | Obesity - physiopathology | Diabetes Mellitus, Type 2 - physiopathology | Female | Adenosine Triphosphate - physiology | Sweetening Agents - administration & dosage | Diabetes Mellitus, Type 2 - complications | Fructose - administration & dosage | Diabetes | Liver cirrhosis | Rodents | Hepatology
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8. Full Text Intensive Glycemic Control in the Intensive Care Unit: Promises and Pitfalls
by Balasubramanyam, Ashok
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 02/2009, Volume 94, Issue 2, pp. 416 - 417
VARIABILITY | SEPSIS | ILL PATIENTS | TIGHT GLUCOSE CONTROL | ENDOCRINOLOGY & METABOLISM | INSULIN THERAPY | Blood Glucose - drug effects | Critical Care - methods | Hypoglycemic Agents - therapeutic use | Intensive Care Units | Humans | Critical Illness - therapy | Insulin - administration & dosage | Blood Glucose - metabolism | Insulin - therapeutic use
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9. Full Text The Malnourished Heart: An unusual case of heart failure
by Bruera, Sebastian, MD and Kalakota, Neeharika Reddy, MD and Balasubramanyam, Ashok, MD
American Journal of Medicine, The, ISSN 0002-9343, 2017, Volume 130, Issue 7, pp. e297 - e298
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2017.01.027 Byline: Sebastian Bruera, Neeharika Reddy... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | Heart failure
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10. Full Text Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes
by Mulukutla, Surya N and Tersey, Sarah A and Hampe, Christiane S and Mirmira, Raghavendra G and Balasubramanyam, Ashok
Journal of Diabetes and Its Complications, ISSN 1056-8727, 02/2018, Volume 32, Issue 2, pp. 193 - 195
A + β + ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA... 
Ketosis prone diabetes | Diabetic Ketoacidosis | Insulin DNA | Islet dysfunction | Beta cell death | beta cell death | islet dysfunction | insulin DNA
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11. Full Text Evaluation and management of ketosis-prone diabetes
by Gaba, Ruchi and Mehta, Paras and Balasubramanyam, Ashok
Expert Review of Endocrinology & Metabolism, ISSN 1744-6651, 01/2019, Volume 14, Issue 1, pp. 43 - 48
Introduction: Patients presenting with diabetic ketoacidosis (DKA) who lack the classic phenotype of autoimmune type 1 diabetes have become increasingly... 
beta cell | Atypical diabetes | diabetic ketoacidosis | classification | autoantibodies | C-peptide
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12. Full Text Thiazolidinediones: A review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability
by Vasudevan, Abu R and Balasubramanyam, Ashok
Diabetes Technology and Therapeutics, ISSN 1520-9156, 12/2004, Volume 6, Issue 6, pp. 850 - 863
The thiazolidinediones (TZDs) rosiglitazone and pioglitazone are newer additions to the antidiabetic armamentarium and are indicated for the treatment of type... 
Hypoglycemic Agents - therapeutic use | Islets of Langerhans - drug effects | Humans | Blood Glucose - drug effects | Insulin - metabolism | Thiazolidinediones - therapeutic use | Hypoglycemic Agents - administration & dosage | Islets of Langerhans - metabolism | Lipids - blood | PPAR gamma - agonists | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Thiazolidinediones - pharmacology | Insulin Secretion
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13. Full Text Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes
by Mulukutla, Surya N and Acevedo-Calado, Maria and Hampe, Christiane S and Pietropaolo, Massimo and Balasubramanyam, Ashok
Diabetes care, ISSN 0149-5992, 12/2018, Volume 41, Issue 12, p. 2637
Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the... 
Autoantibodies - blood | Humans | Middle Aged | Male | Diabetes Mellitus, Type 1 - complications | Young Adult | Sensitivity and Specificity | Immunoassay - methods | Adult | Female | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - chemistry | Protein Domains - immunology | Child | Diabetes Mellitus, Type 2 - complications | Diagnosis, Differential | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology | Reproducibility of Results | Biomarkers - blood | Diabetic Ketoacidosis - diagnosis | Diabetic Ketoacidosis - blood | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 1 - blood | Diabetic Ketoacidosis - classification | Adolescent | Cohort Studies | Autoantibodies | Research | Diabetes | Membrane proteins
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14. Full Text Preserved Beta-Cell Function during Acute DKA in Ketosis-Prone Diabetes
by MEHTA, PARAS B and MULUKUTLA, SURYA N and HSU, JEAN W and KEENE, KELLY R and RAM, NALINI and BALASUBRAMANYAM, ASHOK
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1782
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15. Evaluation and management of ketosis-prone diabetes
by Gaba, Ruchi and Mehta, Paras and Balasubramanyam, Ashok
Expert review of endocrinology & metabolism, 01/2019, Volume 14, Issue 1, p. 43
Patients presenting with diabetic ketoacidosis (DKA) who lack the classic phenotype of autoimmune type 1 diabetes have become increasingly identified in recent... 
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16. Full Text Effectiveness of a Group-Based Culturally Tailored Lifestyle Intervention Program on Changes in Risk Factors for Type 2 Diabetes among Asian Indians in the United States
by Patel, Rupal M and Misra, Ranjita and Raj, Sudha and Balasubramanyam, Ashok
Journal of Diabetes Research, ISSN 2314-6745, 2017, Volume 2017, pp. 2751980 - 13
This study used an experimental, pretest-posttest control group repeated measures design to evaluate the effectiveness of a community-based culturally... 
MEDICINE, RESEARCH & EXPERIMENTAL | COMMUNITY | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | IMPAIRED GLUCOSE-TOLERANCE | BODY-MASS INDEX | PREVENTION-PROGRAM | PHYSICAL-ACTIVITY | AFRICAN-AMERICANS | POWER ANALYSIS PROGRAM | SOUTH ASIANS | Life Style | Body Weight | United States | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Risk Factors | Diabetes Mellitus, Type 2 - prevention & control | India - ethnology | Male | Treatment Outcome | Culturally Competent Care | Health Behavior | Diabetes Mellitus, Type 2 - ethnology | Exercise | Waist Circumference - physiology | Weight Loss - physiology | Adult | Female | Aged
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17. Full Text Prevalence of diabetes, metabolic syndrome, and cardiovascular risk factors in US Asian Indians: results from a national study
by Misra, Ranjita and Patel, Thakor and Kotha, Purushotham and Raji, Annaswamy and Ganda, Om and Banerji, MaryAnn and Shah, Viral and Vijay, Kris and Mudaliar, Sundar and Iyer, Dinakar and Balasubramanyam, Ashok
Journal of Diabetes and Its Complications, ISSN 1056-8727, 2010, Volume 24, Issue 3, pp. 145 - 153
Abstract Background Although studies of immigrant Asian Indians in other countries show high rates of diabetes (DM), metabolic syndrome (MetS), and... 
Endocrinology & Metabolism | Metabolic syndrome | CVD risk factors | Diabetes prevalence | Asian Indian | GLUCOSE-INTOLERANCE | MELLITUS | PHYSICIANS | BODY-FAT PATTERN | OBESITY | INSULIN-RESISTANCE | DISEASE | ENDOCRINOLOGY & METABOLISM | ASSOCIATION | United States - epidemiology | Prevalence | Cholesterol - blood | Humans | Middle Aged | Male | Young Adult | Aged, 80 and over | Cardiovascular Diseases - epidemiology | Adult | Cholesterol, LDL - blood | Female | C-Reactive Protein - analysis | Prediabetic State - epidemiology | Metabolic Syndrome - epidemiology | Blood Glucose - analysis | Risk Factors | Homocysteine - blood | Waist Circumference | Diabetes Mellitus - epidemiology | Adolescent | Sex Factors | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Asian Americans
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18. Full Text Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques
by Couturier, Jacob and Agarwal, Neeti and Nehete, Pramod N and Baze, Wallace B and Barry, Michael A and Jagannadha Sastry, K and Balasubramanyam, Ashok and Lewis, Dorothy E
Retrovirology, ISSN 1742-4690, 04/2016, Volume 13, Issue 1, p. 30
Background: HIV reservoirs pose major challenges to viral eradication. The main cellular reservoirs include CD4 T cells and macrophages, whereas anatomic... 
Rhesus macaques | SIV reservoirs | HIV reservoirs | CD4 T cells | Adipose tissue | HIV latency | PROTEIN | CD4(+) T-CELLS | HUMAN-IMMUNODEFICIENCY-VIRUS | ADIPOGENESIS | OBESITY | VIROLOGY | INSULIN-RESISTANCE | INFLAMMATION | PERSISTENT HIV-1 REPLICATION | EXPRESSION | LYMPHOCYTE-ACTIVATION | Simian Immunodeficiency Virus - isolation & purification | Simian Acquired Immunodeficiency Syndrome - virology | Animals | Adipose Tissue - virology | Polymerase Chain Reaction | DNA, Viral - analysis | Female | Male | Macaca mulatta | Leukocytes, Mononuclear - virology | Simian Immunodeficiency Virus - physiology | Adipose tissues | Complications and side effects | Care and treatment | Physiological aspects | Research | Simian immunodeficiency virus | HIV infection
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19. Full Text Accuracy and Predictive Value of Classification Schemes for Ketosis-Prone Diabetes
by Ashok Balasubramanyam and Gilberto Garza and Lucille Rodriguez and Christiane S. Hampe and Lakshmi Gaur and Åke Lernmark and Mario R. Maldonado
Diabetes Care, ISSN 0149-5992, 12/2006, Volume 29, Issue 12, pp. 2575 - 2579
Accuracy and Predictive Value of Classification Schemes for Ketosis-Prone Diabetes Ashok Balasubramanyam , MD 1 2 , Gilberto Garza , MD 1 2 , Lucille Rodriguez... 
DIAGNOSTIC-TEST | ARTICLE | USERS GUIDES | ENDOCRINOLOGY & METABOLISM | MEDICAL LITERATURE | KETOACIDOSIS | AFRICAN-AMERICANS | TYPE-1 | OBESE | NORMOGLYCEMIC REMISSION | NIDDM | Body Mass Index | Obesity | Predictive Value of Tests | Reproducibility of Results | Diabetes Mellitus, Type 1 - classification | Humans | Age of Onset | Adult | Female | Male | Thinness | Longitudinal Studies | Diabetic acidosis | Practice guidelines (Medicine) | Complications and side effects | Ketoacidosis | Medical research | Accuracy | Diabetes | Clinical outcomes | Classification
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20. Full Text HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: Implications for HIV-specific pathogenesis of NAFLD
by Agarwal, Neeti and Iyer, Dinakar and Gabbi, Chiara and Saha, Pradip and Patel, Sanjeet G and Mo, Qianxing and Chang, Benny and Goswami, Biman and Schubert, Ulrich and Kopp, Jeffrey B and Lewis, Dorothy E and Balasubramanyam, Ashok
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 13362 - 15
HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and... 
TRIGLYCERIDE TRANSFER PROTEIN | ACTIVATED-RECEPTOR-ALPHA | RISK-FACTORS | ACID | GENE | DE-NOVO LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | DISEASE | ELEMENT-BINDING PROTEIN | RETINOID-X-RECEPTOR | HUMAN-IMMUNODEFICIENCY-VIRUS | Liver Function Tests | HIV Infections - genetics | HIV Infections - virology | Gene Expression Regulation | Non-alcoholic Fatty Liver Disease - etiology | Lipid Metabolism | Male | Mice, Transgenic | PPAR alpha - genetics | Liver X Receptors - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Gene Products, vpr - metabolism | Hepatocytes - metabolism | Animals | HIV-1 - physiology | HIV Infections - complications | Non-alcoholic Fatty Liver Disease - diagnosis | Mice | PPAR alpha - metabolism | Liver X Receptors - genetics | Disease Models, Animal | Alkaline phosphatase | Adipose tissue | Liver diseases | Liver X receptors | Glucocorticoids | Liver | Transgenic mice | Bilirubin | Gene expression | Fatty acids | Lipoproteins (very low density) | Steatosis | Proteins | Vpr protein | Fatty liver | Hepatocytes | Diacylglycerol O-acyltransferase | Rodents | Human immunodeficiency virus--HIV | Oxidation | Lipogenesis
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