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Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 112
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2019, Volume 37, Issue 1, pp. 33 - 41
Journal Article
Stem Cells, ISSN 1066-5099, 01/2019, Volume 37, Issue 1, p. 33
Pancreatic [beta]-cells are the only source of insulin. Disturbances in [beta]-cell development or function may thus result in insulin deficiency or excess,... 
Journal Article
Population, Space and Place, ISSN 1544-8444, 05/2019, Volume 25, Issue 4, pp. e2239 - n/a
Analyses of health and mortality disparities between today's urban and rural populations appear to be exclusively focused on vastly urbanising countries. By... 
small area differences | urban population | mixed effects survival model | urban environment | urbanicity | SMALL AREAS | CITIES | TIME | DEMOGRAPHY | URBANIZATION | IMPACT | DISEASES | HEALTH | GEOGRAPHY | Mortality | Analysis | Census | Rural urban differences | Urban population | Homogeneity | Hazards | Risk factors
Journal Article
Diabetologia, ISSN 0012-186X, 8/2019, Volume 62, Issue 8, pp. 1329 - 1336
Journal Article
Stem Cell Reports, ISSN 2213-6711, 09/2015, Volume 5, Issue 3, pp. 448 - 459
CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion... 
SYSTEM | CRISPR | TALE | PROTEIN | REPRESSION | TRANSCRIPTION | CAS9 | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cellular Reprogramming Techniques | Humans | Adolescent | CRISPR-Cas Systems | Gene Expression Regulation | HEK293 Cells | Female | Male | Aged | Cell Differentiation | Cellular Reprogramming
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 12
CRISPR-Cas9-based gene activation (CRISPRa) is an attractive tool for cellular reprogramming applications due to its high multiplexing capacity and direct... 
STEM-CELLS | MULTIDISCIPLINARY SCIENCES | SINGLE-CELL TRANSCRIPTOME | GENERATION | DIFFERENTIATION | ENHANCERS | REGULATORY ELEMENTS | EXPRESSION | FIBROBLASTS | GENOME | MEDIATED REGULATION | Multiplexing | CRISPR | Oct-4 protein | Activation | Genomes | Myc protein | KLF4 protein | Somatic cells | Stem cells | Fibroblasts | Skin | Pluripotency | Inhibitory postsynaptic potentials
Journal Article
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2018, Volume 10, Issue 1, pp. 13 - 21
DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous... 
Spinal cord | Interneurons | Disease | Gene regulation | Central nervous system | Nervous system | Mitochondrial DNA | Ribonucleic acid--RNA | Folic acid | Enhancers | Neurodegeneration | Coding | Vitamin B | Replicase | Stem cells | DNA replicase | Neural stem cells | Mutation | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase
Journal Article
Nature communications, ISSN 2041-1723, 02/2019, Volume 10, Issue 1, pp. 932 - 1
The original version of this Article contained an error in Fig. 7. In panel b, the survival curves were shifted relative to the y axis. This error has been... 
Activation | Pharmacology | Error correction | PD-1 protein | Immunotherapy | Apoptosis
Journal Article
Stem Cell Reports, ISSN 2213-6711, 07/2017, Volume 9, Issue 1, pp. 67 - 76
Journal Article