EPMA Journal, ISSN 1878-5077, 02/2014, Volume 5, Issue S1, p. 1
Journal Article
EPMA Journal, ISSN 1878-5077, 01/2014, Volume 5, Issue 1, p. 3
The most commonly used biomarkers to predict the response of breast cancer patients to therapy are the oestrogen receptor (ER), progesterone receptor (PgR),...
Personalised medicine | PP2A | Therapeutic groups | Predictive biomarkers | Web portals | Medical research | Care and treatment | Epidermal growth factor | Phosphatases | Estrogen | Monoclonal antibodies | Medicine, Experimental | Breast cancer | Progesterone | Cancer | Biomarkers | Deregulation | Phosphatase | Genomics
Personalised medicine | PP2A | Therapeutic groups | Predictive biomarkers | Web portals | Medical research | Care and treatment | Epidermal growth factor | Phosphatases | Estrogen | Monoclonal antibodies | Medicine, Experimental | Breast cancer | Progesterone | Cancer | Biomarkers | Deregulation | Phosphatase | Genomics
Journal Article
International Journal of Hematology, ISSN 0925-5710, 1/2014, Volume 99, Issue 1, pp. 4 - 11
Haematopoiesis is a complex process regulated at various levels facilitating rapid responses to external factors including stress, modulation of lineage...
Translation efficiency | Alternative splicing | Medicine & Public Health | Hematology | Transcript variants | Isoforms | Transcriptome | Oncology | MESSENGER-RNA TRANSLATION | STEM-CELLS | GRANULOCYTIC DIFFERENTIATION | ALTERNATIVE PROMOTERS | GATA-2 GENE | ACUTE MYELOID-LEUKEMIA | C/EBP-ALPHA | GENE-EXPRESSION | HEMATOLOGY | TRANSCRIPTION FACTOR | PROTEIN-TYROSINE-PHOSPHATASE | Promoter Regions, Genetic | Animals | RNA Isoforms | Alternative Splicing | Humans | RNA, Messenger - genetics | Transcriptional Activation | Gene Expression Regulation | Hematopoiesis - genetics | Transcription, Genetic | Codon, Initiator | Genetic transcription | RNA | Developmental biology | Genetic translation
Translation efficiency | Alternative splicing | Medicine & Public Health | Hematology | Transcript variants | Isoforms | Transcriptome | Oncology | MESSENGER-RNA TRANSLATION | STEM-CELLS | GRANULOCYTIC DIFFERENTIATION | ALTERNATIVE PROMOTERS | GATA-2 GENE | ACUTE MYELOID-LEUKEMIA | C/EBP-ALPHA | GENE-EXPRESSION | HEMATOLOGY | TRANSCRIPTION FACTOR | PROTEIN-TYROSINE-PHOSPHATASE | Promoter Regions, Genetic | Animals | RNA Isoforms | Alternative Splicing | Humans | RNA, Messenger - genetics | Transcriptional Activation | Gene Expression Regulation | Hematopoiesis - genetics | Transcription, Genetic | Codon, Initiator | Genetic transcription | RNA | Developmental biology | Genetic translation
Journal Article
Tumor Biology, ISSN 1010-4283, 9/2016, Volume 37, Issue 9, pp. 11691 - 11700
The complexity of the phosphatase, PP2A, is being unravelled and current research is increasingly providing information on the association of deregulated PP2A...
Molecular targets | Biomedicine | Colorectal cancer | Cancer Research | Novel therapeutics | Breast cancer | Phosphatase activation | Kinase inhibitors | PP2A complex | REGULATORY SUBUNIT | TUMOR-SUPPRESSOR PP2A | KINASE PATHWAY | CIP2A EXPRESSION | ACUTE MYELOID-LEUKEMIA | OVARIAN-CANCER | NEGATIVE BREAST-CANCER | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | PROSTATE-CANCER | Protein Phosphatase 2 - physiology | Protein Subunits | Animals | Protein Phosphatase 2 - antagonists & inhibitors | Protein Phosphatase 2 - chemistry | Humans | Neoplasms - enzymology | Enzyme Activation | Neoplasms - drug therapy | Care and treatment | Deregulation | Phosphatases | Development and progression | Methylation | Health aspects | Cancer | Phosphates | Kinases | Cancer therapies
Molecular targets | Biomedicine | Colorectal cancer | Cancer Research | Novel therapeutics | Breast cancer | Phosphatase activation | Kinase inhibitors | PP2A complex | REGULATORY SUBUNIT | TUMOR-SUPPRESSOR PP2A | KINASE PATHWAY | CIP2A EXPRESSION | ACUTE MYELOID-LEUKEMIA | OVARIAN-CANCER | NEGATIVE BREAST-CANCER | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | PROSTATE-CANCER | Protein Phosphatase 2 - physiology | Protein Subunits | Animals | Protein Phosphatase 2 - antagonists & inhibitors | Protein Phosphatase 2 - chemistry | Humans | Neoplasms - enzymology | Enzyme Activation | Neoplasms - drug therapy | Care and treatment | Deregulation | Phosphatases | Development and progression | Methylation | Health aspects | Cancer | Phosphates | Kinases | Cancer therapies
Journal Article
Oncotarget, 2017, Volume 8, Issue 17, pp. 28939 - 28958
MiR-29 family dysregulation occurs in various cancers including breast cancers. We investigated miR-29b-1 functional role in human triple negative breast...
SPIN1 | Cancer stem cells | Wnt/β-catenin and Akt signaling pathways | MiR-29b-1 | Triple-negative breast cancer | APOPTOSIS | triple-negative breast cancer | STEM-CELLS | DEDIFFERENTIATION | PROLIFERATION | CELL BIOLOGY | MIR-29 | PATHWAY | MYC | OSTEOSARCOMA | cancer stem cells | Wnt/beta-catenin and Akt signaling pathways | IN-VITRO PROPAGATION | MICRORNA | Cell Proliferation | Paclitaxel - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Phosphoproteins - metabolism | Triple Negative Breast Neoplasms - drug therapy | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Breast - pathology | Down-Regulation | Carcinogenesis - genetics | Cell Cycle Proteins - metabolism | Signal Transduction - genetics | Phosphoproteins - genetics | Paclitaxel - therapeutic use | Drug Resistance, Neoplasm - genetics | Triple Negative Breast Neoplasms - genetics | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | MicroRNAs - genetics | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasm Invasiveness - genetics | Nanog Homeobox Protein - metabolism | Cell Movement
SPIN1 | Cancer stem cells | Wnt/β-catenin and Akt signaling pathways | MiR-29b-1 | Triple-negative breast cancer | APOPTOSIS | triple-negative breast cancer | STEM-CELLS | DEDIFFERENTIATION | PROLIFERATION | CELL BIOLOGY | MIR-29 | PATHWAY | MYC | OSTEOSARCOMA | cancer stem cells | Wnt/beta-catenin and Akt signaling pathways | IN-VITRO PROPAGATION | MICRORNA | Cell Proliferation | Paclitaxel - pharmacology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Phosphoproteins - metabolism | Triple Negative Breast Neoplasms - drug therapy | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents, Phytogenic - therapeutic use | Breast - pathology | Down-Regulation | Carcinogenesis - genetics | Cell Cycle Proteins - metabolism | Signal Transduction - genetics | Phosphoproteins - genetics | Paclitaxel - therapeutic use | Drug Resistance, Neoplasm - genetics | Triple Negative Breast Neoplasms - genetics | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | MicroRNAs - genetics | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasm Invasiveness - genetics | Nanog Homeobox Protein - metabolism | Cell Movement
Journal Article
Tumor Biology, ISSN 1010-4283, 10/2017, Volume 39, Issue 10, pp. 1 - 7
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance....
tissue microarrays | breast cancer | tamoxifen resistance | CIP2A | immunohistochemistry | Immunohistochemistry | Mesenchyme | Phosphoprotein phosphatase | Leukemia | Metastasis | Myc protein | Multivariate analysis | Kinases | Phosphatase | Metastases | Ovarian cancer | Proteins | Cell growth | Quality | Growth factors | Antigens | Lymphatic system | Statistical analysis | Breast cancer | Tamoxifen | Survival | Medical prognosis | Breast | Protein phosphatase | Prostate | Tumors | Cancer | Apoptosis
tissue microarrays | breast cancer | tamoxifen resistance | CIP2A | immunohistochemistry | Immunohistochemistry | Mesenchyme | Phosphoprotein phosphatase | Leukemia | Metastasis | Myc protein | Multivariate analysis | Kinases | Phosphatase | Metastases | Ovarian cancer | Proteins | Cell growth | Quality | Growth factors | Antigens | Lymphatic system | Statistical analysis | Breast cancer | Tamoxifen | Survival | Medical prognosis | Breast | Protein phosphatase | Prostate | Tumors | Cancer | Apoptosis
Journal Article
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 10/2017, Volume 39, Issue 10, p. 1010428317722064
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance....
Receptors, Estrogen - metabolism | Autoantigens - metabolism | Prognosis | Neoplasm Recurrence, Local - metabolism | Humans | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Immunohistochemistry - methods | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Breast Neoplasms - pathology | Tamoxifen - therapeutic use | Female | Membrane Proteins - metabolism
Receptors, Estrogen - metabolism | Autoantigens - metabolism | Prognosis | Neoplasm Recurrence, Local - metabolism | Humans | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Immunohistochemistry - methods | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Breast Neoplasms - pathology | Tamoxifen - therapeutic use | Female | Membrane Proteins - metabolism
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 12/2018, Volume 7, Issue 1, pp. 1535750 - 43
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
extracellular vesicles | rigor | exosomes | reproducibility | guidelines | standardization | microparticles | microvesicles | minimal information requirements | ectosomes | HUMAN URINARY EXOSOMES | FETAL BOVINE | PREANALYTICAL PARAMETERS | CELL-DERIVED MICROPARTICLES | CELL BIOLOGY | FIELD-FLOW FRACTIONATION | MEMBRANE-VESICLES | PROSTATE-CANCER | SURFACE-PLASMON RESONANCE | SIZE-EXCLUSION CHROMATOGRAPHY | CIRCULATING MICROPARTICLES | Vesicles | Physiology | Biosynthesis | Scientists | Metastasis | Exosomes | Microparticles | Polls & surveys | Cancer | Apoptosis | Membranes cel·lulars | Cell interaction | Cell membranes | Interacció cel·lular | Cellbiologi | Cell Biology
extracellular vesicles | rigor | exosomes | reproducibility | guidelines | standardization | microparticles | microvesicles | minimal information requirements | ectosomes | HUMAN URINARY EXOSOMES | FETAL BOVINE | PREANALYTICAL PARAMETERS | CELL-DERIVED MICROPARTICLES | CELL BIOLOGY | FIELD-FLOW FRACTIONATION | MEMBRANE-VESICLES | PROSTATE-CANCER | SURFACE-PLASMON RESONANCE | SIZE-EXCLUSION CHROMATOGRAPHY | CIRCULATING MICROPARTICLES | Vesicles | Physiology | Biosynthesis | Scientists | Metastasis | Exosomes | Microparticles | Polls & surveys | Cancer | Apoptosis | Membranes cel·lulars | Cell interaction | Cell membranes | Interacció cel·lular | Cellbiologi | Cell Biology
Journal Article
ISSN 2001-3078, 2018
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 2018, Volume 7, Issue 1
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
requirements | extracellular vesicles | rigor | exosomes | reproducibility | guidelines | standardization | microparticles | microvesicles | minimal information requirements | ectosomes
requirements | extracellular vesicles | rigor | exosomes | reproducibility | guidelines | standardization | microparticles | microvesicles | minimal information requirements | ectosomes
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 01/2018, Volume 7, Issue 1
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
extracellular vesicles | rigor | exosomes | reproducibility | guidelines | microparticles | standardization | microvesicles | minimal information requirements | ectosomes
extracellular vesicles | rigor | exosomes | reproducibility | guidelines | microparticles | standardization | microvesicles | minimal information requirements | ectosomes
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 11/2018, Volume 7, Issue 1, p. 1535750
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
extracellular vesicles | HUMAN URINARY EXOSOMES | rigor | FETAL BOVINE | reproducibility | standardization | microparticles | microvesicles | PREANALYTICAL PARAMETERS | minimal information requirements | CELL-DERIVED MICROPARTICLES | FIELD-FLOW FRACTIONATION | MEMBRANE-VESICLES | exosomes | PROSTATE-CANCER | guidelines | SURFACE-PLASMON RESONANCE | SIZE-EXCLUSION CHROMATOGRAPHY | CIRCULATING MICROPARTICLES | ectosomes | CELL BIOLOGY | Life Sciences | Cellular Biology
extracellular vesicles | HUMAN URINARY EXOSOMES | rigor | FETAL BOVINE | reproducibility | standardization | microparticles | microvesicles | PREANALYTICAL PARAMETERS | minimal information requirements | CELL-DERIVED MICROPARTICLES | FIELD-FLOW FRACTIONATION | MEMBRANE-VESICLES | exosomes | PROSTATE-CANCER | guidelines | SURFACE-PLASMON RESONANCE | SIZE-EXCLUSION CHROMATOGRAPHY | CIRCULATING MICROPARTICLES | ectosomes | CELL BIOLOGY | Life Sciences | Cellular Biology
Journal Article
Journal of Visualized Experiments, ISSN 1940-087X, 08/2018, Volume 2018, Issue 138
Nucleic acid degradation in archival tissue, tumor heterogeneity, and a lack of fresh frozen tissue specimens can negatively impact cancer diagnostic services...
Bioengineering | Estrogen receptor | Multiplex bead-based assay | Breast cancer | XMAP | Cancer subtypes | Issue 138 | FFPE | Triple negative | Translational medicine | Classification | Biomarkers | Diagnosis | HER2 | translational medicine | estrogen receptor | MULTIDISCIPLINARY SCIENCES | breast cancer | diagnosis | classification | cancer subtypes | xMAP | triple negative | GENE-EXPRESSION | FIBRONECTIN | multiplex bead-based assay | POLYMERASE CHAIN-REACTION
Bioengineering | Estrogen receptor | Multiplex bead-based assay | Breast cancer | XMAP | Cancer subtypes | Issue 138 | FFPE | Triple negative | Translational medicine | Classification | Biomarkers | Diagnosis | HER2 | translational medicine | estrogen receptor | MULTIDISCIPLINARY SCIENCES | breast cancer | diagnosis | classification | cancer subtypes | xMAP | triple negative | GENE-EXPRESSION | FIBRONECTIN | multiplex bead-based assay | POLYMERASE CHAIN-REACTION
Journal Article
Journal of Extracellular Vesicles, ISSN 2001-3078, 2018, Volume 7, Issue 1
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular...
extracellular vesicles | rigor | reproducibility | microparticles | standardization | Histology | microvesicles | minimal information requirements | Journal Article | Cell Biology | exosomes | guidelines | ectosomes
extracellular vesicles | rigor | reproducibility | microparticles | standardization | Histology | microvesicles | minimal information requirements | Journal Article | Cell Biology | exosomes | guidelines | ectosomes
Journal Article
09/2018
The invention relates to the treatment and classification of cancer, in particular breast cancer. It relates to identifying patients who are likely to respond...
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | TESTING | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES | MEDICAL OR VETERINARY SCIENCE | MEASURING | PHYSICS | HUMAN NECESSITIES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | TESTING | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES | MEDICAL OR VETERINARY SCIENCE | MEASURING | PHYSICS | HUMAN NECESSITIES
Patent
Journal of Cellular Physiology, ISSN 0021-9541, 10/2019, Volume 234, Issue 10, pp. 18432 - 18447
Triple‐negative breast cancer (TNBC) is a form of BC characterized by high aggressiveness and therapy resistance probably determined by cancer stem cells. MCL1...
rh‐TRAIL | cancer stem cells | triple‐negative breast cancer | DR4 receptor | MCL1 | rh-TRAIL | triple-negative breast cancer | APOPTOSIS | PHYSIOLOGY | EXPRESSION | CELL BIOLOGY | Transplantation | Breast cancer | Stem cells | Epithelial cells | Genes | Reverse transcription | mRNA | Kinases | Cell surface | Anticancer properties | Proteins | Mitochondria | Antitumor agents | Cell cycle | Membrane potential | Inhibition | Mammary gland | G1 phase | Recombinant | Gene expression | Mcl-1 protein | DR4 protein | Polymerase chain reaction | Gene silencing | TRAIL protein | Viability | Apoptosis
rh‐TRAIL | cancer stem cells | triple‐negative breast cancer | DR4 receptor | MCL1 | rh-TRAIL | triple-negative breast cancer | APOPTOSIS | PHYSIOLOGY | EXPRESSION | CELL BIOLOGY | Transplantation | Breast cancer | Stem cells | Epithelial cells | Genes | Reverse transcription | mRNA | Kinases | Cell surface | Anticancer properties | Proteins | Mitochondria | Antitumor agents | Cell cycle | Membrane potential | Inhibition | Mammary gland | G1 phase | Recombinant | Gene expression | Mcl-1 protein | DR4 protein | Polymerase chain reaction | Gene silencing | TRAIL protein | Viability | Apoptosis
Journal Article