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1. Full Text Histamine modulates microglia function
by Ferreira, Raquel and Santos, Tiago and Gonçalves, Joana and Baltazar, Graça and Ferreira, Lino and Agasse, Fabienne and Bernardino, Liliana
Journal of Neuroinflammation, ISSN 1742-2094, 05/2012, Volume 9, Issue 1, pp. 90 - 90
Background: Histamine is commonly acknowledged as an inflammatory mediator in peripheral tissues, leaving its role in brain immune responses scarcely studied.... 
Histamine | Inflammation | Migration | Histamine 4 receptor | Microglia | TARGET | ACTIVATION | BETA-1-INTEGRIN | NEUROSCIENCES | ADHESION | ALPHA PRODUCTION | ENDOTHELIAL-CELLS | FIBRONECTIN | ASSAYS | H-4 RECEPTOR | Receptors, Histamine - physiology | Microglia - metabolism | Histamine - physiology | Receptors, G-Protein-Coupled - agonists | Cell Movement - physiology | Cerebral Cortex - metabolism | Microglia - physiology | Inflammation Mediators - metabolism | Receptors, Histamine H4 | Inflammation Mediators - physiology | Lipopolysaccharides - physiology | Organ Culture Techniques | Interleukin-1beta - antagonists & inhibitors | Receptors, G-Protein-Coupled - physiology | Interleukin-1beta - secretion | Cell Line | Interleukin-1beta - physiology | Histamine - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Rats | Hippocampus - pathology | Hippocampus - metabolism | Animals | Lipopolysaccharides - pharmacology | Cerebral Cortex - physiology | Mice | Immune response | Scientific equipment and supplies industry | Interleukins | Mitogens | Enzyme-linked immunosorbent assay | Integrins | Brain | Cell culture | Health sciences | Neurosciences | Biomedical research | Motility | Cytokines | Pharmacology | Kinases | Experiments | Manuscripts | Studies | Laboratory animals
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2. Full Text Histamine: A new immunomodulatory player in the neuron-glia crosstalk
by Rocha, Sandra M and Pires, Joel and Esteves, Marta and Baltazar, Graça and Bernardino, Liliana
Frontiers in Cellular Neuroscience, ISSN 1662-5102, 04/2014, Volume 8, Issue 1, p. 120
Histamine is an amine acting as a major peripheral inflammatory mediator. In the brain, histamine was initially viewed as a neurotransmitter, but new evidences... 
Histamine | Neuroinflammation | Parkinson's disease | Nitric oxide | Substantia nigra | Microglia | nitric oxide | substantia nigra | ACTIVATION | histamine | ALZHEIMERS-DISEASE | RECEPTOR | CELL-PROLIFERATION | CEREBROSPINAL-FLUID | NEUROSCIENCES | RESPONSES | neuroinflammation | NITRIC-OXIDE | DIFFERENTIATION | microglia | EXPRESSION | Health sciences | Multiple sclerosis | Traumatic brain injury | Disease | Pathogenesis | Nervous system | Neuronal-glial interactions | Blood-brain barrier | Neurodegeneration | Lymphocytes | Microglial cells | Tumor necrosis factor-TNF | Movement disorders | Dopamine receptors | Antihistamines | Immune response | Dopamine | Neurodegenerative diseases | Immunomodulation | Secretome | Inflammation | Permeability | Neurotransmission | Nitric Oxide | Substantia Nigra | Parkinson’s disease
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3. Full Text G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
by Roque, Cláudio and Mendes‐Oliveira, Julieta and Baltazar, Graça
Journal of Neurochemistry, ISSN 0022-3042, 04/2019, Volume 149, Issue 1, pp. 27 - 40
Selective activation of the G protein‐coupled estrogen receptor has been proposed to avoid some of the side effects elicited by the activation of classical... 
intracellular calcium | Astrocytes | GPER | ischemia | G1 | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPR30 | NEUROSCIENCES | GROWTH-FACTOR RECEPTOR | IN-VITRO | DOPAMINERGIC NEURODEGENERATION | CALCIUM | GLOBAL CEREBRAL-ISCHEMIA | UP-REGULATION | BRAIN | Phenols | Estrogen | G proteins | Neuroprotection | Brain | Calcium | Estrogens | Estrogen receptors | Activation | Estradiol | Proteins | Signal transduction | Receptors | Pathways | Ischemia | Deprivation | Stroke | Calcium (intracellular) | Cell survival | Neurons | Cortex | Cultures | Survival | Phospholipase C | Phospholipase | Signaling | Sex hormones | Side effects | Viability | Apoptosis
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4. Full Text Impact of Astrocytes on the Injury Induced by In Vitro Ischemia
by Roque, Cláudio and Baltazar, Graça
Cellular and Molecular Neurobiology, ISSN 0272-4340, 11/2017, Volume 37, Issue 8, pp. 1521 - 1528
Cell cultures are characterized by their simplicity, controllability, and ability to provide detailed basic information on how a particular cell population... 
Neurosciences | Biomedicine | Ischemia | Astrocytes | Oxygen and glucose deprivation | Neurobiology | Neuron-enriched cultures | Neuron–glia cultures | Cell Biology | Microglia | PROTEIN | MOUSE | Neuron-glia cultures | MECHANISMS | DEATH | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | OXYGEN-GLUCOSE DEPRIVATION | CELL BIOLOGY | METABOLISM | CELL-CULTURE | GLIA | BRAIN | Medical research | Usage | Neurons | Analysis | Medicine, Experimental | Glucose | Dextrose
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5. Full Text STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
by Pradeep K. Kurup and Jian Xu and Rita Alexandra Videira and Chimezie Ononenyi and Graça Baltazar and Paul J. Lombroso and Angus C. Nairn
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2015, Volume 112, Issue 4, pp. 1202 - 1207
In neurons, STEP 61 (striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the protein’s up-regulation is implicated in... 
Biological Sciences | STEP | Parkinson's disease | synaptic plasticity | parkin | ubiquitination
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6. Full Text The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death
by Cristóvão, Ana Clara and Choi, Dong-Hee and Baltazar, Graça and Beal, M. Flint and Kim, Yoon-Seong
Antioxidants & Redox Signaling, ISSN 1523-0864, 09/2009, Volume 11, Issue 9, pp. 215 - 2118
Oxidative stress is the common downstream effect of a variety of environmental neurotoxins that are strongly implicated in the pathogenesis of Parkinson's... 
Forum Original Research Communications | OXIDATIVE STRESS | MICROGLIAL ACTIVATION | POSSIBLE INVOLVEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOX1/NADPH OXIDASE | ENDOCRINOLOGY & METABOLISM | ENVIRONMENTAL RISK-FACTORS | EXPERIMENTAL STROKE | HERBICIDE PARAQUAT | ALPHA-SYNUCLEIN | SUBSTANTIA-NIGRA | PARKINSONS-DISEASE | Immunohistochemistry | Cell Line | NADH, NADPH Oxidoreductases - genetics | Reactive Oxygen Species - metabolism | Mice, Inbred C57BL | Rats | Male | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | NADPH Oxidase 1 | Animals | Base Sequence | Mice | RNA, Small Interfering | Cell Death - drug effects | NADH, NADPH Oxidoreductases - metabolism | Paraquat - toxicity | Dopamine - metabolism | Oxidases | Care and treatment | Parkinson's disease | Active oxygen | Physiological aspects | Genetic aspects | Research
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7. Full Text GPER: A new tool to protect dopaminergic neurons?
by Bessa, Agustina and Campos, Filipa Lopes and Videira, Rita Alexandra and Mendes-Oliveira, Julieta and Bessa-Neto, Diogo and Baltazar, Graça
BBA - Molecular Basis of Disease, ISSN 0925-4439, 10/2015, Volume 1852, Issue 10, pp. 2035 - 2041
Parkinson's disease (PD) is characterized by a selective degeneration of nigrostriatal dopaminergic pathway. Epidemiological studies revealed a male... 
Dopaminergic neurons | Parkinson's disease | GDNF | Estradiol | GPER | SIGNALING PATHWAYS | NEUROTROPHIC FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPR30 | ESTROGEN-RECEPTOR | COUPLED RECEPTOR 30 | BIOPHYSICS | CHOLINERGIC NEURONS | BASAL FOREBRAIN | MICE | PARKINSONS-DISEASE | Neurons | Estrogen | Tyrosine | Phosphates | Surface active agents | RNA | G proteins | Sulfates | Mitogens | Epidemiology | Protein kinases | Index Medicus
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8. Full Text SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3
by Vieira, Filipa Quintela and Costa-Pinheiro, Pedro and Almeida-Rios, Diogo and Graça, Inês and Monteiro-Reis, Sara and Simões-Sousa, Susana and Carneiro, Isa and Sousa, Elsa Joana and Godinho, Maria Inês and Baltazar, Fátima and Henrique, Rui and Jerónimo, Carmen
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 15, pp. 13644 - 13657
Prostate cancer (PCa) is one of the most incident cancers worldwide but clinical and pathological parameters have limited ability to discriminate between... 
Histone methyltransferase | SMYD3 | Prostate cancer | SET domain | Cyclin D2 | Cyclin D2 - genetics | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Cyclin D2 - metabolism | Histone-Lysine N-Methyltransferase - genetics | Humans | Cell Proliferation - physiology | Male | Chick Embryo | Cell Movement - physiology | Gene Knockdown Techniques | Phenotype | Animals | Prostatic Neoplasms - genetics | Histone-Lysine N-Methyltransferase - metabolism | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Cell Survival - physiology
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9. Full Text G protein-coupled estrogen receptor 1 (GPER) activation triggers different signaling pathways on neurons and astrocytes
by Roque, C and Baltazar, G
NEURAL REGENERATION RESEARCH, ISSN 1673-5374, 12/2019, Volume 14, Issue 12, pp. 2069 - 2070
APOPTOSIS | NEUROSCIENCES | CAMP | KINASE | CELL BIOLOGY | Receptors | Astrocytes | Neurons | Estrogen | Physiological aspects | Cellular signal transduction | Health aspects
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10. Full Text H2O2- or l-DOPA-injured dopaminergic neurons trigger the release of soluble mediators that up-regulate striatal GDNF through different signalling pathways
by Fonseca, Carla Pais and Gama, Susana and Saavedra, Ana and Baltazar, Graça
BBA - Molecular Basis of Disease, ISSN 0925-4439, 07/2014, Volume 1842, Issue 7, pp. 927 - 934
Glial cell line-derived neurotrophic factor (GDNF) is a potent neuroprotective molecule for dopaminergic neurons of the nigrostriatal pathway that degenerate... 
Signalling pathway | Neuroprotection | Striatum | Dopaminergic neuron | Parkinson's disease | GDNF | PROTEIN-KINASE PATHWAY | DRUG-DELIVERY | NEUROTROPHIC FACTOR | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AGED RHESUS-MONKEYS | INTRAPUTAMENAL INFUSION | BIOPHYSICS | GENE-EXPRESSION | PHOSPHOINOSITIDE 3-KINASES | NIGROSTRIATAL SYSTEM | PARKINSONS-DISEASE
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11. Full Text G protein-coupled estrogen receptor activates cell type-specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
by Roque, Cláudio and Mendes-Oliveira, Julieta and Baltazar, Graça
Journal of neurochemistry, 12/2018
Selective activation of the G protein-coupled estrogen receptor has been proposed to avoid some of the side effects elicited by the activation of classical... 
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12. Full Text Pneumothorax after acupuncture
by Corado, Sofia Costa and Graça Santos, Margarida and Quaresma, Luísa and Baltazar, José Rodrigues
BMJ Case Reports, ISSN 1757-790X, 06/2019, Volume 12, Issue 6, p. e228770
Acupuncture is a well-known form of complementary medicine that is increasingly being used worldwide. Despite being rare, pneumothorax is the most common... 
Radiography | Case studies | Hepatitis | Hospitals | Pain | Dyspnea | Systematic review | Acupuncture | Patients
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13. Full Text Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for parkinson's disease
by Esteves, Marta and Cristóvão, Ana C and Saraiva, Tatiana and Rocha, Sandra M and Baltazar, Graça and Ferreira, Lino and Bernardino, Liliana
Frontiers in Aging Neuroscience, ISSN 1663-4365, 2015, Volume 7, p. 20
Retinoic acid (RA) plays an important role in the commitment, maturation and survival of neural cells. Recently, RA was pointed as a therapeutic option for... 
Dopaminergic neurons | Nanoparticles | Neuroprotection | Parkinson's disease | Retinoic acid | SYSTEM | TRANSCRIPTION | SUBSTANTIA-NIGRA | NEUROSCIENCES | MIDBRAIN DOPAMINERGIC-NEURONS | GERIATRICS & GERONTOLOGY | retinoic acid | nanoparticles | neuroprotection | dopaminergic neurons | NURR1 | MICE | MPTP | EXPRESSION | BRAIN | AGE | Health sciences | Neurosciences | Transcription factors | Substantia nigra | Parkinsons disease | Proteins | Neurodegeneration | Neostriatum | Controlled release | Movement disorders | Dopamine receptors | Enzymes | Cell survival | Dopamine | Young adults | Neurodegenerative diseases | Gene expression | Nuclear receptors | Nurr1 protein | Animals | Brain research | Acids
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14. Full Text Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal
by Guiomar, Raquel and Pereira da Silva, Susana and Conde, Patrícia and Cristóvão, Paula and Maia, Ana Carina and Pechirra, Pedro and Rodrigues, Ana Paula and Nunes, Baltazar and Milho, Luís and Coelho, Ana Paula and Fernandes, Aida and Caseiro, Paula and Rodrigues, Fernando and Correia, Lurdes and Pereira-Vaz, João and Almeida, Sofia and Branquinho, Paula and Côrte-Real, Rita and Viseu, Regina and Peres, Maria João and Sanches, Raquel and Dantas, Filipa and Freitas, Ludovina and Andrade, Graça and Maurílio, Manuel and Caldeira, Filomena and Cabral Veloso, Rita and Mota-Vieira, Luisa and Soares, Marta and Couto, Ana Rita and Bruges-Armas, Jácome and Pinto, Rita Mouro and Sobrinho Simões, Joana and Costa, Maria do Rosário and Guimarães, João Tiago and Martins, Luís and Cunha, Mário and Portuguese Lab Network Diag Influe and Portuguese Laboratory Network for the Diagnosis of Influenza Infection
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 16, pp. 2092 - 2099
Highlights • Low pre-existing cross-protection against new A(H3) drift viruses. • Seroprevalences for A(H3) and A(H1)pdm09 were higher than influenza B. •... 
Allergy and Immunology | Seroepidemiologic studies | Cross-protection | Influenza | Seroprevalence | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOLOGY | CHILDREN | Cross-Sectional Studies | Humans | Middle Aged | Child, Preschool | Cross Protection | Infant | Influenza, Human - epidemiology | Male | Seroepidemiologic Studies | Antibodies, Viral - blood | Incidence | Hemagglutination Inhibition Tests | Young Adult | Adolescent | Portugal - epidemiology | Aged, 80 and over | Adult | Female | Influenza A virus - immunology | Influenza, Human - virology | Aged | Child | Infant, Newborn | Influenza, Human - immunology | Viral antibodies | Antibodies | Epidemiology | Pandemics | Laboratories | Vaccination | Health risks | Viruses | Infections | Vaccines | Immunity | Population (statistical) | Drift | Seasons
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15. Full Text Proceedings of the 3rd IPLeiria’s International Health Congress
: Leiria, Portugal. 6-7 May 2016
by Tomás, Catarina Cardoso and Oliveira, Emanuel and Sousa, D and Uba-Chupel, M and Furtado, G and Rocha, C and Teixeira, A and Ferreira, P and Alves, Celeste and Gisin, Stefan and Catarino, Elisabete and Carvalho, Nelma and Coucelo, Tiago and Bonfim, Luís and Silva, Carina and Franco, Débora and González, Jesús Alcoba and Jardim, Helena G and Silva, Rita and Baixinho, Cristina L and Presado, Mª Helena and Marques, Mª Fátima and Cardoso, Mário E and Cunha, Marina and Mendes, Joana and Xavier, Ana and Galhardo, Ana and Couto, Margarida and Frade, João G and Nunes, Carla and Mesquita, João R and Nascimento, Maria S and Gonçalves, Guilherme and Castro, Conceição and Mártires, Alice and Monteiro, Mª João and Rainho, Conceição and Caballero, Francisco P and Monago, Fatima M and Guerrero, Jose T and Monago, Rocio M and Trigo, Africa P and Gutierrez, Milagros L and Milanés, Gemma M and Reina, Mercedes G and Villanueva, Ana G and Piñero, Ana S and Aliseda, Isabel R and Ramirez, Francisco B and Ribeiro, Andrea and Quelhas, Ana and Manso, Conceição and Santos, Rafael B and Jimenez, Nuria R and Nuñez, Cristina G and Gomez, Inmaculada R and Fernandez, Mª Jose L and Marquez, Laura A and Moreno, Ana L and Huertas, Mª Jesus Tena and Seabra, Daniel and Salvador, Mª Céu and Braga, Luciene and Parreira, Pedro and Salgueiro-Oliveira, Anabela and Arreguy-Sena, Cristina and Oliveira, Bibiana F and Henriques, Mª Adriana and Santos, Joana and Lebre, Sara and Marques, Alda and Festas, Clarinda and Rodrigues, Sandra and Lumini, José and Figueiredo, Ana G and Hernandez-Martinez, Francisco J and Campi, Liliana and Quintana-Montesdeoca, Mª Pino and Jimenez-Diaz, Juan F and Rodriguez-De-Vera, Bienvenida C and Parente, Alexandra and Mata, Mª Augusta and Pereira, Ana Mª and Fernandes, Adília and Brás, Manuel and Pinto, Mª Rosário and Basto, Marta L and Rei, Ana C and Mónico, Lisete M and Sousa, Gilberta and Morna, Clementina and Freitas, Otília and Freitas, Gregório and Jardim, Ana and Vasconcelos, Rita and Horta, Lina G and Rosa, Roger S and Kranz, Luís F and Nugem, Rita C and Siqueira, Mariana S and ...
BMC Health Services Research, ISSN 1472-6963, 07/2016, Volume 16, Issue S3
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16. Full Text STEP61is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
by Pradeep K. Kurup and Jian Xu and Rita Alexandra Videira and Chimezie Ononenyi and Graça Baltazar and Paul J. Lombroso and Angus C. Nairn
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2015, Volume 112, Issue 4, pp. 1202 - 1207
Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The loss of SNc dopaminergic... 
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