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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7514, pp. 333 - 337
Cys-loop receptors are neurotransmitter-gated ion channels that are essential mediators of fast chemical neurotransmission and are associated with a large...
M2 DOMAIN | GATED ION-CHANNEL | PROTEIN | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | COMPLEXES | CRYSTAL-STRUCTURES | NICOTINIC ACETYLCHOLINE-RECEPTORS | ANTAGONISTS | COUPLING AGONIST BINDING | PERMEATION | Apoproteins - chemistry | Caenorhabditis elegans - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Ivermectin - chemistry | Phosphatidylcholines - metabolism | Ivermectin - metabolism | Cell Membrane - metabolism | Binding Sites | Apoproteins - metabolism | Allosteric Regulation - drug effects | Movement - drug effects | Drug Partial Agonism | Chloride Channels - chemistry | Phosphatidylcholines - pharmacology | Models, Molecular | Ivermectin - pharmacology | Phosphatidylcholines - chemistry | Binding, Competitive - drug effects | Chloride Channels - metabolism | Cysteine Loop Ligand-Gated Ion Channel Receptors - chemistry | Cysteine Loop Ligand-Gated Ion Channel Receptors - metabolism | Animals | Protein Binding | Ligands | Glutamic Acid - metabolism | Ion Channel Gating | Protein Multimerization - drug effects | Protein Structure, Tertiary - drug effects | Nervous system diseases | Crystals | Physiological aspects | Development and progression | Ion channels | Genetic aspects | Research | Structure | Lipids | Neurotransmitters | Crystal structure
M2 DOMAIN | GATED ION-CHANNEL | PROTEIN | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | COMPLEXES | CRYSTAL-STRUCTURES | NICOTINIC ACETYLCHOLINE-RECEPTORS | ANTAGONISTS | COUPLING AGONIST BINDING | PERMEATION | Apoproteins - chemistry | Caenorhabditis elegans - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Ivermectin - chemistry | Phosphatidylcholines - metabolism | Ivermectin - metabolism | Cell Membrane - metabolism | Binding Sites | Apoproteins - metabolism | Allosteric Regulation - drug effects | Movement - drug effects | Drug Partial Agonism | Chloride Channels - chemistry | Phosphatidylcholines - pharmacology | Models, Molecular | Ivermectin - pharmacology | Phosphatidylcholines - chemistry | Binding, Competitive - drug effects | Chloride Channels - metabolism | Cysteine Loop Ligand-Gated Ion Channel Receptors - chemistry | Cysteine Loop Ligand-Gated Ion Channel Receptors - metabolism | Animals | Protein Binding | Ligands | Glutamic Acid - metabolism | Ion Channel Gating | Protein Multimerization - drug effects | Protein Structure, Tertiary - drug effects | Nervous system diseases | Crystals | Physiological aspects | Development and progression | Ion channels | Genetic aspects | Research | Structure | Lipids | Neurotransmitters | Crystal structure
Journal Article
Microbiology and Immunology, ISSN 0385-5600, 10/2017, Volume 61, Issue 10, pp. 452 - 458
ABSTRACT The primordial immunoglobulin class, IgD, was the first non‐IgM isotype discovered in teleosts. The crucial roles of IgM and IgZ in imparting systemic...
pathogen challenge | PAMPs | Catla catla | IgD | IMMUNE-RESPONSE | INDIAN MAJOR CARP | RAINBOW-TROUT | RECOGNITION | INDUCTIVE EXPRESSION | MICROBIOLOGY | IG HEAVY-CHAIN | IMMUNOLOGY | LABEO-ROHITA | TELEOST FISH | BACTERIAL-INFECTION | INNATE IMMUNITY | DNA, Complementary - genetics | Streptococcal Infections - veterinary | Gram-Negative Bacterial Infections - immunology | Immunoglobulin Heavy Chains - chemistry | Immunoglobulin D - genetics | Phylogeny | Aeromonas hydrophila - immunology | Streptococcus - pathogenicity | Kidney | Fish Diseases - parasitology | Host-Pathogen Interactions - immunology | Immunoglobulin Isotypes - genetics | Immunoglobulin D - classification | Sequence Analysis, Protein | Host-Parasite Interactions - genetics | Pathogen-Associated Molecular Pattern Molecules | Aeromonas hydrophila - pathogenicity | Bacterial Infections - immunology | Cloning, Molecular | Fish Diseases - immunology | Fresh Water | Gram-Negative Bacterial Infections - veterinary | Rhabdoviridae - pathogenicity | Skin - immunology | Amino Acid Sequence | Arguloida - pathogenicity | Gene Expression | Cyprinidae - immunology | Fish Diseases - microbiology | Immunoglobulin D - chemistry | Immunoglobulin Isotypes - chemistry | Virus Diseases - immunology | Gene Expression Regulation | Host-Parasite Interactions - immunology | Carps - immunology | Gene Expression Profiling - veterinary | Animals | Fish Diseases - virology | Host-Pathogen Interactions - genetics | Parasitic Diseases - immunology | Streptococcal Infections - immunology | Carps - genetics | Immunoglobulin Heavy Chains - genetics | Genetic research | Immunoglobulins | Gene expression | Analysis | Cloning | Immunoglobulin M | Antigens | Pathogens | Carp | Mucosal immunity | Kidneys | Mucosa | Aeromonas hydrophila | Amino acids | Homology | Stimulation | Infections | Immunoglobulin D | Immunity | Parasitic diseases | Animal tissues | Bacteria | Fish | Skin | Neutralization
pathogen challenge | PAMPs | Catla catla | IgD | IMMUNE-RESPONSE | INDIAN MAJOR CARP | RAINBOW-TROUT | RECOGNITION | INDUCTIVE EXPRESSION | MICROBIOLOGY | IG HEAVY-CHAIN | IMMUNOLOGY | LABEO-ROHITA | TELEOST FISH | BACTERIAL-INFECTION | INNATE IMMUNITY | DNA, Complementary - genetics | Streptococcal Infections - veterinary | Gram-Negative Bacterial Infections - immunology | Immunoglobulin Heavy Chains - chemistry | Immunoglobulin D - genetics | Phylogeny | Aeromonas hydrophila - immunology | Streptococcus - pathogenicity | Kidney | Fish Diseases - parasitology | Host-Pathogen Interactions - immunology | Immunoglobulin Isotypes - genetics | Immunoglobulin D - classification | Sequence Analysis, Protein | Host-Parasite Interactions - genetics | Pathogen-Associated Molecular Pattern Molecules | Aeromonas hydrophila - pathogenicity | Bacterial Infections - immunology | Cloning, Molecular | Fish Diseases - immunology | Fresh Water | Gram-Negative Bacterial Infections - veterinary | Rhabdoviridae - pathogenicity | Skin - immunology | Amino Acid Sequence | Arguloida - pathogenicity | Gene Expression | Cyprinidae - immunology | Fish Diseases - microbiology | Immunoglobulin D - chemistry | Immunoglobulin Isotypes - chemistry | Virus Diseases - immunology | Gene Expression Regulation | Host-Parasite Interactions - immunology | Carps - immunology | Gene Expression Profiling - veterinary | Animals | Fish Diseases - virology | Host-Pathogen Interactions - genetics | Parasitic Diseases - immunology | Streptococcal Infections - immunology | Carps - genetics | Immunoglobulin Heavy Chains - genetics | Genetic research | Immunoglobulins | Gene expression | Analysis | Cloning | Immunoglobulin M | Antigens | Pathogens | Carp | Mucosal immunity | Kidneys | Mucosa | Aeromonas hydrophila | Amino acids | Homology | Stimulation | Infections | Immunoglobulin D | Immunity | Parasitic diseases | Animal tissues | Bacteria | Fish | Skin | Neutralization
Journal Article
Protein Science, ISSN 0961-8368, 10/2019, Volume 28, Issue 10, pp. 1771 - 1784
In the last step of glycolysis Pyruvate kinase catalyzes the irreversible conversion of ADP and phosphoenolpyruvate to ATP and pyruvic acid, both crucial for...
protein structure | allosteric enzyme | cryptosporidium | glycolysis | pyruvate kinase | crystal structure | holo‐enzyme | ALLOSTERIC REGULATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYPTOSPORIDIUM-PARVUM | RABBIT MUSCLE | BACILLUS-STEAROTHERMOPHILUS | DOMAIN MOVEMENTS | ENZYME | holo-enzyme | CARBOHYDRATE-METABOLISM | BINDING | Pyruvate kinase | Pyruvic acid | Metabolism | ADP | Metabolic flux | Allosteric properties | Effectors | Glycolysis | Evolution | Catalysis | Protein structure | ATP | Structure-function relationships
protein structure | allosteric enzyme | cryptosporidium | glycolysis | pyruvate kinase | crystal structure | holo‐enzyme | ALLOSTERIC REGULATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYPTOSPORIDIUM-PARVUM | RABBIT MUSCLE | BACILLUS-STEAROTHERMOPHILUS | DOMAIN MOVEMENTS | ENZYME | holo-enzyme | CARBOHYDRATE-METABOLISM | BINDING | Pyruvate kinase | Pyruvic acid | Metabolism | ADP | Metabolic flux | Allosteric properties | Effectors | Glycolysis | Evolution | Catalysis | Protein structure | ATP | Structure-function relationships
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 362 - 366
Integration of the reverse-transcribed viral DNA into the host genome is an essential step in the life cycle of retroviruses. Retrovirus integrase catalyses...
DOMAIN | PROTEIN | HIV-1 INTEGRASE | DETERMINANTS | POL GENE | MULTIDISCIPLINARY SCIENCES | MURINE LEUKEMIA-VIRUS | TYPE-1 INTEGRASE | SYNAPTIC COMPLEX | TARGET DNA RECOGNITION | RETROVIRAL INTEGRATION | Spumavirus - enzymology | HIV-1 - metabolism | Catalytic Domain | Protein Multimerization | DNA, Viral - metabolism | Models, Molecular | Crystallography, X-Ray | Virus Integration | Rous sarcoma virus - metabolism | DNA, Viral - chemistry | Rous sarcoma virus - genetics | Protein Binding | Rous sarcoma virus - enzymology | HIV-1 - enzymology | Integrases - metabolism | Rous sarcoma virus - chemistry | Integrases - chemistry | Complications and side effects | Care and treatment | Sarcoma | Analysis | Crystals | Research | Structure | Chromosomes | Proteins | Amino acids | Viruses | Deoxyribonucleic acid--DNA | Crystal structure | X-ray crystallography | Retrovirus | BASIC BIOLOGICAL SCIENCES | DNA | DNA-binding proteins
DOMAIN | PROTEIN | HIV-1 INTEGRASE | DETERMINANTS | POL GENE | MULTIDISCIPLINARY SCIENCES | MURINE LEUKEMIA-VIRUS | TYPE-1 INTEGRASE | SYNAPTIC COMPLEX | TARGET DNA RECOGNITION | RETROVIRAL INTEGRATION | Spumavirus - enzymology | HIV-1 - metabolism | Catalytic Domain | Protein Multimerization | DNA, Viral - metabolism | Models, Molecular | Crystallography, X-Ray | Virus Integration | Rous sarcoma virus - metabolism | DNA, Viral - chemistry | Rous sarcoma virus - genetics | Protein Binding | Rous sarcoma virus - enzymology | HIV-1 - enzymology | Integrases - metabolism | Rous sarcoma virus - chemistry | Integrases - chemistry | Complications and side effects | Care and treatment | Sarcoma | Analysis | Crystals | Research | Structure | Chromosomes | Proteins | Amino acids | Viruses | Deoxyribonucleic acid--DNA | Crystal structure | X-ray crystallography | Retrovirus | BASIC BIOLOGICAL SCIENCES | DNA | DNA-binding proteins
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 02/2017, Volume 24, Issue 2, pp. 131 - 139
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC...
HIV-1 RESTRICTION | CRYSTAL-STRUCTURE | AID/APOBEC FAMILY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | CYTIDINE DEAMINASE | BREAST | CELL BIOLOGY | LUNG-CANCER | FOREIGN DNA | SUBSTRATE-BINDING | BIOPHYSICS | HYPERMUTATION | Consensus Sequence | Minor Histocompatibility Antigens - physiology | Protein Conformation, alpha-Helical | Proteins - physiology | Catalytic Domain | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Cytidine Deaminase - physiology | DNA, Single-Stranded - chemistry | Amination | Hydrogen Bonding | Mutagenesis | Base Sequence | Protein Binding | Cytosine | Kinetics | Proteins - chemistry | Binding Sites | Cytidine Deaminase - chemistry | Minor Histocompatibility Antigens - chemistry | Proteins | Enzymes | Molecular targeted therapy | Gene mutations | Hydrolases | Models | Properties | Structure | Observations | Vertebrates | Viruses | Cytokines | Deoxyribonucleic acid--DNA | Index Medicus
HIV-1 RESTRICTION | CRYSTAL-STRUCTURE | AID/APOBEC FAMILY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | CYTIDINE DEAMINASE | BREAST | CELL BIOLOGY | LUNG-CANCER | FOREIGN DNA | SUBSTRATE-BINDING | BIOPHYSICS | HYPERMUTATION | Consensus Sequence | Minor Histocompatibility Antigens - physiology | Protein Conformation, alpha-Helical | Proteins - physiology | Catalytic Domain | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Cytidine Deaminase - physiology | DNA, Single-Stranded - chemistry | Amination | Hydrogen Bonding | Mutagenesis | Base Sequence | Protein Binding | Cytosine | Kinetics | Proteins - chemistry | Binding Sites | Cytidine Deaminase - chemistry | Minor Histocompatibility Antigens - chemistry | Proteins | Enzymes | Molecular targeted therapy | Gene mutations | Hydrolases | Models | Properties | Structure | Observations | Vertebrates | Viruses | Cytokines | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Microbiology and Immunology, ISSN 0385-5600, 09/2019, Volume 63, Issue 9, pp. 379 - 391
The immune system with large number of molecules protects the host against a plethora of continuously evolving microbes. Major histocompatibility complex (MHC)...
CXCR4 | MHC | tissue expression | chemokines | CXCR3 | Catla catla | SEQUENCE-ANALYSIS | CHANNEL CATFISH | CELLS | MICROBIOLOGY | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | CHALLENGE | CLASS-I | TELEOST FISH | INFECTION | DISEASE RESISTANCE | RECEPTOR CXCR3 | Analysis | Cloning | Fishes | Genes | Genetic research | Skin | Phylogeny | Gene expression | Adaptive systems | Amino acids | Tissue analysis | Nucleotides | Tissues | Immunity | Intestine | Evolutionary conservation | Fish | Freshwater fish | Immune system | Spleen | Carp | Nucleotide sequence | Adaptive immunity | CXCR3 protein | CXCR4 protein | Vertebrates | Major histocompatibility complex | Histocompatibility | Chemokines | Index Medicus
CXCR4 | MHC | tissue expression | chemokines | CXCR3 | Catla catla | SEQUENCE-ANALYSIS | CHANNEL CATFISH | CELLS | MICROBIOLOGY | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | CHALLENGE | CLASS-I | TELEOST FISH | INFECTION | DISEASE RESISTANCE | RECEPTOR CXCR3 | Analysis | Cloning | Fishes | Genes | Genetic research | Skin | Phylogeny | Gene expression | Adaptive systems | Amino acids | Tissue analysis | Nucleotides | Tissues | Immunity | Intestine | Evolutionary conservation | Fish | Freshwater fish | Immune system | Spleen | Carp | Nucleotide sequence | Adaptive immunity | CXCR3 protein | CXCR4 protein | Vertebrates | Major histocompatibility complex | Histocompatibility | Chemokines | Index Medicus
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2018, Volume 18, Issue 30, pp. 2614 - 2629
Colorectal cancer (CRC) is a heterogeneous malignancy leading to increased mortality and poor prognosis due to the lack of efficient early diagnostics....
Biomarker | MicroRNA | Diagnosis | Non-coding RNA | Colorectal cancer | Cancer | CHEMISTRY, MEDICINAL | METASTASIS | CELL-PROLIFERATION | PROGNOSTIC VALUE | COLON-CANCER | BIOMARKERS | PLASMA MICRORNAS | microRNA | UP-REGULATION | EXPRESSION | PROMOTES | GENETIC ALTERATIONS | Regulators | Target recognition | Transcription | Colorectal carcinoma | Homeostasis | Malignancy | Carcinogenesis | Metastases | Gene sequencing | Carcinogens | Cell fate | Therapeutic applications | Mortality | MiRNA | Gene expression | Biological activity | Ribonucleic acids | MicroRNAs | Medical prognosis | Regulatory mechanisms (biology) | Diagnostic systems | Color coding | Apoptosis
Biomarker | MicroRNA | Diagnosis | Non-coding RNA | Colorectal cancer | Cancer | CHEMISTRY, MEDICINAL | METASTASIS | CELL-PROLIFERATION | PROGNOSTIC VALUE | COLON-CANCER | BIOMARKERS | PLASMA MICRORNAS | microRNA | UP-REGULATION | EXPRESSION | PROMOTES | GENETIC ALTERATIONS | Regulators | Target recognition | Transcription | Colorectal carcinoma | Homeostasis | Malignancy | Carcinogenesis | Metastases | Gene sequencing | Carcinogens | Cell fate | Therapeutic applications | Mortality | MiRNA | Gene expression | Biological activity | Ribonucleic acids | MicroRNAs | Medical prognosis | Regulatory mechanisms (biology) | Diagnostic systems | Color coding | Apoptosis
Journal Article
Materials Chemistry and Physics, ISSN 0254-0584, 05/2019, Volume 229, pp. 106 - 116
Pharmaceutical and Personal Care Products (PPCPs) consists of diverse group of organic chemicals, which becomes a source of emerging concern, if their...
Algal toxicity | CuO | Ciprofloxacin | TiO2 | Ceramic ultrafiltration membrane | ACID | PHARMACEUTICALS | ACETAMINOPHEN | MATERIALS SCIENCE, MULTIDISCIPLINARY | DEGRADATION | ADSORPTION | WATER | Performance evaluation | Infrared spectroscopy | Atomic force microscopy | Surgical implants | Fourier transforms | Toxicity | Fluorescence | X-ray diffraction | Nanoparticles | Ultrafiltration | Aqueous solutions | Biocompatibility | Titanium dioxide | Cross flow | Scanning electron microscopy | Ceramics | Field emission microscopy | Aluminum oxide | Organic chemistry | Antibiotics | Nanocomposites | Microscopy | Contaminants | Process parameters | Flow velocity | Organic chemicals | Copper oxides
Algal toxicity | CuO | Ciprofloxacin | TiO2 | Ceramic ultrafiltration membrane | ACID | PHARMACEUTICALS | ACETAMINOPHEN | MATERIALS SCIENCE, MULTIDISCIPLINARY | DEGRADATION | ADSORPTION | WATER | Performance evaluation | Infrared spectroscopy | Atomic force microscopy | Surgical implants | Fourier transforms | Toxicity | Fluorescence | X-ray diffraction | Nanoparticles | Ultrafiltration | Aqueous solutions | Biocompatibility | Titanium dioxide | Cross flow | Scanning electron microscopy | Ceramics | Field emission microscopy | Aluminum oxide | Organic chemistry | Antibiotics | Nanocomposites | Microscopy | Contaminants | Process parameters | Flow velocity | Organic chemicals | Copper oxides
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 06/2017, Volume 8, p. 1083
Acquired immune deficiency syndrome (AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV). Two types of HIV have...
Evolutionary rate | Slow progressor | Long-term non-progressor | Rapid progressor | Disease progression | EFFECTIVE NUMBER | SEQUENCES | BIAS | slow progressor | PATTERNS | MICROBIOLOGY | disease progression | long-term non-progressor | rapid progressor | RATES | EVOLUTION | POSITIVE SELECTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFECTION | evolutionary rate
Evolutionary rate | Slow progressor | Long-term non-progressor | Rapid progressor | Disease progression | EFFECTIVE NUMBER | SEQUENCES | BIAS | slow progressor | PATTERNS | MICROBIOLOGY | disease progression | long-term non-progressor | rapid progressor | RATES | EVOLUTION | POSITIVE SELECTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFECTION | evolutionary rate
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2018, Volume 48, Issue 22, pp. 2923 - 2934
A series of β-hydroxyazides were effectively synthesized from the regioselective ring opening of epoxides by sodium azide using montmorillonite K10 as a novel...
Azidolysis | montmorillonite K10 | epoxide | phenylglycine | β-azido alcohols | SODIUM-AZIDE | CEPHALOSPORIN ANTIBIOTICS | RING-OPENING REACTIONS | azido alcohols | CHEMISTRY, ORGANIC | METABOTROPIC GLUTAMATE RECEPTORS | AZIRIDINES | CLEAVAGE | CHEMOENZYMATIC SYNTHESIS | CHEMISTRY | DERIVATIVES | WATER
Azidolysis | montmorillonite K10 | epoxide | phenylglycine | β-azido alcohols | SODIUM-AZIDE | CEPHALOSPORIN ANTIBIOTICS | RING-OPENING REACTIONS | azido alcohols | CHEMISTRY, ORGANIC | METABOTROPIC GLUTAMATE RECEPTORS | AZIRIDINES | CLEAVAGE | CHEMOENZYMATIC SYNTHESIS | CHEMISTRY | DERIVATIVES | WATER
Journal Article
Molecular Biotechnology, ISSN 1073-6085, 6/2018, Volume 60, Issue 6, pp. 435 - 453
The disparate diversity in immunoglobulin (Ig) repertoire has been a subject of fascination since the emergence of prototypic adaptive immune system in...
Biochemistry, general | Protein Science | Human Genetics | Activation-induced deaminase (AID) | Biotechnology | B cell activating factor (BAFF) | Chemistry | Immunoglobulins | Biological Techniques | Isotype switching | Teleosts | Cell Biology | SOMATIC HYPERMUTATION | AFFINITY MATURATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SINGLE-STRANDED-DNA | ADAPTIVE IMMUNE-SYSTEM | ANTIBODY DIVERSIFICATION | HEAVY-CHAIN | LIGHT-CHAIN GENES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TOLL-LIKE RECEPTORS | CLASS-SWITCH RECOMBINATION | VARIABLE LYMPHOCYTE RECEPTORS | T cells | B cells | Adaptive systems | Recombination | Activation-induced cytidine deaminase | Lymphocytes T | Activation | Loci | Switching | Class switching | Vertebrates | Cell activation | Isotypes | Lymphocytes B | BLyS protein | Heavy chains | Fish | Catalysis | Immune system | Cytidine deaminase
Biochemistry, general | Protein Science | Human Genetics | Activation-induced deaminase (AID) | Biotechnology | B cell activating factor (BAFF) | Chemistry | Immunoglobulins | Biological Techniques | Isotype switching | Teleosts | Cell Biology | SOMATIC HYPERMUTATION | AFFINITY MATURATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SINGLE-STRANDED-DNA | ADAPTIVE IMMUNE-SYSTEM | ANTIBODY DIVERSIFICATION | HEAVY-CHAIN | LIGHT-CHAIN GENES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TOLL-LIKE RECEPTORS | CLASS-SWITCH RECOMBINATION | VARIABLE LYMPHOCYTE RECEPTORS | T cells | B cells | Adaptive systems | Recombination | Activation-induced cytidine deaminase | Lymphocytes T | Activation | Loci | Switching | Class switching | Vertebrates | Cell activation | Isotypes | Lymphocytes B | BLyS protein | Heavy chains | Fish | Catalysis | Immune system | Cytidine deaminase
Journal Article
Journal of Chemical Sciences, ISSN 0974-3626, 8/2019, Volume 131, Issue 8, pp. 1 - 9
We present a practical method for Suzuki coupling by which unprotected or N-protected indoles may be selectively arylated in the C2-position through direct C–H...
Chemistry | air | boronic acid | Chemistry/Food Science, general | Pd catalysis | C–H arylation of indole | AZOLES | ROOM-TEMPERATURE | C-H arylation of indole | FREE (NH)-INDOLES | INCLUDING FREE (NH)-IMIDAZOLE | DIRECT C-2 ARYLATION | POTENT INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | CROSS-COUPLING REACTIONS | (NH)-BENZIMIDAZOLE | SELECTIVE ARYLATION | Palladium catalysts | Substitution reactions | Palladium | Thiophene | Catalysis
Chemistry | air | boronic acid | Chemistry/Food Science, general | Pd catalysis | C–H arylation of indole | AZOLES | ROOM-TEMPERATURE | C-H arylation of indole | FREE (NH)-INDOLES | INCLUDING FREE (NH)-IMIDAZOLE | DIRECT C-2 ARYLATION | POTENT INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | CROSS-COUPLING REACTIONS | (NH)-BENZIMIDAZOLE | SELECTIVE ARYLATION | Palladium catalysts | Substitution reactions | Palladium | Thiophene | Catalysis
Journal Article