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1. Full Text The SCUBA-2 Cosmology Legacy Survey: 850 μm maps, catalogues and number counts
by Geach, J.E and Dunlop, J.S and Halpern, M and Smail, Ian and van der Werf, P and Alexander, D.M and Almaini, O and Aretxaga, I and Arumugam, V and Asboth, V and Banerji, M and Beanlands, J and Best, P.N and Blain, A.W and Birkinshaw, M and Chapin, E.L and Chapman, S.C and Chen, C.-C and Chrysostomou, A and Clarke, C and Clements, D.L and Conselice, C and Coppin, K.E.K and Cowley, W.I and Danielson, A.L.R and Eales, S and Edge, A.C and Farrah, D and Gibb, A and Harrison, C.M and Hine, N.K and Hughes, D and Ivison, R.J and Jarvis, M and Jenness, T and Jones, S.F and Karim, A and Koprowski, M and Knudsen, K.K and Lacey, C.G and Mackenzie, T and Marsden, G and McAlpine, K and McMahon, R and Meijerink, R and Michalowski, M.J and Oliver, S.J and Page, M.J and Peacock, J.A and Rigopoulou, D and Robson, E.I and Roseboom, I and Rotermund, K and Scott, Douglas and Serjeant, S and Simpson, C and Simpson, J.M and Smith, D.J.B and Spaans, M and Stanley, F and Stevens, J.A and Swinbank, A.M and Targett, T and Thomson, A.P and Valiante, E and Wake, D.A and Webb, T.M.A and Willott, C and Zavala, J.A and Zemcov, M
Monthly Notices of the Royal Astronomical Society, ISSN 0035-8711, 2017, Volume 465, Issue 2, pp. 1789 - 1806
Surveys | Galaxies: evolution | Catalogues | Galaxies: high-redshift | Cosmology: observations
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2. Full Text First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014
by Basu, Bristi and Dean, Emma and Puglisi, Martina and Greystoke, Alastair and Ong, Michael and Burke, Wendy and Cavallin, Maria and Bigley, Graham and Womack, Christopher and Harrington, Elizabeth A and Green, Stephen and Oelmann, Elisabeth and De Bono, Johann S and Ranson, Malcolm and Banerji, Udai
Clinical Cancer Research, ISSN 1078-0432, 08/2015, Volume 21, Issue 15, pp. 3412 - 3419
Purpose: AZD2014 is a novel, oral, m-TORC 1/2 inhibitor that has shown in vitro and in vivo efficacy across a range of preclinical human cancer models.... 
PHASE-III TRIAL | MAMMALIAN TARGET | RAPAMYCIN | ADVANCED SOLID TUMORS | MTORC2 | EVEROLIMUS | ONCOLOGY | I TRIAL | KINASE INHIBITOR | ANTITUMOR-ACTIVITY | RENAL-CELL CARCINOMA | Administration, Oral | Humans | Middle Aged | Morpholines - administration & dosage | Male | Mechanistic Target of Rapamycin Complex 2 | Drug-Related Side Effects and Adverse Reactions - pathology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Neoplasms - drug therapy | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Adult | Female | Aged | Morpholines - pharmacokinetics | Neoplasms - pathology | Morpholines - adverse effects | pharmacokinetics | Phase I | m-TORC2 inhibitor | pharmacodynamics | m-TORC1 inhibitor
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3. Full Text The SCUBA-2 Cosmology Legacy Survey: Galaxies in the deep 850μm survey, and the star-forming 'main sequence'
by Koprowski, M.P and Dunlop, J.S and Michałowski, M.J and Roseboom, I and Geach, J.E and Cirasuolo, M and Aretxaga, I and Bowler, R.A.A and Banerji, M and Bourne, N and Coppin, K.E.K and Chapman, S and Hughes, D.H and Jenness, T and McLure, R.J and Symeonidis, M and Van Der Werf, P
Monthly Notices of the Royal Astronomical Society, ISSN 0035-8711, 03/2016, Volume 458, Issue 4, pp. 4321 - 4344
Cosmology: Observations | Galaxies: High-redshift | Galaxies: Starburst | Submillimetre: Galaxies | Galaxies: Evolution
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4. Full Text The SCUBA-2 Cosmology Legacy Survey: 850 mu m maps, catalogues and number counts
by Geach, JE and Dunlop, JS and Halpern, M and Smail, I and van der Werf, P and Alexander, DM and Almaini, O and Aretxaga, I and Arumugam, V and Asboth, V and Banerji, M and Beanlands, J and Best, PN and Blain, AW and Birkinshaw, M and Chapin, EL and Chapman, SC and Chen, CC and Chrysostomou, A and Clarke, C and Clements, DL and Conselice, C and Coppin, KEK and Cowley, WI and Danielson, ALR and Eales, S and Edge, AC and Farrah, D and Gibb, A and Harrison, CM and Hine, NK and Hughes, D and Ivison, RJ and Jarvis, M and Jenness, T and Jones, SF and Karim, A and Koprowski, M and Knudsen, KK and Lacey, CG and Mackenzie, T and Marsden, G and McAlpine, K and McMahon, R and Meijerink, R and Michalowski, MJ and Oliver, SJ and Page, MJ and Peacock, JA and Rigopoulou, D and Robson, EI and Roseboom, I and Rotermund, K and Scott, D and Serjeant, S and Simpson, C and Simpson, JM and Smith, DJB and Spaans, M and Stanley, F and Stevens, JA and Swinbank, AM and Targett, T and Thomson, AP and Valiante, E and Wake, DA and Webb, TMA and Willott, C and Zavala, JA and Zemcov, M
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, ISSN 0035-8711, 02/2017, Volume 465, Issue 2, pp. 1789 - 1806
We present a catalogue of similar to 3000 submillimetre sources detected (>= 3.5 sigma) at 850 mu m over similar to 5 deg(2) surveyed as part of the James... 
STAR-FORMING GALAXIES | REDSHIFT DISTRIBUTION | galaxies: evolution | BOLOMETER CAMERA | surveys | galaxies: high-redshift | INFRARED PROPERTIES | SUBMILLIMETER GALAXY POPULATION | SURVEY ALMA RESOLVES | ASTRONOMY & ASTROPHYSICS | SUPER-MAP | DEEP FIELD-SOUTH | MOLECULAR GAS | cosmology: observations | catalogues | DEGREE EXTRAGALACTIC SURVEY | resolves | 14 hour field | high-redshift | star-forming galaxies | submillimeter galaxy population | degree extragalactic | molecular gas | bolometer camera | Astronomy, Astrophysics and Cosmology | Astronomi, astrofysik och kosmologi | survey alma | clerk maxwell telescope | deep field-south | survey
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5. Full Text Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
by Ismail-Beigi, Faramarz, Dr and Craven, Timothy, MSPH and Banerji, Mary Ann, MD and Basile, Jan, MD and Calles, Jorge, MD and Cohen, Robert M, MD and Cuddihy, Robert, MD and Cushman, William C, MD and Genuth, Saul, MD and Grimm, Richard H, MD and Hamilton, Bruce P, MD and Hoogwerf, Byron, MD and Karl, Diane, MD and Katz, Lois, MD and Krikorian, Armand, MD and O'Connor, Patrick, MD and Pop-Busui, Rodica, MD and Schubart, Ulrich, MD and Simmons, Debra, MD and Taylor, Harris, MD and Thomas, Abraham, MD and Weiss, Daniel, MD and Hramiak, Irene, MD and ACCORD Trial Grp and ACCORD trial group
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9739, pp. 419 - 430
Summary Background Hyperglycaemia is associated with increased risk of cardiovascular complications in people with type 2 diabetes. We investigated whether... 
Internal Medicine | URINARY ALBUMIN EXCRETION | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | MICROALBUMINURIA | CLINICAL-TRIALS | UKPDS | COMPLICATIONS | MELLITUS | HYPERTENSION | BLOOD-GLUCOSE CONTROL | PROGRESSION | Glycated Hemoglobin A - analysis | Blood Glucose - analysis | Diabetic Neuropathies - prevention & control | Humans | Middle Aged | Diabetes Mellitus, Type 2 - blood | Diabetic Retinopathy - prevention & control | Hypoglycemic Agents - administration & dosage | Lipids - blood | Adult | Aged | Diabetic Angiopathies - prevention & control | Diabetes Mellitus, Type 2 - drug therapy | Diabetic Nephropathies - prevention & control | Type 2 diabetes | Complications and side effects | Care and treatment | Hyperglycemia | Patient outcomes | Cardiovascular diseases | Risk factors | Clinical trials | Cardiovascular disease | Diabetes | Eye
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6. Full Text Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
by Peifer, Martin and Fernández-Cuesta, Lynnette and Sos, Martin L and George, Julie and Seidel, Danila and Kasper, Lawryn H and Plenker, Dennis and Leenders, Frauke and Sun, Ruping and Zander, Thomas and Menon, Roopika and Koker, Mirjam and Dahmen, Ilona and Müller, Christian and Di Cerbo, Vincenzo and Schildhaus, Hans-Ulrich and Altmüller, Janine and Baessmann, Ingelore and Becker, Christian and De Wilde, Bram and Vandesompele, Jo and Böhm, Diana and Ansén, Sascha and Gabler, Franziska and Wilkening, Ines and Heynck, Stefanie and Heuckmann, Johannes M and Lu, Xin and Carter, Scott L and Cibulskis, Kristian and Banerji, Shantanu and Getz, Gad and Park, Kwon-Sik and Rauh, Daniel and Grütter, Christian and Fischer, Matthias and Pasqualucci, Laura and Wright, Gavin and Wainer, Zoe and Russell, Prudence and Petersen, Iver and Chen, Yuan and Stoelben, Erich and Ludwig, Corinna and Schnabel, Philipp and Hoffmann, Hans and Muley, Thomas and Brockmann, Michael and Engel-Riedel, Walburga and Muscarella, Lucia A and Fazio, Vito M and Groen, Harry and Timens, Wim and Sietsma, Hannie and Thunnissen, Erik and Smit, Egber and Heideman, Daniëlle A. M and Snijders, Peter J. F and Cappuzzo, Federico and Ligorio, Claudia and Damiani, Stefania and Field, John and Solberg, Steinar and Brustugun, Odd Terje and Lund-Iversen, Marius and Sänger, Jörg and Clement, Joachim H and Soltermann, Alex and Moch, Holger and Weder, Walter and Solomon, Benjamin and Soria, Jean-Charles and Validire, Pierre and Besse, Benjamin and Brambilla, Elisabeth and Brambilla, Christian and Lantuejoul, Sylvie and Lorimier, Philippe and Schneider, Peter M and Hallek, Michael and Pao, William and Meyerson, Matthew and Sage, Julien and Shendure, Jay and Schneider, Robert and Büttner, Reinhard and Wolf, Jürgen and Nürnberg, Peter and Perner, Sven and Heukamp, Lukas C and Brindle, Paul K and Haas, Stefan and Thomas, Roman K
Nature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1104 - 1110
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis(1-3). We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and... 
EPH-RECEPTOR | NEUROENDOCRINE TUMORS | GENE | ACUTE LYMPHOBLASTIC-LEUKEMIA | MOUSE MODEL | PROSTATE-CANCER | GENETICS & HEREDITY | FREQUENT MUTATION | EGFR MUTATIONS | E-CADHERIN | P53 REGULATION | Oligonucleotide Array Sequence Analysis | Humans | Protein Processing, Post-Translational - genetics | E1A-Associated p300 Protein - genetics | Gene Expression Profiling | Gene Regulatory Networks | Tumor Suppressor Protein p53 - genetics | DNA Copy Number Variations | CREB-Binding Protein - genetics | DNA Mutational Analysis | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Genome-Wide Association Study | Histone-Lysine N-Methyltransferase | Intercellular Signaling Peptides and Proteins - genetics | Models, Molecular | Small Cell Lung Carcinoma - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Retinoblastoma Protein - genetics | Cell Line, Tumor | Mice | Polymorphism, Single Nucleotide | Mutation | Genome, Human | Amino Acid Substitution | Gene mutations | Physiological aspects | Lung cancer, Small cell | Genetic aspects | Research | Diagnosis | Risk factors | Medical research | Lung cancer | Tumors | small-cell lung cancer | cancer genome | integrated analysis
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7. Full Text The SCUBA-2 Cosmology Legacy Survey: galaxies in the deep 850 mu m survey, and the star-forming 'main sequence'
by Koprowski, MP and Dunlop, JS and Michalowski, MJ and Roseboom, I and Geach, JE and Cirasuolo, M and Aretxaga, I and Bowler, RAA and Banerji, M and Bourne, N and Coppin, KEK and Chapman, S and Hughes, DH and Jenness, T and McLure, RJ and Symeonidis, M and van der Werf, P
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, ISSN 0035-8711, 06/2016, Volume 458, Issue 4, pp. 4321 - 4344
We investigate the properties of the galaxies selected from the deepest 850-mu m survey undertaken to date with (Submillimetre Common-User Bolometer Array 2)... 
galaxies: starburst | galaxies: evolution | HUBBLE-SPACE-TELESCOPE | SQUARE DEGREE SURVEY | STELLAR MASS DENSITY | UV LUMINOSITY FUNCTIONS | LYMAN BREAK GALAXIES | HIGH-REDSHIFT GALAXIES | TO 7 GALAXIES | galaxies: high-redshift | CLERK MAXWELL TELESCOPE | SPECTRAL ENERGY-DISTRIBUTIONS | ASTRONOMY & ASTROPHYSICS | cosmology: observations | submillimetre: galaxies | DEGREE EXTRAGALACTIC SURVEY
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8. Full Text Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high grade serous ovarian and squamous non-small cell lung cancer
by Basu, Bristi and Krebs, MG and Sundar, R and Wilson, RH and Spicer, J and Jones, R and Brada, M and Talbot, DC and Steele, N and Ingles Garces, AH and Brugger, W and Harrington, EA and Evans, J and Hall, E and Tovey, H and de Oliveira, FM and Carreira, S and Swales, K and Ruddle, R and Raynaud, FI and Purchase, B and Dawes, JC and Parmar, M and Turner, AJ and Tunariu, N and Banerjee, S and de Bono, JS and Banerji, U
ISSN 0923-7534, 2018
Background: We have previously shown that raised p-S6K levels correlate with resistance to chemotherapy in ovarian cancer. We hypothesised that inhibiting... 
combination therapy | squamous non-small cell lung cancer | m-TORC1/m-TORC2 inhibitor | Phase 1 | ovarian cancer
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9. Full Text Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer
by Broutin, Sophie and Stewart, Adam and Thavasu, Parames and Paci, Angelo and Bidart, Jean-Michel and Banerji, Udai
British Journal of Cancer, ISSN 0007-0920, 08/2016, Volume 115, Issue 5, pp. 549 - 552
Background: We aimed to understand the dependence of MEK and m-TOR inhibition in EGFR(WT)/ALK(non-rearranged) NSCLC cell lines. Methods: In a panel of KRAS(M)... 
drug combinations; NSCLC; KRAS mutant; MEK inhibitor; trametinib; m-TOR inhibitor; AZD2014 | PATHWAYS | NSCLC | EVEROLIMUS | EFFICACY | m-TOR inhibitor | PHASE-II | MEK inhibitor | DOCETAXEL | TUMORS | CHEMOTHERAPY | drug combinations | trametinib | AZD2014 | COMBINATIONS | KRAS mutant | ONCOLOGY | ADVANCED NSCLC | TRAMETINIB GSK1120212 | Lung Neoplasms - genetics | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Cell Line, Tumor | MAP Kinase Kinase Kinases - metabolism | Genes, ras | Translational Therapeutics
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