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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 6, pp. 1737 - 1742
As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from targetbased antibacterial screening... 
Pharmaceutical preparations | Enzymes | Antibacterials | Antibiotics | Biosynthesis | Infections | Drug discovery | Genetic mutation | Fatty acids | Crystal structure | ANTIBIOTICS | biotin carboxylase | fatty acid biosynthesis | MULTIDISCIPLINARY SCIENCES | high-throughput screening | crystal structure | TARGETS | AGENTS | IDENTIFICATION | DISCOVERY | acetylcoenzyme A carboxylase | Haemophilus influenzae - drug effects | Moraxella (Branhamella) catarrhalis - enzymology | Moraxella (Branhamella) catarrhalis - drug effects | Pyrimidines - pharmacology | Drug Discovery | Pyrimidines - chemistry | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Protein Kinase Inhibitors - chemistry | Small Molecule Libraries | Anti-Bacterial Agents - chemistry | Haemophilus influenzae - enzymology | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Carbon-Nitrogen Ligases - antagonists & inhibitors | Drug Evaluation, Preclinical | Research | Properties | Protein kinases | Antibacterial agents | CRYSTAL STRUCTURE | HAEMOPHILUS | SPACE | ENZYMES | IN VITRO | DRUGS | GENES | BIOTIN | CHEMISTRY | SCREENING | MICROBIAL DRUG RESISTANCE | PATHOGENS | HUMAN POPULATIONS | BACTERIA | MATERIALS SCIENCE | IN VIVO | LIBRARIES | CARBOXYLASE | BIOSYNTHESIS | CARBOXYLIC ACIDS | PHOSPHOTRANSFERASES | PROTEINS | RECEPTORS | Biological Sciences
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3438 - 3442
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3443 - 3447
Journal Article
Journal Article
Protein Science, ISSN 0961-8368, 12/2007, Volume 16, Issue 12, pp. 2657 - 2666
N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU) catalyzes the first step in peptidoglycan biosynthesis in both Gram-positive and Gram-negative... 
Journal Article
Journal of Structural Biology, ISSN 1047-8477, 2008, Volume 162, Issue 1, pp. 152 - 169
In this article, we describe for the first time the high-resolution crystal structure of a phenylalanine tRNA synthetase from the pathogenic bacterium . We... 
Protein engineering | Antibacterial drug design | Phenylalanine tRNA synthetase | Rational mutagenesis | Crystal structure | SMALL-ANGLE SCATTERING | CCA END | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | BETA-SUBUNITS | SUBUNIT STRUCTURE | TRNA SYNTHETASE | CELL BIOLOGY | phenylalanine tRNA synthetase | rational mutagenesis | antibacterial drug design | protein engineering | BIOPHYSICS | ANTIBACTERIAL ACTIVITY | crystal structure | INHIBITORS | THERMUS-THERMOPHILUS | ANTI-INFECTIVES | Protein Structure, Tertiary | Amino Acid Sequence | Protein Engineering - methods | Protein Structure, Secondary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Molecular Sequence Data | Staphylococcus haemolyticus - enzymology | Staphylococcus haemolyticus - genetics | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Crystallography, X-Ray - methods | Phenylalanine-tRNA Ligase - chemistry | Mutagenesis | Phenylalanine-tRNA Ligase - metabolism | Bacterial Proteins - metabolism | Molecular Structure | Phenylalanine | Structure | Ligases | Crystals | Transfer RNA | MUTAGENESIS | TRANSFER RNA | MODE RATIONAL SURFACES | ENZYME INHIBITORS | X-RAY DIFFRACTION | PROTEIN ENGINEERING | RESOLUTION | CRYSTAL STRUCTURE | 60 APPLIED LIFE SCIENCES | STAPHYLOCOCCUS | STRUCTURE-ACTIVITY RELATIONSHIPS | AMINO ACIDS | ENZYMES | CRYSTALS | LIGASES | PHENYLALANINE | PROTEINS | PATHOGENS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2009, Volume 106, Issue 6, p. 1737
  As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial... 
Enzymes | Antibiotics | Pharmacology | Glycoproteins | Drug resistance | Kinases | Fatty acids
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 38, pp. 27781 - 27791
Matrix metalloproteinase-13 (MMP13) is a Zn super(2+)-dependent protease that catalyzes the cleavage of type II collagen, the main structural protein in... 
Journal Article
Proteins: Structure, Function, and Genetics, ISSN 0887-3585, 1998, Volume 33, Issue S2, pp. 28 - 37
Journal Article
01/1998, ISBN 0591935252
Dietary exposure to the trichothecene VT results in reduced body weight gain, elevated production of serum IgA, terminal differentiation of Peyer's patch B... 
Toxicology | Immunology | Food science
Dissertation
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