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1. Full Text Translating nucleic acid-sensing pathways into therapies
by Junt, Tobias and Barchet, Winfried
Nature reviews. Immunology, ISSN 1474-1733, 09/2015, Volume 15, Issue 9, pp. 529 - 544
Life Sciences & Biomedicine | Immunology | Science & Technology | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Immunosuppressive Agents - immunology | Humans | Immunosuppressive Agents - therapeutic use | Toll-Like Receptors - immunology | DEAD-box RNA Helicases - immunology | Nucleic Acids - immunology | Drug Discovery | Autoimmune Diseases - drug therapy | Molecular Targeted Therapy - methods | Neoplasms - drug therapy | Molecular targeted therapy | Immune response | Communicable diseases | Innovations | Development and progression | Genetic aspects | Cellular signal transduction | Health aspects | Index Medicus
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2. Full Text Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5 '-diphosphates
by Goubau, Delphine and Schlee, Martin and Deddouche, Safia and Pruijssers, Andrea J and Zillinger, Thomas and Goldeck, Marion and Schuberth, Christine and Van der Veen, Annemarthe G and Fujimura, Tsutomu and Rehwinkel, Jan and Iskarpatyoti, Jason A and Barchet, Winfried and Ludwig, Janos and Dermody, Terence S and Hartmann, Gunther and Reis e Sousa, Caetano
Nature (London), ISSN 0028-0836, 10/2014, Volume 514, Issue 7522, pp. 372 - 375
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | DEAD Box Protein 58 | Reoviridae - genetics | Diphosphates - metabolism | Genome, Viral - genetics | Male | Immunity, Innate | Animals | RNA, Viral - chemistry | RNA, Viral - genetics | Base Pairing | Reoviridae - physiology | Base Sequence | Reoviridae - immunology | Female | Mice | RNA, Viral - metabolism | DEAD-box RNA Helicases - metabolism | Antiviral agents | Synthesis | RNA | Analysis | Research | Health aspects | Pyrophosphates | Phosphates | Immunology | Viruses | Infections | Genomes | Phosphatase | Transfer RNA | Index Medicus
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3. Full Text Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
by Gehrke, Nadine and Mertens, Christina and Zillinger, Thomas and Wenzel, Jörg and Bald, Tobias and Zahn, Sabine and Tüting, Thomas and Hartmann, Gunther and Barchet, Winfried
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2013, Volume 39, Issue 3, pp. 482 - 495
Life Sciences & Biomedicine | Immunology | Science & Technology | Guanosine - analogs & derivatives | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress | Humans | Mice, Inbred C57BL | Cells, Cultured | Lupus Erythematosus, Systemic - metabolism | DNA - metabolism | Guanosine - metabolism | Phosphoproteins - metabolism | Interferon Type I | Animals | DNA Repair | Lupus Erythematosus, Systemic - genetics | Exodeoxyribonucleases - metabolism | Lupus Erythematosus, Systemic - immunology | Membrane Proteins - metabolism | Mice | DNA Damage | Neutrophils - metabolism | Lupus | Autoimmunity | Antiviral agents | Biological response modifiers | DNA | Biopsy | Laboratories | Light | Skin | Deoxyribonucleic acid--DNA | Immune system | Apoptosis | Index Medicus
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4. Full Text Ribose 2′- O -methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
by Cervantes-Barragan, Luisa and Siddell, Stuart G and Habjan, Matthias and Thiel, Volker and Ziebuhr, John and Züst, Roland and Ludewig, Burkhard and Neuman, Benjamin W and Szretter, Kristy J and Baker, Susan C and Diamond, Michael S and Barchet, Winfried and Maier, Reinhard
Nature immunology, ISSN 1529-2908, 02/2011, Volume 12, Issue 2, pp. 137 - 143
Life Sciences & Biomedicine | Immunology | Science & Technology | Virus Replication - genetics | Humans | Methyltransferases - metabolism | Immunity, Innate - genetics | Methyltransferases - genetics | Viral Proteins - immunology | Methyltransferases - immunology | Interferon Type I - immunology | Viral Proteins - metabolism | Interferon-Induced Helicase, IFIH1 | Coronavirus Infections - metabolism | Virulence - genetics | Interferon Type I - metabolism | RNA, Viral - metabolism | Receptor, Interferon alpha-beta - genetics | DEAD-box RNA Helicases - metabolism | Coronavirus - physiology | Cell Line | Coronavirus - pathogenicity | Ribose - metabolism | Mice, Inbred C57BL | Coronavirus Infections - genetics | Viral Proteins - genetics | Coronavirus Infections - immunology | Mice, Knockout | DEAD-box RNA Helicases - genetics | Animals | DEAD-box RNA Helicases - immunology | Interferon Type I - genetics | Receptors, Pattern Recognition - genetics | Mice | Methylation | Messenger RNA | Physiological aspects | Viruses | Genetic aspects | Research | Health aspects | Index Medicus
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5. Full Text Exonuclease TREX1 also Has a Sweet Tooth
by Barchet, Winfried and Zillinger, Thomas
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 411 - 413
Life Sciences & Biomedicine | Immunology | Science & Technology | Cytosol - enzymology | Animals | Humans | Exodeoxyribonucleases - metabolism | Hexosyltransferases - metabolism | Membrane Proteins - metabolism | Phosphoproteins - metabolism | Proteins | Inflammation | Mutation | Kinases | Rodents | Index Medicus
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6. Full Text CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming
by Brewitz, Anna and Eickhoff, Sarah and Dähling, Sabrina and Quast, Thomas and Bedoui, Sammy and Kroczek, Richard A and Kurts, Christian and Garbi, Natalio and Barchet, Winfried and Iannacone, Matteo and Klauschen, Frederick and Kolanus, Waldemar and Kaisho, Tsuneyasu and Colonna, Marco and Germain, Ronald N and Kastenmüller, Wolfgang
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2017, Volume 46, Issue 2, pp. 205 - 219
chemokine | viral infection | spatiotemporal | CXCR3 | CCL4 | migration | CCL3 | XCL1 | CCR5 | cooperation | Life Sciences & Biomedicine | Immunology | Science & Technology | Animals | Flow Cytometry | Cross-Priming - immunology | Enzyme-Linked Immunosorbent Assay | Dendritic Cells - immunology | Fluorescent Antibody Technique | Mice, Transgenic | Mice | CD8-Positive T-Lymphocytes - immunology | Chemotaxis, Leukocyte - immunology | Antigens | Statistical analysis | Peptides | Microscopy | Lymphocytes | T cell receptors | Infections | Viral infections | Chemokines | Index Medicus
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7. Full Text Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
by Daniela Niemeyer and Thomas Zillinger and Doreen Muth and Florian Zielecki and Gabor Horvath and Tasnim Suliman and Winfried Barchet and Friedemann Weber and Christian Drosten and Marcel A. Müller
Journal of Virology, ISSN 0022-538X, 11/2013, Volume 87, Issue 22, pp. 12489 - 12495
Life Sciences & Biomedicine | Science & Technology | Virology | Amino Acid Sequence | Coronavirus - pathogenicity | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - immunology | Molecular Sequence Data | Coronavirus Infections - immunology | Viral Regulatory and Accessory Proteins - metabolism | Middle East | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Coronavirus Infections - metabolism | Coronavirus Infections - virology | Severe Acute Respiratory Syndrome - metabolism | RNA, Double-Stranded - metabolism | Coronavirus - growth & development | Interferon Type I - antagonists & inhibitors | Index Medicus | Pathogenesis and Immunity
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8. Full Text Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus
by Schlee, Martin and Roth, Andreas and Hornung, Veit and Hagmann, Cristina Amparo and Wimmenauer, Vera and Barchet, Winfried and Coch, Christoph and Janke, Markus and Mihailovic, Aleksandra and Wardle, Greg and Juranek, Stefan and Kato, Hiroki and Kawai, Taro and Poeck, Hendrik and Fitzgerald, Katherine A and Takeuchi, Osamu and Akira, Shizuo and Tuschl, Thomas and Latz, Eicke and Ludwig, Janos and Hartmann, Gunther
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2009, Volume 31, Issue 1, pp. 25 - 34
MOLIMMUNO | CELLIMMUNO | Life Sciences & Biomedicine | Immunology | Science & Technology | DEAD Box Protein 58 | Oligoribonucleotides - chemical synthesis | Interferon-alpha - biosynthesis | Humans | Cells, Cultured | Monocytes - metabolism | Monocytes - immunology | Polyphosphates - metabolism | Interferon-alpha - immunology | DEAD-box RNA Helicases - genetics | Animals | Mice, Mutant Strains | Polyphosphates - immunology | RNA Viruses - immunology | RNA, Double-Stranded - immunology | DEAD-box RNA Helicases - immunology | RNA, Viral - immunology | Mice | RNA, Double-Stranded - metabolism | RNA, Viral - metabolism | Oligoribonucleotides - immunology | Virus diseases | Medical colleges | RNA | Health aspects | Ligands | Infections | Kinases | Viral infections | Immune system | Index Medicus | Conformation | RIG-I | immunorecognition of RNA virus | 5′-triphosphate RNA
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