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Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. SY21-03 - SY21-03
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7655, pp. 417 - 418
Journal Article
Cancer Research, ISSN 0008-5472, 02/2017, Volume 77, Issue 3 Supplement, pp. IA22 - IA22
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. PL04-03 - PL04-03
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. CN02-03 - CN02-03
Journal Article
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 961 - 961
RAS mutations are frequent in human cancer, especially in pancreatic, colorectal and non-small-cell lung cancers (NSCLCs)(1-3). Inhibition of the RAS... 
MEDICINE, RESEARCH & EXPERIMENTAL | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEK INHIBITORS | INDUCED SENESCENCE | CELL BIOLOGY | THERAPY | K-RAS | RESISTANCE | MUTATIONS | EXPRESSION | PROGRESSION | PHOSPHOTYROSINE PHOSPHATASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Cellular Senescence - drug effects | Lung Neoplasms - pathology | Guanosine Triphosphate - metabolism | Mutation - genetics | Xenograft Model Antitumor Assays | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins p21(ras) - metabolism | Tyrosine | Ras genes | Genetic aspects | Epidermal growth factor | Lung cancer, Non-small cell | Analysis | Cell culture | Senescence | Lung cancer | Extracellular signal-regulated kinase | Antibodies | Raf protein | Signaling | Immunotherapy | Pancreatic cancer | Protein-tyrosine kinase receptors | Colon | Inhibition | Mutation | Pancreas | Growth factors | Protein-tyrosine kinase | Cancer | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 100 - 104
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma(1). However, colon... 
PANITUMUMAB | TARGET | CETUXIMAB | MELANOMA | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CARCINOMA | KRAS | METASTATIC COLORECTAL-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - agonists | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cetuximab | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Colorectal Neoplasms - enzymology | Antibodies, Monoclonal - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Quinazolines - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Feedback, Physiological - drug effects | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Library collections | Studies | Phosphorylation | Kinases | Tumors | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2287 - 12
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2018, Volume 19, Issue 10, pp. 1360 - 1371
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2008, Volume 26, Issue 35, pp. 5705 - 5712
Purpose Cetuximab or panitumumab are effective in 10% to 20% unselected metastatic colorectal cancer (CRC) patients. KRAS mutations account for approximately... 
GROWTH-FACTOR RECEPTOR | PHASE-II TRIAL | PROGNOSTIC-FACTOR | MUTATION STATUS | THERAPY | ONCOLOGY | MISMATCH-REPAIR | OPEN-LABEL | KRAS | GENE COPY NUMBER | CHEMOTHERAPY | Niacinamide - analogs & derivatives | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Phenylurea Compounds | Patient Selection | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Benzenesulfonates - pharmacology | Neoplasm Metastasis | Time Factors | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Retrospective Studies | Cetuximab | Cell Survival - drug effects | Colorectal Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Treatment Outcome | Switzerland | HT29 Cells | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Italy | Aged | Biomarkers, Tumor - genetics | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Mutation | Colorectal Neoplasms - pathology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2012, Volume 109, Issue 6, pp. E353 - E359
Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the... 
Personalized medicine | Targeted therapy | Tumor suppressor gene | targeted therapy | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CANCER | TUMOR ANGIOGENESIS | METASTATIC COLORECTAL-CANCER | personalized medicine | LUNG-CANCER | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | SIGNALING PATHWAY | GENE-EXPRESSION | B-RAF | tumor suppressor gene | INDUCIBLE FACTOR-1-ALPHA EXPRESSION | Blood Vessels - pathology | Humans | Molecular Targeted Therapy | Bevacizumab | Necrosis | Neovascularization, Pathologic - pathology | Neovascularization, Pathologic - enzymology | Angiogenesis Inducing Agents - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Chorioallantoic Membrane - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Cytostatic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Chorioallantoic Membrane - blood supply | Cell Hypoxia - drug effects | Protein-Serine-Threonine Kinases - genetics | Neoplasms - enzymology | Neoplasms - blood supply | Down-Regulation - drug effects | Mutation - genetics | Sulfonamides - pharmacology | Gene Knock-In Techniques | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Chickens | Alleles | Blood Vessels - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Angiogenesis | Hypoxia | Kinases | Cells | Cancer | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7404, pp. 532 - 536
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 795 - 801
Journal Article
Biochimica et biophysica acta. Reviews on cancer, ISSN 0304-419X, 05/2019
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 262 - 269
Journal Article