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Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 18, Issue 1, pp. 132 - 142
Journal Article
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 554 - n/a
Numerous lineage‐specific expansions of the transcription factor B (TFB) family in archaea suggests an important role for expanded TFBs in encoding... 
transcription factor B | evolution by gene family expansion | niche adaptation | fitness | reprogramming of gene regulatory network | OXIDATIVE STRESS | BACTERIA | FACTOR-B | SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | NETWORKS | HALOPHILIC ARCHAEON | GENOME | EVOLUTION | GROWTH | Archaeal Proteins - metabolism | Recombinant Proteins - metabolism | Transcription Factor TFIIB - metabolism | Gene Expression Regulation, Archaeal | Stress, Physiological | Recombinant Proteins - genetics | Transcription Factor TFIIB - genetics | Phylogeny | Adaptation, Physiological - genetics | Halobacterium salinarum - genetics | Archaeal Proteins - genetics | Halobacterium salinarum - metabolism | Salt-Tolerance | Evolution, Molecular | Regulations | Regulators | Temperature | Transcription factors | Biological evolution | Halophilic archaea | Environmental changes | Organisms | Genomes | Systems analysis | DNA-directed RNA polymerase | Extreme environments | Proteins | Eukaryotes | Hierarchies | Odors | Reproduction (copying) | Completeness | Evolution | Deoxyribonucleic acid--DNA | Adaptation | Transducers | Phenotypes | Archaea | V(D)J recombination | Amino acid sequence | Environmental factors | RNA polymerase | Gene expression | Ribonucleic acid--RNA | Conversion | Environmental conditions | Hypotheses | Functional integration | Biofilms | Lakes | Environment | Environmental testing | Mutation | Transcription initiation factor TFIIB | Variation | Gene mapping | Gene conversion | Combinatorial analysis | Recognition | Fitness | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 10, pp. e107957 - e107957
New algorithms are continuously proposed in computational biology. Performance evaluation of novel methods is important in practice. Nonetheless, the field... 
DRUG-SENSITIVITY | A-PRIORI DISTINCTIONS | MULTIDISCIPLINARY SCIENCES | LEARNING ALGORITHMS | REGULARIZATION | SELECTION | CANCER | Regression (Psychology) | Research Design | Computer Simulation | Humans | Comparative analysis | Algorithms | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2013, Volume 304, Issue 4, pp. 600 - 609
Mesenchymal stem cells (MSCs) were shown to improve cell survival and alleviate cardiac arrhythmias when transplanted into cardiac tissue; however, little is... 
Microelectrode array | Connexin 43 | Wnt | Conditioned media | Mesenchymal stem cells | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOCARDIAL-INFARCTION | conditioned media | OVEREXPRESSING AKT | VENTRICULAR MYOCYTES | BETA-CATENIN | microelectrode array | IN-VITRO | REPAIR | CARDIOMYOCYTE | mesenchymal stem cells | PROTEIN-2 SFRP2 | PERIPHERAL VASCULAR DISEASE | connexin 43 | STROMAL CELLS | EXPRESSION | Phosphorylation | Heart Conduction System - enzymology | Wnt Signaling Pathway - physiology | Glycogen Synthase Kinase 3 beta | Myocytes, Cardiac - enzymology | Paracrine Communication - physiology | Lithium Chloride - pharmacology | Heart Conduction System - physiology | Up-Regulation - physiology | Chalcones - pharmacology | Cell Line | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Connexin 43 - biosynthesis | Heart Conduction System - drug effects | Up-Regulation - drug effects | Culture Media, Conditioned | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Myocytes, Cardiac - drug effects | Wnt Signaling Pathway - drug effects | Myocytes, Cardiac - physiology | beta Catenin - antagonists & inhibitors | Paracrine Communication - drug effects | Mice | Mesenchymal Stem Cell Transplantation | Physiological aspects | Cell interaction | Research | Health aspects | Stem cells | Heart cells | Molecules | Cardiac arrhythmia | Signal transduction | Index Medicus | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
by Eduati, Federica and Mangravite, Lara M and Wang, Tao and Tang, Hao and Bare, J. Christopher and Huang, Ruili and Norman, Thea and Kellen, Mike and Menden, Michael P and Yang, Jichen and Zhan, Xiaowei and Zhong, Rui and Xiao, Guanghua and Xia, Menghang and Abdo, Nour and Kosyk, Oksana and Friend, Stephen and Dearry, Allen and Simeonov, Anton and Tice, Raymond R and Rusyn, Ivan and Wright, Fred A and Stolovitzky, Gustavo and Xie, Yang and Saez-Rodriguez, Julio and Aittokallio, Tero and Alaimo, Salvatore and Amadoz, Alicia and Ammad-ud-din, Muhammad and Azencott, Chloé-Agathe and Bacardit, Jaume and Barron, Pelham and Bernard, Elsa and Beyer, Andreas and Bin, Shao and van Bömmel, Alena and Borgwardt, Karsten and Brys, April M and Caffrey, Brian and Chang, Jeffrey and Chang, Jungsoo and Chheda, Himanshu and Christodoulou, Eleni G and Clément-Ziza, Mathieu and Cohen, Trevor and Cowherd, Marianne and Demeyer, Sofie and Dopazo, Joaquin and Elhard, Joel D and Falcao, Andre O and Ferro, Alfredo and Friedenberg, David A and Giugno, Rosalba and Gong, Yunguo and Gorospe, Jenni W and Granville, Courtney A and Grimm, Dominik and Heinig, Matthias and Hernansaiz, Rosa D and Hintsanen, Petteri and Hochreiter, Sepp and Huang, Liang-Chin and Huska, Matthew and Jaiswal, Alok and Jiao, Yunlong and Kaski, Samuel and Kaur, Ismeet and Ali Khan, Suleiman and Klambauer, Günter and Krasnogor, Natalio and Kuhn, Michael and Bartosz Kursa, Miron and Kutum, Rintu and Lazzarini, Nicola and Lee, Inhan and Leung, Michael K.K and Khong Lim, Weng and Liu, Charlie and Llinares López, Felipe and Mammana, Alessandro and Mayr, Andreas and Michoel, Tom and Mongiovì, Misael and Moore, Jonathan D and Mpindi, John-Patrick and Narasimhan, Ravi and Opiyo, Stephen O and Pandey, Gaurav and Peabody, Andrea L and Perner, Juliane and Poso, Antti and Pulvirenti, Alfredo and Rawlik, Konrad and Reinhardt, Susanne and Riffle, Carol G and Ruderfer, Douglas and Sander, Aaron J and Savage, Richard S and Scornet, Erwan and Sebastian-Leon, Patricia and ... and NIEHS-NCATS-UNC DREAM and The NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration
Nature Biotechnology, ISSN 1087-0156, 09/2015, Volume 33, Issue 9, pp. 933 - 940
The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here,... 
PROFILES | DATABASE | CHEMICALS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | KNOWLEDGE | SENSITIVITY | LIBRARY | PRINCIPLE | MODEL | EXPRESSION | GENOME-WIDE ASSOCIATION | Genetic aspects | Health risk assessment | Health aspects | Methods | Cell lines | Toxicity | Population genetics | Cells | Population biology | Index Medicus | Life Sciences | Quantitative Methods
Journal Article
by Menden, Michael P and Wang, Dennis and Mason, Mike J and Szalai, Bence and Bulusu, Krishna C and Guan, Yuanfang and Yu, Thomas and Kang, Jaewoo and Jeon, Minji and Wolfinger, Russ and Nguyen, Tin and Zaslavskiy, Mikhail and Abante, Jordi and Abecassis, Barbara Schmitz and Aben, Nanne and Aghamirzaie, Delasa and Aittokallio, Tero and Akhtari, Farida S and Al-lazikani, Bissan and Alam, Tanvir and Allam, Amin and Allen, Chad and de Almeida, Mariana Pelicano and Altarawy, Doaa and Alves, Vinicius and Amadoz, Alicia and Anchang, Benedict and Antolin, Albert A and Ash, Jeremy R and Aznar, Victoria Romeo and Ba-alawi, Wail and Bagheri, Moeen and Bajic, Vladimir and Ball, Gordon and Ballester, Pedro J and Baptista, Delora and Bare, Christopher and Bateson, Mathilde and Bender, Andreas and Bertrand, Denis and Wijayawardena, Bhagya and Boroevich, Keith A and Bosdriesz, Evert and Bougouffa, Salim and Bounova, Gergana and Brouwer, Thomas and Bryant, Barbara and Calaza, Manuel and Calderone, Alberto and Calza, Stefano and Capuzzi, Stephen and Carbonell-Caballero, Jose and Carlin, Daniel and Carter, Hannah and Castagnoli, Luisa and Celebi, Remzi and Cesareni, Gianni and Chang, Hyeokyoon and Chen, Guocai and Chen, Haoran and Chen, Huiyuan and Cheng, Lijun and Chernomoretz, Ariel and Chicco, Davide and Cho, Kwang-Hyun and Cho, Sunghwan and Choi, Daeseon and Choi, Jaejoon and Choi, Kwanghun and Choi, Minsoo and Cock, Martine De and Coker, Elizabeth and Cortes-Ciriano, Isidro and Cserzö, Miklós and Cubuk, Cankut and Curtis, Christina and Daele, Dries Van and Dang, Cuong C and Dijkstra, Tjeerd and Dopazo, Joaquin and Draghici, Sorin and Drosou, Anastasios and Dumontier, Michel and Ehrhart, Friederike and Eid, Fatma-Elzahraa and ElHefnawi, Mahmoud and Elmarakeby, Haitham and van Engelen, Bo and Engin, Hatice Billur and de Esch, Iwan and Evelo, Chris and Falcao, Andre O and Farag, Sherif and Fernandez-Lozano, Carlos and Fisch, Kathleen and Flobak, Asmund and Fornari, Chiara and Foroushani, Amir B. K and Fotso, Donatien Chedom and Fourches, Denis and ... and AstraZeneca-Sanger Drug Combinatio and AstraZeneca-Sanger Drug Combination DREAM Consortium
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2674 - 17
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the... 
BREAST-CANCER | ANDROGEN RECEPTOR | INHIBITION | GENE | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | MUTATIONS | CELL | RESOURCE | Identification methods | Pharmacology | Tumor cell lines | 1-Phosphatidylinositol 3-kinase | Antagonism | Computation | Cell lines | Computer applications | Predictions | Biomarkers | Bioindicators | Cancer | Tumors | Index Medicus
Journal Article