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parkinson's disease (4) 4
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1. Full Text Advances in GBA-associated Parkinson's disease – Pathology, presentation and therapies
by Barkhuizen, Melinda and Anderson, David G and Grobler, Anne F
Neurochemistry International, ISSN 0197-0186, 02/2016, Volume 93, pp. 6 - 25
mutations are to date the most common genetic risk factor for Parkinson's disease. The gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic... 
α-Synuclein | Glucocerebrosidase | Gaucher disease | Parkinson's disease | LIMP-2 | Parkinson Disease - therapy | Glucosylceramidase - genetics | Parkinson Disease - pathology | Humans | Adult | Mutation | Parkinson Disease - genetics | Enzymes | Genetics | Health aspects | Aquaporins
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2. Full Text Advances in GSA-associated Parkinson's disease - Pathology, presentation and therapies
by Barkhuizen, Melinda and Anderson, David G and Grobler, Anne F
Neurochemistry International, ISSN 0197-0186, 02/2016, Volume 93, pp. 6 - 25
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst... 
Glucocerebrosidase | Gaucher disease | Parkinson's disease | LIMP-2 | alpha-Synuclein | GBA MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COGNITIVE IMPAIRMENT | NEUROSCIENCES | SLEEP BEHAVIOR DISORDER | MULTIPLE SYSTEM ATROPHY | MUTANT GLUCOCEREBROSIDASE VARIANTS | ACID BETA-GLUCOSIDASE | ENZYME REPLACEMENT THERAPY | PHARMACOLOGICAL CHAPERONE | TYPE-1 GAUCHER-DISEASE
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3. Full Text The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb
by Barkhuizen, Melinda and van Dijck, Fleur J. P and Jellema, Reint K and Gussenhoven, Ruth and Engelbertink, Imke and van Mechele, Ralph and Cleutjens, Jack P. M and Seehase, Matthias and Steinbusch, Harry W. M and Zimmerman, Luc J and Gavilanes, A. W. Danilo and Kramer, Boris W
Pediatric Research, ISSN 0031-3998, 06/2018, Volume 83, Issue 6, pp. 1190 - 1199
BACKGROUND: General anesthetics could protect key neurotransmitter systems, such as the dopaminergic system, from hypoxic-ischemic encephalopathy (HIE) by... 
ENCEPHALOPATHY | ACTIVATION | BRAIN-INJURY | DISEASE | SHEEP | GENERAL-ANESTHETICS | FETAL | PATHOLOGY | PRETERM | PERINATAL ASPHYXIA | PEDIATRICS | Hypoxia | Phosphorylation
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4. Full Text “Benign” GBA variants may alter gene splicing in South African Parkinson's disease cases
by Barkhuizen, Melinda and Anderson, David G and van der Westhuizen, Francois H and Grobler, Anne F
Parkinsonism and Related Disorders, ISSN 1353-8020, 2015, Volume 22, pp. e172 - e172
Neurology
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5. Full Text "Benign" GBA variants may alter gene splicing in South African Parkinson's disease cases
by Barkhuizen, Melinda and Anderson, David G and Van der Westhuizen, Francois H and Grobler, Anne F
Parkinsonism and Related Disorders, ISSN 1353-8020, 01/2016, Volume 22, p. e172
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6. Full Text Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats
by Barkhuizen, M and Vles, JSH and van Mechelen, R and Vermeer, M and Kramer, BW and Chedraui, P and Bergs, P and van Kranen-Mastenbroek, VHJM and Gavilanes, AWD
DIAGNOSTICS, ISSN 2075-4418, 09/2019, Volume 9, Issue 3, p. 123
Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor... 
BEHAVIORAL CONSEQUENCES | MEDICINE, GENERAL & INTERNAL | hypoxia-ischemia | rat model | ASPHYXIA | preterm brain | cerebral palsy | INJURY | somatosensory evoked potential | SPINAL-CORD | DEFICITS | CHILDREN
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7. Full Text Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy
by Barkhuizen, Melinda and van Mechelen, Ralph and Vermeer, Marijne and Chedraui, Peter and Paes, Dean and van den Hove, Daniel L.A and Vaes, Bart and Mays, Robert W and Steinbusch, Harry W.M and Robertson, Nicola J and Kramer, Boris W and Gavilanes, Antonio W.D
Behavioural Brain Research, ISSN 0166-4328, 04/2019, Volume 362, pp. 77 - 81
There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects... 
Neurodevelopment | Stem cell therapy | Preterm brain | Hypoxic-ischemic encephalopathy | EFFICACY | BRAIN-INJURY | SAFETY | MATURATION | MESENCHYMAL STEM-CELLS | PERINATAL ASPHYXIA | BORN | INFANTS | DOUBLE-BLIND | NEURONS | NEUROSCIENCES | BEHAVIORAL SCIENCES | Neurosciences | Transplantation | Encephalopathy | Analysis | Stem cells
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8. Full Text A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
by Barkhuizen, Melinda and Anderson, David G and van der Wethuizen, Francois H and Grobler, Anne F
Molecular genetics & genomic medicine, ISSN 2324-9269, 03/2017, Volume 5, Issue 2, pp. 147 - 156
Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most... 
modeling | Parkinson's disease | VARIANTS | RISK | MECHANISMS | IDENTIFICATION | glucocerebrosidase | GAUCHER-DISEASE | GLUCOCEREBROSIDASE GENE | genetic screening | Gaucher disease | Afrikaner | COHORT | MUTATIONS | ONSET | GENETICS & HEREDITY | Enzyme activity | Neurodegenerative diseases | Genes | Parkinsons disease | Health risks | Leukocytes | Risk analysis | Disease control | Risk factors | Proteins | Studies | Enzymatic activity | Population | Glucosylceramidase | Mutation | Age | Movement disorders | Predictive control | Gaucher's disease
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9. Full Text Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis
by Barkhuizen, Melinda and Rodrigues, Filipe B and Anderson, David G and Winkens, Bjorn and Wild, Edward J and Kramer, Boris W and Gavilanes, A.W.Danilo and REGISTRY Investigators European and REGISTRY Investigators of the European Huntington's Disease Network
Parkinsonism and Related Disorders, ISSN 1353-8020, 10/2018, Volume 55, pp. 55 - 60
The age of diagnosis of Huntington's disease (HD) varies among individuals with the same CAG-repeat expansion size. We investigated whether early-life events,... 
Developmental disorders | Neonatal | Huntington's disease | Epidemiological | Modifier | PREVALENCE | OUTCOMES | ASSOCIATION | TRENDS | CLINICAL NEUROLOGY | Medicine, Experimental | Medical research | Epidemiology | Analysis
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10. Full Text A molecular analysis of theGBAgene in Caucasian South Africans with Parkinson's disease
by Barkhuizen, Melinda and Anderson, David G and van der Westhuizen, Francois H and Grobler, Anne F
Molecular Genetics & Genomic Medicine, ISSN 2324-9269, 03/2017, Volume 5, Issue 2, pp. 147 - 156
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11. Full Text Using global team science to identify genetic parkinson's disease worldwide
by Vollstedt, Eva‐Juliane and Kasten, Meike and Klein, Christine and Aasly, Jan and Adler, Charles and Ahmad‐Annuar, Azlina and Albanese, Alberto and Alcalay, Roy N and Al‐Mubarak, Bashayer and Alvarez, Victoria and Andree‐Muñoz, Brennie and Annesi, Grazia and Appel‐Cresswell, Silke and Arkadir, David and Armasu, Sebastian and Barber, Thomas R and Bardien, Soraya and Barkhuizen, Melinda and Barrett, Matthew J and Başak, A. Nazlı and Beach, Thomas and Benitez, Bruno A and Berg, Daniela and Bhatia, Kailash and Binkofski, Ferdinand and Blauwendraat, Cornelis and Bonifati, Vincenzo and Borges, Vanderci and Bozi, Maria and Brice, Alexis and Brighina, Laura and Brockmann, Kathrin and Brücke, Thomas and Brüggemann, Norbert and Camacho, Marta and Cardoso, Francisco and Belin, Andrea Carmine and Carr, Jonathan and Chan, Piu and Chang‐Castello, Jorge and Chase, Bruce and Chen‐Plotkin, Alice and Ju Chung, Sun and Cilia, Roberto and Clarimon, Jordi and Clark, Lorraine and Cornejo‐Olivas, Mario and Corvol, Jean‐Christophe and Cosentino, Carlos and Cras, Patrick and Crosiers, David and Damásio, Joana and Das, Parimal and de Carvalho Aguiar, Patricia and De Michele, Giuseppe and De Rosa, Anna and Dieguez, Elena and Dorszewska, Jolanta and Erer, Sevda and Ertan, Sibel and Farrer, Matthew and Fedotova, Ekaterina and Ferese, Rosangela and Ferrarese, Carlo and Ferraz, Henrique and Fiala, Ondrej and Foroud, Tatiana and Friedman, Andrzej and Frigerio, Roberta and Funayama, Manabu and Gambardella, Stefano and Garraux, Gaetan and Gatto, Emilia M and Genç, Gençer and Giladi, Nir and Goldwurm, Stefano and Gomez‐Esteban, Juan Carlos and Gómez‐Garre, Pilar and Gorostidi, Ana and Grosset, Donald and Hanagasi, Hasmet and Hardy, John and Hassan, Anhar and Hattori, Nobutaka and Hauser, Robert A and Hedera, Peter and Hentati, Faycal and Hertz, Jens Michael and Holton, Janice L and Houlden, Henry and Hutz, Mara H and Ikeuchi, Takeshi and Illarioshkin, Sergey and Inca‐Martinez, Miguel and Infante, Jon and Jankovic, Joseph and Jeon, Beom Seok and Jesús, Silvia and Jimenez‐Del‐Rio, Marlene and Kaasinen, Valtteri and ... and MJFF Global Geneic Parkinsons D and MJFF Global Genetic Parkinson's Disease Study Group
Annals of Neurology, ISSN 0364-5134, 08/2019, Volume 86, Issue 2, pp. 153 - 157
NEUROSCIENCES | CLINICAL NEUROLOGY | Neurodegenerative diseases | Movement disorders | Parkinson's disease
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12. Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy
by Barkhuizen, Melinda and van Mechelen, Ralph and Vermeer, Marijne and Chedraui, Peter and Paes, Dean and van den Hove, Daniel L A and Vaes, Bart and Mays, Robert W and Steinbusch, Harry W M and Robertson, Nicola J and Kramer, Boris W and Gavilanes, Antonio W D
Behavioural brain research, 04/2019, Volume 362, p. 77
There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects... 
Animals, Newborn | Asphyxia Neonatorum - physiopathology | Hypoxia - drug therapy | Animals | Multipotent Stem Cells - cytology | Brain - physiopathology | Female | Male | Rats, Sprague-Dawley | Disease Models, Animal | Hypoxia-Ischemia, Brain - physiopathology
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