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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 3, pp. 1101 - 1106
Journal Article
The Lancet, ISSN 0140-6736, 2014, Volume 383, Issue 9923, pp. 1129 - 1137
Background Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1... 
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1715, pp. 359 - 371
There has been recent growth in the number and magnitude of clinical trials for various forms of retinal gene therapy. Because of regulatory requirements, and... 
Clinical trials | Viral vector shedding | Immunogenicity | Gene therapy | AAV | Dependovirus - genetics | Genetic Therapy | Retina - metabolism | Immunity, Humoral | Humans | Dependovirus - immunology | Virus Shedding | Genetic Vectors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2015, Volume 112, Issue 27, pp. 8415 - 8420
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2016, Volume 374, Issue 20, pp. 1996 - 1998
In this study, the subfoveal injection of a gene-therapy vector carrying nonmutated CHM, the gene that, when mutated, causes a form of blindness called... 
MEDICINE, GENERAL & INTERNAL | Cataract - complications | Genetic Therapy | Choroideremia - complications | Humans | Retina | Choroideremia - therapy | Visual Acuity | Cataracts | Diabetic retinopathy | Medical research | Congenital diseases | Blindness | Traffic accidents & safety | Injection | Gene therapy | Patients | Acuity | Index Medicus | Abridged Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 13537 - 13537
Photoreceptor transplantation is a potential future treatment for blindness caused by retinal degeneration. Photoreceptor transplantation restores visual... 
RETINAL DEGENERATION | CELLS | VISUAL FUNCTION | REGENERATION | INTEGRATE | MULTIDISCIPLINARY SCIENCES | MOUSE | MATURE | MICE | RESTORATION | EXPRESSION | Index Medicus
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2008, Volume 4, Issue 5
  Progress in unravelling the cellular and molecular basis of mammalian circadian regulation over the past decade has provided us with new avenues through... 
Studies | Rodents | Circadian rhythm | Mutation | Biological clocks
Journal Article
Science, ISSN 0036-8075, 5/2007, Volume 316, Issue 5826, pp. 897 - 900
By screening N-ethyl-N-nitrosourea--mutagenized animals for alterations in rhythms of wheel-running activity, we identified a mouse mutation, after hours... 
Homozygotes | Proteins | Animal genetics | Phenotypes | Messenger RNA | Chronometry | Liver | Reports | Mice | Mammals | Genetic mutation | GENE | SUPRACHIASMATIC NUCLEUS | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | DEGRADATION | RHYTHM | ARABIDOPSIS | CLOCK | FAMILY | Cercopithecus aethiops | Molecular Sequence Data | Male | Basic Helix-Loop-Helix Transcription Factors - metabolism | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Female | Suprachiasmatic Nucleus - metabolism | Transcription, Genetic | Lung - metabolism | Nuclear Proteins - genetics | ARNTL Transcription Factors | Amino Acid Sequence | Basic Helix-Loop-Helix Transcription Factors - genetics | Flavoproteins - metabolism | Flavoproteins - genetics | Liver - metabolism | Cell Cycle Proteins - metabolism | Circadian Rhythm - genetics | Gene Expression Regulation | Nuclear Proteins - metabolism | Transcription Factors - genetics | Period Circadian Proteins | Mice, Inbred C3H | Transcription Factors - metabolism | Point Mutation | Animals | CLOCK Proteins | F-Box Proteins - physiology | Cryptochromes | Trans-Activators - metabolism | Mice, Inbred BALB C | COS Cells | F-Box Proteins - genetics | Amino Acid Substitution | Crosses, Genetic | Circadian rhythms | Physiological aspects | Influence | Research | Mutation | Circadian rhythm | Gene expression | Rodents | Index Medicus
Journal Article
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 06/2019, Volume 60, Issue 7, pp. 2733 - 2742
PURPOSE. The role of light exposure in accelerating retinitis pigmentosa (RP) remains controversial. Faster degeneration has however been observed in the... 
RETINAL DEGENERATION | MECHANISM | ROD | INDUCED DAMAGE | RPE65 | CELL-DEATH | rhodopsin | GENE | light | MOUSE MODEL | retinitis pigmentosa | OPHTHALMOLOGY | MICE | sector | PHOTORECEPTOR DEGENERATION | red filter
Journal Article
Journal Article