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1. Full Text Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction
by Wilk, Jemma and Shrine, Nick and Loehr, Laura and Zhao, Jing Hua and Manichaikul, Ani and Lopez, Lorna and Smith, G.D and Heckbert, Susan and Smolonska, Joanna and Tang, Wenbo and Loth, Daan and Curjuric, Ivan and Hui, Jennie and Cho, Michael and Latourelle, Jeanne and Henry, Amanda and Alich, Melinda and Bakke, Arnold B and Beaty, Terri and Bentley, Amy and Borecki, Ingrid and Brusselle, Guy and Burkart, Kristin and Chen, T.H and Couper, David and Crapo, Robert and Davies, Gail and Dupuis, Josée and Franceschini, Nora and Gulsvik, Amund and Hancock, Dana and Harris, Tamara and Hofman, Albert and Imboden, Medea and James, Alan and Khaw, Kay-Tee and Lahousse, Lies and Launer, Lenore and Litonjua, Augusto and Liu, Yongmei and Lohman, Kurt and Lomas, David John and Lumley, Thomas and Marciante, Kristin and McArdle, Wendy and Meibohm, Bernd and Morrison, Alanna and Musk, Arthur and Myers, Richard and North, Kari and Postma, Dirkje and Psaty, Bruce and Rich, Stephen and Rivadeneira Ramirez, Fernando and Rochat, Thierry and Rotter, Jerome and Soler Artigas, Maria and Starr, John and Uitterlinden, Ané and Wareham, Nick and Wijmenga, Cisca and Zanen, Pieter and Province, Mike and Silverman, Edwin and Deary, Ian and Palmer, Cameron and Cassano, Patricia and Gudnason, Vilmundur and Barr, Graham and Loos, Ruth and Strachan, David and London, Stephanie and Boezen, Marike and Probst-Hensch, Nicole and Gharib, Sina and Hall, Ian and O'Connor, George and Tobin, Martin and Stricker, Bruno
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2012, Volume 186, Issue 7, pp. 622 - 632
Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary... 
Genes | Chronic obstructive pulmonary disease | Single-nucleotide polymorphism | VARIANTS | genes | RISK | LUNG-CANCER | RESPIRATORY SYSTEM | NICOTINIC ACETYLCHOLINE-RECEPTOR | SUSCEPTIBILITY LOCUS | 15Q25 LOCUS | single-nucleotide polymorphism | SMOKING-BEHAVIOR | PULMONARY-DISEASE | EXPRESSION | chronic obstructive pulmonary disease | COPD | CRITICAL CARE MEDICINE | Forced Expiratory Volume - genetics | Genome-Wide Association Study | Humans | Middle Aged | Vital Capacity - genetics | Male | Smoking - genetics | Receptors, Serotonin, 5-HT4 - genetics | Nerve Tissue Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Female | Aged | Receptors, Nicotinic - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Index Medicus | Abridged Index Medicus
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2. Full Text Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10–pulmonary function association
by Xu, Jiayi and Gaddis, Nathan C and Bartz, Traci M and Hou, Ruixue and Manichaikul, Ani W and Pankratz, Nathan and Smith, Albert V and Sun, Fangui and Terzikhan, Natalie and Markunas, Christina A and Patchen, Bonnie K and Schu, Matthew and Beydoun, May A and Brusselle, Guy G and Eiriksdottir, Gudny and Zhou, Xia and Wood, Alexis C and Graff, Mariaelisa and Harris, Tamara B and Arfan Ikram, M and Jacobs, David R and Launer, Lenore J and Lemaitre, Rozenn N and O’Connor, George T and Oelsner, Elizabeth C and Psaty, Bruce M and Vasan, Ramachandran S and Rohde, Rebecca R and Rich, Stephen S and Rotter, Jerome I and Seshadri, Sudha and Smith, Lewis J and Tiemeier, Henning and Tsai, Michael Y and Uitterlinden, André G and Saroja Voruganti, V and Xu, Hanfei and Zilhão, Nuno R and Fornage, Myriam and Carola Zillikens, M and London, Stephanie J and Graham Barr, R and Dupuis, Josée and Gharib, Sina A and Gudnason, Vilmundur and Lahousse, Lies and North, Kari E and Steffen, Lyn M and Cassano, Patricia A and Hancock, Dana B
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2019, Volume 199, Issue 5, pp. 631 - 642
Rationale: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that could benefit adults with comprised pulmonary health.... 
FVC | Genome-wide association study | FEV | Omega-3 fatty acids | Smoking | STATES | METAANALYSIS | LUNG-FUNCTION | NATIONAL-HEALTH | omega-3 fatty acids | FATTY-ACIDS | GENE-ENVIRONMENT INTERACTION | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | DOCOSAHEXAENOIC ACID | smoking | genome-wide association study | ASTHMA | FEV1 | CRITICAL CARE MEDICINE | Plasma | Statistical analysis | Disease | Fish oils | Genes | Genomes | Epidemiology | Fatty acids | Asthma | Meta-analysis | Studies | Consortia | Aging | Biomarkers | Chronic obstructive pulmonary disease | Diabetes | Health risk assessment
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3. Full Text Sex and race differences in right ventricular structure and function: The multi-ethnic study of atherosclerosis-right ventricle study
by Kawut, Steven M and Lima, João A.C and Barr, R. Graham and Chahal, Harjit and Jain, Aditya and Tandri, Harikrishna and Praestgaard, Amy and Bagiella, Emilia and Kizer, Jorge R and Johnson, W. Craig and Kronmal, Richard A and Bluemke, David A
Circulation, ISSN 0009-7322, 06/2011, Volume 123, Issue 22, pp. 2542 - 2551
Background-Right ventricular (RV) morphology is an important predictor of outcomes in heart and lung disease; however, determinants of RV anatomy have not been... 
pulmonary heart disease | pulmonary | magnetic resonance imaging | heart ventricles | hypertension | sex | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY ARTERIAL-HYPERTENSION | BODY-SIZE | CARDIOVASCULAR MAGNETIC-RESONANCE | HEART-FAILURE | hypertension, pulmonary | SYSTOLIC FUNCTION | REFERENCE VALUES | EJECTION FRACTION | MASS | PERIPHERAL VASCULAR DISEASE | GENDER-DIFFERENCES | Atherosclerosis - pathology | Prospective Studies | African Continental Ancestry Group - ethnology | Ethnic Groups - ethnology | Continental Population Groups - ethnology | Humans | Middle Aged | Male | Atherosclerosis - ethnology | Sex Characteristics | European Continental Ancestry Group - ethnology | Asian Americans - ethnology | Aged, 80 and over | Heart Ventricles - anatomy & histology | Female | Aged | Hispanic Americans - ethnology | Ventricular Function, Right - physiology | Cohort Studies | Index Medicus | Abridged Index Medicus
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4. Full Text Association Between Emphysema-like Lung on Cardiac Computed Tomography and Mortality in Persons Without Airflow Obstruction A Cohort Study
by Oelsner, EC and Hoffman, EA and Folsom, AR and Carr, JJ and Enright, PL and Kawut, SM and Kronmal, R and Lederer, D and Lima, JAC and Lovasi, GS and Shea, S and Barr, RG
ANNALS OF INTERNAL MEDICINE, ISSN 0003-4819, 12/2014, Volume 161, Issue 12, pp. 863 - U54
Background: Low lung function is known to predict mortality in the general population, but the prognostic significance of emphysema on computed tomography (CT)... 
DENSITY | POPULATION | MEDICINE, GENERAL & INTERNAL | CIGARETTE-SMOKING | ATHEROSCLEROSIS MESA | QUANTIFICATION | CALCIUM | NATIONAL-HEALTH | PULMONARY-DISEASE | REFERENCE VALUES | Smoking - adverse effects | Pulmonary Emphysema - complications | Spirometry | Pulmonary Emphysema - physiopathology | Prospective Studies | Pulmonary Ventilation | Humans | Middle Aged | Mortality | Risk Factors | Tomography, X-Ray Computed - methods | Male | Lung - diagnostic imaging | Lung - physiopathology | Pulmonary Emphysema - diagnostic imaging | Heart - diagnostic imaging | Lung Volume Measurements | Aged, 80 and over | Female | Aged | Tomography, X-Ray Computed - instrumentation | CT imaging | Usage | Prognosis | Emphysema, Pulmonary | Research | Diagnosis | Tomography | Chronic obstructive pulmonary disease | Lungs | Emphysema | Index Medicus | Abridged Index Medicus
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5. Alignment of inhaled chronic obstructive pulmonary disease therapies with published strategies :analysis of the Global Initiative for Chronic Obstructive Lung Disease recommendations in SpiroMics
by Ghosh, Sohini and Anderson, Wayne H and Putcha, Nirupama and Han, Meilan K and Curtis, Jeffrey L and Criner, Gerard J and Dransfield, Mark T and Graham Barr, R and Krishnan, Jerry A and Lazarus, Stephen C and Cooper, Christopher B and Paine, Robert and Peters, Stephen P and Hansel, Nadia N and Martinez, Fernando J and Bradley Drummond, M and Alexis, Neil E and Arjomandi, Mehrdad and Barjaktarevic, Igor and Bateman, Lori A and Bhatt, Surya P and Bleecker, Eugene R and Boucher, Richard C and Bowler, Russell P and Christenson, Stephanie A and Comellas, Alejandro P and Couper, David J and Crystal, Ronald G and Doerschuk, Claire M and Drummond, Brad and Freeman, Christine M and Galban, Craig and Hastie, Annette T and Hoffman, Eric A and Huang, Yvonne and Kaner, Robert J and Kanner, Richard E and Kleerup, Eric C and LaVange, Lisa M and Meyers, Deborah A and Moore, Wendy C and Newell, John D and Paulin, Laura and Pirozzi, Cheryl and Putcha, Nirupama and Oelsner, Elizabeth C and O'Neal, Wanda K and Ortega, Victor E and Raman, Sanjeev and Rennard, Stephen I and Tashkin, Donald P and Michael Wells, J and Wise, Robert A and Woodruff, Prescott G and Postow, Lisa and Viviano, Lisa and SPIROMICS Investigators and Current and former investigators of the SPIROMICS sites and reading centers
Annals of the American Thoracic Society, ISSN 2325-6621, 02/2019, Volume 16, Issue 2, pp. 200 - 208
Rationale: Despite awareness of chronic obstructive pulmonary disease (COPD) treatment recommendations, uptake is poor. The Subpopulations and Intermediate... 
Chronic obstructive pulmonary disease | Treatment | Inhaled therapy | treatment | MANAGEMENT | RESPIRATORY SYSTEM | GUIDELINES | BARRIERS | inhaled therapy | CLINICAL-PRACTICE | ADHERENCE | chronic obstructive pulmonary disease | COPD
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6. Full Text Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The multi-ethnic study of atherosclerosis (MESA)-right ventricle study
by Kawut, Steven M and Barr, R. Graham and Lima, João A.C and Praestgaard, Amy and Johnson, W. Craig and Chahal, Harjit and Ogunyankin, Kofo O and Bristow, Michael R and Kizer, Jorge R and Tandri, Harikrishna and Bluemke, David A
Circulation, ISSN 0009-7322, 10/2012, Volume 126, Issue 14, pp. 1681 - 1688
Background-Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of... 
pulmonary heart disease | hypertension, pulmonary | magnetic resonance imaging | heart ventricles | survival | LUNG | CARDIAC & CARDIOVASCULAR SYSTEMS | VOLUMES | PULMONARY ARTERIAL-HYPERTENSION | SEX | PROGNOSTIC VALUE | REFERENCE VALUES | DISEASE | MASS | PERIPHERAL VASCULAR DISEASE | Heart Failure - ethnology | Prospective Studies | Follow-Up Studies | Ethnic Groups - ethnology | Humans | Middle Aged | Male | Coronary Artery Disease - mortality | Heart Failure - pathology | Coronary Artery Disease - ethnology | Coronary Artery Disease - pathology | Aged, 80 and over | Death | Female | Aged | Heart Ventricles - pathology | Cohort Studies | Heart Failure - mortality | Heart failure | Complications and side effects | Prognosis | Heart enlargement | Physiological aspects | Research | Risk factors | Heart ventricle, Right | Index Medicus | Abridged Index Medicus
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7. Full Text Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study
by Labaki, WW and Gu, T and Murray, S and Curtis, JL and Yeomans, L and Bowler, RP and Barr, RG and Comellas, AP and Hansel, NN and Cooper, CB and Barjaktarevic, I and Kanner, RE and Paine, R and Mcdonald, MLN and Krishnan, JA and Peters, SP and Woodruff, PG and O'Neal, WK and Diao, WQ and He, B and Martinez, FJ and Standiford, TJ and Stringer, KA and Han, MLK
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2019, Volume 9, Issue 1, pp. 1 - 9
Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum... 
OBSTRUCTIVE PULMONARY-DISEASE | PROFILES | PLASMA | ACUTE EXACERBATIONS | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | MUSCLE | QUANTITATIVE COMPUTED-TOMOGRAPHY | EXPRESSION | COPD | Metabolomics | Phenotypes | Nuclear magnetic resonance--NMR | Diabetes mellitus | Tryptophan | Amino acids | Leucine | Magnetic resonance spectroscopy | Body mass index | Metabolites | Valine | Chronic obstructive pulmonary disease | Smoking | Isoleucine | Index Medicus
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8. Full Text Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease
by Kesimer, Mehmet and Kesimer, Mehmet and Smith, Benjamin M and Smith, Benjamin M and Ceppe, Agathe and Ceppe, Agathe and Ford, Amina A and Ford, Amina A and Anderson, Wayne H and Anderson, Wayne H and Barr, R Graham and Barr, R. Graham and O’Neal, Wanda K and O'Neal, Wanda K and Boucher, Richard C and Boucher, Richard C and Woodruff, Prescott G and Han, MeiLan K and Hoffman, Eric A and Martinez, Fernando and Curtis, Jeffrey L and Paine, Robert and Cooper, Christopher B and Bleecker, Eugene R and SPIROMICS Investigative Grp and SPIROMICS Investigative Group
American journal of respiratory and critical care medicine, ISSN 1073-449X, 12/2018, Volume 198, Issue 11, pp. 1453 - 1456
[...]we tested for associations between sputum mucin concentrations and characteristics with complementary spirometric and computed tomography (CT) measures of... 
TRANSPORT | SUBPOPULATIONS | INTERMEDIATE OUTCOMES | RESPIRATORY SYSTEM | COPD | CRITICAL CARE MEDICINE | Medicine | Studies | Airway management | Internal medicine | Tomography | Critical care | Bronchitis | Chronic obstructive pulmonary disease | Index Medicus | Abridged Index Medicus
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9. Full Text Collagen biomarkers and subclinical interstitial lung disease: The Multi-Ethnic Study of Atherosclerosis
by Madahar, Purnema and Duprez, Daniel A and Podolanczuk, Anna J and Bernstein, Elana J and Kawut, Steven M and Raghu, Ganesh and Barr, R. Graham and Gross, Myron D and Jacobs, David R and Lederer, David J
Respiratory Medicine, ISSN 0954-6111, 07/2018, Volume 140, pp. 108 - 114
Lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover. We examined the association of two... 
Subclinical interstitial lung disease | Collagen biomarkers | Extracellular matrix | Lung fibrosis | MESA | CARDIAC & CARDIOVASCULAR SYSTEMS | TURNOVER | ABNORMALITIES | ADULTS | COMPUTED-TOMOGRAPHY | PNEUMONIAS | HIGH-ATTENUATION | RESPIRATORY SYSTEM | EMPHYSEMA | ASSOCIATION | PULMONARY-FIBROSIS | Collagen Type I - blood | Peptides - blood | United States - epidemiology | Prospective Studies | Cross-Sectional Studies | Asian Americans - statistics & numerical data | Humans | Middle Aged | Hispanic Americans - statistics & numerical data | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Procollagen - blood | Biomarkers - blood | Lung Diseases, Interstitial - ethnology | Smoking - ethnology | Lung Diseases, Interstitial - diagnostic imaging | African Americans - statistics & numerical data | Lung Diseases, Interstitial - diagnosis | Peptide Fragments - blood | Sex Factors | Aged, 80 and over | Female | Aged | Medical research | Collagen | Analysis | Lung diseases | Atherosclerosis | Medicine, Experimental | Diagnostic imaging | Biological markers | Collagen (type I) | Disease | Lung | Collagens | Gender | Remodeling | Computed tomography | Radioimmunoassay | Race | Attenuation | Bioindicators | Medical imaging | Procollagen | Cytokines | Epidermal growth factor receptors | Abnormalities | Inflammation | Ethnicity | Statistical models | Arteriosclerosis | Fibrosis | Biomarkers | Adults | Emphysema | Smoking | Index Medicus
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10. Full Text NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort
by Labaki, Wassim W and Xia, Meng and Murray, Susan and Curtis, Jeffrey L and Barr, R. Graham and Bhatt, Surya P and Bleecker, Eugene R and Hansel, Nadia N and Cooper, Christopher B and Dransfield, Mark T and Wells, J. Michael and Hoffman, Eric A and Kanner, Richard E and Paine, Robert and Ortega, Victor E and Peters, Stephen P and Krishnan, Jerry A and Bowler, Russell P and Couper, David J and Woodruff, Prescott G and Martinez, Carlos H and Martinez, Fernando J and Han, MeiLan K
Respiratory Medicine, ISSN 0954-6111, 07/2018, Volume 140, pp. 87 - 93
High N-terminal pro-brain natriuretic peptide (NT-proBNP) during COPD exacerbations is associated with worse clinical outcomes. The prognostic value of... 
Cardiovascular disease | Respiratory exacerbation | Chronic obstructive pulmonary disease | Brain natriuretic peptides | MORTALITY | POPULATION | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | BRAIN NATRIURETIC PEPTIDE | HEART-FAILURE | OBSTRUCTIVE PULMONARY-DISEASE | PREDICT | RESPIRATORY SYSTEM | CARDIOVASCULAR-DISEASE | DYSFUNCTION | STRATIFICATION | Pulmonary Disease, Chronic Obstructive - diagnosis | Risk Assessment - methods | Acute Disease | Prognosis | Follow-Up Studies | Forced Expiratory Volume - physiology | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Biomarkers - blood | Spirometry - methods | Vital Capacity - physiology | Peptide Fragments - blood | Aged, 80 and over | Adult | Female | Aged | Natriuretic Peptide, Brain - blood | Lung diseases, Obstructive | Natriuretic peptides | Myocardial infarction | Brain | Lung | Congestive heart failure | Body mass index | Regression models | Poisson density functions | Age | Gastroesophageal reflux | Gold | Brain natriuretic peptide | Statistical analysis | Mortality | Medical treatment | Coronary artery | Regression analysis | Risk analysis | Coronary artery disease | Quality of life | Brain research | Body mass | Coronary vessels | Body size | Infarction | Cardiovascular diseases | Smoking | Index Medicus | cardiovascular disease | brain natriuretic peptides | chronic obstructive pulmonary disease | respiratory exacerbation
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11. Full Text Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort
by Martinez, Fernando J and Martinez, Carlos H and Li, Sara X and Hirzel, Andrew J and Stolberg, Valerie R and Alexis, Neil E and Barr, R. Graham and Bleecker, Eugene R and Carretta, Elizabeth E and Christenson, Stephanie A and Cooper, Christopher B and Couper, David J and Doerschuk, Claire M and Han, MeiLan K and Hansel, Nadia N and Hastie, Annette T and Hoffman, Eric A and Kaner, Robert J and Meyers, Deborah A and O'Neal, Wanda K and Paine, Robert and Putcha, Nirupama and Rennard, Stephen I and Woodruff, Prescott G and Zeidler, Michelle and Curtis, Jeffrey L and Freeman, Christine M and SPIROMICS Investigators
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2018, Volume 141, Issue 1, pp. 429 - 432
[...]we analyzed eosinophil receptor-positivity in the 3 sample types regardless of subject groups (see Fig E2 in this article's Online Repository at... 
EXACERBATIONS | IMMUNOLOGY | ALLERGY | SPUTUM | BRONCHOALVEOLAR LAVAGE | COPD | Flow cytometry | Biopsy | Lung diseases | Obstructive lung disease | Chronic obstructive pulmonary disease | Inflammation | Retention | Alveoli | Eosinophilia | Allergies | Index Medicus | Abridged Index Medicus | Human | BAL | Cigarette smoke | Eosinophil
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