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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 491 - 495
-substituted azaindoles were discovered as promising pan-PIM inhibitors. Lead optimization is described en route toward the identification of a clinical... 
AML | Lead | PK/PD | Pan-PIM kinases | Tumor growth inhibition | Cancer | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | BAD | CHEMISTRY, ORGANIC | IDENTIFICATION | POTENT | HIT | SELECTIVE INHIBITORS | DERIVATIVES | BINDING | EXPRESSION | Prevention | Permeability | Chemical properties | Liability (Law) | Analysis
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2005, Volume 70, Issue 2, pp. 533 - 539
A study designed to assess the diastereoselectivity of the intramolecular aldol reaction of two differently sized monocyclic 1,3-diketones bearing a chiral,... 
ASYMMETRIC-SYNTHESIS | ENANTIOSELECTIVE SYNTHESIS | MECHANISM | ALKYLATION | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | TRANSITION-STATES | TRIMETHYLSILYL CYANIDE | (-)-ACANTHOIC ACID | PROLINE | STEREOCONTROLLED SYNTHESIS | Amino acids | Research | Chemical properties | Ketones | Chirality
Journal Article
Journal Article
Synthesis (Germany), ISSN 0039-7881, 01/2014, Volume 46, Issue 1, pp. 96 - 100
Journal Article
Synthesis, ISSN 0039-7881, 01/2014, Volume 46, Issue 1, pp. 96 - 100
Abstract A practical synthesis of multigram quantities of 1 H -thi­eno[3,2- c ]pyrazole is presented in which the Jacobson reaction serves as the key step. 
paper | HETEROAROMATIC AZIDO COMPOUNDS | REACTIVITY | CHEMISTRY, ORGANIC | APIXABAN | DIAZONIUM | cyclizations | SYNTHETIC UTILITY | INDAZOLE | REDUCTION | aminations | heterocycles | THIOPHENES | INHIBITOR | DERIVATIVES | polycycles
Journal Article
07/2019
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
09/2018
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
01/2018
resumo patente de invenção: "compostos heteroarila e usos dos mesmos". a presente invenção refere-se a compostos úteis como inibidores de proteínas quinases,... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
09/2017
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
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