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Cancer Discovery, ISSN 2159-8274, 07/2013, Volume 3, Issue 7, pp. 742 - 750
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e98515 - e98515
Aberrant kinase activation resulting from mutation, amplification, or translocation can drive growth and survival in a subset of human cancer. FGFR2 is... 
LUNG-CANCER | PROTEIN | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | RESISTANCE | GENE AMPLIFICATION | RECEPTOR | INHIBITOR | CARCINOMA | MET | HER-2 | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Cell Survival | Colorectal Neoplasms - genetics | Humans | NF-kappa B - metabolism | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Gene Amplification | Mice, Nude | Cell Line, Tumor | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Downstream effects | Liver | Lung cancer | Colorectal carcinoma | Colorectal cancer | AKT protein | Activation | Metastasis | Kinases | Stomach cancer | Lymph nodes | Metastases | Proteins | Colon cancer | Xenografts | Colon | Inhibition | Gastric cancer | Fibroblast growth factor receptor 2 | Translocation | NF-κB protein | Cell survival | Extracellular signal-regulated kinase | Breast cancer | Artificial chromosomes | Survival | Amplification | Signaling | Gene amplification | Inhibitors | Addiction | Medical prognosis | Mutation | Aberration | Ascites | Viability | Cancer | Fibroblast growth factor receptors | Tumors | Index Medicus
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2010, Volume 177, Issue 1, pp. 415 - 423
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 10/2001, Volume 21, Issue 19, pp. 6470 - 6483
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
NUCLEAR RECEPTOR COREPRESSORS | PROMYELOCYTIC LEUKEMIA | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-COR | TRANSCRIPTIONAL REPRESSION | FUSION PROTEIN | CLASS-I | GRANULOCYTIC DIFFERENTIATION | CELL-CYCLE | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | Translocation, Genetic | Transcription Factors - chemistry | Nuclear Receptor Co-Repressor 1 | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Oncogene Proteins, Fusion - physiology | Core Binding Factor Alpha 2 Subunit | Transcription, Genetic | Proto-Oncogene Proteins | Binding Sites | Hydroxamic Acids - pharmacology | Repressor Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | DNA-Binding Proteins - physiology | Leukemia, Myelomonocytic, Acute - genetics | Transcription Factors - physiology | Enzyme Inhibitors - pharmacology | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | DNA-Binding Proteins - chemistry | RUNX1 Translocation Partner 1 Protein | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Animals | Oncogene Proteins, Fusion - antagonists & inhibitors | Histone Deacetylase Inhibitors | Mice | Models, Genetic | Nuclear Proteins - physiology | AML-1 protein | HDAC-2 protein | N-CoR protein | ETO protein | trichostatin A | chromosome 21 | mSin3A protein | chromosome 8 | histone deacetylase | HDAC-3 protein | Index Medicus | Transcriptional Regulation
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 4, pp. 1524 - 1533
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 8, pp. 6433 - 6448
Phosphoinositide-dependent kinase 1 (PDK1) is a critical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable interest... 
SIGNAL-TRANSDUCTION | AGC KINASES | STRUCTURAL MECHANISM | SMALL-MOLECULE INHIBITORS | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | 3-PHOSPHOINOSITIDE-DEPENDENT KINASE-1 | TUMOR-SUPPRESSOR | HUMAN BREAST-CANCER | Allosteric Regulation - drug effects | Allosteric Regulation - genetics | Drug Screening Assays, Antitumor - methods | Humans | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Neoplasms - enzymology | Crystallography, X-Ray | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms - drug therapy | Phosphorylation - genetics | Protein Kinase Inhibitors - chemistry | Animals | Neoplasms - genetics | Dogs | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | BENCHMARKS | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | PHOSPHORYLATION | COLONY FORMATION | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | TISSUE CULTURES | GENETICS | IN VITRO | CONVERGENCE | PHOSPHOTRANSFERASES | PROTEINS | Cancer Therapy | Enzyme Inhibitors | Biomarker | Signal Transduction | Protein Kinases | X-ray Crystallography | Allosteric Regulation | Phosphatidylinositol 3-Kinase | Phosphatidylinositol-dependent Kinase-1 (PDK1) | Protein-Drug Interactions | AKT PKB
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2011, Volume 54, Issue 12, pp. 4092 - 4108
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2013, Volume 56, Issue 6, pp. 2294 - 2310
Journal Article
Journal Article