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animals (15) 15
metabolic-activation (11) 11
reductive activation (11) 11
urothelial cancer (11) 11
balkan endemic nephropathy (10) 10
dna adducts (9) 9
humans (9) 9
enzymes (8) 8
history (8) 8
male (8) 8
mice (8) 8
rats (8) 8
toxicology (7) 7
aristolochic acid nephropathy (6) 6
aristolochic acids - metabolism (6) 6
chinese herbs nephropathy (6) 6
liver (6) 6
liver - drug effects (6) 6
metabolites (6) 6
physiological aspects (6) 6
risk-factor (6) 6
aristolochic acids - toxicity (5) 5
carcinogens - toxicity (5) 5
dna adducts - metabolism (5) 5
genetic research (5) 5
liver - metabolism (5) 5
metabolism (5) 5
mice, knockout (5) 5
nadh/quinone oxidoreductase (5) 5
rats, wistar (5) 5
aristolochic acid (4) 4
chemistry (4) 4
chemistry, multidisciplinary (4) 4
cytochrome (4) 4
cytochrome p-450 cyp1a1 - metabolism (4) 4
cytochrome p-450 cyp1a2 (4) 4
cytochrome p450 (4) 4
cytochromes p450 1a1 (4) 4
dna (4) 4
dna adduct formation (4) 4
dna-adducts (4) 4
female (4) 4
inorganic chemistry (4) 4
liver - enzymology (4) 4
microsomes, liver - metabolism (4) 4
organic chemistry (4) 4
p-32 postlabeling analysis (4) 4
rodents (4) 4
acids (3) 3
activation (3) 3
anticancer drug ellipticine (3) 3
aristolactam-dna adducts (3) 3
aristolochic acid i (3) 3
aristolochic acids - pharmacokinetics (3) 3
biochemistry & molecular biology (3) 3
biology (3) 3
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cancer (3) 3
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carcinogens - metabolism (3) 3
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cytochrome p-450 cyp1a1 - genetics (3) 3
deoxyribonucleic acid--dna (3) 3
dna adducts - drug effects (3) 3
endocrinology & metabolism (3) 3
environmental health (3) 3
gene-expression (3) 3
genetics & heredity (3) 3
inactivation, metabolic (3) 3
kidney - drug effects (3) 3
kidney - metabolism (3) 3
law, ancient (3) 3
metabolic activation (3) 3
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molecular biology (3) 3
nadh dehydrogenase (3) 3
neurosciences (3) 3
occupational medicine/industrial medicine (3) 3
oxidation-reduction (3) 3
pharmacology/toxicology (3) 3
prostaglandin-h synthase (3) 3
protein expression (3) 3
research (3) 3
advance directive (2) 2
analysis (2) 2
aristolochic acids - urine (2) 2
base sequence (2) 2
benzopyrene (2) 2
binding sites (2) 2
biomedicine, general (2) 2
biotechnology & applied microbiology (2) 2
biotransformation (2) 2
body weight (2) 2
carcinogen (2) 2
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2012, 1., ISBN 3902811633
Book
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2015, Volume 16, Issue 11, pp. 27561 - 27575
...  Article Marie Stiborov 1,*, Frantiek Brta 1, Kateina Levov 1, Petr Hodek 1, Heinz H. Schmeiser 2, Volker M. Arlt 3 and Vclav Martnek 1,* Received: 14 October... 
Plant nephrotoxin and carcinogen aristolochic acid I | Cytochrome P450-mediated detoxification of aristolochic acid I | Molecular modeling | Contribution of cytochromes P450 in detoxification of aristolochic acid I in human and rat livers | cytochrome P450-mediated detoxification of aristolochic acid I | ANTICANCER DRUG ELLIPTICINE | UROTHELIAL CANCER | SUDAN-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | NAD(P)H/QUINONE OXIDOREDUCTASE | METABOLIC-ACTIVATION | P-32 POSTLABELING ANALYSIS | DNA ADDUCT FORMATION | CHEMISTRY, MULTIDISCIPLINARY | RENAL TISSUE | RISK-FACTOR | molecular modeling | contribution of cytochromes P450 in detoxification of aristolochic acid I in human and rat livers | REDUCTIVE ACTIVATION | plant nephrotoxin and carcinogen aristolochic acid I | Activation, Metabolic | Inactivation, Metabolic | Humans | Microsomes, Liver - metabolism | Molecular Conformation | Cytochrome P-450 Enzyme System - metabolism | Male | Liver - drug effects | Microsomes, Liver - drug effects | Oxidation-Reduction - drug effects | Catalysis | Kidney Diseases - metabolism | Catalytic Domain | Liver - metabolism | Models, Molecular | Rats | Aristolochic Acids - adverse effects | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Cytochrome P-450 Enzyme System - chemistry | Animals | Aristolochic Acids - metabolism | Methylation - drug effects | Protein Binding | Aristolochic Acids - chemistry | Kidney Diseases - etiology | Cytochrome | Chemical reactions | Acids | Rodents | Liver
Journal Article
Journal Article
Archives of toxicology, ISSN 1432-0738, 2016, Volume 91, Issue 4, pp. 1957 - 1975
... Stiborova 3 · Heinz H. Schmeiser 6 Received: 4 June 2016 / Accepted: 4 August 2016 / Published online: 24 August 2016 © The Author(s) 2016. This article is published... 
Biomedicine, general | Biomedicine | Environmental Health | 3-Nitrobenzanthrone | Occupational Medicine/Industrial Medicine | Carcinogen metabolism | DNA adducts | Pharmacology/Toxicology | Balkan endemic nephropathy | Aristolochic acid nephropathy | Sulfotransferase 1A1 | CARCINOGENIC AIR-POLLUTANT | UROTHELIAL CANCER | SALMONELLA-TYPHIMURIUM STRAINS | METABOLIC-ACTIVATION | CHINESE HERBS NEPHROPATHY | HUMAN CANCER HAZARD | ENVIRONMENTAL CONTAMINANT 3-NITROBENZANTHRONE | REDUCTASE NULL HRN | CYTOCHROMES P450 1A1/2 | TOXICOLOGY | HUMAN SULFOTRANSFERASES | Multigene Family | Kidney - drug effects | DNA Adducts - drug effects | Benz(a)Anthracenes - toxicity | Humans | Liver - metabolism | Cytosol - drug effects | Male | Mice, Transgenic | Arylsulfotransferase - genetics | Carcinogens - toxicity | Mice, Knockout | Kidney - metabolism | Animals | Liver - drug effects | Cytosol - metabolism | DNA Adducts - genetics | Mice | Aristolochic Acids - toxicity | Genetic research | Physiological aspects | Enzymes | Genetic engineering | Kidney diseases | DNA | Nephrology | Acids | Deoxyribonucleic acid--DNA | Index Medicus | Genotoxicity and Carcinogenicity | Hälsovetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Arbetsmedicin och miljömedicin | Health Sciences | Environmental Health and Occupational Health
Journal Article
Archives of Toxicology, ISSN 0340-5761, 11/2015, Volume 89, Issue 11, pp. 2141 - 2158
Journal Article
Archives of Toxicology, ISSN 0340-5761, 04/2018, Volume 92, Issue 4, pp. 1625 - 1638
Benzo[ a ]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic... 
Genotoxicity and Carcinogenicity
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 9/2010, Volume 74, Issue 1, pp. 61 - 75
... • Jennifer Popko • Philippe Schmitt-Kopplin • Barbara Ehlting • Heinz Rennenberg • Csengele Barta • Francesco Loreto • Jo ¨rg-Peter Schnitzler Received: 10 December 2009... 
Life Sciences | Plant Pathology | Biochemistry, general | H 2 O 2 | Phenolic compounds | Plant Sciences | Populus x canescens | Isoprene | Environmental stress | H | Populus xcanescens | O | BIOCHEMISTRY & MOLECULAR BIOLOGY | LEAVES | DROUGHT | H2O2 | INCREASES THERMOTOLERANCE | PLANT SCIENCES | NORWAY SPRUCE | PATHWAY | BIOSYNTHESIS | OZONE | PLANTS | ARABIDOPSIS | ABSCISIC-ACID | Genes, Plant | Down-Regulation | Carbohydrate Metabolism | Stress, Physiological | Metabolome | DNA Primers - genetics | Gene Expression Profiling | Populus - genetics | Hot Temperature | Phenols - metabolism | Hemiterpenes - genetics | Hydrogen Peroxide - metabolism | Hemiterpenes - metabolism | Terpenes - metabolism | RNA Interference | Droughts | Models, Biological | Base Sequence | Butadienes - metabolism | Light | Plants, Genetically Modified | Populus - metabolism | Seasons | Pentanes - metabolism | Anthocyanin | Enzymes | Hydrogen peroxide | Chromophores | Gene expression | Chemotherapy | Anopheles | Particle accelerators | Metabolites | Phytochemistry | Photosynthesis | Mass spectrometry | Cancer | Plant biology | Oxidative stress | Ribonucleic acid--RNA | Molecular biology | Metabolism | Chemical compounds | Tannic acid | Transcription | Membrane structure | phenolic compounds | Genomes | Leaves | Signal transduction | Temperature effects | metabolomics | Light intensity | Genotypes | phenylpropanoids | Mass spectroscopy | Stomata | Light effects | DNA microarrays | Anthocyanins
Journal Article
1999, Schriftenreihe Recht der Medizin, ISBN 321406598X, Volume Bd. 6, 77
Book
Toxicological sciences, ISSN 1096-0929, 2012, Volume 125, Issue 2, pp. 345 - 358
Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. Individual susceptibility to AA-induced disease likely reflects... 
Aristolochic acid ia | Cytochrome P450 | Cyp1a-humanized mouse models | Balkan endemic nephropathy | Metabolism | Aristolochic acid nephropathy | Dna adducts | aristolochic acid nephropathy | DNA-ADDUCTS | P450 1A1 | PHASE-II | METABOLIC-ACTIVATION | cytochrome P450 | MOUSE LINE | RISK-FACTOR | REDUCTIVE ACTIVATION | GENE-EXPRESSION | metabolism | TOXICOLOGY | DNA adducts | CYP1A-humanized mouse models | aristolochic acid Ia | CHINESE HERBS | Cytochrome P-450 CYP1A1 - genetics | Inactivation, Metabolic | Liver - enzymology | Humans | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Chromatography, High Pressure Liquid | Carcinogens - metabolism | Aristolochic Acids - urine | DNA Adducts - metabolism | Carcinogens - toxicity | Cytochrome P-450 CYP1A2 Inhibitors | Cytosol - enzymology | Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Female | Microsomes, Liver - enzymology | Aristolochic Acids - toxicity | Recombinant Proteins - metabolism | Oxidation-Reduction | Dealkylation | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Urologic Neoplasms - chemically induced | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Mice, Knockout | Animals | Aristolochic Acids - metabolism | Mice | Urothelium - drug effects | Index Medicus | Biotransformation and Toxicokinetics
Journal Article
Toxicology, ISSN 0300-483X, 2016, Volume 344-346, pp. 7 - 18
Highlights • Oxidation and reduction of aristolochic acid I (AAI) dictate its (geno)toxicity in vivo. • Cytochrome P450 (CYP) 1A1 and 1A2 are induced in rats... 
Emergency | Aristolochic acid I | Cytochromes P450 1A1 and 1A2 | DNA adducts | Oxidative detoxification | Reductive activation | UROTHELIAL CANCER | NAD(P)H/QUINONE OXIDOREDUCTASE | METABOLIC-ACTIVATION | P-32 POSTLABELING ANALYSIS | CHINESE HERBS NEPHROPATHY | MASS-SPECTROMETRY | 1-PHENYLAZO-2-NAPHTHOL SUDAN-I | BALKAN ENDEMIC NEPHROPATHY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | LIVER-MICROSOMES | Animals | Cytochrome P-450 CYP1A2 - biosynthesis | Rats, Wistar | DNA Adducts - antagonists & inhibitors | Enzyme Induction - drug effects | Rats | Male | Cytochrome P-450 CYP1A1 - biosynthesis | Enzyme Induction - physiology | Aristolochic Acids - toxicity | DNA Adducts - biosynthesis | Carcinogens - toxicity | DNA | Cytochrome P-450 | Metabolites | Liver | Cellulose | Physiological aspects | Genetic research | Enzymes | Kidneys | Lungs | Formations | Adducts | Cytochromes P450 | AAII, aristolochic acid II | UUC, upper urothelial tract carcinoma | dA-AAI, 7-deoxyadenosine-N6-yl)aristolactam I | AAIa, aristolochic acid Ia | cT, cycle threshold | HPLC, high performance liquid chromatography | HUFs, Hupki (human TP53 knock-in) mouse fibroblasts | r.t., retention time | dG-AAI, 7-deoxyguanosin-N2-yl)aristolactam I | MROD, methoxyresorufin O-demethylation | SD, standard deviation | NQO1, NAD(P)H:quinone oxidoreductase | CYP, cytochrome P450 | BEN, Balkan endemic nephropathy | dA-AAII, 7-deoxyadenosine-N6-yl)aristolactam II | POR, P450 oxidoreductase | PEI-cellulose, polyethylenimine-cellulose | RT-PCR, real-time polymerase chain reaction | AA, aristolochic acid | AAI, aristolochic acid I | UV–vis, ultraviolet–visible | bw, body weight | AAN, aristolochic acid nephropathy | RAL, relative adduct labeling | TLC, thin-layer chromatography
Journal Article
Theoretical Chemistry Accounts, ISSN 1432-881X, 3/2010, Volume 125, Issue 3, pp. 583 - 591
Journal Article